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1دورية أكاديمية
المؤلفون: Matthijs J. van Haren, Yongzhi Gao, Ned Buijs, Roberto Campagna, Davide Sartini, Monica Emanuelli, Lukasz Mateuszuk, Agnieszka Kij, Stefan Chlopicki, Pol Escudé Martinez de Castilla, Raymond Schiffelers, Nathaniel I. Martin
المصدر: Biomolecules, Vol 11, Iss 9, p 1357 (2021)
مصطلحات موضوعية: NNMT, inhibition, prodrug, cell permeability, esterase, cellular activity, Microbiology, QR1-502
وصف الملف: electronic resource
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المؤلفون: Yang Yu, Junhong Huang, Hu He, Jing Han, Geyan Ye, Tingyang Xu, Xianqiang Sun, Xiumei Chen, Xiaoming Ren, Chunlai Li, Huijuan Li, Wei Huang, Yangyang Liu, Xinjuan Wang, Yongzhi Gao, Nianhe Cheng, Na Guo, Xibo Chen, Jianxia Feng, Yuxia Hua, Chong Liu, Guoyun Zhu, Zhi Xie, Lili Yao, Wenge Zhong, Xinde Chen, Wei Liu, Hailong Li
المصدر: ACS Medicinal Chemistry Letters. 14:297-304
مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry
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المؤلفون: Agnieszka Kij, Davide Sartini, Roberto Campagna, Nathaniel I. Martin, Monica Emanuelli, Seino A. K. Jongkees, Ned Buijs, Matthijs J. van Haren, Yurui Zhang, Filip A. Fedak, Stefan Chlopicki, Yongzhi Gao, Lukasz Mateuszuk, Vito Thijssen
المساهمون: Chemistry and Pharmaceutical Sciences, AIMMS
المصدر: RSC Chemical Biology, 2(5), 1546-1555
RSC Chemical Biology, 2(5), 1546-1555. Royal Society of Chemistry
Van Haren, M J, Zhang, Y, Thijssen, V, Buijs, N, Gao, Y, Mateuszuk, L, Fedak, F A, Kij, A, Campagna, R, Sartini, D, Emanuelli, M, Chlopicki, S, Jongkees, S A K & Martin, N I 2021, ' Macrocyclic peptides as allosteric inhibitors of nicotinamide : N-methyltransferase (NNMT) ', RSC Chemical Biology, vol. 2, no. 5, pp. 1546-1555 . https://doi.org/10.1039/d1cb00134eمصطلحات موضوعية: chemistry.chemical_classification, Nicotinamide, Chemistry, Allosteric regulation, Nicotinamide N-methyltransferase, Biochemistry, Genetics and Molecular Biology (miscellaneous), Biochemistry, Cyclic peptide, chemistry.chemical_compound, SDG 3 - Good Health and Well-being, Downregulation and upregulation, Chemistry (miscellaneous), Ic50 values, mRNA display, Methyl donor, Molecular Biology
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1116988d55e21d6626c3b65db4b9d7f9
https://doi.org/10.1039/d1cb00134e -
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المؤلفون: Nathaniel I. Martin, Agnieszka Kij, Lukasz Mateuszuk, Monica Emanuelli, Ned Buijs, Stefan Chlopicki, Roberto Campagna, Yongzhi Gao, Matthijs J. van Haren, Raymond M. Schiffelers, Pol Escudé Martinez de Castilla, Davide Sartini
المصدر: Biomolecules
Biomolecules, 11(9)
Biomolecules, Vol 11, Iss 1357, p 1357 (2021)
Volume 11
Issue 9مصطلحات موضوعية: esterase, cellular activity, Cell Survival, Carboxylic acid, NNMT, Nicotinamide N-methyltransferase, Buffers, 01 natural sciences, Biochemistry, Microbiology, Article, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, Cell Line, Tumor, Nicotinamide N-Methyltransferase, Humans, Prodrugs, Enzyme Inhibitors, Protecting group, Molecular Biology, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Nicotinamide, 010405 organic chemistry, Chemistry, Hydrolysis, Esterases, cell permeability, Prodrug, Hydrogen-Ion Concentration, QR1-502, inhibition, 0104 chemical sciences, Enzyme, Amine gas treating, Biological Assay, prodrug, Isopropyl
وصف الملف: application/pdf
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المؤلفون: Matthijs J, van Haren, Yurui, Zhang, Vito, Thijssen, Ned, Buijs, Yongzhi, Gao, Lukasz, Mateuszuk, Filip A, Fedak, Agnieszka, Kij, Roberto, Campagna, Davide, Sartini, Monica, Emanuelli, Stefan, Chlopicki, Seino A K, Jongkees, Nathaniel I, Martin
