المؤلفون: Matchett, KP, Wilson-Kanamori, JR, Portman, JR, Kapourani, CA, Fercoq, F, May, S, Zajdel, E, Beltran, M, Sutherland, EF, Mackey, JBG, Brice, M, Wilson, GC, Wallace, SJ, Kitto, L, Younger, NT, Dobie, R, Mole, DJ, Oniscu, GC, Wigmore, SJ, Ramachandran, P, Vallejos, CA, Carragher, NO, Saeidinejad, MM, Quaglia, A, Jalan, R, Simpson, KJ, Kendall, TJ, Rule, JA, Lee, WM, Hoare, M, Weston, CJ, Marioni, JC, Teichmann, SA, Bird, TG, Carlin, LM, Henderson, NC

المصدر: Nature. 629(630):158-165

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:158226172

المؤلفون: Dobie, R, Wilson-Kanamori, JR, Henderson, BEP, Smith, JR, Matchett, KP, Portman, JR, Wallenborg, K, Picelli, S, Zagorska, A, Pendem, SV, Hudson, TE, Wu, MM, Budas, GR, Breckenridge, DG, Harrison, EM, Mole, DJ, Wigmore, SJ, Ramachandran, P, Ponting, CP, Teichmann, SA, Marioni, JC, Henderson, NC

المصدر: Cell reports. 29(7):1832

مصطلحات موضوعية: Medicin och hälsovetenskap, Klinisk medicin, Gastroenterologi, Medicinska och farmaceutiska grundvetenskaper, Cell- och molekylärbiologi

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:142320271

المؤلفون: van Kuijk K; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands.; Institute of Experimental Medicine and Systems Biology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany., McCracken IR; BHF Centre for Cardiovascular Sciences (CVS), Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK., Tillie RJHA; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands., Asselberghs SEJ; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands.; Department of Vascular Surgery, Maastricht University Medical Center, Maastricht, The Netherlands., Kheder DA; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands., Muitjens S; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands., Jin H; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands., Taylor RS; BHF Centre for Cardiovascular Sciences (CVS), Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK., Wichers Schreur R; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands., Kuppe C; Institute of Experimental Medicine and Systems Biology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.; Division of Nephrology and Clinical Immunology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany., Dobie R; Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK., Ramachandran P; Department of Medical Biochemistry, Experimental Vascular Biology, Amsterdam UMC, Amsterdam, The Netherlands., Gijbels MJ; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands.; Department of Medical Biochemistry, Experimental Vascular Biology, Amsterdam UMC, Amsterdam, The Netherlands.; GROW, School for Oncology and Development Biology, Maastricht University, Maastricht, The Netherlands., Temmerman L; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands., Kirkwoord PM; Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK., Luyten J; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands.; Department of Vascular Surgery, Maastricht University Medical Center, Maastricht, The Netherlands., Li Y; Division of Cardiothoracic Surgery, Baylor College of Medicine, Houston, TX, USA.; Department of Cardiovascular Surgery, Texas Heart Institute, Houston, TX, USA., Noels H; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands., Goossens P; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands., Wilson-Kanamori JR; Division of Nephrology and Clinical Immunology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany., Schurgers LJ; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands.; Institute of Experimental Medicine and Systems Biology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany., Shen YH; Division of Cardiothoracic Surgery, Baylor College of Medicine, Houston, TX, USA.; Department of Cardiovascular Surgery, Texas Heart Institute, Houston, TX, USA., Mees BME; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands.; Department of Vascular Surgery, Maastricht University Medical Center, Maastricht, The Netherlands., Biessen EAL; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands.; Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany., Henderson NC; Division of Nephrology and Clinical Immunology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Kramann R; Institute of Experimental Medicine and Systems Biology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.; Department of Vascular Surgery, Maastricht University Medical Center, Maastricht, The Netherlands., Baker AH; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands.; BHF Centre for Cardiovascular Sciences (CVS), Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK., Sluimer JC; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands.; BHF Centre for Cardiovascular Sciences (CVS), Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

