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1
المؤلفون: Yasuyoshi Iso, Shigeru Ando, Harrie J.M. Gijsen, Yasuto Kido, Shinji Suzuki, Herman Borghys, Kenji Morimoto, Vijay Urmaliya, Deborah Dhuyvetter, Takahiko Yamamoto, Ard Teisman, Gaku Sakaguchi, Naoki Kanegawa, Nigel Austin, Eriko Matsuoka, An Van Den Bergh, Hisanori Ito, Takuya Oguma, Francois Paul Bischoff, Tamio Fukushima, Peter Verboven, Tomoyuki Kawachi, Kenji Nakahara, Yoshinori Yamano, Kosuke Anan, Ken-ichi Kusakabe
المصدر: ChemMedChem. 14:1894-1910
مصطلحات موضوعية: Male, Models, Molecular, hERG, Thiazines, Pharmacology, 01 natural sciences, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Oral administration, Oxazines, Drug Discovery, Hydrolase, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Humans, General Pharmacology, Toxicology and Pharmaceutics, Mice, Knockout, chemistry.chemical_classification, Mice, Inbred ICR, Amyloid beta-Peptides, Trifluoromethyl, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Rats, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Enzyme, Drug Design, Hepatocytes, Microsomes, Liver, biology.protein, Microsome, Molecular Medicine, Efflux, Amyloid Precursor Protein Secretases
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2
المؤلفون: Yasuyoshi Iso, Naoki Kanegawa, Vijay Urmaliya, Kazuki Fujimoto, Kazuo Komano, Ard Teisman, An Van Den Bergh, Herman Borghys, Hisanori Ito, Shuhei Yoshida, Shigeru Ando, Yasuto Kido, Nigel E. Austin, Naoya Asada, Shinji Suzuki, Kenji Nakahara, Ken-ichi Kusakabe, Eriko Matsuoka, Harrie J.M. Gijsen, Gaku Sakaguchi, Genta Tadano, Yoshinori Yamano, Tamio Fukushima, Takahiko Yamamoto, Deborah Dhuyvetter, Kouki Fuchino
المصدر: Journal of medicinal chemistry. 62(20)
مصطلحات موضوعية: Male, Liver toxicity, Drug Evaluation, Preclinical, Thiazines, Pharmacology, 01 natural sciences, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Mice, Dogs, In vivo, Thiazine, Alzheimer Disease, mental disorders, Drug Discovery, Amyloid precursor protein, Animals, Humans, Protease Inhibitors, Volume concentration, 030304 developmental biology, Cytochrome P-450 CYP2C9, 0303 health sciences, Amyloid beta-Peptides, biology, Half-life, Brain, Heart, Haplorhini, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, chemistry, Liver, biology.protein, β secretase, Molecular Medicine, Trough level, Female, Amyloid Precursor Protein Secretases, Half-Life
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3
المؤلفون: Takahiko Yamamoto, Yasuyoshi Iso, Harrie J.M. Gijsen, Tsuyoshi Hasegawa, Tamio Fukushima, Hisanori Ito, Yoshinori Yamano, Ken-ichi Kusakabe, Yasuto Kido, Herman Borghys, Motoko Hosono, Kenji Nakahara, Kouki Fuchino, Yusuke Sako, Shigeru Ando, Naoya Asada, Kazuo Komano, Gaku Sakaguchi, Masayoshi Ogawa, Genta Tadano, Chie Unemura, Deborah Dhuyvetter, Shuichi Ohnishi
المصدر: Journal of Medicinal Chemistry. 61:5525-5546
مصطلحات موضوعية: 0301 basic medicine, Pyrazine, Protein Conformation, Stereochemistry, hERG, 01 natural sciences, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Protein structure, In vivo, Oxazines, Drug Discovery, Animals, Humans, Structure–activity relationship, Potency, Tissue Distribution, Enzyme Inhibitors, Dose-Response Relationship, Drug, biology, 010405 organic chemistry, Drug discovery, Brain, Rats, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, chemistry, biology.protein, Molecular Medicine, Efflux, Amyloid Precursor Protein Secretases
