المؤلفون: He Y; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Koch R; Department of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany., Budamagunta V; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Zhang P; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA., Zhang X; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA., Khan S; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Thummuri D; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Ortiz YT; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Zhang X; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Lv D; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Wiegand JS; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Li W; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Palmer AC; Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Zheng G; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA., Weinstock DM; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Dana 510B, Boston, MA, USA. dweinstock@partners.org., Zhou D; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA. zhoudaohong@cop.ufl.edu.

المصدر: Journal of hematology & oncology [J Hematol Oncol] 2020 Jul 16; Vol. 13 (1), pp. 95. Date of Electronic Publication: 2020 Jul 16.

نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Biomed Central Country of Publication: England NLM ID: 101468937 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-8722 (Electronic) Linking ISSN: 17568722 NLM ISO Abbreviation: J Hematol Oncol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*therapeutic use , Lymphoma, T-Cell/*drug therapy , Neoplasm Proteins/*antagonists & inhibitors , bcl-X Protein/*antagonists & inhibitors, Aniline Compounds/therapeutic use ; Aniline Compounds/toxicity ; Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/toxicity ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Blood Platelets/drug effects ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Cell Line, Tumor ; Drug Design ; Drug Screening Assays, Antitumor ; Drug Synergism ; Female ; Graft Survival ; Humans ; Liver/pathology ; Lymphoma, T-Cell/metabolism ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Neoplasm Proteins/metabolism ; Neoplasm Transplantation ; Piperazines ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Random Allocation ; Spleen/pathology ; Sulfonamides/therapeutic use ; Sulfonamides/toxicity ; Ubiquitin-Protein Ligases/chemistry ; Xenograft Model Antitumor Assays ; bcl-X Protein/metabolism

المؤلفون: He Y; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Zhang X; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA., Chang J; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Kim HN; Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Zhang P; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA., Wang Y; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Khan S; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Liu X; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Zhang X; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Lv D; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Song L; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Li W; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Thummuri D; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Yuan Y; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Wiegand JS; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Ortiz YT; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Budamagunta V; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA., Elisseeff JH; Translational Tissue Engineering Center, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA., Campisi J; Buck Institute for Research on Aging, Novato, CA, USA.; Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Almeida M; Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Zheng G; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA. zhengg@cop.ufl.edu., Zhou D; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA. zhoudaohong@cop.ufl.edu.

المصدر: Nature communications [Nat Commun] 2020 Apr 24; Vol. 11 (1), pp. 1996. Date of Electronic Publication: 2020 Apr 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Aging/*drug effects , Aniline Compounds/*pharmacology , Blood Platelets/*drug effects , Cellular Senescence/*drug effects , Sulfonamides/*pharmacology, Adaptor Proteins, Signal Transducing/metabolism ; Aniline Compounds/chemistry ; Animals ; Cell Line ; Female ; Humans ; Male ; Mice ; Mice, Transgenic ; Models, Animal ; Primary Cell Culture ; Proteolysis/drug effects ; Sulfonamides/chemistry ; Ubiquitin-Protein Ligases ; bcl-X Protein/antagonists & inhibitors ; bcl-X Protein/metabolism

المؤلفون: Khan S; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., Zhang X; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA., Lv D; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., Zhang Q; Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., He Y; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., Zhang P; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA., Liu X; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., Thummuri D; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., Yuan Y; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., Wiegand JS; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., Pei J; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., Zhang W; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA., Sharma A; Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA., McCurdy CR; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA., Kuruvilla VM; Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Baran N; Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Ferrando AA; Department of Pediatrics, Pathology, Cell Biology and Systems of Biology and Institute for Cancer Genetics, Columbia University, New York, NY, USA., Kim YM; Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, USA., Rogojina A; Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Houghton PJ; Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Huang G; Department of Medicine, the Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Hromas R; Department of Medicine, the Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Konopleva M; Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Zheng G; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA. zhengg@cop.ufl.edu., Zhou D; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA. zhoudaohong@cop.ufl.edu.

المصدر: Nature medicine [Nat Med] 2019 Dec; Vol. 25 (12), pp. 1938-1947. Date of Electronic Publication: 2019 Dec 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Aniline Compounds/*pharmacology , Sulfonamides/*pharmacology , Thrombocytopenia/*drug therapy , Von Hippel-Lindau Tumor Suppressor Protein/*genetics , bcl-X Protein/*genetics, Aniline Compounds/chemistry ; Animals ; Antineoplastic Agents/pharmacology ; Blood Platelets/drug effects ; Blood Platelets/metabolism ; Gene Expression Regulation, Neoplastic/drug effects ; Heterografts ; Humans ; Mice ; Proteolysis ; Sulfonamides/chemistry ; Thrombocytopenia/genetics ; Thrombocytopenia/pathology ; bcl-X Protein/antagonists & inhibitors