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المؤلفون: Lazear MR; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Remsberg JR; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA. Electronic address: remsberg@scripps.edu., Jaeger MG; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Rothamel K; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Her HL; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., DeMeester KE; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Njomen E; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Hogg SJ; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Rahman J; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Whitby LR; Vividion Therapeutics, 5820 Nancy Ridge Drive, San Diego, CA 92121, USA., Won SJ; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Schafroth MA; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Ogasawara D; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Yokoyama M; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Lindsey GL; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Li H; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Germain J; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Barbas S; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Vaughan J; Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, CA, USA., Hanigan TW; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Vartabedian VF; Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037, USA., Reinhardt CJ; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Dix MM; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Koo SJ; Molecular and Cellular Pharmacology, Discovery Technologies and Molecular Pharmacology, Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Heo I; Molecular and Cellular Pharmacology, Discovery Technologies and Molecular Pharmacology, Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Teijaro JR; Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037, USA., Simon GM; Vividion Therapeutics, 5820 Nancy Ridge Drive, San Diego, CA 92121, USA., Ghosh B; Discovery Chemistry, Janssen Research & Development, Spring House, PA 19477, USA., Abdel-Wahab O; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Ahn K; Molecular and Cellular Pharmacology, Discovery Technologies and Molecular Pharmacology, Janssen Research and Development, Spring House, PA 19477, USA., Saghatelian A; Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, CA, USA., Melillo B; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA., Schreiber SL; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Yeo GW; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Cravatt BF; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA. Electronic address: cravatt@scripps.edu.

المصدر: Molecular cell [Mol Cell] 2023 May 18; Vol. 83 (10), pp. 1725-1742.e12. Date of Electronic Publication: 2023 Apr 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Proteomics*/methods , Transcription Factors*, Humans ; Cysteine/metabolism ; Ligands

المؤلفون: Kavanagh ME; Department of Chemistry, Scripps Research, La Jolla, CA, USA., Horning BD; Vividion Therapeutics, San Diego, CA, USA., Khattri R; Vividion Therapeutics, San Diego, CA, USA., Roy N; Vividion Therapeutics, San Diego, CA, USA., Lu JP; Vividion Therapeutics, San Diego, CA, USA., Whitby LR; Vividion Therapeutics, San Diego, CA, USA., Ye E; Department of Chemistry, Scripps Research, La Jolla, CA, USA., Brannon JC; Vividion Therapeutics, San Diego, CA, USA., Parker A; Vividion Therapeutics, San Diego, CA, USA., Chick JM; Vividion Therapeutics, San Diego, CA, USA., Eissler CL; Vividion Therapeutics, San Diego, CA, USA., Wong AJ; Vividion Therapeutics, San Diego, CA, USA., Rodriguez JL; Vividion Therapeutics, San Diego, CA, USA., Rodiles S; Vividion Therapeutics, San Diego, CA, USA., Masuda K; Department of Chemistry, Scripps Research, La Jolla, CA, USA., Teijaro JR; Department of Immunology and Microbial Science, Scripps Research, La Jolla, CA, USA., Simon GM; Vividion Therapeutics, San Diego, CA, USA., Patricelli MP; Vividion Therapeutics, San Diego, CA, USA. mattp@vividion.com., Cravatt BF; Department of Chemistry, Scripps Research, La Jolla, CA, USA. cravatt@scripps.edu.

المصدر: Nature chemical biology [Nat Chem Biol] 2022 Dec; Vol. 18 (12), pp. 1388-1398. Date of Electronic Publication: 2022 Sep 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Cysteine* , Proteomics*, Signal Transduction ; Cytokines ; Protein Isoforms

