المؤلفون: Matthijs J. van Haren, Yongzhi Gao, Ned Buijs, Roberto Campagna, Davide Sartini, Monica Emanuelli, Lukasz Mateuszuk, Agnieszka Kij, Stefan Chlopicki, Pol Escudé Martinez de Castilla, Raymond Schiffelers, Nathaniel I. Martin

المصدر: Biomolecules, Vol 11, Iss 9, p 1357 (2021)

مصطلحات موضوعية: NNMT, inhibition, prodrug, cell permeability, esterase, cellular activity, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2218-273X/11/9/1357; https://doaj.org/toc/2218-273X

URL الوصول: https://doaj.org/article/fc2a2d1438314007a87c09a76e4ca9c2

المؤلفون: Yang Yu, Junhong Huang, Hu He, Jing Han, Geyan Ye, Tingyang Xu, Xianqiang Sun, Xiumei Chen, Xiaoming Ren, Chunlai Li, Huijuan Li, Wei Huang, Yangyang Liu, Xinjuan Wang, Yongzhi Gao, Nianhe Cheng, Na Guo, Xibo Chen, Jianxia Feng, Yuxia Hua, Chong Liu, Guoyun Zhu, Zhi Xie, Lili Yao, Wenge Zhong, Xinde Chen, Wei Liu, Hailong Li

المصدر: ACS Medicinal Chemistry Letters. 14:297-304

مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c73db8910c8f2071e78fb665160a3975
https://doi.org/10.1021/acsmedchemlett.2c00515

المؤلفون: Agnieszka Kij, Davide Sartini, Roberto Campagna, Nathaniel I. Martin, Monica Emanuelli, Seino A. K. Jongkees, Ned Buijs, Matthijs J. van Haren, Yurui Zhang, Filip A. Fedak, Stefan Chlopicki, Yongzhi Gao, Lukasz Mateuszuk, Vito Thijssen

المساهمون: Chemistry and Pharmaceutical Sciences, AIMMS

المصدر: RSC Chemical Biology, 2(5), 1546-1555
RSC Chemical Biology, 2(5), 1546-1555. Royal Society of Chemistry
Van Haren, M J, Zhang, Y, Thijssen, V, Buijs, N, Gao, Y, Mateuszuk, L, Fedak, F A, Kij, A, Campagna, R, Sartini, D, Emanuelli, M, Chlopicki, S, Jongkees, S A K & Martin, N I 2021, ' Macrocyclic peptides as allosteric inhibitors of nicotinamide : N-methyltransferase (NNMT) ', RSC Chemical Biology, vol. 2, no. 5, pp. 1546-1555 . https://doi.org/10.1039/d1cb00134e

مصطلحات موضوعية: chemistry.chemical_classification, Nicotinamide, Chemistry, Allosteric regulation, Nicotinamide N-methyltransferase, Biochemistry, Genetics and Molecular Biology (miscellaneous), Biochemistry, Cyclic peptide, chemistry.chemical_compound, SDG 3 - Good Health and Well-being, Downregulation and upregulation, Chemistry (miscellaneous), Ic50 values, mRNA display, Methyl donor, Molecular Biology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1116988d55e21d6626c3b65db4b9d7f9
https://doi.org/10.1039/d1cb00134e

المؤلفون: Nathaniel I. Martin, Agnieszka Kij, Lukasz Mateuszuk, Monica Emanuelli, Ned Buijs, Stefan Chlopicki, Roberto Campagna, Yongzhi Gao, Matthijs J. van Haren, Raymond M. Schiffelers, Pol Escudé Martinez de Castilla, Davide Sartini

المصدر: Biomolecules
Biomolecules, 11(9)
Biomolecules, Vol 11, Iss 1357, p 1357 (2021)
Volume 11
Issue 9

مصطلحات موضوعية: esterase, cellular activity, Cell Survival, Carboxylic acid, NNMT, Nicotinamide N-methyltransferase, Buffers, 01 natural sciences, Biochemistry, Microbiology, Article, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, Cell Line, Tumor, Nicotinamide N-Methyltransferase, Humans, Prodrugs, Enzyme Inhibitors, Protecting group, Molecular Biology, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Nicotinamide, 010405 organic chemistry, Chemistry, Hydrolysis, Esterases, cell permeability, Prodrug, Hydrogen-Ion Concentration, QR1-502, inhibition, 0104 chemical sciences, Enzyme, Amine gas treating, Biological Assay, prodrug, Isopropyl

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a82080b3566645d2fc3ce0473dfe73
http://europepmc.org/articles/PMC8466754

