المؤلفون: Crivelli, Simone M, Luo, Qian, Kruining, Daan van, Giovagnoni, Caterina, Mané-Damas, Marina, den Hoedt, Sandra, Berkes, Dusan, De Vries, Helga E, Mulder, Monique T, Walter, Jochen, Waelkens, Etienne, Derua, Rita, Swinnen, Johannes V, Dehairs, Jonas, Wijnands, Erwin P M, Bieberich, Erhard, Losen, Mario, Martinez-Martinez, Pilar

المساهمون: Molecular cell biology and Immunology, ACS - Microcirculation, Amsterdam Neuroscience - Neuroinfection & -inflammation, Amsterdam Neuroscience - Neurovascular Disorders, RS: MHeNs - R3 - Neuroscience, Psychiatrie & Neuropsychologie, Basic Neuroscience 3, Basic Neuroscience 1, Internal Medicine

المصدر: Biomedicine and Pharmacotherapy, 152:113240. Elsevier Masson
Biomedicine & Pharmacotherapy, 152:113240. Elsevier Masson
Crivelli, S M, Luo, Q, Kruining, D V, Giovagnoni, C, Mané-Damas, M, den Hoedt, S, Berkes, D, De Vries, H E, Mulder, M T, Walter, J, Waelkens, E, Derua, R, Swinnen, J V, Dehairs, J, Wijnands, E P M, Bieberich, E, Losen, M & Martinez-Martinez, P 2022, ' FTY720 decreases ceramides levels in the brain and prevents memory impairments in a mouse model of familial Alzheimer's disease expressing APOE4 ', Biomedicine and Pharmacotherapy, vol. 152, 113240, pp. 113240 . https://doi.org/10.1016/j.biopha.2022.113240

مصطلحات موضوعية: FTY720, Sphingomyelin, APOE4, APOE3, Apolipoprotein E4, Anxiety, METABOLISM, Ceramides, S1P, 1-PHOSPHATE, INCREASE, MECHANISMS, Ceramide, Mice, SDG 3 - Good Health and Well-being, Alzheimer Disease, Memory, Animals, Humans, ACCUMULATION, Pharmacology, Memory Disorders, Sphingolipids, ROLES, SPHINGOSINE-1-PHOSPHATE, Fingolimod Hydrochloride, Brain, PATHWAYS, General Medicine, S1P Ceramide, 5xFAD, APOPTOSIS, AMYLOID PRECURSOR PROTEIN, Disease Models, Animal, lipids (amino acids, peptides, and proteins)

وصف الملف: Print-Electronic; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94372c593410c51b4547c0939a09af13
https://research.vumc.nl/en/publications/ae57e17b-8ff8-465c-9b2b-7677b089f2fc

المؤلفون: Crivelli SM; Maastricht University, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht 6200MD, the Netherlands; Department of Physiology, University of Kentucky College of Medicine, Lexington 40506, KY, USA. Electronic address: s.crivelli@uky.edu., Luo Q; Maastricht University, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht 6200MD, the Netherlands., Kruining DV; Maastricht University, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht 6200MD, the Netherlands., Giovagnoni C; Maastricht University, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht 6200MD, the Netherlands., Mané-Damas M; Maastricht University, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht 6200MD, the Netherlands., den Hoedt S; Department of Internal Medicine, Laboratory Vascular Medicine, Erasmus MC University Medical Center, Rotterdam 3000CA, the Netherlands., Berkes D; Department of Organic Chemistry, Slovak University of Technology, Radlinského 9, 81237 Bratislava, Slovak Republic., De Vries HE; Department of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam 1007MB, the Netherlands., Mulder MT; Department of Internal Medicine, Laboratory Vascular Medicine, Erasmus MC University Medical Center, Rotterdam 3000CA, the Netherlands., Walter J; Department of Neurology, University Hospital Bonn, University of Bonn, Bonn D-53127, Germany., Waelkens E; Laboratory of Protein Phosphorylation and Proteomics, KU Leuven, Leuven 3000, Belgium., Derua R; Laboratory of Protein Phosphorylation and Proteomics, KU Leuven, Leuven 3000, Belgium., Swinnen JV; Laboratory of Lipid Metabolism and Cancer, KU Leuven, Leuven 3000, Belgium., Dehairs J; Laboratory of Lipid Metabolism and Cancer, KU Leuven, Leuven 3000, Belgium., Wijnands EPM; Department of Pathology, Maastricht University, Maastricht 6200MD, the Netherlands., Bieberich E; Department of Physiology, University of Kentucky College of Medicine, Lexington 40506, KY, USA; Veterans Affairs Medical Center, Lexington, KY 40502, USA., Losen M; Maastricht University, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht 6200MD, the Netherlands., Martinez-Martinez P; Maastricht University, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht 6200MD, the Netherlands. Electronic address: p.martinez@maastrichtuniversity.nl.

المصدر: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Aug; Vol. 152, pp. 113240. Date of Electronic Publication: 2022 Jun 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease*/drug therapy , Alzheimer Disease*/genetics , Alzheimer Disease*/prevention & control , Apolipoprotein E4*/genetics , Apolipoprotein E4*/metabolism , Apolipoprotein E4*/therapeutic use, Animals ; Brain/metabolism ; Ceramides/metabolism ; Disease Models, Animal ; Fingolimod Hydrochloride/metabolism ; Fingolimod Hydrochloride/pharmacology ; Fingolimod Hydrochloride/therapeutic use ; Humans ; Memory Disorders/drug therapy ; Memory Disorders/metabolism ; Memory Disorders/prevention & control ; Mice ; Sphingolipids/metabolism