المؤلفون: Su-Ying Wu, Tsu Hsu, Weir-Torn Jiaang, Ching-Cheng Hsueh, Hsin-Huei Chang, Fang-Chun Kung, Cheng-Tai Lu, Yi-Hui Peng, Ching-Chuan Kuo, Lung-Chun Lee, Chih-Hsiang Huang

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: Models, Molecular, Allosteric regulation, Xanthine, Article, Cofactor, Structure-Activity Relationship, chemistry.chemical_compound, Downregulation and upregulation, Aminohydrolases, Drug Discovery, Humans, Enzyme Inhibitors, MTHFD2 Gene, Methylenetetrahydrofolate Dehydrogenase (NADP), Dose-Response Relationship, Drug, Molecular Structure, biology, Substrate (chemistry), Metabolism, Multifunctional Enzymes, Biochemistry, chemistry, biology.protein, Molecular Medicine, Uncompetitive inhibitor, Allosteric Site

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cefd173f9bbcc3bc6e5f8b46d32a1935
https://doi.org/10.1021/acs.jmedchem.1c00663

المؤلفون: Yi-Hui Peng, Fang-Yu Liao, Chen-Tso Tseng, Ramajayam Kuppusamy, An-Siou Li, Chi-Han Chen, Yu-Shiou Fan, Sing-Yi Wang, Mine-Hsine Wu, Ching-Cheng Hsueh, Jia-Yu Chang, Lung-Chun Lee, Chuan Shih, Kak-Shan Shia, Teng-Kuang Yeh, Ming-Shiu Hung, Ching-Chuan Kuo, Jen-Shin Song, Su-Ying Wu, Shau-Hua Ueng

المصدر: Journal of Medicinal Chemistry. 63:1642-1659

مصطلحات موضوعية: Structure-Activity Relationship, Thiazoles, Binding Sites, Molecular Structure, Drug Discovery, Imidazoles, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Molecular Medicine, Enzyme Inhibitors, Crystallography, X-Ray, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4258e7674e4456ad315cdaea64c49e02
https://doi.org/10.1021/acs.jmedchem.9b01549

المؤلفون: Hui-You Lin, Yi-Hui Peng, Kuo Wei Huang, Chen-Lung Huang, Mine-Hsine Wu, Chuan Shih, Teng-Kuang Yeh, Weir-Torn Jiaang, Ching-Chuan Kuo, Tsu Hsu, Ching-Ping Chen, Ya-Ling Weng, Chiung-Tong Chen, Fang-Chun Kung, Wen-Hsing Lin, Hui Yi Shiao, Jen-Shin Song, Ling-Hui Chou, Tsung-Sheng Wu, Kuei-Jung Yen, Pei-Chen Wang, Ching-Cheng Hsueh, Yu-Chieh Su, Cheng-Tai Lu, Hui-Jen Tsai, Su-Ying Wu, Li-Tzong Chen, Po-Chu Kuo

المصدر: Journal of Medicinal Chemistry. 62:11135-11150

مصطلحات موضوعية: Male, Stromal cell, Gastrointestinal Stromal Tumors, medicine.drug_class, Mice, Nude, Antineoplastic Agents, Apoptosis, Stem cell factor, Mice, SCID, Tyrosine-kinase inhibitor, Receptor tyrosine kinase, Rats, Sprague-Dawley, Mice, Mice, Inbred NOD, hemic and lymphatic diseases, Drug Discovery, Tumor Cells, Cultured, medicine, Animals, Humans, Phosphorylation, Kinase activity, Protein Kinase Inhibitors, neoplasms, Cell Proliferation, Gastrointestinal Neoplasms, Mice, Inbred ICR, biology, Chemistry, Kinase, Cell growth, Myeloid leukemia, Xenograft Model Antitumor Assays, digestive system diseases, Leukemia, Myeloid, Acute, Proto-Oncogene Proteins c-kit, Pyrimidines, fms-Like Tyrosine Kinase 3, Mutation, biology.protein, Cancer research, Molecular Medicine, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60499fc4136ddd2d5cf080a65b7dda3b
https://doi.org/10.1021/acs.jmedchem.9b01229