المؤلفون: Matthijs J, van Haren, Yurui, Zhang, Vito, Thijssen, Ned, Buijs, Yongzhi, Gao, Lukasz, Mateuszuk, Filip A, Fedak, Agnieszka, Kij, Roberto, Campagna, Davide, Sartini, Monica, Emanuelli, Stefan, Chlopicki, Seino A K, Jongkees, Nathaniel I, Martin

المصدر: RSC Chemical Biology

مصطلحات موضوعية: Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::62e64ffa1d22b318e9cb743b72c2568b
https://pubmed.ncbi.nlm.nih.gov/34704059

المؤلفون: Yongzhi Gao, Matthijs J. van Haren, Nathaniel I. Martin

المصدر: Drug Discovery Today, 26(11), 2699-2706

مصطلحات موضوعية: 0301 basic medicine, Niacinamide, S-Adenosylmethionine, Methyltransferase, 03 medical and health sciences, chemistry.chemical_compound, Human health, 0302 clinical medicine, S-Adenosyl-l-methionine, Metabolic Diseases, Neoplasms, Drug Discovery, Nicotinamide N-Methyltransferase, Medicine, Humans, Enzyme Inhibitors, Pharmacology, chemistry.chemical_classification, Nicotinamide, business.industry, Neurodegenerative Diseases, 030104 developmental biology, Enzyme, chemistry, 030220 oncology & carcinogenesis, Cancer research, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffaa2d6ae58cac9fac8b4aab8f55d86
https://doi.org/10.1016/j.drudis.2021.05.011

المؤلفون: Yongzhi, Gao, Matthijs J, van Haren, Ed E, Moret, Johannes J M, Rood, Davide, Sartini, Alessia, Salvucci, Monica, Emanuelli, Pierrick, Craveur, Nicolas, Babault, Jian, Jin, Nathaniel I, Martin

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: Models, Molecular, Niacinamide, Catalytic Domain, Cell Line, Tumor, Nicotinamide N-Methyltransferase, Humans, Antineoplastic Agents, Mouth Neoplasms, Enzyme Inhibitors, Naphthalenes, Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::ba590ab88457a15e0f7c54ea07dffd66
https://pubmed.ncbi.nlm.nih.gov/31265285

المؤلفون: Hai-Bing Zhou, Yongzhi Gao, Guofu Qiu, Chao Yan, Ze Dong, Chune Dong

المصدر: Advanced Synthesis & Catalysis. 357:2132-2142

مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Chemistry, Squaramide, Organic chemistry, Baylis–Hillman reaction, General Chemistry, Bifunctional, Phosphine, Alkyl, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c5273421be72420fbcf1ff59ccee98cf
https://doi.org/10.1002/adsc.201500110

المؤلفون: Yongzhi Gao, Wei Wang, Hai-Bing Zhou, Bin Liu, Chune Dong

المصدر: RSC Advances. 5:24392-24398

مصطلحات موضوعية: Quinine, Hydrogen bond, Chemistry, General Chemical Engineering, Yield (chemistry), medicine, Squaramide, Enantioselective synthesis, Organic chemistry, General Chemistry, Amination, Catalysis, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d4dc7b8cd1125a8692087cc282a40035
https://doi.org/10.1039/c4ra13789b

المؤلفون: Alexander Dömling, Yongzhi Gao, Grzegorz Dubin, Tad A. Holak, Dobroslawa Krzemien, Krzysztof M. Zak, Tryfon Zarganes-Tzitzikas, Markella Konstantinidou

المساهمون: Drug Design, Medicinal Chemistry and Bioanalysis (MCB)

المصدر: Expert Opin Ther Pat
Expert Opinion on Therapeutic Patents, 26(9), 973-977. Taylor & Francis Ltd

مصطلحات موضوعية: 0301 basic medicine, PD-L1, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Antineoplastic Agents, Disease, 01 natural sciences, immune-oncology, B7-H1 Antigen, Article, DISEASE, Patents as Topic, 03 medical and health sciences, Cancer immunotherapy, Neoplasms, Programmed cell death 1, T-cell exhaustion, Drug Discovery, PD-1, medicine, Animals, Humans, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), immune checkpoint, programmed death-1, Pharmacology, biology, 010405 organic chemistry, Cancer, General Medicine, medicine.disease, Immune checkpoint, 3. Good health, 0104 chemical sciences, 030104 developmental biology, Programmed death-1, Drug Design, Immunology, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, biology.protein, Cancer research, CANCER-IMMUNOTHERAPY, Immunotherapy, Antibody, Magic bullet

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38281bfe8ba8e6b95abebf45dc90901