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المؤلفون: Watson EV; Department of Genetics, Harvard Medical School and Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA.; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Lee JJ; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Gulhan DC; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Melloni GEM; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Venev SV; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Magesh RY; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Frederick A; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Chiba K; Department of Genetics, Harvard Medical School and Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA., Wooten EC; Department of Genetics, Harvard Medical School and Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA., Naxerova K; Department of Genetics, Harvard Medical School and Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA.; Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Dekker J; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Park PJ; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. peter_park@hms.harvard.edu., Elledge SJ; Department of Genetics, Harvard Medical School and Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA. selledge@genetics.med.harvard.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. selledge@genetics.med.harvard.edu.

المصدر: Nature genetics [Nat Genet] 2024 May; Vol. 56 (5), pp. 900-912. Date of Electronic Publication: 2024 Feb 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Aneuploidy*, Humans ; Female ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; DNA Copy Number Variations ; Neoplasms/genetics ; Neoplasms/pathology ; Translocation, Genetic ; Evolution, Molecular ; Cell Proliferation/genetics ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Organ Specificity/genetics ; Epithelial Cells/metabolism ; Epithelial Cells/pathology

المؤلفون: Patel RS; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Scripps Green Hospital, San Diego, CA, USA., Romero R; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Watson EV; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Liang AC; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Burger M; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Westcott PMK; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Mercer KL; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Bronson RT; Harvard Medical School, Boston, MA, USA., Wooten EC; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Bhutkar A; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Jacks T; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Elledge SJ; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. selledge@genetics.med.harvard.edu.; Department of Genetics, Harvard Medical School, Boston, MA, USA. selledge@genetics.med.harvard.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. selledge@genetics.med.harvard.edu.

المصدر: Nature communications [Nat Commun] 2022 Jan 11; Vol. 13 (1), pp. 256. Date of Electronic Publication: 2022 Jan 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Biological Transport/*physiology , GATA4 Transcription Factor/*metabolism , Neoplasms/*metabolism , T-Lymphocytes, Cytotoxic/*metabolism, Animals ; Antibodies, Monoclonal, Humanized ; Chemokine CCL2/metabolism ; GATA4 Transcription Factor/genetics ; Gene Expression Regulation, Neoplastic ; Homeodomain Proteins ; Humans ; Immune Evasion ; Lung/pathology ; Melanoma ; Mice ; Mice, Inbred C57BL ; Myocytes, Cardiac/metabolism ; Neoplasms/immunology ; Neoplasms/pathology ; Transcriptome

المؤلفون: Naxerova K; Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA., Di Stefano B; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA., Makofske JL; Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA., Watson EV; Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., de Kort MA; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA., Martin TD; Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Dezfulian M; Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Ricken D; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA., Wooten EC; Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Kuroda MI; Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA., Hochedlinger K; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA., Elledge SJ; Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

المصدر: Genes & development [Genes Dev] 2021 Nov 01; Vol. 35 (21-22), pp. 1527-1547. Date of Electronic Publication: 2021 Oct 28.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 8711660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-5477 (Electronic) Linking ISSN: 08909369 NLM ISO Abbreviation: Genes Dev Subsets: MEDLINE

مواضيع طبية MeSH: Human Embryonic Stem Cells*, Cell Differentiation/genetics ; Embryonic Stem Cells ; Gain of Function Mutation ; Germ Layers ; Humans

المؤلفون: Sack LM; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA., Davoli T; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA., Li MZ; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA., Li Y; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Shandong Provincial Hospital affiliated to Shandong University, Jinan 250021, China., Xu Q; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA., Naxerova K; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA., Wooten EC; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA., Bernardi RJ; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Department of Molecular and Human Genetics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Martin TD; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA., Chen T; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA., Leng Y; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA., Liang AC; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA., Scorsone KA; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Department of Molecular and Human Genetics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Westbrook TF; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Department of Molecular and Human Genetics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Wong KK; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA., Elledge SJ; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: selledge@genetics.med.harvard.edu.

المصدر: Cell [Cell] 2018 Apr 05; Vol. 173 (2), pp. 499-514.e23. Date of Electronic Publication: 2018 Mar 22.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Aneuploidy*, Neoplasms/*pathology, Animals ; Cell Line, Tumor ; Cell Proliferation ; Chromosome Mapping ; Chromosomes/genetics ; E2F1 Transcription Factor/antagonists & inhibitors ; E2F1 Transcription Factor/genetics ; E2F1 Transcription Factor/metabolism ; Female ; Gene Library ; Genomics ; Humans ; Keratins/metabolism ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Oncogenes ; Open Reading Frames/genetics ; RNA Interference ; RNA, Small Interfering/metabolism

المؤلفون: Davoli T; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA., Uno H; Dana-Farber Cancer Institute, Boston, MA 02215-5450, USA., Wooten EC; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA., Elledge SJ; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA. selledge@genetics.med.harvard.edu.

المصدر: Science (New York, N.Y.) [Science] 2017 Jan 20; Vol. 355 (6322).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: DNA Copy Number Variations*, Lymphocytes, Tumor-Infiltrating/*immunology , Neoplasms/*genetics , Neoplasms/*therapy , T-Lymphocytes, Cytotoxic/*immunology , Tumor Escape/*genetics, Biomarkers, Tumor/immunology ; CTLA-4 Antigen/antagonists & inhibitors ; Cell Cycle/immunology ; Cell Proliferation ; Cytotoxicity, Immunologic ; Humans ; Immunotherapy ; Models, Biological ; Neoplasms/immunology ; Neoplasms/mortality ; Point Mutation ; Prognosis ; Transcriptome

المؤلفون: Davoli T; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA., Mengwasser KE; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA., Duan J; Department of Neurobiology, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Department of Cellular and Molecular Physiology, Centers for Mendelian Genomics, Yale School of Medicine, New Haven, Connecticut 06511, USA., Chen T; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA., Christensen C; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA., Wooten EC; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA., Anselmo AN; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA., Li MZ; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA., Wong KK; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA., Kahle KT; Department of Neurobiology, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Department of Cellular and Molecular Physiology, Centers for Mendelian Genomics, Yale School of Medicine, New Haven, Connecticut 06511, USA., Elledge SJ; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

المصدر: Genes & development [Genes Dev] 2016 Dec 15; Vol. 30 (24), pp. 2684-2695.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 8711660 Publication Model: Print Cited Medium: Internet ISSN: 1549-5477 (Electronic) Linking ISSN: 08909369 NLM ISO Abbreviation: Genes Dev Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Neoplastic*, Colorectal Neoplasms/*enzymology , Colorectal Neoplasms/*genetics , Phosphatidylinositol 3-Kinases/*genetics , Phosphatidylinositol 3-Kinases/*metabolism , Signal Transduction/*genetics, Animals ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/physiopathology ; Genomics ; HCT116 Cells ; HEK293 Cells ; Humans ; Mice ; Mutation ; Proteasome Endopeptidase Complex/genetics ; Ribosomes/genetics