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المؤلفون: Giardina SF; Department of Microbiology and Immunology, Weill Cornell Medicine, 1300 York Avenue, Box 62, New York, New York 10065, United States., Werner DS; Coferon, Inc., 25 Health Sciences Drive, Mailbox 123, Stony Brook, New York 11790, United States., Pingle M; Department of Microbiology and Immunology, Weill Cornell Medicine, 1300 York Avenue, Box 62, New York, New York 10065, United States.; Coferon, Inc., 25 Health Sciences Drive, Mailbox 123, Stony Brook, New York 11790, United States., Feinberg PB; Department of Microbiology and Immunology, Weill Cornell Medicine, 1300 York Avenue, Box 62, New York, New York 10065, United States., Foreman KW; Coferon, Inc., 25 Health Sciences Drive, Mailbox 123, Stony Brook, New York 11790, United States., Bergstrom DE; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall, West Lafa-yette, Indiana 47907, United States., Arnold LD; Coferon, Inc., 25 Health Sciences Drive, Mailbox 123, Stony Brook, New York 11790, United States., Barany F; Department of Microbiology and Immunology, Weill Cornell Medicine, 1300 York Avenue, Box 62, New York, New York 10065, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2020 Mar 26; Vol. 63 (6), pp. 3004-3027. Date of Electronic Publication: 2020 Feb 27.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Protease Inhibitors/*chemistry , Protease Inhibitors/*pharmacology , Tryptases/*antagonists & inhibitors, Animals ; Boronic Acids/chemistry ; Boronic Acids/pharmacology ; Crystallography, X-Ray ; Female ; Humans ; Mice ; Molecular Docking Simulation ; Protein Conformation/drug effects ; Protein Multimerization/drug effects ; Tryptases/chemistry ; Tryptases/metabolism

المؤلفون: Giardina SF; Department of Microbiology and Immunology, Weill Cornell Medicine, 1300 York Avenue, Box 62, New York, New York 10065, United States., Werner DS; Coferon, Inc., 25 Health Sciences Drive, Mailbox 123, Stony Brook, New York 11790, United States., Pingle M; Department of Microbiology and Immunology, Weill Cornell Medicine, 1300 York Avenue, Box 62, New York, New York 10065, United States.; Coferon, Inc., 25 Health Sciences Drive, Mailbox 123, Stony Brook, New York 11790, United States., Foreman KW; Coferon, Inc., 25 Health Sciences Drive, Mailbox 123, Stony Brook, New York 11790, United States., Bergstrom DE; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall, West Lafayette, Indiana 47907, United States., Arnold LD; Coferon, Inc., 25 Health Sciences Drive, Mailbox 123, Stony Brook, New York 11790, United States., Barany F; Department of Microbiology and Immunology, Weill Cornell Medicine, 1300 York Avenue, Box 62, New York, New York 10065, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Jul 05; Vol. 9 (8), pp. 827-831. Date of Electronic Publication: 2018 Jul 05 (Print Publication: 2018).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Giardina SF; Department of Microbiology and Immunology, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York, USA, sfg2001@med.cornell.edu., Werner DS; Coferon, Inc., 25 Health Sciences Drive, Stony Brook, New York, USA.; BlinkBio, Inc., The Scripps Research Institute, Jupiter, Florida, USA., Pingle M; Department of Microbiology and Immunology, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York, USA.; Coferon, Inc., 25 Health Sciences Drive, Stony Brook, New York, USA.; BlinkBio, Inc., The Scripps Research Institute, Jupiter, Florida, USA., Bergstrom DE; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, USA., Arnold LD; Coferon, Inc., 25 Health Sciences Drive, Stony Brook, New York, USA.; Fount Therapeutics, LLC, Wilmington, Delaware, USA., Barany F; Department of Microbiology and Immunology, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York, USA.

