المؤلفون: Rial, Nathaniel S, Meyskens, Frank L, Gerner, Eugene W

المصدر: Essays in biochemistry. 46

مصطلحات موضوعية: Adenomatous Polyposis Coli Protein: metabolism, Animals, Clinical Trials as Topic, Eflornithine: administration & dosage, Genetic Predisposition to Disease, Humans, Inflammation, Intestinal Neoplasms: metabolism, prevention & control, Models, Biological, Polyamines: metabolism, Risk Factors, Sulindac: administration & dosage, Wnt Proteins: metabolism, Murinae, APC protein, eflornithine, polyamine, sulindac, Wnt protein, animal, biological model, clinical trial, genetic predisposition, human, inflammation, intestine tumor, metabolism, review, risk factor, Adenomatous Polyposis Coli Protein, Animals, Clinical Trials as Topic, Eflornithine, Genetic Predisposition to Disease, Humans, Inflammation, Intestinal Neoplasms, Models, Biological, Polyamines, Risk Factors, Sulindac, Wnt Proteins

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8k6012pm

المؤلفون: Arpan Parichha, Varun Suresh, Mallika Chatterjee, Aditya Kshirsagar, Lihi Ben-Reuven, Tsviya Olender, M. Mark Taketo, Velena Radosevic, Mihaela Bobic-Rasonja, Sara Trnski, Michael J. Holtzman, Nataša Jovanov-Milosevic, Orly Reiner, Shubha Tole

المصدر: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

مصطلحات موضوعية: Telencephalon, Male, beta Catenin / genetics, Science, Telencephalon / metabolism, General Physics and Astronomy, Epithelium, General Biochemistry, Genetics and Molecular Biology, Epithelium / metabolism, Mice, Wnt Signaling Pathway / genetics, beta Catenin / metabolism, Animals, Humans, Choroid Plexus / pathology, Wnt Signaling Pathway, beta Catenin, Cell Nucleus, Multidisciplinary, Cell Nucleus / metabolism, Cell Differentiation, Wnt Signaling Pathway / physiology, General Chemistry, eye diseases, Wnt Proteins, telencephalic ventricles, beta-catenin, cerebrospinal fluid, neuronal identity, hESC organoid, Wnt Proteins / metabolism, Choroid Plexus, Female, sense organs, Choroid Plexus / metabolism

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78188af730de0afd2ce5c5adc776ba8f
https://doi.org/10.1038/s41467-021-27602-z

المؤلفون: Van Du T. Tran, Gabriela Aguileta, Béatrice Desvergne, Aurélien Thomas, Nasim Bararpour, Carine Winkler, Anne Wilson, Nicolas Guex, Greta Maria Paola Giordano Attianese, Marco Pagni, Federica Gilardi, Khanh B. Trang, Tiziana Caputo

المصدر: Cellular and molecular life sciences, vol. 78, no. 1, pp. 227-247
Cellular and Molecular Life Sciences

مصطلحات موضوعية: Male, System biology, Interleukin-1beta, Adipose tissue, White adipose tissue, Transcriptome, Mice, chemistry.chemical_compound, 0302 clinical medicine, Genome-scale metabolic network, Adipocyte, Metaflammation, 0303 health sciences, Adipogenesis, Stem Cells, Adipocyte precursors, Cell Differentiation, Adipose Tissue, White/cytology, Adipose Tissue, White/metabolism, Adipose Tissue, White/pathology, Animals, Diet, High-Fat, Fatty Acid-Binding Proteins/genetics, Fatty Acid-Binding Proteins/metabolism, Gene Expression Regulation, Inflammation/etiology, Inflammation/metabolism, Inflammation/pathology, Interleukin-1beta/genetics, Interleukin-1beta/metabolism, Intra-Abdominal Fat/cytology, Intra-Abdominal Fat/metabolism, Intra-Abdominal Fat/pathology, Lipid Metabolism, Mice, Inbred C57BL, Obesity/complications, Obesity/pathology, Signal Transduction/genetics, Stem Cells/cytology, Stem Cells/metabolism, Subcutaneous Fat/cytology, Subcutaneous Fat/metabolism, Subcutaneous Fat/pathology, Tumor Necrosis Factor-alpha/genetics, Tumor Necrosis Factor-alpha/metabolism, Wnt Proteins/metabolism, Angiogenesis, Epigenetics, Transcriptomics, 3. Good health, Molecular Medicine, Original Article, medicine.symptom, Signal Transduction, medicine.medical_specialty, Adipose Tissue, White, Subcutaneous Fat, Inflammation, Intra-Abdominal Fat, Biology, Fatty Acid-Binding Proteins, 03 medical and health sciences, Cellular and Molecular Neuroscience, Internal medicine, medicine, Obesity, Molecular Biology, 030304 developmental biology, Pharmacology, Tumor Necrosis Factor-alpha, Cell Biology, Beige Adipocytes, medicine.disease, Wnt Proteins, Endocrinology, chemistry, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d560e66d0cd72ae04098a74c1047d7bf
https://doi.org/10.1007/s00018-020-03485-z

