المؤلفون: Wu MJ; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Kondo H; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Kammula AV; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Shi L; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Xiao Y; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA., Dhiab S; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Xu Q; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Slater CJ; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Universite Paris-Saclay, Institut Gustave Roussy, INSERM U1015, Villejuif, France.; Servier Pharmaceuticals LLC, Boston, MA, USA., Avila OI; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Merritt J; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Kato H; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Kattel P; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Sussman J; Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Graduate Group in Genomics and Computational Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Gritti I; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Eccleston J; Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Sun Y; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA., Cho HM; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Olander K; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Katsuda T; Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Shi DD; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, MA, USA., Savani MR; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Medical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas, TX, USA., Smith BC; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA., Cleary JM, Mostoslavsky R; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Vijay V; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Kitagawa Y; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Jenkins RW; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, MA, USA., Yates KB; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Paik J; Department of Pathology and Laboratory Medicine, Sandra and Edward Meyer Cancer Center, Weill Medical College of Cornell University, New York, NY, USA., Tassinari A; Servier Pharmaceuticals LLC, Boston, MA, USA., Saatcioglu DH; Servier Pharmaceuticals LLC, Boston, MA, USA., Tron AE; Servier Pharmaceuticals LLC, Boston, MA, USA., Haas W; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Cahill D; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., McBrayer SK; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA., Manguso RT; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Bardeesy N; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.

المصدر: Science (New York, N.Y.) [Science] 2024 Jul 12; Vol. 385 (6705), pp. eadl6173. Date of Electronic Publication: 2024 Jul 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Immunity, Innate*/genetics , Isocitrate Dehydrogenase*/genetics , Isocitrate Dehydrogenase*/metabolism , Neoplasms*/immunology , Neoplasms*/genetics , Immune Evasion*/genetics, Animals ; Humans ; Mice ; Cell Line, Tumor ; DNA/metabolism ; DNA Demethylation ; DNA Methylation ; DNA Transposable Elements ; Epigenesis, Genetic ; Glutarates/metabolism ; Mutation ; Nucleotidyltransferases/genetics ; Tumor Escape

المؤلفون: Senkpeil L; Division of Infectious Diseases, Department of Medicine.; Department of Microbiology and Immunology, and., Bhardwaj J; Division of Infectious Diseases, Department of Medicine., Little MR; Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Holla P; Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Upadhye A; Division of Infectious Diseases, Department of Medicine., Fusco EM; Department of Microbiology and Immunology, and., Swanson PA 2nd; Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA., Wiegand RE; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Macklin MD; Division of Infectious Diseases, Department of Medicine., Bi K; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Flynn BJ; Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA., Yamamoto A; Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA., Gaskin EL; Division of Infectious Diseases, Department of Medicine., Sather DN; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA., Oblak AL; Stark Neurosciences Research Institute and., Simpson E; Center for Medical Genomics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Gao H; Center for Medical Genomics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Haining WN; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Yates KB; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Liu X; Deming Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA., Murshedkar T; Sanaria, Rockville, Maryland, USA., Richie TL; Sanaria, Rockville, Maryland, USA., Sim BKL; Sanaria, Rockville, Maryland, USA., Otieno K; Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya., Kariuki S; Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya., Xuei X; Center for Medical Genomics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Liu Y; Center for Medical Genomics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Polidoro RB; Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Hoffman SL; Sanaria, Rockville, Maryland, USA., Oneko M; Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya., Steinhardt LC; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Schmidt NW; Department of Microbiology and Immunology, and.; Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Seder RA; Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA., Tran TM; Division of Infectious Diseases, Department of Medicine.; Department of Microbiology and Immunology, and.; Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

المصدر: JCI insight [JCI Insight] 2024 Apr 30; Vol. 9 (11). Date of Electronic Publication: 2024 Apr 30.