المؤلفون: Teng-Kuang Yeh, Jen-Shin Song, Po-Wei Chang, Jin-Chen Yu, Chia-Hwa Chang, Fang-Yu Liao, Ya-Wen Tien, Ramajayam Kuppusamy, An-Siou Li, Chi-Han Chen, Chieh-Wen Chen, Li-Mei Lin, Hsin-Huei Chang, Chih-Hsiang Huang, Jau-Ying Yao, Mine-Hsine Wu, Yi-Hui Peng, Ching-Cheng Hsueh, Wen-Chi Hsiao, Pei-Husan Chen, Chin-Yu Lin, Su-Huei Hsieh, Chuan Shih, Ming-Shiu Hung, Su-Ying Wu, Ching-Chuan Kuo, Shau-Hua Ueng

المصدر: European journal of medicinal chemistry. 229

مصطلحات موضوعية: Pharmacology, Mice, Inbred ICR, Binding Sites, Organic Chemistry, Transplantation, Heterologous, General Medicine, Thiophenes, Amides, Molecular Docking Simulation, Mice, Structure-Activity Relationship, Cell Line, Tumor, Drug Design, Neoplasms, Drug Discovery, Animals, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Enzyme Inhibitors, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c490b623ec9a953cd1fcf3690ae527
https://pubmed.ncbi.nlm.nih.gov/34929581

المؤلفون: Tsu Hsu, Yi-Hui Peng, Yu-Chieh Su, Weir-Torn Jiaang, Jia-Yu Chang, Hui-You Lin, Teng-Kuang Yeh, Cheng-Tai Lu, Tsung-Sheng Wu, Hui Yi Shiao, Chiung-Tong Chen, Jen-Shin Song, Wen-Hsing Lin, Pei-Chen Wang, Su-Ying Wu, Li-Tzong Chen, Ching-Cheng Hsueh, Fang-Chun Kung, Hui-Jen Tsai, Lung-Chun Lee, Chih-Hsiang Tu

المصدر: Journal of Medicinal Chemistry. 62:3940-3957

مصطلحات موضوعية: Stromal cell, Gastrointestinal Stromal Tumors, Mutant, Drug Evaluation, Preclinical, Drug resistance, Crystallography, X-Ray, 01 natural sciences, Mice, Structure-Activity Relationship, 03 medical and health sciences, Cell Line, Tumor, Drug Discovery, Animals, Humans, Urea, Protein Kinase Inhibitors, Cell Proliferation, 030304 developmental biology, Mice, Inbred ICR, 0303 health sciences, Binding Sites, Chemistry, Xenograft Model Antitumor Assays, Molecular biology, Protein Structure, Tertiary, 0104 chemical sciences, Molecular Docking Simulation, Proto-Oncogene Proteins c-kit, 010404 medicinal & biomolecular chemistry, Inhibitory potency, Pyrimidines, Activation loop, Cell culture, Imatinib Mesylate, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01c2cdf54c196cc57b9d74b4e146ba3
https://doi.org/10.1021/acs.jmedchem.8b01845

المؤلفون: Sing Yi Wang, Pei Yi Chen, Yung Chang Hsu, Teng Kuang Yeh, Hsu Yi Sun, Chun Hwa Chen, Kai-Chia Yeh, Shu Yu Lin, Su Ying Wu, Hsing Pang Hsieh, Ching Ping Chen, Chiung-Tong Chen, Hui Yi Shiao, Yi Hui Peng, Tzu Wen Lien, Fu Ming Kuo, Yi Yu Ke, Wen-Hsing Lin, Chang Ying Chu, Tsu An Hsu

المصدر: Journal of medicinal chemistry. 62(22)

مصطلحات موضوعية: Male, Lung Neoplasms, Receptor, ErbB-2, Afatinib, Phases of clinical research, Mice, Nude, Antineoplastic Agents, Crystallography, X-Ray, 01 natural sciences, 03 medical and health sciences, T790M, Structure-Activity Relationship, In vivo, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Osimertinib, Epidermal growth factor receptor, Receptor, Lung cancer, Protein Kinase Inhibitors, 030304 developmental biology, 0303 health sciences, Mice, Inbred ICR, Binding Sites, biology, Chemistry, Exons, medicine.disease, Xenograft Model Antitumor Assays, 0104 chemical sciences, Rats, ErbB Receptors, 010404 medicinal & biomolecular chemistry, Pyrimidines, Drug Resistance, Neoplasm, Drug Design, Mutation, Cancer research, biology.protein, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c0a7f2358d5cec8f896161d0fefb55
https://pubmed.ncbi.nlm.nih.gov/31560541

