المؤلفون: Xiaojun Wang, Andrew L. Adler, Andrew R. Lisowski, Heidi S. Camp, Bradley A. Zinker, Jeffrey F. Waring, Scott E. Warder, Teresa Mcnally, Yi Yang, Yu Gui Gu, Xiangdong Xu, Eric A.G. Blomme, Moshe Weitzberg, Robert Dickinson, Christine H Healan-Greenberg

المصدر: Journal of Pharmacology and Experimental Therapeutics. 324:507-516

مصطلحات موضوعية: Mice, Obese, Peroxisome proliferator-activated receptor, Biology, Gene Expression Regulation, Enzymologic, Rats, Sprague-Dawley, Mice, Lipid oxidation, Gene expression, Animals, Humans, PPAR alpha, Enzyme Inhibitors, Receptor, Pharmacology, chemistry.chemical_classification, Acetyl-CoA carboxylase, Biological activity, Peroxisome, Molecular biology, Rats, chemistry, Biochemistry, Hepatocytes, Molecular Medicine, Signal transduction, Acetyl-CoA Carboxylase, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6ce83ab778b186c59ca2fd92bba088
https://doi.org/10.1124/jpet.107.126938

المؤلفون: Tianyuan Zhang, Richard A. G. Smith, Rohinton Edalji, Yu-Gui Gu, John L. Baranowski, William J. Sanders, Bruce A. Beutel, Liping Yu, Philip J. Hajduk, Annapur Gurulingappa Shivakumar, Stephan J. Kakavas, Frank L. Wagenaar, Darlene J. Balli, Steven F. Betz, Richard F. Clark, Kenneth M. Comess, Eric J. Hebert, J. Owen McCall, Jamey Mack, Linda E. Chovan, Randy E. Metzger, Thomas F. Holzman, Anne Y. Saiki, Sarah A. Dorwin, Niru B. Soni, Mai Bui, Angela M. Nilius, Susan J. Thornewell, Cooper Curt S, Mark E. Schurdak, Michael L. Coen, Rolf Wagner, Alan S. Florjancic, Philip J. Merta, Claude G. Lerner, Charlotte Woodall, Candace Black-Schaefer, John E. Harlan, Mengli Cai, Karl A. Walter, Xenia B. Searle, Stephen W. Fesik

المصدر: Chemical Biology & Drug Design. 69:395-404

مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Chemistry, Pharmaceutical, Molecular Sequence Data, Plasma protein binding, Bacterial genome size, medicine.disease_cause, Biochemistry, Mass Spectrometry, Microbiology, Haemophilus influenzae, Structure-Activity Relationship, Bacterial Proteins, Drug Discovery, medicine, Animals, Amino Acid Sequence, Adenosine Triphosphatases, Pharmacology, B-Lymphocytes, biology, Drug discovery, Organic Chemistry, Genomics, biology.organism_classification, Anti-Bacterial Agents, Mechanism of action, Essential gene, Drug Design, Molecular Medicine, medicine.symptom, Antibacterial activity, Genome, Bacterial, Bacteria, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5518c2506c2d9a00a67d68a32abac6
https://doi.org/10.1111/j.1747-0285.2007.00521.x

المؤلفون: Bruce A. Beutel, T. Matthew Hansen, Tianyuan Zhang, Rongqi Wang, Hing L. Sham, Xiaojun Wang, Yu Gui Gu, Ying Wang, Gang Liu, Ernst U. Frevert, Richard F. Clark, Xiaolin Zhang, Heidi S. Camp, Zhili Xin

المصدر: Bioorganic & Medicinal Chemistry Letters. 16:6078-6081

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Ether, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Moiety, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Chemistry, Phenyl Ethers, Aryl, Organic Chemistry, Acetyl-CoA carboxylase, In vitro, Pyruvate carboxylase, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, Acetyl-CoA Carboxylase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9999e4ea9913427411e2084136d89b48
https://doi.org/10.1016/j.bmcl.2006.08.100

المؤلفون: Kenton L. Longenecker, Karl A. Walter, Rohinton Edalji, John E. Harlan, Diane Bartley, Philip J. Hajduk, Larry R. Solomon, Thomas F. Holzman, Geoffrey F. Stamper, Yu Gui Gu, Vincent S. Stoll, Claude G. Lerner, Bruce A. Beutel, Elizabeth H. Fry, Clarissa G. Jakob