نوع المنشور: Journal Article; Randomized Controlled Trial

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

مواضيع طبية MeSH: Malaria Vaccines*/immunology , Malaria Vaccines*/administration & dosage , Immunity, Innate*/immunology , Malaria, Falciparum*/prevention & control , Malaria, Falciparum*/immunology , Plasmodium falciparum*/immunology , Vaccines, Attenuated*/immunology , Vaccines, Attenuated*/administration & dosage , Sporozoites*/immunology , Sporozoites*/radiation effects, Humans ; Animals ; Mice ; CD8-Positive T-Lymphocytes/immunology ; Infant ; Protozoan Proteins/immunology ; Antibodies, Protozoan/immunology ; Female ; Parasitemia/immunology ; Parasitemia/prevention & control ; Immunoglobulin G/immunology ; Immunoglobulin G/blood ; Vaccine Efficacy

المؤلفون: Iorgulescu JB; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.; The Eli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, MA, United States., Ruthen N; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States., Ahn R; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States., Panagioti E; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States., Gokhale PC; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, United States., Neagu M; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, United States., Speranza MC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States., Eschle BK; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, United States., Soroko KM; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, United States., Piranlioglu R; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States., Datta M; Edwin L. Steele Laboratories for Tumor Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.; Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN, United States., Krishnan S; Edwin L. Steele Laboratories for Tumor Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Yates KB; The Eli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, MA, United States.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, United States., Baker GJ; Laboratory of Systems Pharmacology, Program in Therapeutic Science, Harvard Medical School, Boston, MA, United States.; Ludwig Center for Cancer Research at Harvard, Harvard Medical School, Boston, MA, United States., Jain RK; Edwin L. Steele Laboratories for Tumor Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Suvà ML; The Eli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, MA, United States.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, United States.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Neuberg D; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States., White FM; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States., Chiocca EA; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States., Freeman GJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States., Sharpe AH; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.; The Eli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, MA, United States.; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, United States., Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.; The Eli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, MA, United States., Reardon DA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.

المصدر: Frontiers in immunology [Front Immunol] 2023 Dec 28; Vol. 14, pp. 1297932. Date of Electronic Publication: 2023 Dec 28 (Print Publication: 2023).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Antigen Presentation* , Glioblastoma*, Humans ; Animals ; Mice ; Janus Kinases ; Signal Transduction ; STAT Transcription Factors ; Interferon-gamma ; Immunotherapy

المؤلفون: Ramos A; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Koch CE; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Liu-Lupo Y; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Hellinger RD; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Kyung T; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Abbott KL; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Fröse J; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Goulet D; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Gordon KS; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Eidell KP; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Leclerc P; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Whittaker CA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Larson RC; Cellular Immunotherapy Program, Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Immunology Program, Harvard Medical School, Boston, MA, USA., Muscato AJ; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142, USA., Yates KB; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142, USA., Dubrot J; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142, USA.; Solid Tumors Program, Division of Oncology, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain., Doench JG; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142, USA., Regev A; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Vander Heiden MG; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Maus MV; Cellular Immunotherapy Program, Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Immunology Program, Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142, USA.; Ragon Institute of MIT, MGH, and Harvard, Cambridge, MA, USA., Manguso RT; Immunology Program, Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142, USA., Birnbaum ME; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Hemann MT; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. hemann@mit.edu.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. hemann@mit.edu.

المصدر: Nature communications [Nat Commun] 2023 Dec 05; Vol. 14 (1), pp. 8048. Date of Electronic Publication: 2023 Dec 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Chimeric Antigen* , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/genetics , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/therapy , Leukemia* , Burkitt Lymphoma*, Humans ; Animals ; Mice ; RNA, Guide, CRISPR-Cas Systems ; Immunotherapy, Adoptive ; T-Lymphocytes ; Tumor Microenvironment