المؤلفون: Yi-Hui Peng, Fang-Yu Liao, Chen-Tso Tseng, Ramajayam Kuppusamy, An-Siou Li, Chi-Han Chen, Yu-Shiou Fan, Sing-Yi Wang, Mine-Hsine Wu, Ching-Cheng Hsueh, Jia-Yu Chang, Lung-Chun Lee, Chuan Shih, Kak-Shan Shia, Teng-Kuang Yeh, Ming-Shiu Hung, Ching-Chuan Kuo, Jen-Shin Song, Su-Ying Wu, Shau-Hua Ueng

المصدر: Journal of Medicinal Chemistry. 63:7445-7445

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0154a3670cb148194c67d82c213cc4c4
https://doi.org/10.1021/acs.jmedchem.0c00966

المؤلفون: John T.A. Hsu, Jian-Sung Wu, Shiu Hwa Yeh, Shu Yu Lin, Wen-Chi Hsiao, Andrew Yueh, Jen-Shin Song, Chia-Ling Hsieh, Yi-Hui Peng, Ming-Shiu Hung, Lung-Chun Lee, Chia-Yeh Liu, Shau-Hua Ueng, Su-Ying Wu, Mine-Hsine Wu, Chuan Shih, Shu-Yi Lin, Teng-Kuang Yeh, Fang-Yu Liao, Chun-Hwa Chen

المصدر: Journal of Medicinal Chemistry. 58:7807-7819

مصطلحات موضوعية: Virtual screening, Binding Sites, Stereochemistry, Chemistry, medicine.medical_treatment, Drug Evaluation, Preclinical, Tryptophan, Triazoles, Ligands, Molecular Docking Simulation, Tryptophan Oxygenase, Targeted therapy, Structure-Activity Relationship, Drug Discovery, medicine, Humans, Molecular Medicine, Structure–activity relationship, Homology modeling, Enzyme Inhibitors, Binding site, IC50, Databases, Chemical

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f6d48ff04d4c03236ee06acbd01311
https://doi.org/10.1021/acs.jmedchem.5b00921

المؤلفون: Weir-Torn Jiaang, Ping-Chiang Lyu, Wen-Hsing Lin, Chuan Shih, Su-Ying Wu, Jian-Sung Wu, Chih-Hsiang Tu, Chun-Yu Chang, Cheng-Tai Lu, Yi-Hui Peng, Tsu Hsu

المصدر: Journal of medicinal chemistry. 59(8)

مصطلحات موضوعية: 0301 basic medicine, Conformational change, medicine.drug_class, Stereochemistry, Molecular Conformation, Plasma protein binding, Crystallography, X-Ray, 03 medical and health sciences, Structure-Activity Relationship, Protein structure, hemic and lymphatic diseases, Drug Discovery, medicine, Structure–activity relationship, Anaplastic lymphoma kinase, Anaplastic Lymphoma Kinase, Protein Kinase Inhibitors, Chemistry, Receptor Protein-Tyrosine Kinases, Small molecule, ALK inhibitor, 030104 developmental biology, Structural biology, Biochemistry, Molecular Medicine, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14dbb1d6b01301cb128a028280c6e5ca
https://pubmed.ncbi.nlm.nih.gov/27031565

المؤلفون: Fang Yu Liao, Yi Hui Peng, Chia-Ling Hsieh, Han Li Huang, Wen-Chi Hsiao, Shau-Hua Ueng, Shu Yu Lin, Ming Fu Cheng, Chun Yu Yang, Jian Sung Wu, Ming Shiu Hung, Manwu Sun, Su Ying Wu, Chuan Shih, Jen Shin Song, Shiow Lin Pan, Teng Kuang Yeh, Li Mei Lin, Ching Chuan Kuo, Min Wu Chao, Mine Hsine Wu, Yi Lin Chen, Yu-Sheng Chao

المصدر: Journal of medicinal chemistry. 59(1)

مصطلحات موضوعية: Male, Kynurenine pathway, Biological Availability, Antineoplastic Agents, Pharmacology, Immune tolerance, Rats, Sprague-Dawley, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, In vivo, Oral administration, Drug Discovery, Animals, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Enzyme Inhibitors, Indoleamine 2,3-dioxygenase, Kynurenine, Mice, Inbred BALB C, Tryptophan, Xenograft Model Antitumor Assays, Bioavailability, Rats, Mice, Inbred C57BL, chemistry, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574ce1bb194f18e4a4b093cc5fdc5c1f
https://pubmed.ncbi.nlm.nih.gov/26653033