المصدر: Protein Science. 14:3039-3047

مصطلحات موضوعية: Models, Molecular, Molecular Sequence Data, Sequence Homology, Sequence alignment, Biology, Crystallography, X-Ray, Ligands, Biochemistry, Article, Substrate Specificity, chemistry.chemical_compound, Amino Acid Sequence, Enzyme Inhibitors, Peptide Synthases, Binding site, Nuclear Magnetic Resonance, Biomolecular, Molecular Biology, Peptide sequence, chemistry.chemical_classification, DNA ligase, Binding Sites, Small molecule, Protein Structure, Tertiary, Streptococcus pneumoniae, Enzyme, chemistry, Essential gene, Peptidoglycan, Sequence Alignment

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b06c072a2f62481b44713f237f720cb
https://doi.org/10.1110/ps.051604805

المؤلفون: Angela M. Nilius, Yu-Gui Gu, Tamara Rehm, Mai H. Bui, Peter J. Dandliker, Bruce A. Beutel, T. Matthew Hansen, Linda E. Chovan

المصدر: Bioorganic & Medicinal Chemistry Letters. 15:2716-2719

مصطلحات موضوعية: chemistry.chemical_classification, Bicyclic molecule, biology, Stereochemistry, Carboxylic acid, Organic Chemistry, Clinical Biochemistry, Carboxylic Acids, Pharmaceutical Science, biology.organism_classification, Biochemistry, Chemical synthesis, In vitro, Anti-Bacterial Agents, chemistry, Drug Discovery, Molecular Medicine, Potency, Antibacterial activity, Molecular Biology, Bacteria, Antibacterial agent

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3637a6908cb60f0759027f2d716168
https://doi.org/10.1016/j.bmcl.2005.04.007

المؤلفون: David R. Williams, Yu-Gui Gu, Patrick D. Lowder

المصدر: Tetrahedron Letters. 41:9397-9401

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Organic Chemistry, Drug Discovery, Organic chemistry, Dimethyl ether, Alcohol, Biochemistry, Conjugate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::69d9b64642c6b87aaaf5244c5e5365bf
https://doi.org/10.1016/s0040-4039(00)01496-9

المؤلفون: Yu Gui Gu, Erol K. Bayburt, Michael R. Michaelides, Chun Wei Lin, Kazumi Shiosaki

المصدر: Bioorganic & Medicinal Chemistry Letters. 9:1341-1346

مصطلحات موضوعية: Receptors, Dopamine D2, Chemistry, Stereochemistry, Receptors, Dopamine D1, Attention deficit disorder, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Phenanthrene, Ring (chemistry), Biochemistry, Chemical synthesis, Phenanthridines, Structure-Activity Relationship, chemistry.chemical_compound, Dopamine, Dopamine Agonists, Drug Discovery, Pyridine, medicine, Humans, Molecular Medicine, Cognitive impairment, Molecular Biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e74f6c4ae181c08ae6088b4e11469e1
https://doi.org/10.1016/s0960-894x(99)00214-0

المؤلفون: Patrick D. Lowder, Yu-Gui Gu, David R. Williams

المصدر: Tetrahedron Letters. 38:327-330

مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Intramolecular force, Croconic acid, Organic Chemistry, Drug Discovery, Organic chemistry, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::074a6bc1423ccacef084303c2dd28bc7
https://doi.org/10.1016/s0040-4039(96)02343-x

المؤلفون: Dawn A. Brooks, David R. Williams, Yu-Gui Gu, Patrick D. Lowder

المصدر: Tetrahedron Letters. 38:331-334

مصطلحات موضوعية: Stereochemistry, Chemistry, Organic Chemistry, Drug Discovery, Biochemistry, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6d7d95452b4f33d51b84c778d6b2a2c4
https://doi.org/10.1016/s0040-4039(96)02344-1

المؤلفون: Sabesan Yoganathan, Michael F. Mesleh, Ning Yin, Yong He, Yu Gui Gu, Scott J. Miller

المصدر: Organicbiomolecular chemistry. 11(28)

مصطلحات موضوعية: chemistry.chemical_classification, Aspartic Acid, Isostere, Stereochemistry, Carboxylic acid, Organic Chemistry, Carboxylic Acids, Glutamic Acid, Glutamic acid, Chemistry Techniques, Synthetic, Biochemistry, Chemical synthesis, Article, chemistry.chemical_compound, chemistry, Daptomycin, Amide, Aspartic acid, Side chain, Carboxylate, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb48f77dd5f03ae457a6f4980bd4e118
https://pubmed.ncbi.nlm.nih.gov/23752953