المؤلفون: Baumgartner CK; AbbVie, North Chicago, IL, USA. christina.baumgartner@abbvie.com., Ebrahimi-Nik H; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Ohio State University Comprehensive Cancer Center and Pelotonia Institute for Immuno-Oncology, Columbus, OH, USA., Iracheta-Vellve A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Pfizer, Groton, CT, USA., Hamel KM; AbbVie, North Chicago, IL, USA., Olander KE; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Davis TGR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., McGuire KA; AbbVie, North Chicago, IL, USA., Halvorsen GT; AbbVie, North Chicago, IL, USA., Avila OI; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Patel CH; Calico Life Sciences, South San Francisco, CA, USA., Kim SY; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Kammula AV; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Muscato AJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Halliwill K; AbbVie, South San Francisco, CA, USA., Geda P; AbbVie, North Chicago, IL, USA.; Bristol Myers Squibb, Summit, NJ, USA., Klinge KL; AbbVie, North Chicago, IL, USA., Xiong Z; AbbVie, North Chicago, IL, USA.; Ipsen Biosciences, Cambridge, MA, USA., Duggan R; AbbVie, North Chicago, IL, USA., Mu L; AbbVie, North Chicago, IL, USA., Yeary MD; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Patti JC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Balon TM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Mathew R; AbbVie, South San Francisco, CA, USA., Backus C; AbbVie, South San Francisco, CA, USA., Kennedy DE; AbbVie, North Chicago, IL, USA., Chen A; AbbVie, North Chicago, IL, USA., Longenecker K; AbbVie, North Chicago, IL, USA., Klahn JT; AbbVie, North Chicago, IL, USA., Hrusch CL; AbbVie, North Chicago, IL, USA., Krishnan N; AbbVie, North Chicago, IL, USA.; Monte Rosa Therapeutics, Boston, MA, USA., Hutchins CW; AbbVie, North Chicago, IL, USA., Dunning JP; AbbVie, North Chicago, IL, USA., Bulic M; AbbVie, North Chicago, IL, USA., Tiwari P; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Colvin KJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Chuong CL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Kohnle IC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Rees MG; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Boghossian A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ronan M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Roth JA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wu MJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Suermondt JSMT; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Knudsen NH; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Cheruiyot CK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Sen DR; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Griffin GK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Golub TR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., El-Bardeesy N; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Decker JH; AbbVie, North Chicago, IL, USA., Yang Y; AbbVie, North Chicago, IL, USA., Guffroy M; AbbVie, North Chicago, IL, USA., Fossey S; AbbVie, North Chicago, IL, USA., Trusk P; AbbVie, North Chicago, IL, USA., Sun IM; Calico Life Sciences, South San Francisco, CA, USA., Liu Y; Calico Life Sciences, South San Francisco, CA, USA., Qiu W; AbbVie, North Chicago, IL, USA., Sun Q; AbbVie, North Chicago, IL, USA., Paddock MN; Calico Life Sciences, South San Francisco, CA, USA., Farney EP; AbbVie, North Chicago, IL, USA., Matulenko MA; AbbVie, North Chicago, IL, USA., Beauregard C; Calico Life Sciences, South San Francisco, CA, USA.; Vir Biotechnology, San Francisco, CA, USA., Frost JM; AbbVie, North Chicago, IL, USA. jennifer.frost@abbvie.com., Yates KB; Broad Institute of MIT and Harvard, Cambridge, MA, USA. yates@broadinstitute.org.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. yates@broadinstitute.org., Kym PR; AbbVie, North Chicago, IL, USA. phil.r.kym@abbvie.com., Manguso RT; Broad Institute of MIT and Harvard, Cambridge, MA, USA. rmanguso@mgh.harvard.edu.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. rmanguso@mgh.harvard.edu.

المصدر: Nature [Nature] 2023 Oct; Vol. 622 (7984), pp. 850-862. Date of Electronic Publication: 2023 Oct 04.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Immunotherapy*/methods , Neoplasms*/drug therapy , Neoplasms*/enzymology , Neoplasms*/immunology , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/antagonists & inhibitors, Animals ; Humans ; Mice ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; Disease Models, Animal ; Drug Resistance, Neoplasm ; Immune Checkpoint Inhibitors ; Interferons/immunology ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/immunology ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology

المؤلفون: Lane-Reticker SK; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Kessler EA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Muscato AJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Kim SY; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Doench JG; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Yates KB; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA., Manguso RT; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: rmanguso@broadinstitute.org., Dubrot J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Solid Tumors Program, Division of Oncology, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain. Electronic address: jdubrot@unav.es.

المصدر: STAR protocols [STAR Protoc] 2023 Mar 17; Vol. 4 (1), pp. 102082. Date of Electronic Publication: 2023 Feb 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101769501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-1667 (Electronic) Linking ISSN: 26661667 NLM ISO Abbreviation: STAR Protoc Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Cas Systems*/genetics , RNA, Guide, CRISPR-Cas Systems*, Mice ; Animals ; Gene Library ; Genome ; Cell Line

