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المؤلفون: Maja Malnar, Angela Bachi, Helena H. Chowdhury, Anemari Horvat, Patrizia D’Adamo, Antonia Gurgone, Saša Trkov Bobnar, Marko Muhič, Lorenzo Piemonti, Maria Lidia Mignogna, Michela Masetti, Jelena Velebit, Veronica Bianchi, Robert Zorec, Matjaž Stenovec, Alessia Mercalli, Katja Fink, Sara Belloli, Stefano Taverna, Maja Potokar, Marko Kreft, Rosa Maria Moresco, Nina Vardjan, Maddalena Ripamonti, Umberto Restuccia
المساهمون: D'Adamo, Patrizia, Horvat, Anemari, Gurgone, Antonia, Mignogna, Maria Lidia, Bianchi, Veronica, Masetti, Michela, Ripamonti, Maddalena, Taverna, Stefano, Velebit, Jelena, Malnar, Maja, Muhič, Marko, Fink, Katja, Bachi, Angela, Restuccia, Umberto, Belloli, Sara, Moresco, Rosa Maria, Mercalli, Alessia, Piemonti, Lorenzo, Potokar, Maja, Bobnar, Saša Trkov, Kreft, Marko, Chowdhury, Helena H, Stenovec, Matjaž, Vardjan, Nina, Zorec, R, D'Adamo, P, Horvat, A, Gurgone, A, Mignogna, M, Bianchi, V, Masetti, M, Ripamonti, M, Taverna, S, Velebit, J, Malnar, M, Muhic, M, Fink, K, Bachi, A, Restuccia, U, Belloli, S, Moresco, R, Mercalli, A, Piemonti, L, Potokar, M, Bobnar, S, Kreft, M, Chowdhury, H, Stenovec, M, Vardjan, N
المصدر: Metabolism
Metabolism, clinical and experimental
116 (2021): 154463. doi:10.1016/j.metabol.2020.154463
info:cnr-pdr/source/autori:D'Adamo P.; Horvat A.; Gurgone A.; Mignogna M.L.; Bianchi V.; Masetti M.; Ripamonti M.; Taverna S.; Velebit J.; Malnar M.; Muhic M.; Fink K.; Bachi A.; Restuccia U.; Belloli S.; Moresco R.M.; Mercalli A.; Piemonti L.; Potokar M.; Bobnar S.T.; Kreft M.; Chowdhury H.H.; Stenovec M.; Vardjan N.; Zorec R./titolo:Inhibiting glycolysis rescues memory impairment in an intellectual disability Gdi1-null mouse/doi:10.1016%2Fj.metabol.2020.154463/rivista:Metabolism, clinical and experimental (Print)/anno:2021/pagina_da:154463/pagina_a:/intervallo_pagine:154463/volume:116مصطلحات موضوعية: 0301 basic medicine, CTX, context memory, Male, Endocrinology, Diabetes and Metabolism, Glucose uptake, Intellectual disability, FRET, Förster Resonance Energy Transfer, SV, synaptic vesicle, XLID, X-linked intellectual disability, Mice, 0302 clinical medicine, Endocrinology, Basic Science, GDI1 knockout mice, Aerobic glycolysis, Astrocytes, cAMP, Glycolysis, Gdi1 KO, full knockout of Gdi1, Cells, Cultured, Guanine Nucleotide Dissociation Inhibitors, NA, noradrenaline, Mice, Knockout, Cultured, 3-Cl-5-OH-BA, 3-chloro-5-hydroxybenzoic acid, Animals, Brain, Deoxyglucose, Down-Regulation, Glucose, Intellectual Disability, Maze Learning, Memory, Memory Disorders, [18F]-FDG, [18F]-fluoro-2-deoxy-d-glucose, Aerobic glycolysi, cAMP, cyclic adenosine monophosphate, GlastGdi1flox/Y, GLAST:CreERT2+/Gdi1lox/Y inducible astrocyte-specific Gdi1 KO male mice, medicine.anatomical_structure, intellectual disability, Knockout mouse, Astrocyte, Gdi1 WT, wild type, medicine.medical_specialty, Cells, Knockout, 030209 endocrinology & metabolism, Biology, 2-DG, 2-deoxy-d-glucose, sEPSCs, spontaneous excitatory postsynaptic currents, CNS, central nervous system, SEM, standard error of the mean, 03 medical and health sciences, αGDI, α guanosine dissociation inhibitor protein coded by GDI1 gene, CFP, cyan fluorescent protein, Downregulation and upregulation, Internal medicine, medicine, aerobic glycolysis, GlastGdi1X/Y, male mice (Gdi1X/Y) carrying the GLAST:CreERT2 transgene, GLUT1, d-glucose transporter, Wild type, astrocytes, GFAP, glial fibrillary acidic protein, PSD, postsynaptic density, GDI1, guanosine dissociation inhibitor 1 gene, YFP, yellow fluorescent protein, 030104 developmental biology, GPCR, G-protein coupled receptor, Anaerobic glycolysis, GPR81, G-protein receptor 81, CS, conditional stimulus, tone, PKA, protein kinase A, MCTs, monocarboxylate transporters, Homeostasis
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2Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B
المؤلفون: Hunter, Morag R, Hesketh, Geoffrey G, Benedyk, Tomasz H, Gingras, Anne-Claude, Graham, Stephen C
المساهمون: Benedyk, Tomasz [0000-0001-6420-3665], Graham, Stephen [0000-0003-4547-4034], Apollo - University of Cambridge Repository
المصدر: Journal of Molecular Biology