المؤلفون: Pirjo Nummela, Colin Nixon, William C. Clark, Ella Gilchrist, Simon J. Leedham, Michael C. Hodder, Nalle Pentinmikko, Arafath Kaja Najumudeen, Nathalie Sphyris, E. Yvonne Jones, Jean-Paul Vincent, Hans Clevers, Nicky J. Willis, Alexander Raven, Kristina Kirschner, Dustin J. Flanagan, Paul V. Fish, Emma Minnee, Pekka Katajisto, Ville Hietakangas, Owen J. Sansom, Christine Perret, Lynn McGarry, Nadia Nasreddin, Rachel A. Ridgway, Ann C. Williams, Kathryn Gilroy, Kalle Luopajärvi, Sandra Scharaw, Béatrice Romagnolo, Marianne Lähde, Ari Ristimäki, Johanna Englund, Anna Taylor Webb, Kari Alitalo, Ann Hedley

المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research, Institute of Biotechnology (-2009), University of Helsinki, CAN-PRO - Translational Cancer Medicine Program, Centre of Excellence in Stem Cell Metabolism, Helsinki Institute of Life Science HiLIFE, Institute of Biotechnology, Juha Klefström / Principal Investigator, Research Programs Unit, Department of Pathology, Doctoral Programme in Biomedicine, ATG - Applied Tumor Genomics, Doctoral Programme in Integrative Life Science, HUSLAB, Kari Alitalo / Principal Investigator, Molecular and Integrative Biosciences Research Programme, Biosciences, Nutrient sensing laboratory

المصدر: Nature, 594(7863), 430-435. Nature Publishing Group
Flanagan, D J, Williams, A C, Katajisto, P K, Sampson, O J & al., E 2021, ' NOTUM from Apc-mutant cells biases clonal competition to initiate cancer ', Nature, vol. 594, pp. 430–435 (2021) . https://doi.org/10.1038/s41586-021-03525-z

مصطلحات موضوعية: 0301 basic medicine, Male, HOMEOSTASIS, Cell, medicine.disease_cause, Cell Transformation, Inbred C57BL, Ligands, BETA-CATENIN, ACTIVATION, PATHWAY, Mice, 0302 clinical medicine, Conditioned, INTESTINE, Stem Cells/cytology, Wnt Signaling Pathway, Cell Competition/genetics, Esterases/antagonists & inhibitors, Mutation, Multidisciplinary, biology, Stem Cells, Cell Transformation, Neoplastic/genetics, Wnt signaling pathway, Esterases, Cell Differentiation, Neoplastic/genetics, Cell biology, Organoids, POLYPOSIS, medicine.anatomical_structure, Cell Transformation, Neoplastic, 030220 oncology & carcinogenesis, Disease Progression, Organoids/cytology, Female, Stem cell, Colorectal Neoplasms, STEM-CELLS, BONE-FORMATION, Adenoma, Beta-catenin, Genes, APC, 3122 Cancers, Crypt, Adenomatous Polyposis Coli Protein, WNT, 03 medical and health sciences, Cancer stem cell, Wnt Proteins/metabolism, medicine, Animals, Humans, Adenomatous Polyposis Coli Protein/genetics, Cell Proliferation, Adenoma/genetics, Colorectal Neoplasms/genetics, Notum, Culture Media, APC, Wnt Proteins, Mice, Inbred C57BL, 030104 developmental biology, Genes, Cell Competition, Culture Media, Conditioned, biology.protein, 1182 Biochemistry, cell and molecular biology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5733edf6d5fc44fd62aea7978eb694e
https://pure.knaw.nl/portal/en/publications/69a3582f-fc29-4f40-bc5f-17ba7825a11a