المؤلفون: Sun Y; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Revach OY; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Anderson S; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kessler EA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wolfe CH; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jenney A; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, MA, USA., Mills CE; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, MA, USA., Robitschek EJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Davis TGR; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kim S; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fu A; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ma X; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Gwee J; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Tiwari P; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Du PP; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sindurakar P; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Tian J; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Mehta A; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Schneider AM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Yizhak K; Department of Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Institute of Technology, Technion, Haifa, Israel., Sade-Feldman M; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., LaSalle T; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Sharova T; Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Xie H; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Liu S; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, MA, USA., Michaud WA; Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Saad-Beretta R; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Yates KB; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Iracheta-Vellve A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Spetz JKE; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, MA, USA.; Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, MA, USA.; John B. Little Center for Radiation Sciences, Harvard School of Public Health, Boston, MA, USA., Qin X; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, MA, USA.; Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, MA, USA.; John B. Little Center for Radiation Sciences, Harvard School of Public Health, Boston, MA, USA., Sarosiek KA; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, MA, USA.; Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, MA, USA.; John B. Little Center for Radiation Sciences, Harvard School of Public Health, Boston, MA, USA., Zhang G; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.; Preston Robert Tisch Brain Tumor Center, Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.; Preston Robert Tisch Brain Tumor Center, Department of Pathology, Duke University School of Medicine, Durham, NC, USA., Kim JW; Moores Cancer Center, UC San Diego, La Jolla, CA, USA.; Center for Novel Therapeutics, UC San Diego, La Jolla, CA, USA.; Department of Medicine, UC San Diego, La Jolla, CA, USA., Su MY; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Cicerchia AM; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Rasmussen MQ; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Klempner SJ; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Juric D; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Pai SI; Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA., Miller DM; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Giobbie-Hurder A; Division of Biostatistics, Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA., Chen JH; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Pelka K; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Frederick DT; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Stinson S; Gilead Sciences, Foster City, CA, USA., Ivanova E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Aref AR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA.; Xsphera Biosciences, Boston, MA, USA., Paweletz CP; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Barbie DA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Sen DR; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Fisher DE; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Corcoran RB; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Hacohen N; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sorger PK; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, MA, USA., Flaherty KT; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Boland GM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Manguso RT; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jenkins RW; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. rjenkins@mgh.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. rjenkins@mgh.harvard.edu.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, MA, USA. rjenkins@mgh.harvard.edu.

المصدر: Nature [Nature] 2023 Mar; Vol. 615 (7950), pp. 158-167. Date of Electronic Publication: 2023 Jan 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Immune Evasion*/genetics , Immune Evasion*/immunology , Immunotherapy*/methods , Protein Serine-Threonine Kinases*/antagonists & inhibitors , Protein Serine-Threonine Kinases*/genetics , Drug Resistance, Neoplasm*, Humans ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Organoids ; Tumor Necrosis Factors/immunology ; Interferon-gamma/immunology ; Spheroids, Cellular ; Caspases ; Janus Kinases ; STAT Transcription Factors

المؤلفون: Dubrot J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain., Du PP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanford University School of Medicine, Stanford, CA, USA., Lane-Reticker SK; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kessler EA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Muscato AJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mehta A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Freeman SS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Allen PM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Olander KE; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ockerman KM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wolfe CH; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wiesmann F; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Knudsen NH; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Tsao HW; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Iracheta-Vellve A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Schneider EM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rivera-Rosario AN; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kohnle IC; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Pope HW; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ayer A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mishra G; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zimmer MD; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kim SY; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mahapatra A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ebrahimi-Nik H; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Frederick DT; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Boland GM; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Haining WN; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.; ArsenalBio, South San Francisco, CA, USA., Root DE; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Doench JG; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hacohen N; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Yates KB; Broad Institute of MIT and Harvard, Cambridge, MA, USA. yates@broadinstitute.org.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA. yates@broadinstitute.org.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. yates@broadinstitute.org., Manguso RT; Broad Institute of MIT and Harvard, Cambridge, MA, USA. rmanguso@mgh.harvard.edu.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA. rmanguso@mgh.harvard.edu.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. rmanguso@mgh.harvard.edu.

