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1
المؤلفون: Fugang Zhu, Sudhir Agrawal, Wayne Jiang, Xianzhi Mao, Daqing Wang
المصدر: International journal of oncology. 53(3)
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, medicine.medical_treatment, CD3, Phosphorothioate Oligonucleotides, Biology, CD8-Positive T-Lymphocytes, Injections, Intralesional, 03 medical and health sciences, Mice, 0302 clinical medicine, Immune system, Antineoplastic Agents, Immunological, Cancer immunotherapy, Antigen, Costimulatory and Inhibitory T-Cell Receptors, Antigens, Neoplasm, Cell Line, Tumor, Neoplasms, medicine, Tumor Microenvironment, Cytotoxic T cell, Animals, Humans, Tumor microenvironment, Mice, Inbred BALB C, Th1 Cells, Xenograft Model Antitumor Assays, Immune checkpoint, Up-Regulation, 030104 developmental biology, Treatment Outcome, Oncology, Oligodeoxyribonucleotides, 030220 oncology & carcinogenesis, Toll-Like Receptor 9, Cancer research, biology.protein, Female, Immunotherapy, Drug Screening Assays, Antitumor, CD8
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2
المؤلفون: Steven M. Stirdivant, Carolyn A. Buser, Weikang Tao, Laura Sepp-Lorenzino, Cheng Wang, Mark E. Fraley, Robert B. Lobell, Keith W. Rickert, Kenneth L. Arrington, Kelly Hamilton, Vadim Y. Dudkin, James Hardwick, Eileen S. Walsh, George D. Hartman, Xianzhi Mao, Robert A. Drakas, Stephen C. Beck
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:2613-2619
مصطلحات موضوعية: Cell Membrane Permeability, Halogenation, Pyridines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Polar surface area, Structure-Activity Relationship, chemistry.chemical_compound, Aminothiazole, Cell Line, Tumor, Drug Discovery, Humans, Potency, Protein Kinase Inhibitors, Molecular Biology, Molecular Structure, Kinase, Organic Chemistry, Cell Cycle Checkpoints, Biochemical Activity, Cyclin-Dependent Kinases, Kinetics, Thiazoles, chemistry, Drug Design, Checkpoint Kinase 1, Lipophilicity, Molecular Medicine, Cyclin-dependent kinase 7, Selectivity, Protein Kinases, Cyclin-Dependent Kinase-Activating Kinase
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3
المؤلفون: Laura Sepp-Lorenzino, Brett Connolly, Nancy E. Kohl, Rosemary C. McFall, Bin Shi, James S. Hardwick, Susan Hill, Kenneth A. Thomas, Xianzhi Mao
المصدر: Journal of Histotechnology. 33:15-24
مصطلحات موضوعية: Pathology, medicine.medical_specialty, Histology, Angiogenesis, business.industry, Cell, Kinase insert domain receptor, medicine.disease, Primary tumor, Metastasis, Medical Laboratory Technology, Breast cancer, medicine.anatomical_structure, Cancer cell, medicine, Immunohistochemistry, Anatomy, business
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4
المؤلفون: Joseph P. Davide, Xianzhi Mao, Martha A. DiPietro, Jessica Seitzer, Weimin Wang, Marc Abrams, Laura Sepp-Lorenzino, Steven M. Stirdivant, Martin Koser, Paul A. Burke, Stephanie Williams, Vasant Jadhav, Andrew W. Shaw, Alan B. Sachs
المصدر: Molecular Therapy. 18:171-180
مصطلحات موضوعية: Agonist, Biodistribution, medicine.drug_class, medicine.medical_treatment, media_common.quotation_subject, Inflammation, Pharmacology, Biology, Dexamethasone, Mice, Receptors, Glucocorticoid, Glucocorticoid receptor, Drug Discovery, Genetics, medicine, Animals, Gene silencing, Gene Silencing, RNA, Small Interfering, Internalization, Molecular Biology, media_common, Original Articles, Cytokine, Mechanism of action, Nanoparticles, Molecular Medicine, Female, medicine.symptom
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5
المؤلفون: Marc Abrams, Laura Sepp-Lorenzino, Steve Stirdivant, Joan Zugay-Murphy, Keith W. Rickert, Xianzhi Mao, Stephen C. Beck, Mark E. Fraley, Robert M. Garbaccio, Rob Lobell, Youwei Yan, Bob Drakas, Paul Zuck, Sylvie Jezequel-Sur, Kelly Hamilton, Timothy J. Hartingh, Constantine Kreatsoulas, Edward S. Tasber, Sanjeev Munshi, Antonella Converso, Eileen S. Walsh, George D. Hartman, Carolyn A. Buser, Weikang Tao, V V Sardana
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:1240-1244
مصطلحات موضوعية: Clinical Biochemistry, Allosteric regulation, Molecular Conformation, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Molecular conformation, Drug Discovery, Combinatorial Chemistry Techniques, Humans, Transferase, Potency, CHEK1, Binding site, Protein Kinase Inhibitors, Molecular Biology, High concentration, Binding Sites, Molecular Structure, Chemistry, Chk1 Kinase, Organic Chemistry, Checkpoint Kinase 1, Quinazolines, Molecular Medicine, Protein Kinases
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6
المؤلفون: James Hardwick, Xianzhi Mao, Constanine Kreatsoulas, Eileen S. Walsh, Sanjeev Munshi, Marc Abrams, George D. Hartman, Laura Sepp-Lorenzino, Mark E. Fraley, Rob Lobell, Kelly Hamilton, Lawrence Kuo, Carolyn A. Buser, Weikang Tao, Robert M. Garbaccio, Mari Ikuta, Keith W. Rickert, Edward S. Tasber, Bob Drakas, Steve Stirdivant, Stephen C. Beck, Shaei Huang, Youwei Yan
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:6280-6285