المؤلفون: Papachristou, Panagiotis

مصطلحات موضوعية: Wnt Signaling Pathway, Brain -- cytology, Brain -- embryology, Brain -- growth & development, Cell Line, Tumor, Wnt Proteins -- genetics, Wnt Proteins -- metabolism, Stem Cells -- cytology, Neurons, Cell Differentiation, Cell Adhesion, Gene Expression Regulation, Developmental

Degree: Diss. (sammanfattning) Stockholm : Karolinska Institutet, 2014

المؤلفون: Warsito, Dudi

مصطلحات موضوعية: Receptor, IGF Type 1 -- genetics, Receptor, IGF Type 1 -- metabolism, Transcription, Genetic, Signal Transduction, Trans-Activators -- genetics, Trans-Activators -- metabolism, Wnt Proteins -- genetics, Wnt Proteins -- metabolism, Carcinogenesis, Receptors, Cytoplasmic and Nuclear -- genetics, Receptors, Cytoplasmic and Nuclear -- metabolism

Degree: Diss. (sammanfattning) Stockholm : Karolinska Institutet, 2014

المؤلفون: Kilander, Michaela Brita Christina

مصطلحات موضوعية: Frizzled Receptors -- metabolism, Heterotrimeric GTP-Binding Proteins -- metabolism, Wnt Signaling Pathway, Wnt Proteins -- metabolism, Receptors, G-Protein Coupled, Phosphoproteins -- metabolism, Adaptor Proteins, Signal Transducing -- metabolism, Paint Mutation

Degree: Diss. (sammanfattning) Stockholm : Karolinska Institutet, 2013

المؤلفون: Halleskog, Carina

مصطلحات موضوعية: Microglia -- drug effects, Microglia -- metabolism, Wnt Signaling Pathway, Wnt Proteins -- genetics, Wnt Proteins -- metabolism, Receptors, Wnt -- genetics, Receptors, Wnt -- metabolism, Receptors, G-Protein-Coupled -- genetics, Receptors, G-Protein-Coupled -- metabolism, beta Catenin -- metabolism, Frizzled Receptors -- genetics, Frizzled Receptors -- metabolism, Inflammation, Lipopolysaccharides -- immunology, Lipopolysaccharides -- metabolism

Degree: Diss. (sammanfattning) Stockholm : Karolinska institutet, 2013

المؤلفون: Ungerbäck, Jonas

مصطلحات موضوعية: Cell Transformation, Neoplastic -- genetics, Colorectal Neoplasms -- genetics, Dinoprostone -- metabolism, Gene Deletion, Gene Expression Regulation, Neoplastic, Genes, APC, Inflammasomes, Intramolecular Oxidoreductases -- genetics, Receptor, Notch2 -- genetics, Signal Transduction -- genetics, Wnt Proteins -- metabolism

URL الوصول: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-72993

Degree: Diss. (sammanfattning) Linköping : Linköpings universitet, 2012

المؤلفون: Gonzalo Córdova, Jessica Y Vargas, Frida Loria, Chiara Zurzolo, Masato Hasegawa, Geeske M. van Woerden, Yuan-Ju Wu, Sebastien Bellow, Takashi Nonaka, Capucine Trollet, Sylvie Syan