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المؤلفون: Narumi Horita, Daiki Nagamatsu, Yasuhide Morioka, Miki Tanimura, Gaku Sakaguchi, Azusa Nozu, Yasuyoshi Iso, Toshiyuki Kanemasa, Natsue Yamanada, Mikie Hinata, Toshiyuki Asaki, Masayuki Imai, Hidetoshi Matsuda, Kenji Takaya, Osamu Yoshida, Hiromi Nakai, Akira Yukimasa, Shinji Suzuki, Masahiko Soga, Naoki Tsuno, Tomoyuki Ogawa, Hiroki Yamaguchi, Miyuki Yamamoto, Satoko Funaki, Motohiro Fujiu
المصدر: Bioorganic & Medicinal Chemistry. 25:2177-2190
مصطلحات موضوعية: 0301 basic medicine, Analgesic effect, TRPV4, Spectrometry, Mass, Electrospray Ionization, Stereochemistry, Proton Magnetic Resonance Spectroscopy, Guinea Pigs, Clinical Biochemistry, TRPV Cation Channels, Pharmaceutical Science, Biochemistry, Guinea pig, Structure-Activity Relationship, 03 medical and health sciences, Mechanical Hyperalgesia, 0302 clinical medicine, Microsomes, Drug Discovery, Animals, Humans, Pain Management, Molecular Biology, Analgesics, Chemistry, Organic Chemistry, Antagonist, Complete adjuvant, Rats, Thiazoles, 030104 developmental biology, Molecular Medicine, Azabicyclo Compounds, 030217 neurology & neurosurgery
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المؤلفون: Gaku Sakaguchi, Tetsuji Ito, Naoki Tsuno, Mikie Hinata, Akira Yukimasa, Yasuyoshi Iso, Satoko Funaki, Daiki Nagamatsu, Miki Tanimura, Miyuki Yamamoto, Tatsuhiko Ueno, Toshiyuki Kanemasa, Yoko Nishimura, Masahiko Soga, Natsue Yamanada, Yasuhide Morioka, Osamu Yoshida, Narumi Horita, Masayuki Imai, Takatsugu Inoue, Yusuke Ichihashi, Hiroki Yamaguchi, Hidetoshi Matsuda
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:4930-4935
مصطلحات موضوعية: 0301 basic medicine, Agonist, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Administration, Oral, Biological Availability, TRPV Cation Channels, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Molecular Biology, ADME, Analgesics, Drug discovery, Chemistry, Organic Chemistry, Antagonist, Bioavailability, 030104 developmental biology, Competitive antagonist, Molecular Medicine, Lead compound, 030217 neurology & neurosurgery
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المؤلفون: Yasuyoshi Iso, Harrie J.M. Gijsen, Gaku Sakaguchi, Shuhei Yoshida, Deborah Dhuyvetter, Yasunori Mitsuoka, Shigeru Ando, Shuichi Hiroyama, Yoshinori Yamano, Kiyotaka Koyabu, Moriyasu Masui, Herman Borghys, Yasuto Kido, Noriyuki Kurose, Motoko Hosono, Masayoshi Ogawa, Hisanori Ito, Chie Unemura, Shuichi Ohnishi, Takahiko Yamamoto, Ken-ichi Kusakabe, Kazuo Komano, Hirofumi Miyajima, Tamio Fukushima, Kouki Fuchino
المصدر: Journal of medicinal chemistry. 61(12)
مصطلحات موضوعية: ERG1 Potassium Channel, ATP Binding Cassette Transporter, Subfamily B, hERG, Guinea Pigs, ATP-binding cassette transporter, Oxazines, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Madin Darby Canine Kidney Cells, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Dogs, Drug Discovery, Structure–activity relationship, Animals, Aspartic Acid Endopeptidases, Humans, Protease Inhibitors, ATP Binding Cassette Transporter, Subfamily B, Member 1, chemistry.chemical_classification, Mice, Knockout, Amyloid beta-Peptides, biology, 010405 organic chemistry, Rational design, Brain, Peptide Fragments, 0104 chemical sciences, Mice, Inbred C57BL, chemistry, Drug Design, Knockout mouse, biology.protein, Molecular Medicine, Efflux, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, 030217 neurology & neurosurgery