المصدر: Pharmacology [Pharmacology] 2018; Vol. 102 (5-6), pp. 233-243. Date of Electronic Publication: 2018 Aug 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Karger Country of Publication: Switzerland NLM ID: 0152016 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0313 (Electronic) Linking ISSN: 00317012 NLM ISO Abbreviation: Pharmacology Subsets: MEDLINE

مواضيع طبية MeSH: Mast Cells/*drug effects , Silanes/*chemistry , Silanes/*pharmacology , Tryptases/*antagonists & inhibitors, Animals ; Cell Line ; Crystallography, X-Ray ; Dose-Response Relationship, Drug ; Drug Design ; Humans ; Immunohistochemistry ; Male ; Mast Cells/enzymology ; Mast Cells/pathology ; Mice ; Mice, Inbred C57BL ; Models, Molecular ; Molecular Structure ; Pharmacokinetics ; Silanes/analysis ; Silanes/pharmacokinetics

المؤلفون: Wanner J; Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America., Romashko D; Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America., Werner DS; Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America., May EW; Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America., Peng Y; Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America., Schulz R; Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America., Foreman KW; Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America., Russo S; Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America., Arnold LD; Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America., Pingle M; Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America., Bergstrom DE; Purdue University, West Lafayette, Indiana, United States of America., Barany F; Department of Microbiology, Weill Cornell Medical College, New York, New York, United States of America., Thomson S; Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America.

المصدر: PloS one [PLoS One] 2015 Apr 15; Vol. 10 (4), pp. e0121793. Date of Electronic Publication: 2015 Apr 15 (Print Publication: 2015).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/*genetics , Cell Proliferation/*drug effects , Neoplasms/*genetics , Proto-Oncogene Proteins c-myc/*biosynthesis, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/biosynthesis ; Cell Line, Tumor ; Drug Design ; Gene Expression Regulation, Neoplastic/drug effects ; Glycols/chemistry ; Humans ; Ligands ; Neoplasms/drug therapy ; Protein Interaction Maps/drug effects ; Proto-Oncogene Proteins c-myc/antagonists & inhibitors ; Proto-Oncogene Proteins c-myc/genetics ; RNA, Messenger/biosynthesis ; Small Molecule Libraries/administration & dosage

المؤلفون: Crew AP; OSI Oncology, OSI Pharmaceuticals, Inc, 1 Bioscience Park Drive, Farmingdale, NY 11735, USA. acrew@osip.com, Bhagwat SV, Dong H, Bittner MA, Chan A, Chen X, Coate H, Cooke A, Gokhale PC, Honda A, Jin M, Kahler J, Mantis C, Mulvihill MJ, Tavares-Greco PA, Volk B, Wang J, Werner DS, Arnold LD, Pachter JA, Wild R, Gibson NW

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Apr 01; Vol. 21 (7), pp. 2092-7. Date of Electronic Publication: 2011 Feb 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Imidazoles/*pharmacology , Proteins/*antagonists & inhibitors , Pyrazines/*pharmacology , Transcription Factors/*antagonists & inhibitors, Administration, Oral ; Cell Line, Tumor ; Humans ; Imidazoles/administration & dosage ; Mechanistic Target of Rapamycin Complex 1 ; Models, Molecular ; Multiprotein Complexes ; Pyrazines/administration & dosage ; TOR Serine-Threonine Kinases ; Xenograft Model Antitumor Assays

المؤلفون: Jin M; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Gokhale PC; OSI Oncology, OSI Pharmaceuticals, Inc., 2860 Wilderness Place, Boulder, Colorado 80301., Cooke A; OSI Oncology, OSI Pharmaceuticals, Inc., 2860 Wilderness Place, Boulder, Colorado 80301., Foreman K; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Buck E; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., May EW; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Feng L; OSI Oncology, OSI Pharmaceuticals, Inc., 2860 Wilderness Place, Boulder, Colorado 80301., Bittner MA; OSI Oncology, OSI Pharmaceuticals, Inc., 2860 Wilderness Place, Boulder, Colorado 80301., Kadalbajoo M; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Landfair D; OSI Oncology, OSI Pharmaceuticals, Inc., 2860 Wilderness Place, Boulder, Colorado 80301., Siu KW; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Stolz KM; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Werner DS; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Laufer RS; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Li AH; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Dong H; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Steinig AG; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Kleinberg A; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Yao Y; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Pachter JA; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Wild R; OSI Oncology, OSI Pharmaceuticals, Inc., 2860 Wilderness Place, Boulder, Colorado 80301., Mulvihill MJ; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2010 Aug 30; Vol. 1 (9), pp. 510-5. Date of Electronic Publication: 2010 Aug 30 (Print Publication: 2010).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE