المؤلفون: Whitson, RJ, Lee, A, Urman, NM, Mirza, A, Yao, CY, Brown, AS, Li, JR, Shankar, G, Fry, MA, Atwood, SX, Lee, EY, Hollmig, ST, Aasi, SZ, Sarin, KY, Scott, MP, Epstein, EH, Tang, JY, Oro, AE

المصدر: Whitson, RJ; Lee, A; Urman, NM; Mirza, A; Yao, CY; Brown, AS; et al.(2018). Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas. Nature Medicine, 24(3), 271-281. doi: 10.1038/nm.4476. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8hs9c3sv

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od_______325::93553ba47d1b5fc46da3b0f02f345fa5
http://www.escholarship.org/uc/item/8hs9c3sv

المؤلفون: Yao CD; Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA, 94305, USA., Haensel D; Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA, 94305, USA., Gaddam S; Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA, 94305, USA., Patel T; Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA, 94305, USA., Atwood SX; Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA, 94305, USA.; Department of Developmental and Cell Biology, University of California, Irvine, USA., Sarin KY; Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA, 94305, USA., Whitson RJ; Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA, 94305, USA.; Genomics Institute of the Novartis Research Foundation, La Jolla, CA, USA., McKellar S; Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA, 94305, USA.; University of Washington School of Medicine, Seattle, WA, 98195, USA., Shankar G; Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA, 94305, USA.; Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA., Aasi S; Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA, 94305, USA., Rieger K; Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA, 94305, USA., Oro AE; Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA, 94305, USA. oro@stanford.edu.

المصدر: Nature communications [Nat Commun] 2020 Oct 08; Vol. 11 (1), pp. 5079. Date of Electronic Publication: 2020 Oct 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Signal Transduction*, Carcinoma, Basal Cell/*metabolism , Hedgehog Proteins/*metabolism , Skin Neoplasms/*metabolism , Transcription Factor AP-1/*metabolism , Transforming Growth Factor beta/*metabolism, Animals ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Chromatin/metabolism ; DNA, Neoplasm/metabolism ; Drug Resistance, Neoplasm ; Extracellular Matrix/metabolism ; Gene Ontology ; Guanine Nucleotide Exchange Factors/metabolism ; Hair Follicle/metabolism ; Humans ; Mice ; Mice, Inbred C57BL ; NIH 3T3 Cells ; Neoplasm Proteins/metabolism ; Protein Binding ; Smad3 Protein/metabolism ; Trans-Activators/metabolism ; Up-Regulation

المؤلفون: Kuonen F; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA., Huskey NE; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA., Shankar G; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA., Jaju P; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA., Whitson RJ; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA., Rieger KE; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA., Atwood SX; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA., Sarin KY; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA., Oro AE; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA. Electronic address: oro@stanford.edu.

المصدر: The Journal of investigative dermatology [J Invest Dermatol] 2019 Jul; Vol. 139 (7), pp. 1439-1448. Date of Electronic Publication: 2019 Jan 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1747 (Electronic) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE

مواضيع طبية MeSH: Basal Cell Nevus Syndrome/*metabolism , Carcinoma, Basal Cell/*metabolism , Cilia/*pathology , Extracellular Signal-Regulated MAP Kinases/*metabolism , Hedgehog Proteins/*metabolism , Skin Neoplasms/*metabolism , ras Proteins/*metabolism, Anilides/therapeutic use ; Antineoplastic Agents/therapeutic use ; Basal Cell Nevus Syndrome/genetics ; Basal Cell Nevus Syndrome/pathology ; Carcinogenesis ; Carcinoma, Basal Cell/genetics ; Carcinoma, Basal Cell/pathology ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Hedgehog Proteins/antagonists & inhibitors ; Humans ; Mutation/genetics ; Pyridines/therapeutic use ; Signal Transduction ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology

المؤلفون: Whitson RJ; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Lee A; Children's Hospital Oakland Research Institute, Oakland, California, USA., Urman NM; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Mirza A; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Yao CY; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Brown AS; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Li JR; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Shankar G; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Fry MA; Children's Hospital Oakland Research Institute, Oakland, California, USA., Atwood SX; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA., Lee EY; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Hollmig ST; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Aasi SZ; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Sarin KY; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Scott MP; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Epstein EH Jr; Children's Hospital Oakland Research Institute, Oakland, California, USA., Tang JY; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Oro AE; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA.

المصدر: Nature medicine [Nat Med] 2018 Mar; Vol. 24 (3), pp. 271-281. Date of Electronic Publication: 2018 Feb 05.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Basal Cell/*drug therapy , Drug Resistance, Neoplasm/*genetics , Serum Response Factor/*genetics , Trans-Activators/*genetics , Zinc Finger Protein GLI1/*genetics, Animals ; Carcinoma, Basal Cell/genetics ; Carcinoma, Basal Cell/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Gene Expression Regulation, Neoplastic/genetics ; Hedgehog Proteins ; Humans ; Mice ; Multiprotein Complexes/genetics ; Signal Transduction ; Transcriptional Activation

المؤلفون: Whitson RJ; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA., Oro AE; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: oro@stanford.edu.

المصدر: Cell stem cell [Cell Stem Cell] 2017 Feb 02; Vol. 20 (2), pp. 149-150.

نوع المنشور: Journal Article; Comment

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Squamous Cell* , Soil*, Epigenomics ; Humans ; Prognosis ; Stem Cells

المؤلفون: Urman NM; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America., Mirza A; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America., Atwood SX; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America.; Department of Developmental and Cell Biology, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA, United States of America., Whitson RJ; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America., Sarin KY; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America., Tang JY; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America., Oro AE; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America.

المصدر: PloS one [PLoS One] 2016 Dec 28; Vol. 11 (12), pp. e0168031. Date of Electronic Publication: 2016 Dec 28 (Print Publication: 2016).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Mutation* , Signal Transduction*, Carcinoma, Basal Cell/*metabolism , Hedgehog Proteins/*metabolism , Repressor Proteins/*genetics , Repressor Proteins/*metabolism , Skin Neoplasms/*metabolism, Animals ; Carcinogenesis ; Carcinoma, Basal Cell/genetics ; Carcinoma, Basal Cell/pathology ; Cell Proliferation ; Disease Progression ; HEK293 Cells ; Humans ; Mice ; Models, Molecular ; NIH 3T3 Cells ; Protein Conformation ; Repressor Proteins/chemistry ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Young Adult ; Zinc Finger Protein GLI1/metabolism

المؤلفون: Zhao X; Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Neurobiology, Harvard Medical School, Boston, Massachusetts., Ponomaryov T; Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Neurobiology, Harvard Medical School, Boston, Massachusetts. University of Birmingham, Centre for Cardiovascular Sciences, College of Medical and Dental Sciences, Edgbaston, Birmingham, United Kingdom., Ornell KJ; Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Neurobiology, Harvard Medical School, Boston, Massachusetts., Zhou P; Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Neurobiology, Harvard Medical School, Boston, Massachusetts., Dabral SK; Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Neurobiology, Harvard Medical School, Boston, Massachusetts., Pak E; Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Neurobiology, Harvard Medical School, Boston, Massachusetts., Li W; Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, Massachusetts., Atwood SX; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California., Whitson RJ; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California., Chang AL; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California., Li J; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California., Oro AE; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California., Chan JA; Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada., Kelleher JF; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Segal RA; Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Neurobiology, Harvard Medical School, Boston, Massachusetts. rosalind_segal@dfci.harvard.edu.

المصدر: Cancer research [Cancer Res] 2015 Sep 01; Vol. 75 (17), pp. 3623-35. Date of Electronic Publication: 2015 Jun 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Basal Cell/*genetics , Hedgehog Proteins/*genetics , Medulloblastoma/*genetics , Receptors, G-Protein-Coupled/*biosynthesis , ras Proteins/*genetics, Anilides/administration & dosage ; Animals ; Carcinoma, Basal Cell/drug therapy ; Carcinoma, Basal Cell/pathology ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Medulloblastoma/drug therapy ; Medulloblastoma/pathology ; Mice ; Mitogen-Activated Protein Kinase Kinases/genetics ; Pyridines/administration & dosage ; Receptors, G-Protein-Coupled/antagonists & inhibitors ; Signal Transduction/drug effects ; Smoothened Receptor ; Xenograft Model Antitumor Assays ; ras Proteins/biosynthesis

المؤلفون: Atwood SX; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA., Sarin KY; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA., Whitson RJ; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA., Li JR; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA., Kim G; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA., Rezaee M; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA., Ally MS; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA., Kim J; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA., Yao C; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA., Chang AL; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA., Oro AE; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: oro@stanford.edu., Tang JY; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: tangy@stanford.edu.

المصدر: Cancer cell [Cancer Cell] 2015 Mar 09; Vol. 27 (3), pp. 342-53.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

مواضيع طبية MeSH: Anilides/*therapeutic use , Carcinoma, Basal Cell/*drug therapy , Drug Resistance, Neoplasm/*genetics , Pyridines/*therapeutic use , Receptors, G-Protein-Coupled/*genetics , Skin Neoplasms/*drug therapy, Anilides/chemistry ; Binding Sites ; Carcinoma, Basal Cell/genetics ; Carcinoma, Basal Cell/pathology ; DNA Mutational Analysis ; Exome ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Humans ; Models, Molecular ; Mutation ; Protein Structure, Tertiary ; Pyridines/chemistry ; Receptors, G-Protein-Coupled/chemistry ; Sequence Analysis, DNA ; Signal Transduction ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Smoothened Receptor

المؤلفون: Lambert JR; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Whitson RJ, Iczkowski KA, La Rosa FG, Smith ML, Wilson RS, Smith EE, Torkko KC, Gari HH, Lucia MS

المصدر: The Prostate [Prostate] 2015 Feb 15; Vol. 75 (3), pp. 255-65. Date of Electronic Publication: 2014 Oct 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8101368 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0045 (Electronic) Linking ISSN: 02704137 NLM ISO Abbreviation: Prostate Subsets: MEDLINE

مواضيع طبية MeSH: Growth Differentiation Factor 15/*metabolism , NF-kappa B/*metabolism , Prostate/*metabolism , Prostatitis/*metabolism, Antigens, CD/metabolism ; Atrophy/metabolism ; Atrophy/pathology ; Humans ; Male ; Prostate/pathology ; Prostatitis/pathology

المؤلفون: Atwood SX; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305., Whitson RJ; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305., Oro AE; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305.

المصدر: Cold Spring Harbor perspectives in medicine [Cold Spring Harb Perspect Med] 2014 Jul 01; Vol. 4 (7), pp. a013581. Date of Electronic Publication: 2014 Jul 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 101571139 Publication Model: Electronic Cited Medium: Internet ISSN: 2157-1422 (Electronic) Linking ISSN: 21571422 NLM ISO Abbreviation: Cold Spring Harb Perspect Med Subsets: MEDLINE

مواضيع طبية MeSH: Anilides/*therapeutic use , Antineoplastic Agents/*therapeutic use , Carcinoma, Basal Cell/*drug therapy , Hedgehog Proteins/*antagonists & inhibitors , Pyridines/*therapeutic use , Skin Neoplasms/*drug therapy, Drug Discovery ; Drug Resistance, Neoplasm ; Humans ; Receptors, G-Protein-Coupled/antagonists & inhibitors ; Smoothened Receptor ; Technology, Pharmaceutical/trends ; Treatment Outcome