المصدر: Nature immunology [Nat Immunol] 2022 Oct; Vol. 23 (10), pp. 1495-1506. Date of Electronic Publication: 2022 Sep 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE

مواضيع طبية MeSH: CD8-Positive T-Lymphocytes* , Neoplasms*, Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Histocompatibility Antigens Class I/metabolism ; Humans ; Immune Checkpoint Inhibitors ; Immune Evasion ; Interferon-gamma/genetics ; Interferon-gamma/metabolism ; NK Cell Lectin-Like Receptor Subfamily C

المؤلفون: Collins NB; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston Children's Hospital, Boston, Massachusetts, USA., Al Abosy R; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Miller BC; Lineberger Comprehensive Cancer Center, Department of Medicine, Division of Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Bi K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Zhao Q; Oncology Discovery Biology, Bristol Myers Squibb, Lawrenceville, New Jersey, USA., Quigley M; Research Biology, Gilead Sciences Inc, Foster City, California, USA., Ishizuka JJ; Department of Internal Medicine (Oncology), Yale Cancer Center and Yale School of Medicine, New Haven, New Jersey, USA., Yates KB; Broad Institute, Cambridge, Massachusetts, USA.; Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA., Pope HW; Arsenal Biosciences, San Francisco, California, USA., Manguso RT; Broad Institute, Cambridge, Massachusetts, USA.; Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA., Shrestha Y; AstraZeneca, Gaithersburg, Maryland, USA., Wadsworth M; Broad Institute, Cambridge, Massachusetts, USA.; Institute for Medical Engineering & Science (IMES), Department of Chemistry and Koch Institute for Integrative Cancer Research, Ragon Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA., Hughes T; Broad Institute, Cambridge, Massachusetts, USA.; Institute for Medical Engineering & Science (IMES), Department of Chemistry and Koch Institute for Integrative Cancer Research, Ragon Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA., Shalek AK; Broad Institute, Cambridge, Massachusetts, USA.; Institute for Medical Engineering & Science (IMES), Department of Chemistry and Koch Institute for Integrative Cancer Research, Ragon Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA., Boehm JS; Broad Institute, Cambridge, Massachusetts, USA., Hahn WC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Broad Institute, Cambridge, Massachusetts, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Doench JG; Broad Institute, Cambridge, Massachusetts, USA., Haining WN; Arsenal Biosciences, San Francisco, California, USA nhaining@arsenalbio.com.

المصدر: Journal for immunotherapy of cancer [J Immunother Cancer] 2022 Mar; Vol. 10 (3).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Print Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms*/metabolism , Tumor Microenvironment*, Animals ; CD8-Positive T-Lymphocytes/metabolism ; Carcinogenesis ; Class I Phosphatidylinositol 3-Kinases/genetics ; Disease Models, Animal ; Humans ; Immune Evasion ; Inositol ; Mice ; Phosphatidylinositol 3-Kinases/metabolism

المؤلفون: Zeng Z; Department of Data Science, Dana Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA., Wong CJ; Department of Data Science, Dana Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115 USA., Yang L; Department of Data Science, Dana Farber Cancer Institute, Boston, MA 02215, USA., Ouardaoui N; Department of Data Science, Dana Farber Cancer Institute, Boston, MA 02215, USA., Li D; Department of Data Science, Dana Farber Cancer Institute, Boston, MA 02215, USA., Zhang W; Department of Data Science, Dana Farber Cancer Institute, Boston, MA 02215, USA.; School of Life Science and Technology, Tongji University, Shanghai, 200060, China., Gu S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Data Science, Dana Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA., Zhang Y; Department of Data Science, Dana Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA., Liu Y; Department of Data Science, Dana Farber Cancer Institute, Boston, MA 02215, USA., Wang X; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Data Science, Dana Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA., Fu J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02129, USA., Zhou L; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Zhang B; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Data Science, Dana Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA., Kim S; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02129, USA., Yates KB; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02129, USA.; Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA., Brown M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Freeman GJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Uppaluri R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Surgery, Brigham and Women's Hospital, Boston, MA 02215, USA., Manguso R; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02129, USA.; Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA., Liu XS; Department of Data Science, Dana Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

المصدر: Nucleic acids research [Nucleic Acids Res] 2022 Jan 07; Vol. 50 (D1), pp. D1391-D1397.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

مواضيع طبية MeSH: Biomarkers, Pharmacological* , Software*, Neoplasms/*genetics , Tumor Microenvironment/*immunology, Animals ; Databases, Genetic ; Disease Models, Animal ; Humans ; Immunotherapy/trends ; Mice ; Neoplasms/immunology ; Neoplasms/therapy ; Tumor Microenvironment/genetics