المصدر: Cardiovascular research [Cardiovasc Res] 2023 Jul 04; Vol. 119 (7), pp. 1509-1523.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford Journals Country of Publication: England NLM ID: 0077427 Publication Model: Print Cited Medium: Internet ISSN: 1755-3245 (Electronic) Linking ISSN: 00086363 NLM ISO Abbreviation: Cardiovasc Res Subsets: MEDLINE

مواضيع طبية MeSH: Plaque, Atherosclerotic*/metabolism , Hypercholesterolemia*/metabolism , Atherosclerosis*/metabolism, Humans ; Mice ; Animals ; Aged ; Transcriptome ; Mice, Inbred C57BL ; Collagen/metabolism ; Receptor Protein-Tyrosine Kinases/metabolism ; Aging/genetics ; Fibroblasts/metabolism ; Cholesterol/metabolism

المؤلفون: Filliol A; Department of Medicine, Columbia University, New York, NY, USA., Saito Y; Department of Medicine, Columbia University, New York, NY, USA., Nair A; Department of Medicine, Columbia University, New York, NY, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Dapito DH; Department of Medicine, Columbia University, New York, NY, USA., Yu LX; Department of Medicine, Columbia University, New York, NY, USA., Ravichandra A; Department of Medicine, Columbia University, New York, NY, USA.; Klinikum Rechts der Isar, Technical University of Munich (TUM), Munich, Germany., Bhattacharjee S; Department of Medicine, Columbia University, New York, NY, USA., Affo S; Department of Medicine, Columbia University, New York, NY, USA.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Fujiwara N; Liver Tumor Translational Research Program, Harold C. Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA., Su H; Department of Pharmacology, School of Medicine, University of California, San Diego, San Diego, CA, USA., Sun Q; Department of Medicine, Columbia University, New York, NY, USA., Savage TM; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Wilson-Kanamori JR; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh, Edinburgh, UK., Caviglia JM; Department of Medicine, Columbia University, New York, NY, USA.; Department of Health and Nutrition Sciences, Brooklyn College, City University of New York, New York, NY, USA., Chin L; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Biomedical Engineering, Widener University, Chester, PA, USA., Chen D; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wang X; Department of Medicine, Columbia University, New York, NY, USA., Caruso S; Functional Genomics of Solid Tumors Laboratory, Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France., Kang JK; Department of Medicine, Columbia University, New York, NY, USA.; Institute of Human Nutrition, Columbia University, New York, NY, USA., Amin AD; Department of Medicine, Columbia University, New York, NY, USA., Wallace S; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh, Edinburgh, UK., Dobie R; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh, Edinburgh, UK., Yin D; Department of Medicine, Columbia University, New York, NY, USA., Rodriguez-Fiallos OM; Department of Medicine, Columbia University, New York, NY, USA., Yin C; Department of Medicine, Columbia University, New York, NY, USA.; Department of Gastroenterology, Changzheng Hospital, Shanghai, China., Mehal A; Department of Medicine, Columbia University, New York, NY, USA., Izar B; Department of Medicine, Columbia University, New York, NY, USA., Friedman RA; Biomedical Informatics Shared Resource, Herbert Irving Comprehensive Cancer Center, and Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, USA., Wells RG; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Pajvani UB; Department of Medicine, Columbia University, New York, NY, USA.; Institute of Human Nutrition, Columbia University, New York, NY, USA., Hoshida Y; Liver Tumor Translational Research Program, Harold C. Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA., Remotti HE; Department of Pathology, Columbia University Irving Medical Center, New York, NY, USA., Arpaia N; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Zucman-Rossi J; Functional Genomics of Solid Tumors Laboratory, Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France., Karin M; Department of Pharmacology, School of Medicine, University of California, San Diego, San Diego, CA, USA., Henderson NC; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Tabas I; Department of Medicine, Columbia University, New York, NY, USA.; Institute of Human Nutrition, Columbia University, New York, NY, USA.; Department of Pathology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Physiology, Columbia University, New York, NY, USA., Schwabe RF; Department of Medicine, Columbia University, New York, NY, USA. rfs2102@cumc.columbia.edu.; Institute of Human Nutrition, Columbia University, New York, NY, USA. rfs2102@cumc.columbia.edu.

المصدر: Nature [Nature] 2022 Oct; Vol. 610 (7931), pp. 356-365. Date of Electronic Publication: 2022 Oct 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Carcinogenesis*/pathology , Carcinoma, Hepatocellular*/pathology , Hepatic Stellate Cells*/metabolism , Hepatic Stellate Cells*/pathology , Liver Neoplasms*/pathology, Animals ; Cell Proliferation ; Collagen Type I/metabolism ; Discoidin Domain Receptor 1/metabolism ; Disease Progression ; Hepatocyte Growth Factor/metabolism ; Hepatocytes ; Humans ; Liver Cirrhosis/complications ; Mice ; Myofibroblasts/pathology

المؤلفون: Dobie R; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, The University of Edinburgh, Edinburgh, United Kingdom., West CC; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, The University of Edinburgh, Edinburgh, United Kingdom; Department of Plastic, Reconstructive and Burns Surgery, St John's Hospital, Livingston, United Kingdom; Department of Plastic, Reconstructive and Hand Surgery, Leeds General Infirmary, Leeds, United Kingdom., Henderson BEP; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, The University of Edinburgh, Edinburgh, United Kingdom., Wilson-Kanamori JR; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, The University of Edinburgh, Edinburgh, United Kingdom., Markose D; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, The University of Edinburgh, Edinburgh, United Kingdom., Kitto LJ; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, The University of Edinburgh, Edinburgh, United Kingdom., Portman JR; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, The University of Edinburgh, Edinburgh, United Kingdom., Beltran M; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, The University of Edinburgh, Edinburgh, United Kingdom., Sohrabi S; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, The University of Edinburgh, Edinburgh, United Kingdom., Akram AR; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, The University of Edinburgh, Edinburgh, United Kingdom., Ramachandran P; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, The University of Edinburgh, Edinburgh, United Kingdom., Yong LY; Department of Plastic, Reconstructive and Burns Surgery, St John's Hospital, Livingston, United Kingdom., Davidson D; Department of Plastic, Reconstructive and Burns Surgery, St John's Hospital, Livingston, United Kingdom., Henderson NC; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, The University of Edinburgh, Edinburgh, United Kingdom; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, United Kingdom. Electronic address: Neil.Henderson@ed.ac.uk.

المصدر: The Journal of investigative dermatology [J Invest Dermatol] 2022 Jan; Vol. 142 (1), pp. 114-123.e8. Date of Electronic Publication: 2021 Jul 16.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1747 (Electronic) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE

مواضيع طبية MeSH: Dermis/*physiology , Dupuytren Contracture/*genetics , Fibroblasts/*physiology , Mesenchymal Stem Cells/*physiology , Myofibrils/*pathology, Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Endopeptidases/metabolism ; Fibrosis/genetics ; Gene Expression Profiling ; Gene Knockdown Techniques ; Humans ; Membrane Glycoproteins/metabolism ; Membrane Proteins/metabolism ; Sequence Analysis, RNA ; Single-Cell Analysis ; TWEAK Receptor/genetics ; TWEAK Receptor/metabolism

المؤلفون: Cordero-Espinoza L; Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge CB2 1QN, UK; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge CB2 1QR, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK., Dowbaj AM; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany., Kohler TN; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge CB2 1QR, UK; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK., Strauss B; Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge CB2 1QN, UK., Sarlidou O; Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge CB2 1QN, UK., Belenguer G; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany., Pacini C; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Martins NP; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany., Dobie R; Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK., Wilson-Kanamori JR; Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK., Butler R; Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge CB2 1QN, UK., Prior N; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany., Serup P; Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen 2200, Denmark., Jug F; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany., Henderson NC; Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK., Hollfelder F; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK., Huch M; Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge CB2 1QN, UK; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge CB2 1QR, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany. Electronic address: huch@mpi-cbg.de.

