المؤلفون: Emert-Sedlak LA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Shi H; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Tice CM; Fox Chase Chemical Diversity Center, Inc., Pennsylvania Biotechnology Center, Doylestown, PA 18902, USA., Chen L; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Alvarado JJ; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Shu ST; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Du S; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Thomas CE; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Wrobel JE; Fox Chase Chemical Diversity Center, Inc., Pennsylvania Biotechnology Center, Doylestown, PA 18902, USA., Reitz AB; Fox Chase Chemical Diversity Center, Inc., Pennsylvania Biotechnology Center, Doylestown, PA 18902, USA., Smithgall TE; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.

المصدر: Viruses [Viruses] 2022 Sep 13; Vol. 14 (9). Date of Electronic Publication: 2022 Sep 13.

نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

مواضيع طبية MeSH: HIV Infections*/drug therapy , HIV Seropositivity* , HIV-1*/physiology, Anti-Retroviral Agents/therapeutic use ; Drug Discovery ; Humans ; Virulence Factors ; nef Gene Products, Human Immunodeficiency Virus

المؤلفون: Han Z; University of Pennsylvania, Philadelphia, Pennsylvania, USA., Ye H; Fox Chase Chemical Diversity Center, Doylestown, Pennsylvania, USA., Liang J; University of Pennsylvania, Philadelphia, Pennsylvania, USA., Shepley-McTaggart A; University of Pennsylvania, Philadelphia, Pennsylvania, USA., Wrobel JE; Fox Chase Chemical Diversity Center, Doylestown, Pennsylvania, USA., Reitz AB; Fox Chase Chemical Diversity Center, Doylestown, Pennsylvania, USA., Whigham A; Texas Biomedical Research Institute, San Antonio, Texas, USA., Kavelish KN; Texas Biomedical Research Institute, San Antonio, Texas, USA., Saporito MS; Intervir, LLC, Philadelphia, Pennsylvania, USA., Freedman BD; University of Pennsylvania, Philadelphia, Pennsylvania, USA., Shtanko O; Texas Biomedical Research Institute, San Antonio, Texas, USA., Harty RN; University of Pennsylvania, Philadelphia, Pennsylvania, USA.

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2021 Jun 17; Vol. 65 (7), pp. e0008621. Date of Electronic Publication: 2021 Jun 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Marburgvirus*, Animals ; HeLa Cells ; Humans ; Mice ; Virus Release

المؤلفون: Shi H; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Suite 523 Bridgeside Point II, 450 Technology Drive , Pittsburgh , Pennsylvania 15219 , United States., Tice CM; Fox Chase Chemical Diversity Center, Inc. , Pennsylvania Biotechnology Center , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States., Emert-Sedlak L; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Suite 523 Bridgeside Point II, 450 Technology Drive , Pittsburgh , Pennsylvania 15219 , United States., Chen L; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Suite 523 Bridgeside Point II, 450 Technology Drive , Pittsburgh , Pennsylvania 15219 , United States., Li WF; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Suite 523 Bridgeside Point II, 450 Technology Drive , Pittsburgh , Pennsylvania 15219 , United States., Carlsen M; Fox Chase Chemical Diversity Center, Inc. , Pennsylvania Biotechnology Center , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States., Wrobel JE; Fox Chase Chemical Diversity Center, Inc. , Pennsylvania Biotechnology Center , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States., Reitz AB; Fox Chase Chemical Diversity Center, Inc. , Pennsylvania Biotechnology Center , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States., Smithgall TE; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Suite 523 Bridgeside Point II, 450 Technology Drive , Pittsburgh , Pennsylvania 15219 , United States.

