المؤلفون: Olsen RR; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA., Ireland AS; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA., Kastner DW; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA., Groves SM; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37212, USA., Spainhower KB; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA., Pozo K; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., Kelenis DP; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., Whitney CP; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA., Guthrie MR; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA., Wait SJ; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA., Soltero D; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA., Witt BL; Department of Pathology, University of Utah, Salt Lake City, Utah 84112, USA.; ARUP Laboratories at University of Utah, Salt Lake City, Utah 84108, USA., Quaranta V; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37212, USA., Johnson JE; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.; Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., Oliver TG; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA.

المصدر: Genes & development [Genes Dev] 2021 Jun; Vol. 35 (11-12), pp. 847-869. Date of Electronic Publication: 2021 May 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 8711660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-5477 (Electronic) Linking ISSN: 08909369 NLM ISO Abbreviation: Genes Dev Subsets: MEDLINE

مواضيع طبية MeSH: Basic Helix-Loop-Helix Transcription Factors/*genetics , Basic Helix-Loop-Helix Transcription Factors/*metabolism , SOX9 Transcription Factor/*genetics , Small Cell Lung Carcinoma/*genetics, Animals ; Animals, Genetically Modified ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Mice ; Neural Crest/cytology ; Small Cell Lung Carcinoma/physiopathology ; Stem Cells/cytology

المؤلفون: Dammert MA; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany., Brägelmann J; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany.; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, 50931, Cologne, Germany., Olsen RR; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA., Böhm S; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany., Monhasery N; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany., Whitney CP; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA., Chalishazar MD; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA., Tumbrink HL; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany., Guthrie MR; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA., Klein S; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany.; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, 50931, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany., Ireland AS; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA., Ryan J; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA., Schmitt A; Department I of Internal Medicine, University Hospital of Cologne, 50931, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, 50931, Cologne, Germany., Marx A; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany., Ozretić L; Department of Cellular Pathology, Royal Free Hospital, London, NW3 2QG, UK., Castiglione R; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, 50931, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany., Lorenz C; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany., Jachimowicz RD; Department I of Internal Medicine, University Hospital of Cologne, 50931, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, 50931, Cologne, Germany., Wolf E; Theodor Boveri Institute, Biocenter, University of Würzburg, 97074, Würzburg, Germany., Thomas RK; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany., Poirier JT; Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Büttner R; Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany., Sen T; Department of Thoracic and Head & Neck Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, 77030, USA., Byers LA; Department of Thoracic and Head & Neck Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, 77030, USA., Reinhardt HC; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, 50931, Cologne, Germany.; Department I of Internal Medicine, University Hospital of Cologne, 50931, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, 50931, Cologne, Germany., Letai A; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA., Oliver TG; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA. trudy.oliver@hci.utah.edu., Sos ML; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany. martin.sos@uni-koeln.de.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany. martin.sos@uni-koeln.de.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany. martin.sos@uni-koeln.de.

المصدر: Nature communications [Nat Commun] 2019 Aug 02; Vol. 10 (1), pp. 3485. Date of Electronic Publication: 2019 Aug 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis/*genetics , Gene Expression Regulation, Neoplastic/*genetics , Lung Neoplasms/*genetics , Proto-Oncogene Proteins c-myc/*metabolism , Small Cell Lung Carcinoma/*genetics, Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; CRISPR-Cas Systems/genetics ; Cell Line, Tumor ; DNA Damage/drug effects ; DNA Damage/genetics ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic/drug effects ; HEK293 Cells ; Humans ; Lung Neoplasms/drug therapy ; Mice ; Molecular Targeted Therapy/methods ; Proto-Oncogene Proteins c-myc/genetics ; RNA, Small Interfering/metabolism ; Small Cell Lung Carcinoma/drug therapy