المصدر: Cell stem cell [Cell Stem Cell] 2021 Nov 04; Vol. 28 (11), pp. 1907-1921.e8. Date of Electronic Publication: 2021 Aug 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE

مواضيع طبية MeSH: Epithelial Cells* , Mesoderm*, Animals ; Cell Proliferation ; Epithelium ; Liver ; Mice

المؤلفون: Monteiro JP; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Rodor J; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Caudrillier A; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Scanlon JP; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Spiroski AM; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Dudnakova T; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Pflüger-Müller B; Institute for Cardiovascular Physiology, Goethe University, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.).; German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.)., Shmakova A; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., von Kriegsheim A; Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine (A.v.K.), University of Edinburgh, Edinburgh, Scotland., Deng L, Taylor RS; The Roslin Institute and Royal (Dick) School of Veterinary Studies (R.S.T.), University of Edinburgh, Edinburgh, Scotland., Wilson-Kanamori JR; The Queen's Medical Research Institute, Centre for Inflammation Research (J.R.W.-K., N.C.H.), University of Edinburgh, Edinburgh, Scotland., Chen SH, Stewart K, Thomson A, Mitić T; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., McClure JD; Institute of Cardiovascular and Medical Sciences, British Heart Foundation (BHF) Glasgow Centre, University of Glasgow, Glasgow, United Kingdom (J.D.M., A.C.B.)., Iynikkel J; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Hadoke PWF; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Denby L; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Bradshaw AC; Institute of Cardiovascular and Medical Sciences, British Heart Foundation (BHF) Glasgow Centre, University of Glasgow, Glasgow, United Kingdom (J.D.M., A.C.B.)., Caruso P; BHF Cambridge (CRE), University of Cambridge, Cambridge, United Kingdom (P.C., N.W.M.)., Morrell NW; BHF Cambridge (CRE), University of Cambridge, Cambridge, United Kingdom (P.C., N.W.M.)., Kovacic JC; The Zena and Michael A. Wiener Cardiovascular Institute, School of Medicine at Mount Sinai, New York, New York (J.C.K.).; Victor Chang Cardiac Research Institute, Darlinghurst, Australia. (J.C.K.)., Ulitsky I; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel (I.U.)., Henderson NC; The Queen's Medical Research Institute, Centre for Inflammation Research (J.R.W.-K., N.C.H.), University of Edinburgh, Edinburgh, Scotland., Caporali A; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland., Leisegang MS; Institute for Cardiovascular Physiology, Goethe University, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.).; German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.)., Brandes RP; Institute for Cardiovascular Physiology, Goethe University, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.).; German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.)., Baker AH; The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland.

المصدر: Circulation research [Circ Res] 2021 Apr 16; Vol. 128 (8), pp. 1173-1190. Date of Electronic Publication: 2021 Mar 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE

مواضيع طبية MeSH: Epithelial-Mesenchymal Transition*, Hypertension, Pulmonary/*metabolism , RNA, Long Noncoding/*metabolism, Animals ; Heterogeneous-Nuclear Ribonucleoproteins/metabolism ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Hypertension, Pulmonary/genetics ; Hypertension, Pulmonary/pathology ; Mice ; Polypyrimidine Tract-Binding Protein/metabolism ; RNA, Long Noncoding/genetics ; Transcriptome ; Vascular Remodeling

المؤلفون: Kirkwood PM; Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom., Gibson DA; Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom., Smith JR; Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom., Wilson-Kanamori JR; Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom., Kelepouri O; Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom., Esnal-Zufiaurre A; Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom., Dobie R; Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom., Henderson NC; Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom., Saunders PTK; Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.

المصدر: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Apr; Vol. 35 (4), pp. e21285.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

مواضيع طبية MeSH: Endometrium/*cytology , Mesenchymal Stem Cells/*physiology, Animals ; Biomarkers ; Female ; Gene Expression Regulation ; Green Fluorescent Proteins ; Homeostasis ; Mice ; Receptor, Platelet-Derived Growth Factor beta/metabolism ; Sequence Analysis, RNA ; Single-Cell Analysis ; Transcriptome

