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المؤلفون: Kitamura S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Lin TH; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Lee CD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Takamura A; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037., Kadam RU; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Zhang D; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Zhu X; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Dada L; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Nagai E; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Yu W; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Yao Y; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037., Sharpless KB; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037., Wolan DW; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 May 28; Vol. 121 (22), pp. e2310677121. Date of Electronic Publication: 2024 May 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Hemagglutinin Glycoproteins, Influenza Virus*/metabolism , Hemagglutinin Glycoproteins, Influenza Virus*/chemistry , Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry, Humans ; Chemistry, Pharmaceutical/methods ; High-Throughput Screening Assays/methods ; Influenza, Human/drug therapy ; Influenza, Human/virology ; Crystallography, X-Ray/methods ; Click Chemistry/methods ; Animals ; Influenza A virus/drug effects ; Madin Darby Canine Kidney Cells ; Viral Fusion Protein Inhibitors/pharmacology ; Viral Fusion Protein Inhibitors/chemistry ; Dogs

المؤلفون: Griffiths JA; Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Yoo BB; Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Thuy-Boun P; Departments of Molecular Medicine and Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Cantu VJ; Department of Pediatrics, University of California, San Diego, San Diego, CA, USA., Weldon KC; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, CA, USA; UCSD Center for Microbiome Innovation, University of California, San Diego, San Diego, CA, USA., Challis C; Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Sweredoski MJ; Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Chan KY; Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Thron TM; Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Sharon G; Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Moradian A; Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Humphrey G; Department of Pediatrics, University of California, San Diego, San Diego, CA, USA., Zhu Q; Department of Pediatrics, University of California, San Diego, San Diego, CA, USA., Shaffer JP; Department of Pediatrics, University of California, San Diego, San Diego, CA, USA., Wolan DW; Departments of Molecular Medicine and Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Dorrestein PC; Department of Pediatrics, University of California, San Diego, San Diego, CA, USA; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, CA, USA; UCSD Center for Microbiome Innovation, University of California, San Diego, San Diego, CA, USA., Knight R; Department of Pediatrics, University of California, San Diego, San Diego, CA, USA; UCSD Center for Microbiome Innovation, University of California, San Diego, San Diego, CA, USA; Department of Computer Science and Engineering, University of California, San Diego, San Diego, CA, USA; Shu Chien-Gene Lay Department of Engineering, University of California, San Diego, San Diego, CA, USA; Halıcıoğlu Data Science Institute, University of California, San Diego, San Diego, CA, USA., Gradinaru V; Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Mazmanian SK; Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA. Electronic address: sarkis@caltech.edu.

المصدر: Cell reports [Cell Rep] 2024 Apr 23; Vol. 43 (4), pp. 113953. Date of Electronic Publication: 2024 Mar 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Gastrointestinal Microbiome*/physiology , Neurons*/metabolism, Animals ; Mice ; Choline O-Acetyltransferase/metabolism ; Enteric Nervous System/physiology ; Mice, Inbred C57BL ; Tyrosine 3-Monooxygenase/metabolism ; Male ; Gastrointestinal Tract/microbiology

المؤلفون: Wang Y; Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, One Shields Avenue, Davis, California 95616, United States., Morisseau C; Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, One Shields Avenue, Davis, California 95616, United States., Takamura A; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037, United States., Wan D; Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, One Shields Avenue, Davis, California 95616, United States., Li D; Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, One Shields Avenue, Davis, California 95616, United States., Sidoli S; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States., Yang J; Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, One Shields Avenue, Davis, California 95616, United States., Wolan DW; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037, United States.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States., Hammock BD; Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, One Shields Avenue, Davis, California 95616, United States., Kitamura S; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037, United States.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States.; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.

المصدر: ACS chemical biology [ACS Chem Biol] 2023 Apr 21; Vol. 18 (4), pp. 884-896. Date of Electronic Publication: 2023 Mar 22.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Epoxide Hydrolases*/chemistry , Epoxide Hydrolases*/metabolism , Proteolysis Targeting Chimera*/pharmacology , Endoplasmic Reticulum Stress*/physiology, Cytosol/metabolism

المؤلفون: Cheng Y; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037., Li G; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037., Smedley CJ; La Trobe Institute for Molecular Science, Melbourne, VIC 3086, Australia., Giel MC; La Trobe Institute for Molecular Science, Melbourne, VIC 3086, Australia., Kitamura S; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Woehl JL; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037., Bianco G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Forli S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Homer JA; Cancer Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724., Cappiello JR; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037., Wolan DW; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Moses JE; Cancer Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724., Sharpless KB; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Sep 13; Vol. 119 (37), pp. e2208540119. Date of Electronic Publication: 2022 Sep 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Click Chemistry*/methods , Fluorides*/chemical synthesis , Fluorides*/chemistry , Fluorides*/pharmacology , Leukocyte Elastase*/antagonists & inhibitors , Proteinase Inhibitory Proteins, Secretory*/chemical synthesis , Proteinase Inhibitory Proteins, Secretory*/chemistry , Proteinase Inhibitory Proteins, Secretory*/pharmacology , Sulfinic Acids*/chemical synthesis , Sulfinic Acids*/chemistry , Sulfinic Acids*/pharmacology, Humans