المؤلفون: Mfg Archer, M Janmohamed, Wb Harris, Lisa Smith, R Feachem, Jf Bates, P Purwell Edwards, Aw Shilston, Dg Roberts, Diane Lloyd, Wj Ray, Pa Banks, T.L Graham, Pi Helmore, Ew Flaxman

المصدر: Proceedings of the Institution of Civil Engineers. 64:299-315

مصطلحات موضوعية: Middle East, business.industry, Sewage, Environmental science, General Medicine, business, Water resource management, Arid, Effluent

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cc6e1aee17e1b3df19b3f072537ae483
https://doi.org/10.1680/iicep.1978.2762

المؤلفون: M Guerra, SM Dawson, TE Brough, WJ Rayment

المصدر: Endangered Species Research, Vol 24, Iss 3, Pp 221-236 (2014)

مصطلحات موضوعية: Zoology, QL1-991, Botany, QK1-989

وصف الملف: electronic resource

Relation: https://www.int-res.com/abstracts/esr/v24/n3/p221-236/; https://doaj.org/toc/1863-5407; https://doaj.org/toc/1613-4796

URL الوصول: https://doaj.org/article/ce923d46b72247d980b0bced1cc3fad1

المؤلفون: Ralvenius WT; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Mungenast AE; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Woolf H; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Huston MM; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Gillingham TZ; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Godin SK; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Penney J; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Cam HP; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Gao F; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Fernandez CG; The Neurodegeneration Consortium, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Czako B; The Neurodegeneration Consortium, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lightfoot Y; The Neurodegeneration Consortium, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ray WJ; The Neurodegeneration Consortium, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Beckmann A; The Neurodegeneration Consortium, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Goate AM; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Marcora E; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Romero-Molina C; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ayata P; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Advanced Science Research Center at the Graduate Center, Neuroscience Initiative, City University of New York , New York, NY, USA., Schaefer A; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Max Planck Institute for Biology of Ageing , Cologne, Germany., Gjoneska E; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC, USA., Tsai LH; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard , Cambridge, MA, USA.

المصدر: The Journal of experimental medicine [J Exp Med] 2023 Nov 06; Vol. 220 (11). Date of Electronic Publication: 2023 Aug 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE

مواضيع طبية MeSH: Neuroinflammatory Diseases* , Alzheimer Disease*/drug therapy , Alzheimer Disease*/genetics, Animals ; Mice ; Humans ; Oncogenes ; Cell Line ; Disease Models, Animal ; Mice, Transgenic

المؤلفون: Le K; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States., Soth MJ; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States., Cross JB; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States., Liu G; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States., Ray WJ; Neurodegenerative Consortium (NDC), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States., Ma J; Neurodegenerative Consortium (NDC), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States., Goodwani SG; Neurodegenerative Consortium (NDC), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States., Acton PJ; Neurodegenerative Consortium (NDC), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States., Buggia-Prevot V; Neurodegenerative Consortium (NDC), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States., Akkermans O; Evotec (UK) Ltd., Abingdon, OX14 4SA, UK., Barker J; Evotec (UK) Ltd., Abingdon, OX14 4SA, UK., Conner ML; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States., Jiang Y; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States., Liu Z; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States., McEwan P; Evotec (UK) Ltd., Abingdon, OX14 4SA, UK., Warner-Schmidt J; Alexandria Center for Life Science, Magnolia Neurosciences Corporation, New York, New York 10016, United States., Xu A; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States., Zebisch M; Evotec (UK) Ltd., Abingdon, OX14 4SA, UK., Heijnen CJ; Laboratories of Neuroimmunology, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.; Department of Psychological Sciences, Rice University, Houston, Texas 77005, United States., Abrahams B; Alexandria Center for Life Science, Magnolia Neurosciences Corporation, New York, New York 10016, United States., Jones P; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2023 Jul 27; Vol. 66 (14), pp. 9954-9971. Date of Electronic Publication: 2023 Jul 12.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Peripheral Nervous System Diseases*/chemically induced , Peripheral Nervous System Diseases*/drug therapy , Antineoplastic Agents*/adverse effects, Mice ; Animals ; Neurons ; MAP Kinase Signaling System ; Brain/metabolism ; MAP Kinase Kinase Kinases

المؤلفون: Hanson SE; Department of Biology, Duke University, Durham, NC 27708, USA., Ray WJ; Department of Biology, Duke University, Durham, NC 27708, USA., Santhanakrishnan A; School of Mechanical and Aerospace Engineering, Oklahoma State University, Stillwater, OK 74078, USA., Patek SN; Department of Biology, Duke University, Durham, NC 27708, USA.