المصدر: ACS infectious diseases [ACS Infect Dis] 2020 Feb 14; Vol. 6 (2), pp. 302-312. Date of Electronic Publication: 2019 Dec 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Retroviral Agents/*pharmacology , Histocompatibility Antigens Class I/*genetics , Pyrazoles/*pharmacology , Virus Replication/*drug effects , nef Gene Products, Human Immunodeficiency Virus/*antagonists & inhibitors, Cell Line ; Down-Regulation ; Drug Development ; HIV-1/drug effects ; HIV-1/physiology ; Humans ; Inhibitory Concentration 50 ; Leukocytes, Mononuclear/virology ; Tissue Donors

المؤلفون: Pelletier JC; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States., Chen S; Department of Chemical Biology, Ernest Mario School of Pharmacy, 164 Frelinghuysen Road, Rutgers University, Piscataway, New Jersey 08854, United States., Bian H; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States., Shah R; Department of Chemical Biology, Ernest Mario School of Pharmacy, 164 Frelinghuysen Road, Rutgers University, Piscataway, New Jersey 08854, United States., Smith GR; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States., Wrobel JE; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States., Reitz AB; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States.; ALS Biopharma, LLC, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Jun 15; Vol. 9 (7), pp. 752-756. Date of Electronic Publication: 2018 Jun 15 (Print Publication: 2018).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Larsen BJ; Fox Chase Chemical Diversity Center, Inc., 3700 Horizon Drive, King of Prussia, PA 19406, USA., Rosano RJ; Fox Chase Chemical Diversity Center, Inc., 3700 Horizon Drive, King of Prussia, PA 19406, USA., Ford-Hutchinson TA; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Road, Doylestown, PA 18902, USA., Reitz AB; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Road, Doylestown, PA 18902, USA., Wrobel JE; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Road, Doylestown, PA 18902, USA.

المصدر: Tetrahedron [Tetrahedron] 2018 May 31; Vol. 74 (22), pp. 2762-2768. Date of Electronic Publication: 2018 Apr 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 2984170R Publication Model: Print-Electronic Cited Medium: Print ISSN: 0040-4020 (Print) Linking ISSN: 00404020 NLM ISO Abbreviation: Tetrahedron Subsets: PubMed not MEDLINE

المؤلفون: Loughran HM; Fox Chase Chemical Diversity Center, Inc, 3805 Old Easton Road, Doylestown, PA 18902, United States., Han Z; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States., Wrobel JE; Fox Chase Chemical Diversity Center, Inc, 3805 Old Easton Road, Doylestown, PA 18902, United States., Decker SE; Fox Chase Chemical Diversity Center, Inc, 3805 Old Easton Road, Doylestown, PA 18902, United States., Ruthel G; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States., Freedman BD; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States., Harty RN; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States., Reitz AB; Fox Chase Chemical Diversity Center, Inc, 3805 Old Easton Road, Doylestown, PA 18902, United States.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Aug 01; Vol. 26 (15), pp. 3429-35. Date of Electronic Publication: 2016 Jun 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents/*pharmacology , Cytochrome P-450 CYP3A Inhibitors/*pharmacology , Quinoxalines/*pharmacology , Vesicular stomatitis Indiana virus/*drug effects , Viral Matrix Proteins/*antagonists & inhibitors, Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Cytochrome P-450 CYP3A/metabolism ; Cytochrome P-450 CYP3A Inhibitors/chemical synthesis ; Cytochrome P-450 CYP3A Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Ebolavirus/chemistry ; HEK293 Cells ; Humans ; Marburgvirus/chemistry ; Mice ; Microbial Sensitivity Tests ; Microsomes, Liver/chemistry ; Microsomes, Liver/metabolism ; Molecular Structure ; Quinoxalines/chemical synthesis ; Quinoxalines/chemistry ; Structure-Activity Relationship