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المؤلفون: Yasuyoshi Iso, Shintani Takuya, John J. Engel, Akira Kato, Jianming Yu, Tsuyoshi Hasegawa, Toshiyuki Asaki, Yoshitaka Yamaguchi, Naoki Tsuno, Laykea Tafesse, Chiyou Ni, Noriyuki Kurose, Kevin C. Brown, Toshiyuki Kanemasa, Gang Wu, Manjunath S. Shet, Yuka Iwamoto, Aniket Patel, Donald J. Kyle, Xiaoming Zhou
المصدر: Journal of Medicinal Chemistry. 57:6781-6794
مصطلحات موضوعية: Trifluoromethyl, medicine.drug_class, Stereochemistry, TRPV1, Antagonist, Carboxamide, Pharmacology, chemistry.chemical_compound, chemistry, Pharmacokinetics, Capsaicin, In vivo, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, lipids (amino acids, peptides, and proteins)
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المؤلفون: Nobuo Chomei, Ken-ichi Kusakabe, Masahiro Sakagami, Kohji Hanasaki, Hiroshi Hamana, Yasuyoshi Iso, Satomi Shinonome, Yukio Tada, Keiko Kawamoto, Hideyuki Takenaka, Kiyoshi Yasui, Yasuhide Morioka
المصدر: Bioorganic & Medicinal Chemistry. 21:2045-2055
مصطلحات موضوعية: Cannabinoid receptor, Pyridones, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Receptor, Cannabinoid, CB2, 2-Pyridone, Structure-Activity Relationship, chemistry.chemical_compound, Catalytic Domain, Drug Discovery, Cannabinoid receptor type 2, Humans, Homology modeling, Molecular Biology, Chemistry, Organic Chemistry, Combinatorial chemistry, Recombinant Proteins, Molecular Docking Simulation, Design synthesis, Drug Design, Molecular Medicine, lipids (amino acids, peptides, and proteins), Selectivity
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9
المؤلفون: Mikie Hinata, Toshiyuki Asaki, Miyuki Yamamoto, Azusa Nozu, Osamu Yoshida, Masayuki Imai, Gaku Sakaguchi, Satoko Funaki, Kenji Takaya, Yasuyoshi Iso, Narumi Horita, Akira Yukimasa, Shinji Suzuki, Naoki Tsuno, Hidetoshi Matsuda, Masahiko Soga, Toshiyuki Kanemasa, Daiki Nagamatsu, Motohiro Fujiu, Hiromi Nakai, Yasuhide Morioka, Hiroki Yamaguchi, Yoko Nishimura, Tetsuji Ito, Tomoyuki Ogawa
المصدر: Bioorganicmedicinal chemistry letters. 26(20)
مصطلحات موضوعية: 0301 basic medicine, TRPV4, Agonist, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biological Availability, TRPV Cation Channels, Pharmacology, Biochemistry, Guinea pig, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Cricetinae, Drug Discovery, medicine, Structure–activity relationship, Animals, Thiazole, Molecular Biology, Chemistry, Drug discovery, Organic Chemistry, Bioavailability, Thiazoles, 030104 developmental biology, Molecular Medicine
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10
المؤلفون: Yasuyoshi Iso, Alan P. Kozikowski
المصدر: Synthesis. :243-246
مصطلحات موضوعية: chemistry.chemical_classification, Trimethylsilyl, Acetylide, Aryl, Organic Chemistry, Iodide, Sonogashira coupling, General Medicine, Aldehyde, Combinatorial chemistry, Catalysis, chemistry.chemical_compound, MTEP, chemistry, Organic chemistry, Oxazole
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a75592ae74ecb39a49941f0d6164640
https://doi.org/10.1055/s-2005-918503
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