المؤلفون: Yashaswini CN; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Medical Scientist Training Program, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Qin T; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Bhattacharya D; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Amor C; Cold Spring Harbor Laboratory. Cold Spring Harbor, NY, United States., Lowe S; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States; Howard Hughes Medical Institute, Chevy Chase, MD, United States., Lujambio A; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Wang S; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Friedman SL; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: Scott.Friedman@mssm.edu.

المصدر: Journal of hepatology [J Hepatol] 2024 Aug; Vol. 81 (2), pp. 207-217. Date of Electronic Publication: 2024 Mar 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE

مواضيع طبية MeSH: Hepatic Stellate Cells*/metabolism , Cellular Senescence*/physiology , Phenotype*, Animals ; Humans ; Mice ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Fatty Liver/metabolism ; Fatty Liver/etiology ; Fatty Liver/pathology ; Receptors, Urokinase Plasminogen Activator/metabolism ; Receptors, Urokinase Plasminogen Activator/genetics ; Disease Models, Animal ; Male ; Mice, Inbred C57BL

المؤلفون: Cogliati B; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil., Yashaswini CN; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wang S; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sia D; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Friedman SL; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Scott.Friedman@mssm.edu.

المصدر: Nature reviews. Gastroenterology & hepatology [Nat Rev Gastroenterol Hepatol] 2023 Oct; Vol. 20 (10), pp. 647-661. Date of Electronic Publication: 2023 Aug 07.

نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101500079 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-5053 (Electronic) Linking ISSN: 17595045 NLM ISO Abbreviation: Nat Rev Gastroenterol Hepatol Subsets: MEDLINE

مواضيع طبية MeSH: Liver Neoplasms*/metabolism , Carcinoma, Hepatocellular*/metabolism, Humans ; Hepatic Stellate Cells/metabolism ; Liver Cirrhosis/pathology

المؤلفون: Ligorio M; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA., Sil S; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Malagon-Lopez J; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA., Nieman LT; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Misale S; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Di Pilato M; Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02114, USA., Ebright RY; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Karabacak MN; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Engineering in Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02114, USA., Kulkarni AS; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Liu A; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Vincent Jordan N; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Franses JW; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Philipp J; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Kreuzer J; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Desai N; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Arora KS; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA., Rajurkar M; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Horwitz E; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Neyaz A; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Tai E; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Magnus NKC; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Vo KD; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Yashaswini CN; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Marangoni F; Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02114, USA., Boukhali M; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Fatherree JP; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Damon LJ; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Xega K; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Desai R; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Choz M; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Bersani F; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Langenbucher A; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Thapar V; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA., Morris R; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Wellner UF; Clinic of Surgery, UKSH Campus Lübeck, Germany., Schilling O; Institute of Pathology, University Medical Center Freiburg, Germany., Lawrence MS; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Liss AS; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA., Rivera MN; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA., Deshpande V; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA., Benes CH; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Maheswaran S; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA., Haber DA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02114, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., Fernandez-Del-Castillo C; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA., Ferrone CR; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA., Haas W; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Aryee MJ; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address: aryee.martin@mgh.harvard.edu., Ting DT; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: dting1@mgh.harvard.edu.

المصدر: Cell [Cell] 2019 Jun 27; Vol. 178 (1), pp. 160-175.e27. Date of Electronic Publication: 2019 May 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Tumor Microenvironment*, Cancer-Associated Fibroblasts/*metabolism , Carcinoma, Pancreatic Ductal/*metabolism , Carcinoma, Pancreatic Ductal/*pathology , Pancreatic Neoplasms/*metabolism , Pancreatic Neoplasms/*pathology, Animals ; Cell Proliferation ; Coculture Techniques ; Epithelial-Mesenchymal Transition ; Female ; HEK293 Cells ; Heterografts ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Mitogen-Activated Protein Kinases/metabolism ; RNA-Seq ; STAT3 Transcription Factor/metabolism ; Stromal Cells/metabolism ; Transfection

المؤلفون: Takahashi N; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139., Gruber CC; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139., Yang JH; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Biological Engineering, Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139.; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Liu X; Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699., Braff D; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Biological Engineering, Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Biomedical Engineering, Boston University, Boston, MA 02215.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115., Yashaswini CN; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139., Bhubhanil S; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.; Applied Biological Sciences, Chulabhorn Graduate Institute, Bangkok, Thailand 10210., Furuta Y; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Biological Engineering, Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139., Andreescu S; Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699., Collins JJ; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Biological Engineering, Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139.; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115., Walker GC; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139; gwalker@mit.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Aug 22; Vol. 114 (34), pp. 9164-9169. Date of Electronic Publication: 2017 Aug 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: PubMed not MEDLINE; MEDLINE