مصطلحات موضوعية: Models, Molecular, Photochemistry, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Apoptosis, Quinolones, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Residue (chemistry), Cell Line, Tumor, Drug Discovery, Humans, Transferase, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, Molecular Structure, biology, Organic Chemistry, Enzyme, chemistry, Enzyme inhibitor, Checkpoint Kinase 1, Lactam, biology.protein, Molecular Medicine, Amine gas treating, Protein Kinases
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7
المؤلفون: Keith Lee Spencer, Barbara Hanney, Eileen S. Walsh, George D. Hartman, Stephen C. Beck, Carolyn A. Buser, Weikang Tao, Robert B. Lobell, Youwei Yan, Lawrence C. Kuo, Kenneth L. Arrington, Edward J. Brnardic, Mari Ikuta, Sanjeev Munshi, Mark E. Fraley, Constantine Kreatsoulas, Justin T. Steen, Bob Drakas, Laura Sepp-Lorenzino, Kelly Hamilton, Yuntae Kim, Xianzhi Mao, James Hardwick, Steven M. Stirdivant, Keith W. Rickert
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:6049-6053
مصطلحات موضوعية: Models, Molecular, Indazoles, Stereochemistry, Clinical Biochemistry, Triazole, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Humans, Structure–activity relationship, Moiety, Potency, Hydroxymethyl, Protein Kinase Inhibitors, Molecular Biology, Indazole, Molecular Structure, biology, Cell Cycle, Organic Chemistry, chemistry, Enzyme inhibitor, Checkpoint Kinase 1, biology.protein, Molecular Medicine, Selectivity, Protein Kinases
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8
المؤلفون: Eileen S. Walsh, Steve Stirdivant, George D. Hartman, Kelly Hamilton, Marc Abrams, Robert M. Garbaccio, Laura Sepp-Lorenzino, Lawrence Kuo, Steve Beck, Joan Zugay Murphy, Constantine Kreatsoulas, Justin T. Steen, Sanjeev Munshi, Carolyn A. Buser, Weikang Tao, Shaei Huang, Youwei Yan, V V Sardana, Bob Drakas, Mari Ikuta, James Hardwick, Keith W. Rickert, Mark E. Fraley, Elizabeth Mahan, Xianzhi Mao, Rob Lobell, Michael Reilly
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:5907-5912
مصطلحات موضوعية: Indoles, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Quinolones, Crystallography, X-Ray, Biochemistry, Polar surface area, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Structure–activity relationship, Potency, Enzyme Inhibitors, Binding site, Molecular Biology, Cell potency, chemistry.chemical_classification, Binding Sites, biology, Organic Chemistry, Active site, Enzyme, chemistry, Enzyme inhibitor, Drug Design, Checkpoint Kinase 1, biology.protein, Molecular Medicine, Hydrophobic and Hydrophilic Interactions, Protein Kinases
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9
المؤلفون: John T. Sisko, Christine Fernandes, Bradley K. Wong, Patrice A. Ciecko, Nancy E. Kohl, Mark T. Bilodeau, Keith W. Rickert, Laura Sepp-Lorenzino, Leonard D. Rodman, Timothy J. Koester, Jackson B. Gibbs, Cynthia Miller-Stein, Debra A. McLoughlin, Joseph J. Lynch, Carolyn A. Buser, George D. Hartman, Xianzhi Mao, Kathleen E. Coll, Kenneth A. Thomas, Jennifer M. Shipman, Thomas J. Tucker
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:1146-1150
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, hERG, Pharmaceutical Science, Sensitivity and Specificity, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Growth factor receptor, Nitriles, parasitic diseases, Drug Discovery, Animals, Thiazole, Protein Kinase Inhibitors, neoplasms, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Chemistry, Kinase, Organic Chemistry, Macaca mulatta, Vascular Endothelial Growth Factor Receptor-2, Rats, Thiazoles, Pyrimidines, Enzyme, Enzyme inhibitor, cardiovascular system, biology.protein, Molecular Medicine, Amine gas treating, circulatory and respiratory physiology
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10
المؤلفون: Keith W. Rickert, Christine Fernandes, Xianzhi Mao, Kathleen E. Coll, George D. Hartman, Bradley K. Wong, Peter J. Manley, Adrienne E. Balitza, Timothy J. Koester, Mark T. Bilodeau, Debra A. McLoughlin, David C. Heimbrook, Rosemary C. McFall, Sean Yu, William R. Huckle, Jackson B. Gibbs, Jennifer M. Shipman, Kenneth A. Thomas, Raju Subramanian, Joseph J. Lynch, Nancy E. Kohl, Leonard D. Rodman, Cynthia Miller-Stein, Laura Sepp-Lorenzino, Carolyn Buser-Doepner
المصدر: Journal of Medicinal Chemistry. 47:6363-6372
مصطلحات موضوعية: Male, ERG1 Potassium Channel, Pyridines, Stereochemistry, hERG, Administration, Oral, Aminopyridines, Biological Availability, In Vitro Techniques, Cell Line, Rats, Sprague-Dawley, Electrocardiography, Mice, Radioligand Assay, Dogs, In vivo, Drug Discovery, Animals, Tissue Distribution, Phosphorylation, Lung, biology, Kinase, Chemistry, Macaca mulatta, Vascular Endothelial Growth Factor Receptor-2, Ether-A-Go-Go Potassium Channels, In vitro, Rats, Thiazoles, Receptors, Vascular Endothelial Growth Factor, Potassium Channels, Voltage-Gated, Enzyme inhibitor, Microsomes, Liver, biology.protein, Molecular Medicine, Amine gas treating, Signal transduction, Tyrosine kinase