المصدر: RSC Chemical Biology
مصطلحات موضوعية: Chemistry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::62e64ffa1d22b318e9cb743b72c2568b
https://pubmed.ncbi.nlm.nih.gov/34704059 -
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المؤلفون: Yongzhi Gao, Matthijs J. van Haren, Nathaniel I. Martin
المصدر: Drug Discovery Today, 26(11), 2699-2706
مصطلحات موضوعية: 0301 basic medicine, Niacinamide, S-Adenosylmethionine, Methyltransferase, 03 medical and health sciences, chemistry.chemical_compound, Human health, 0302 clinical medicine, S-Adenosyl-l-methionine, Metabolic Diseases, Neoplasms, Drug Discovery, Nicotinamide N-Methyltransferase, Medicine, Humans, Enzyme Inhibitors, Pharmacology, chemistry.chemical_classification, Nicotinamide, business.industry, Neurodegenerative Diseases, 030104 developmental biology, Enzyme, chemistry, 030220 oncology & carcinogenesis, Cancer research, business
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffaa2d6ae58cac9fac8b4aab8f55d86
https://doi.org/10.1016/j.drudis.2021.05.011 -
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المؤلفون: Yongzhi, Gao, Matthijs J, van Haren, Ed E, Moret, Johannes J M, Rood, Davide, Sartini, Alessia, Salvucci, Monica, Emanuelli, Pierrick, Craveur, Nicolas, Babault, Jian, Jin, Nathaniel I, Martin
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Models, Molecular, Niacinamide, Catalytic Domain, Cell Line, Tumor, Nicotinamide N-Methyltransferase, Humans, Antineoplastic Agents, Mouth Neoplasms, Enzyme Inhibitors, Naphthalenes, Article
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المؤلفون: Hai-Bing Zhou, Yongzhi Gao, Guofu Qiu, Chao Yan, Ze Dong, Chune Dong
المصدر: Advanced Synthesis & Catalysis. 357:2132-2142
مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Chemistry, Squaramide, Organic chemistry, Baylis–Hillman reaction, General Chemistry, Bifunctional, Phosphine, Alkyl, Catalysis
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المؤلفون: Yongzhi Gao, Wei Wang, Hai-Bing Zhou, Bin Liu, Chune Dong
المصدر: RSC Advances. 5:24392-24398
مصطلحات موضوعية: Quinine, Hydrogen bond, Chemistry, General Chemical Engineering, Yield (chemistry), medicine, Squaramide, Enantioselective synthesis, Organic chemistry, General Chemistry, Amination, Catalysis, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d4dc7b8cd1125a8692087cc282a40035
https://doi.org/10.1039/c4ra13789b -
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المؤلفون: Alexander Dömling, Yongzhi Gao, Grzegorz Dubin, Tad A. Holak, Dobroslawa Krzemien, Krzysztof M. Zak, Tryfon Zarganes-Tzitzikas, Markella Konstantinidou
المساهمون: Drug Design, Medicinal Chemistry and Bioanalysis (MCB)
المصدر: Expert Opin Ther Pat
Expert Opinion on Therapeutic Patents, 26(9), 973-977. Taylor & Francis Ltdمصطلحات موضوعية: 0301 basic medicine, PD-L1, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Antineoplastic Agents, Disease, 01 natural sciences, immune-oncology, B7-H1 Antigen, Article, DISEASE, Patents as Topic, 03 medical and health sciences, Cancer immunotherapy, Neoplasms, Programmed cell death 1, T-cell exhaustion, Drug Discovery, PD-1, medicine, Animals, Humans, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), immune checkpoint, programmed death-1, Pharmacology, biology, 010405 organic chemistry, Cancer, General Medicine, medicine.disease, Immune checkpoint, 3. Good health, 0104 chemical sciences, 030104 developmental biology, Programmed death-1, Drug Design, Immunology, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, biology.protein, Cancer research, CANCER-IMMUNOTHERAPY, Immunotherapy, Antibody, Magic bullet
وصف الملف: application/pdf