مصطلحات موضوعية: Models, Molecular, Proteomics, PI3KC3, class III phosphatidylinositol 3-kinase, Protein Conformation, THP-1 Cells, Vesicular Transport Proteins, EARP, endosome-associated recycling protein, GARP, Golgi-associated retrograde protein, HOPS, homotypic fusion and vacuole protein sorting, Article, XLID, X-linked intellectual disability, Cell Line, SPE-39, BFDR, Bayesian false discovery rate, Protein Interaction Mapping, Humans, CHEVI, class C homologs in endosome–vesicle interaction, VPS16B, Proteins, HEK293T, human embryonic kidney 293T, VIPAS39, HEK293 Cells, X-linked intellectual disability (XLID), Phosphatidylinositol 3-Kinase, Sec1/Munc18, CORVET, class C core vacuole/endosome tethering
وصف الملف: application/pdf
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المؤلفون: Silvia Gatti, Ernesto Fedele, Lorenzo Morè, Veronica Bianchi, Basil Künnecke, Patrizia D'Adamo, Latefa Yekhlef, Andreas Bruns, Antonella Marte, Stefano Taverna
المصدر: Neuroscience
مصطلحات موضوعية: Male, CS, conditioned stimulus, genetic structures, X-linked intellectual disability, Dopamine, Hippocampal formation, MSNs, medium spiny neurons, Appetitive conditioning, Excitatory synapses, Fronto-striatal synaptic plasticity, Gdi1-null mice, X-linked Intellectual Disability, Tissue Culture Techniques, Random Allocation, Discrimination, Psychological, 0302 clinical medicine, Conditioning, Psychological, Neural Pathways, Intellectual disability, αGDI, RAB GDP dissociation inhibitor alpha, Attention, SV, synaptic vesicles, Guanine Nucleotide Dissociation Inhibitors, CI, conditioned inhibition, Mice, Knockout, General Neuroscience, 05 social sciences, Cognition, Amygdala, Executive functions, XLID, X-linked Intellectual Disability, Frontal Lobe, Inhibition, Psychological, fMRI, functional magnetic resonance imaging, Synaptic Vesicles, Psychology, US, unconditioned stimulus, B140, Pr, release probability, Neuroscience(all), Stimulus (physiology), VTA, ventral tegmental area, Article, 03 medical and health sciences, Intellectual Disability, medicine, Animals, 0501 psychology and cognitive sciences, 050102 behavioral science & comparative psychology, LI, latent inhibition, mPFC, medial prefrontal cortex, Association Learning, Excitatory Postsynaptic Potentials, RRP, ready releasable pool, medicine.disease, QP, Associative learning, Neostriatum, Disease Models, Animal, EPSCs, excitatory postsynaptic currents, nervous system, Time Perception, Synaptic plasticity, RC0321, Neuroscience, 030217 neurology & neurosurgery
وصف الملف: application/pdf
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المؤلفون: Ronald A. Merrill, Andrew Y. Usachev, Jianing Song, Stefan Strack
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Doublecortin Domain Proteins, 0301 basic medicine, proteasomal degradation, X-linked intellectual disability, PACAP, pituitary adenylate cyclase-activating polypeptide, CRL, cullin-RING ligase, dendritic complexity, MAP, microtubule-associated protein, Gene mutation, Biochemistry, pulse-chase, XLID, X-linked intellectual disability, AUC, area under the curve, ERK, extracellular signal-regulated kinase, Ubiquitin, PP2A, protein phosphatase 2A, Chlorocebus aethiops, GFP, green fluorescent protein, Neurons, biology, KLHL, Kelch-like, DCX, doublecortin, Microfilament Proteins, IP, immunoprecipitation, Editors' Pick, Ubiquitin ligase, Cell biology, E3 ubiquitin ligase, Cul3, cullin3, COS Cells, BDNF, brain-derived neurotrophic factor, doublecortin-like kinases, Microtubule-Associated Proteins, Research Article, neurite outgrowth, Doublecortin Protein, Ubiquitin-Protein Ligases, Blotting, Western, Protein degradation, ubiquitination, Gene product, 03 medical and health sciences, TMR, tetramethyl rhodamine, Intellectual Disability, GST, glutathione-S-transferase, medicine, Animals, Humans, Immunoprecipitation, Gene silencing, Molecular Biology, Trk, tropomyosin-related kinase, 030102 biochemistry & molecular biology, protein phosphatase 2A, protein turnover, Neuropeptides, DCLK, doublecortin-like kinase, Cell Biology, medicine.disease, microtubule-associated protein, Doublecortin, HEK293 Cells, 030104 developmental biology, Proteostasis, Proteasome, biology.protein
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1eea79e2770ecc33f6d9789a83e9183
https://doi.org/10.1074/jbc.ra120.016210
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