المؤلفون: Emert-Sedlak LA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of School of Medicine, Pittsburgh, PA 15219 USA., Loughran HM; Fox Chase Chemical Diversity Center, Inc., Doylestown, PA 18902 USA., Shi H; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of School of Medicine, Pittsburgh, PA 15219 USA., Kulp JL 3rd; Conifer Point Pharmaceuticals, Doylestown, PA 18902 USA., Shu ST; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of School of Medicine, Pittsburgh, PA 15219 USA., Zhao J; Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261 USA.; University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA 15260 USA., Day BW; Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261 USA.; University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA 15260 USA.; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260 USA., Wrobel JE; Fox Chase Chemical Diversity Center, Inc., Doylestown, PA 18902 USA., Reitz AB; Fox Chase Chemical Diversity Center, Inc., Doylestown, PA 18902 USA., Smithgall TE; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of School of Medicine, Pittsburgh, PA 15219 USA.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Mar 01; Vol. 26 (5), pp. 1480-1484. Date of Electronic Publication: 2016 Jan 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Anti-HIV Agents/*chemical synthesis , Anti-HIV Agents/*pharmacology , Small Molecule Libraries/*pharmacology , nef Gene Products, Human Immunodeficiency Virus/*antagonists & inhibitors, Administration, Oral ; Animals ; Anti-HIV Agents/administration & dosage ; Binding Sites/drug effects ; Dose-Response Relationship, Drug ; HIV-1/drug effects ; Mice ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Conformation ; Molecular Docking Simulation ; Small Molecule Libraries/administration & dosage ; Small Molecule Libraries/chemical synthesis ; Structure-Activity Relationship ; Tumor Cells, Cultured ; Virus Replication/drug effects

المؤلفون: Han Z; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Madara JJ; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Herbert A; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America., Prugar LI; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America., Ruthel G; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Lu J; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Liu Y; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Liu W; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Liu X; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Wrobel JE; Fox Chase Chemical Diversity Center, Inc., Doylestown, Pennsylvania, United States of America., Reitz AB; Fox Chase Chemical Diversity Center, Inc., Doylestown, Pennsylvania, United States of America., Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America., Harty RN; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Freedman BD; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

المصدر: PLoS pathogens [PLoS Pathog] 2015 Oct 29; Vol. 11 (10), pp. e1005220. Date of Electronic Publication: 2015 Oct 29 (Print Publication: 2015).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

مواضيع طبية MeSH: Virus Release*, Arenavirus/*physiology , Filoviridae/*physiology, Animals ; Calcium/metabolism ; Calcium Channels/physiology ; HEK293 Cells ; HeLa Cells ; Humans ; ORAI1 Protein ; Vero Cells ; Viral Matrix Proteins/physiology ; Virion/physiology

المؤلفون: Rubin H; University of Pennsylvania, 522 Johnson Pavilion, Philadelphia, PA 19104, United States. Electronic address: rubinh@upenn.edu., Selwood T; University of Pennsylvania, 522 Johnson Pavilion, Philadelphia, PA 19104, United States., Yano T; University of Pennsylvania, 522 Johnson Pavilion, Philadelphia, PA 19104, United States., Weaver DG; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902, United States., Loughran HM; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902, United States., Costanzo MJ; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902, United States., Scott RW; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902, United States., Wrobel JE; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902, United States., Freeman KB; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902, United States., Reitz AB; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902, United States. Electronic address: areitz@fc-cdci.com.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Jan 15; Vol. 25 (2), pp. 378-83. Date of Electronic Publication: 2014 Nov 22.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Acinetobacter Infections/*drug therapy , Acinetobacter baumannii/*drug effects , Anti-Bacterial Agents/*pharmacology , Antineoplastic Agents/*pharmacology , Benzimidazoles/*pharmacology , Cell Proliferation/*drug effects , Oxidative Phosphorylation/*drug effects , Small Molecule Libraries/*pharmacology, Acinetobacter Infections/microbiology ; Animals ; Anti-Bacterial Agents/chemistry ; Antineoplastic Agents/chemistry ; Benzimidazoles/chemistry ; Hep G2 Cells ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Mice ; Microbial Sensitivity Tests ; Molecular Structure ; NIH 3T3 Cells ; Quinone Reductases/metabolism ; Small Molecule Libraries/chemistry ; Structure-Activity Relationship

المؤلفون: Pelletier JC; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902., Velvadapu V; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902., McDonnell ME; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902., Wrobel JE; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902., Reitz AB; Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902.

المصدر: Tetrahedron letters [Tetrahedron Lett] 2014 Jul 23; Vol. 55 (30), pp. 4193-4195.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 2984819R Publication Model: Print Cited Medium: Print ISSN: 0040-4039 (Print) Linking ISSN: 00404039 NLM ISO Abbreviation: Tetrahedron Lett Subsets: PubMed not MEDLINE