المؤلفون: Kavanagh ME; Department of Chemistry, Scripps Research, La Jolla, CA, USA., Horning BD; Vividion Therapeutics, San Diego, CA, USA., Khattri R; Vividion Therapeutics, San Diego, CA, USA., Roy N; Vividion Therapeutics, San Diego, CA, USA., Lu JP; Vividion Therapeutics, San Diego, CA, USA., Whitby LR; Vividion Therapeutics, San Diego, CA, USA., Ye E; Department of Chemistry, Scripps Research, La Jolla, CA, USA., Brannon JC; Vividion Therapeutics, San Diego, CA, USA., Parker A; Vividion Therapeutics, San Diego, CA, USA., Chick JM; Vividion Therapeutics, San Diego, CA, USA., Eissler CL; Vividion Therapeutics, San Diego, CA, USA., Wong AJ; Vividion Therapeutics, San Diego, CA, USA., Rodriguez JL; Vividion Therapeutics, San Diego, CA, USA., Rodiles S; Vividion Therapeutics, San Diego, CA, USA., Masuda K; Department of Chemistry, Scripps Research, La Jolla, CA, USA., Teijaro JR; Department of Immunology and Microbial Science, Scripps Research, La Jolla, CA, USA., Simon GM; Vividion Therapeutics, San Diego, CA, USA., Patricelli MP; Vividion Therapeutics, San Diego, CA, USA. mattp@vividion.com., Cravatt BF; Department of Chemistry, Scripps Research, La Jolla, CA, USA. cravatt@scripps.edu.

المصدر: Nature chemical biology [Nat Chem Biol] 2022 Nov; Vol. 18 (11), pp. 1288.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Plewe MB; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego, CA 92054, United States., Whitby LR; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States., Naik S; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego, CA 92054, United States., Brown ER; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego, CA 92054, United States., Sokolova NV; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego, CA 92054, United States., Gantla VR; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego, CA 92054, United States., York J; Montana Biotechnology Center, The University of Montana, Missoula, MT 59812, United States., Nunberg JH; Montana Biotechnology Center, The University of Montana, Missoula, MT 59812, United States., Zhang L; Department of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, United States., Kalveram B; Department of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, United States., Freiberg AN; Department of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, United States; Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch, Galveston, TX 77555, United States., Boger DL; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States., Henkel G; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego, CA 92054, United States., McCormack K; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego, CA 92054, United States. Electronic address: kenm@arisanthera.com.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 Nov 15; Vol. 29 (22), pp. 126620. Date of Electronic Publication: 2019 Aug 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents/*pharmacology , Arenavirus/*drug effects , Piperazines/*pharmacology , Viral Envelope Proteins/*antagonists & inhibitors, Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Arenavirus/metabolism ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests ; Molecular Structure ; Piperazines/chemical synthesis ; Piperazines/chemistry ; Structure-Activity Relationship ; Viral Envelope Proteins/metabolism

المؤلفون: Whitby LR; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute , 10550 N. Torrey Pines Rd., La Jolla, California 92307, United States., Obach RS; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States., Simon GM; Vividion Therapeutics , 3033 Science Park Rd Suite D, San Diego, California 92121, United States., Hayward MM; Pfizer Worldwide Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States., Cravatt BF; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute , 10550 N. Torrey Pines Rd., La Jolla, California 92307, United States.

المصدر: ACS chemical biology [ACS Chem Biol] 2017 Aug 18; Vol. 12 (8), pp. 2040-2050. Date of Electronic Publication: 2017 Jun 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Chemical and Drug Induced Liver Injury* , Drug Delivery Systems* , Proteogenomics*, Acetaminophen/*toxicity , Hepatocytes/*drug effects, Acetaminophen/chemistry ; Acetaminophen/pharmacology ; Animals ; Liver/injuries ; Mice ; Molecular Structure

المؤلفون: Zaro BW; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Whitby LR; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Lum KM; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Cravatt BF; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2016 Dec 14; Vol. 138 (49), pp. 15841-15844. Date of Electronic Publication: 2016 Dec 05.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Fumarates/*metabolism , Protein Kinase Inhibitors/*pharmacology , Protein-Tyrosine Kinases/*antagonists & inhibitors , Pyrazoles/*pharmacology , Pyrimidines/*pharmacology, Adenine/analogs & derivatives ; Cells, Cultured ; Fumarates/chemistry ; HEK293 Cells ; Humans ; Kinetics ; Molecular Structure ; Piperidines ; Protein Kinase Inhibitors/chemistry ; Protein-Tyrosine Kinases/metabolism ; Pyrazoles/chemistry ; Pyrazoles/metabolism ; Pyrimidines/chemistry ; Pyrimidines/metabolism ; Structure-Activity Relationship

المؤلفون: Shankar S; Montana Biotechnology Center, The University of Montana, Missoula, Montana, USA Division of Biological Sciences, The University of Montana, Missoula, Montana, USA., Whitby LR; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA., Casquilho-Gray HE; Montana Biotechnology Center, The University of Montana, Missoula, Montana, USA., York J; Montana Biotechnology Center, The University of Montana, Missoula, Montana, USA., Boger DL; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA., Nunberg JH; Montana Biotechnology Center, The University of Montana, Missoula, Montana, USA jack.nunberg@umontana.edu.