المساهمون: Trafic membranaire et Pathogénèse, Institut Pasteur [Paris], Institut de Myologie, Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Association française contre les myopathies (AFM-Téléthon)-Sorbonne Université (SU), Centre de recherche en Myologie – U974 SU-INSERM, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Tokyo Metropolitan University [Tokyo] (TMU), Bioaxial, Department of Neuroscience [Rotterdam, the Netherlands], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Expertise Center for Neurodevelopmental Disorders [Rotterdam, the Netherlands] (ENCORE), This work was supported by the Agence Nationale de la Recherche [ANR‐16‐CE16‐0019‐01], Fondation pour la Recherche Médicale [FRM‐2016‐DEQ20160334896] and grants from LECMA‐Vaincre Alzheimer and France Alzheimer foundations to CZ. Funding from E‐Rare/ERANET (project SIRD) to CT. Grant‐in‐Aid for Scientific Research on Innovative Areas (Brain Protein Aging and Dementia Control) (JP26117005) from MEXT and Grant‐in‐Aid for Scientific Research on Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) (JP14533254) from AMED and JST CREST (JP18071300) to MH. Grant from Brain Science Foundation to TN. FL was recipient of Marie Skłodowska‐Curie individual fellowships and is funded through the Marie Skłodowska‐Curie Action COFUND 2015 (EU project 713366 – InterTalentum). Y‐JW was recipient of Pasteur‐Roux‐Cantarini fellowships., The authors are thankful to Dr. Seng Zhu and Shaarvari Bhat for their help in the acquisition of live imaging experiments., Institut Pasteur [Paris] (IP), ANR-16-CE16-0019,Neurotunn,Role des nanotubes membranaires dans la propagation d'agrégats protéiques impliqués dans les maladie neurodégénératives(2016), Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Biologie Cellulaire du Parasitisme, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Pharmacologie Chimique et Génétique (UPCG - UMR_S 640/UMR 8151), Ecole Nationale Supérieure de Chimie de Paris- Chimie ParisTech-PSL (ENSCP)-Institut des sciences du Médicament -Toxicologie - Chimie - Environnement (IFR71), Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris- Chimie ParisTech-PSL (ENSCP)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Biologia e Patologia Cellulare e Moleculare, Università degli studi di Napoli Federico II, Neurosciences, Centre de Recherche en Myologie, Vargas, J. Y., Loria, F., Wu, Y. -J., Cordova, G., Nonaka, T., Bellow, S., Syan, S., Hasegawa, M., van Woerden, G. M., Trollet, C., Zurzolo, C.

المصدر: EMBO Journal
EMBO Journal, EMBO Press, 2019, 38 (23), ⟨10.15252/embj.2018101230⟩
The EMBO Journal
EMBO Journal, 2019, 38 (23), ⟨10.15252/embj.2018101230⟩
EMBO Journal, 38(23):e101230. Wiley-Blackwell

مصطلحات موضوعية: MESH: Signal Transduction, Wnt Protein, [SDV]Life Sciences [q-bio], MESH: Mice, Knockout, tunneling nanotubes, MESH: Nanotubes/chemistry, Mice, Cell Communication, MESH: Cell Communication, 0302 clinical medicine, MESH: Animals, MESH: Wnt Proteins/metabolism, Cells, Cultured, ComputingMilieux_MISCELLANEOUS, MESH: Neurons/cytology, Mice, Knockout, 0303 health sciences, CaMKII, General Neuroscience, Vesicle, Neurodegeneration, Wnt signaling pathway, musculoskeletal system, 3. Good health, Cell biology, intercellular communication, MESH: Calcium/metabolism, Intracellular, Signal Transduction, MESH: Cells, Cultured, Gene isoform, Wnt pathway, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, MESH: Cell Membrane/metabolism, Biology, MESH: Calcium Signaling, MESH: Calcium-Calmodulin-Dependent Protein Kinase Type 2/physiology, General Biochemistry, Genetics and Molecular Biology, MESH: Neurons/physiology, 03 medical and health sciences, tunneling nanotube, α-synuclein, MESH: Mice, Inbred C57BL, Ca2+/calmodulin-dependent protein kinase, medicine, Calcium Signaling, MESH: Mice, Molecular Biology, Actin, 030304 developmental biology, General Immunology and Microbiology, Animal, Cell Membrane, MESH: Actins/metabolism, Neuron, medicine.disease, Mice, Inbred C57BL, Nanotube, Cell culture, Calcium, Calcium-Calmodulin-Dependent Protein Kinase Type 2, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbbd2a02d2def634543095dbd72de06
https://doi.org/10.15252/embj.2018101230