المصدر: Integrative organismal biology (Oxford, England) [Integr Org Biol] 2023 Jun 27; Vol. 5 (1), pp. obad019. Date of Electronic Publication: 2023 Jun 27 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101767733 Publication Model: eCollection Cited Medium: Internet ISSN: 2517-4843 (Electronic) Linking ISSN: 25174843 NLM ISO Abbreviation: Integr Org Biol Subsets: PubMed not MEDLINE

المؤلفون: Beckmann A; Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; Department of Cell Systems and Anatomy, San Antonio, TX, USA.; University of Texas Health San Antonio, San Antonio, TX, USA., Ramirez P; Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; Department of Cell Systems and Anatomy, San Antonio, TX, USA.; University of Texas Health San Antonio, San Antonio, TX, USA., Gamez M; Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; Department of Cell Systems and Anatomy, San Antonio, TX, USA.; University of Texas Health San Antonio, San Antonio, TX, USA., Gonzalez E; Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; Department of Cell Systems and Anatomy, San Antonio, TX, USA.; University of Texas Health San Antonio, San Antonio, TX, USA., De Mange J; Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; Department of Cell Systems and Anatomy, San Antonio, TX, USA.; University of Texas Health San Antonio, San Antonio, TX, USA., Bieniek KF; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; University of Texas Health San Antonio, San Antonio, TX, USA., Ray WJ; The Neurodegeneration Consortium, Therapeutics Discovery Division, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Frost B; Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; Department of Cell Systems and Anatomy, San Antonio, TX, USA.; University of Texas Health San Antonio, San Antonio, TX, USA.

المصدر: IScience [iScience] 2023 Feb 08; Vol. 26 (3), pp. 106152. Date of Electronic Publication: 2023 Feb 08 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE

المؤلفون: Sohn C; Department of Cell Systems and Anatomy, Barshop Institute for Longevity and Aging Studies, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX, United States., Ma J; The Neurodegeneration Consortium, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Ray WJ; The Neurodegeneration Consortium, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Frost B; Department of Cell Systems and Anatomy, Barshop Institute for Longevity and Aging Studies, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX, United States.

المصدر: Frontiers in aging [Front Aging] 2023 Jan 23; Vol. 4, pp. 1058968. Date of Electronic Publication: 2023 Jan 23 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 9918231199706676 Publication Model: eCollection Cited Medium: Internet ISSN: 2673-6217 (Electronic) Linking ISSN: 26736217 NLM ISO Abbreviation: Front Aging Subsets: PubMed not MEDLINE

المؤلفون: Ochoa E; Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA., Ramirez P; Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA., Gonzalez E; Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA., De Mange J; Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA., Ray WJ; The Neurodegeneration Consortium, Therapeutics Discovery Division, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bieniek KF; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; Department of Pathology and Laboratory Medicine, University of Texas Health San Antonio, San Antonio, TX, USA., Frost B; Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.

المصدر: Science advances [Sci Adv] 2023 Jan 06; Vol. 9 (1), pp. eabq5423. Date of Electronic Publication: 2023 Jan 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease*/metabolism , Tauopathies*/genetics , Tauopathies*/metabolism, Animals ; Mice ; Adult ; Humans ; DNA Transposable Elements ; Retroelements/genetics ; RNA, Double-Stranded/metabolism ; Neuroinflammatory Diseases ; Heterochromatin/metabolism ; tau Proteins/genetics ; tau Proteins/metabolism ; Brain/metabolism ; Mice, Transgenic ; Drosophila/genetics

المؤلفون: Lee DP; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Ray WJ; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Mei TP; Molecular Engineering Laboratory, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore., Hoon S; Molecular Engineering Laboratory, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore., Scolnick J; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Yeo GW; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. gene.w.yeo@gmail.com.; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. gene.w.yeo@gmail.com.

المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2463, pp. 67-80.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Oligonucleotides*/genetics , Proteomics*, Antibodies ; Click Chemistry/methods ; RNA-Seq

المؤلفون: Ramirez P; Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX, United States; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, United States; Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, United States. Electronic address: ramirezp1@livemail.uthscsa.edu., Zuniga G; Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX, United States; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, United States; Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, United States. Electronic address: zunigag3@livemail.uthscsa.edu., Sun W; Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX, United States; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, United States; Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, United States. Electronic address: SunW@uthscsa.edu., Beckmann A; Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX, United States; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, United States; Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, United States. Electronic address: beckmann@uthscsa.edu., Ochoa E; Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX, United States; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, United States; Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, United States. Electronic address: ochoae@livemail.uthscsa.edu., DeVos SL; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States. Electronic address: devos@dnli.com., Hyman B; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States. Electronic address: bhyman@mgh.harvard.edu., Chiu G; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, United States. Electronic address: Gabriel.chiu@bcm.edu., Roy ER; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, United States. Electronic address: ethan.roy@bcm.edu., Cao W; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, United States. Electronic address: wei.cao@bcm.edu., Orr M; Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States; WG Hefner VA Medical Center, Salisbury, NC, United States. Electronic address: morr@wakehealth.edu., Buggia-Prevot V; The Neurodegeneration Consortium, Therapeutics Discovery Division, University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address: vprevot@valohealth.com., Ray WJ; The Neurodegeneration Consortium, Therapeutics Discovery Division, University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address: wjray@mdanderson.org., Frost B; Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX, United States; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, United States; Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, United States. Electronic address: bfrost@uthscsa.edu.

المصدر: Progress in neurobiology [Prog Neurobiol] 2022 Jan; Vol. 208, pp. 102181. Date of Electronic Publication: 2021 Oct 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 0370121 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5118 (Electronic) Linking ISSN: 03010082 NLM ISO Abbreviation: Prog Neurobiol Subsets: MEDLINE

مواضيع طبية MeSH: DNA Transposable Elements*/genetics , tau Proteins*/genetics , tau Proteins*/metabolism, Aging/genetics ; Animals ; Brain/metabolism ; Disease Models, Animal ; Humans ; Mammals/genetics ; Mammals/metabolism ; Mice ; Mice, Transgenic