المؤلفون: Sinha NK; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., McKenney C; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Yeow ZY; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Li JJ; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Nam KH; Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Yaron-Barir TM; Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA; Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Johnson JL; Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Huntsman EM; Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA., Cantley LC; Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Ordureau A; Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: ordureaa@mskcc.org., Regot S; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: sregot@jhmi.edu., Green R; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address: ragreen@jhmi.edu.

المصدر: Cell [Cell] 2024 Jul 11; Vol. 187 (14), pp. 3652-3670.e40. Date of Electronic Publication: 2024 Jun 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Ultraviolet Rays*/adverse effects , Apoptosis*/radiation effects , DNA Damage*, Phosphorylation/radiation effects ; Humans ; Signal Transduction/radiation effects ; Protein Serine-Threonine Kinases/metabolism ; Stress, Physiological/radiation effects ; Ribosomes/metabolism ; Cell Death/radiation effects

المؤلفون: Gliech CR; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Yeow ZY; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Tapias-Gomez D; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Yang Y; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Huang Z; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Tijhuis AE; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, AV, 9713, The Netherlands., Spierings DC; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, AV, 9713, The Netherlands., Foijer F; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, AV, 9713, The Netherlands., Chung G; Oncology Research, Amgen Research, Thousand Oaks, CA, 91320, USA., Tamayo N; Medicinal Chemistry, Amgen Research, Thousand Oaks, CA, 91320, USA., Bahrami-Nejad Z; Genome Analysis Unit, Amgen Research, South San Francisco, CA, 94084, USA., Collins P; Genome Analysis Unit, Amgen Research, South San Francisco, CA, 94084, USA., Nguyen TT; Genome Analysis Unit, Amgen Research, South San Francisco, CA, 94084, USA., Plata Stapper A; Center for Research Acceleration by Digital Innovation, Amgen Research, South San Francisco, CA, 94084, USA., Hughes PE; Oncology Research, Amgen Research, Thousand Oaks, CA, 91320, USA., Payton M; Oncology Research, Amgen Research, Thousand Oaks, CA, 91320, USA., Holland AJ; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. aholland@jhmi.edu.

المصدر: The EMBO journal [EMBO J] 2024 Mar; Vol. 43 (5), pp. 666-694. Date of Electronic Publication: 2024 Jan 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE

مواضيع طبية MeSH: Anaphase-Promoting Complex-Cyclosome*/genetics , Neoplasms*/genetics, Humans ; Dyneins ; Kinesins/genetics ; Kinetochores ; Mitosis

المؤلفون: Yeow ZY; Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Lambrus BG; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Marlow R; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.; The Breast Cancer Now Unit, King's College London, London, UK., Zhan KH; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Durin MA; Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Evans LT; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Scott PM; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Phan T; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Park E; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ruiz LA; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Moralli D; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Knight EG; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, UK., Badder LM; The Breast Cancer Now Unit, King's College London, London, UK., Novo D; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, UK., Haider S; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, UK., Green CM; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Tutt ANJ; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.; The Breast Cancer Now Unit, King's College London, London, UK., Lord CJ; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, UK., Chapman JR; Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. ross.chapman@imm.ox.ac.uk.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. ross.chapman@imm.ox.ac.uk., Holland AJ; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. aholland@jhmi.edu.

المصدر: Nature [Nature] 2020 Sep; Vol. 585 (7825), pp. 447-452. Date of Electronic Publication: 2020 Sep 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms/*genetics , Centrosome/*metabolism , Centrosome/*pathology , Chromosomes, Human, Pair 17/*genetics , Tripartite Motif Proteins/*metabolism , Ubiquitin-Protein Ligases/*metabolism, Antineoplastic Agents/pharmacology ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Centrosome/drug effects ; Female ; G2 Phase ; Genomic Instability ; Humans ; Mitosis/genetics ; Protein Serine-Threonine Kinases/metabolism ; Tripartite Motif Proteins/genetics ; Ubiquitin-Protein Ligases/genetics