المؤلفون: Kuppe C; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Ibrahim MM; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.; Bayer Pharma AG, Berlin, Germany., Kranz J; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.; Department of Urology and Paediatric Urology, St Antonius Hospital, Eschweiler, Germany.; Department of Urology, Kidney Transplantation Centre, Martin-Luther-University, Halle, Germany., Zhang X; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Ziegler S; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Perales-Patón J; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.; Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, BioQuant, Heidelberg, Germany.; Joint Research Center for Computational Biomedicine, RWTH Aachen University Hospital, Aachen, Germany., Jansen J; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.; Department of Pathology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Amalia Children's Hospital, Nijmegen, The Netherlands., Reimer KC; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.; Department of Cell Biology, Institute for Biomedical Technologies, RWTH Aachen University, Aachen, Germany., Smith JR; Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Dobie R; Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Wilson-Kanamori JR; Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Halder M; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Xu Y; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Kabgani N; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Kaesler N; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Klaus M; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Gernhold L; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Puelles VG; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Anatomy and Developmental Biology, Monash Biomedical Discovery Institute, Monash University, Melbourne, Victoria, Australia., Huber TB; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Boor P; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.; Department of Pathology, RWTH Aachen University, Aachen, Germany., Menzel S; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Hoogenboezem RM; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Bindels EMJ; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Steffens J; Department of Urology and Paediatric Urology, St Antonius Hospital, Eschweiler, Germany., Floege J; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany., Schneider RK; Department of Cell Biology, Institute for Biomedical Technologies, RWTH Aachen University, Aachen, Germany.; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Saez-Rodriguez J; Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, BioQuant, Heidelberg, Germany.; Joint Research Center for Computational Biomedicine, RWTH Aachen University Hospital, Aachen, Germany.; Molecular Medicine Partnership Unit, European Molecular Biology Laboratory, Heidelberg University, Heidelberg, Germany., Henderson NC; Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Kramann R; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany. rkramann@gmx.net.; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany. rkramann@gmx.net.; Department of Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands. rkramann@gmx.net.

المصدر: Nature [Nature] 2021 Jan; Vol. 589 (7841), pp. 281-286. Date of Electronic Publication: 2020 Nov 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Cell Lineage*, Fibrosis/*pathology , Kidney Tubules/*pathology , Myofibroblasts/*pathology , Renal Insufficiency, Chronic/*pathology, Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Calcium-Binding Proteins/metabolism ; Case-Control Studies ; Cell Differentiation ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Female ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Humans ; Male ; Mesoderm/cytology ; Mesoderm/pathology ; Mice ; Myofibroblasts/metabolism ; Pericytes/cytology ; Pericytes/pathology ; RNA-Seq ; Receptor, Platelet-Derived Growth Factor alpha/metabolism ; Receptor, Platelet-Derived Growth Factor beta/metabolism ; Single-Cell Analysis ; Transcriptome

المؤلفون: Ramachandran P; Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Matchett KP; Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Dobie R; Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Wilson-Kanamori JR; Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Henderson NC; Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. Neil.Henderson@ed.ac.uk.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. Neil.Henderson@ed.ac.uk.

المصدر: Nature reviews. Gastroenterology & hepatology [Nat Rev Gastroenterol Hepatol] 2020 Aug; Vol. 17 (8), pp. 457-472. Date of Electronic Publication: 2020 Jun 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101500079 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-5053 (Electronic) Linking ISSN: 17595045 NLM ISO Abbreviation: Nat Rev Gastroenterol Hepatol Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Profiling* , Single-Cell Analysis*, Liver/*metabolism , Liver Diseases/*genetics, Endothelial Cells/metabolism ; Endothelial Cells/physiology ; Fibroblasts/metabolism ; Fibroblasts/physiology ; Gastroenterology ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/physiology ; Hepatocytes/metabolism ; Hepatocytes/physiology ; Humans ; Inflammation/immunology ; Kupffer Cells/immunology ; Liver/cytology ; Liver/immunology ; Liver/physiology ; Liver Cirrhosis/genetics ; Liver Cirrhosis/immunology ; Liver Cirrhosis/metabolism ; Liver Diseases/immunology ; Liver Diseases/metabolism ; Macrophages/immunology ; Muscle, Smooth, Vascular/cytology ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/physiology ; Regeneration ; Sequence Analysis, RNA