المصدر: Journal of virology [J Virol] 2016 Jul 11; Vol. 90 (15), pp. 6799-807. Date of Electronic Publication: 2016 Jul 11 (Print Publication: 2016).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE

مواضيع طبية MeSH: Protein Sorting Signals*, Antiviral Agents/*pharmacology , Membrane Fusion/*drug effects , Small Molecule Libraries/*pharmacology , Viral Envelope Proteins/*metabolism , Virus Internalization/*drug effects, Animals ; Chlorocebus aethiops ; Humans ; Hydrogen-Ion Concentration ; Lassa virus ; Protein Subunits ; Vero Cells ; Viral Envelope Proteins/chemistry

المؤلفون: Wang Y; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390;, Su L; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390;, Morin MD; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037;, Jones BT; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037;, Whitby LR; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037;, Surakattula MM; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037;, Huang H; Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037., Shi H; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390;, Choi JH; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390;, Wang KW; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390;, Moresco EM; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390;, Berger M; Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037., Zhan X; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390;, Zhang H; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390; Bruce.Beutler@UTSouthwestern.edu boger@scripps.edu zhang@chop.swmed.edu., Boger DL; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037; Bruce.Beutler@UTSouthwestern.edu boger@scripps.edu zhang@chop.swmed.edu., Beutler B; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390; Bruce.Beutler@UTSouthwestern.edu boger@scripps.edu zhang@chop.swmed.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Feb 16; Vol. 113 (7), pp. E884-93. Date of Electronic Publication: 2016 Feb 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Lipopolysaccharides/*pharmacology , Lymphocyte Antigen 96/*agonists , Peptidomimetics/*pharmacology , Toll-Like Receptor 4/*agonists, Animals ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mitogen-Activated Protein Kinases/metabolism ; NF-kappa B/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Signal Transduction

المؤلفون: Lanning BR; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Rd. La Jolla, CA, 92307., Whitby LR; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Rd. La Jolla, CA, 92307., Dix MM; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Rd. La Jolla, CA, 92307., Douhan J; Pfizer Worldwide Research and Development, 200 Cambridge Park Drive, Cambridge, MA 02140., Gilbert AM; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340., Hett EC; Pfizer Worldwide Research and Development, 200 Cambridge Park Drive, Cambridge, MA 02140., Johnson TO; Pfizer Worldwide Research and Development, 10770 Science Park Drive, San Diego, CA 92121., Joslyn C; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Rd. La Jolla, CA, 92307., Kath JC; Pfizer Worldwide Research and Development, 10770 Science Park Drive, San Diego, CA 92121., Niessen S; Pfizer Worldwide Research and Development, 10770 Science Park Drive, San Diego, CA 92121., Roberts LR; Pfizer Worldwide Research and Development, 200 Cambridge Park Drive, Cambridge, MA 02140., Schnute ME; Pfizer Worldwide Research and Development, 200 Cambridge Park Drive, Cambridge, MA 02140., Wang C; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Rd. La Jolla, CA, 92307., Hulce JJ; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Rd. La Jolla, CA, 92307., Wei B; Pfizer Worldwide Research and Development, 1 Burtt Rd, Andover, MA 01810., Whiteley LO; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340., Hayward MM; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340., Cravatt BF; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Rd. La Jolla, CA, 92307.

المصدر: Nature chemical biology [Nat Chem Biol] 2014 Sep; Vol. 10 (9), pp. 760-767. Date of Electronic Publication: 2014 Jul 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Protein Kinase Inhibitors/*pharmacology , Proteome/*genetics, Adenine/analogs & derivatives ; Agammaglobulinaemia Tyrosine Kinase ; Cell Line, Tumor ; Cell Survival/drug effects ; Cysteine/chemistry ; Genes, erbB-1/genetics ; Humans ; Kinetics ; Piperidines ; Protein Kinases/metabolism ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; Signal Transduction/drug effects ; Signal Transduction/genetics