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المؤلفون: Kenichi Umehara, Yumi Cleary, Stephen Fowler, Neil Parrott, Dietrich Tuerck
المصدر: Drug Metabolism and Disposition. 50:214-223
مصطلحات موضوعية: Isoenzymes, Pharmacology, Leukemia, Myeloid, Acute, Pyrrolidines, para-Aminobenzoates, Cytochrome P-450 CYP3A, Cytochrome P-450 CYP3A Inhibitors, Humans, Pharmaceutical Science, Drug Interactions, Models, Biological, Risk Assessment
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba778aa8ad3f0b7d543d3c6a7fc42f7
https://doi.org/10.1124/dmd.121.000720 -
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المؤلفون: Agnès Poirier, Heidemarie Kletzl, Cordula Stillhart, Stephen Fowler, Kenichi Umehara, Andreas Guenther, Andreas Brink, Nicole A. Kratochwil, Dietrich Tuerck, Christophe Husser, Mark Savage, Mohammed Ullah, Lutz Mueller, Yumi Cleary, Katja Heinig
المصدر: Drug Metabolism and Disposition. 50:65-75
مصطلحات موضوعية: Pharmacology, Drug, Chemistry, In silico, media_common.quotation_subject, Pharmaceutical Science, Computational biology, Small molecule, Drug development, Pharmacokinetics, In vivo, Distribution (pharmacology), ADME, media_common
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a42eb9cb10d47b49d0cb86fb0a1206ac
https://doi.org/10.1124/dmd.121.000563 -
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المؤلفون: Li Yu, Elena Guerini, Georgina Meneses-Lorente, Alex Phipps, Vincent Buchheit, Nassim Djebli, Francois Mercier, Yumi Cleary, Stephen Fowler, Nicolas Frey, Neil Parrott
المصدر: European Journal of Drug Metabolism and Pharmacokinetics. 46:779-791
مصطلحات موضوعية: Pharmacology, Physiologically based pharmacokinetic modelling, Indazoles, Efavirenz, CYP3A4, Cytochrome P-450 CYP3A Inducers, Entrectinib, Carbamazepine, chemistry.chemical_compound, chemistry, Pharmacokinetics, Benzamides, medicine, Cytochrome P-450 CYP3A Inhibitors, Humans, Computer Simulation, Drug Interactions, Pharmacology (medical), Dosing, Active metabolite, medicine.drug
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المؤلفون: Stephen, Fowler, Andreas, Brink, Yumi, Cleary, Andreas, Günther, Katja, Heinig, Christophe, Husser, Heidemarie, Kletzl, Nicole, Kratochwil, Lutz, Mueller, Mark, Savage, Cordula, Stillhart, Dietrich, Tuerck, Mohammed, Ullah, Kenichi, Umehara, Agnès, Poirier
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 50(1)
مصطلحات موضوعية: Survival of Motor Neuron 2 Protein, Pyrimidines, Pharmaceutical Preparations, RNA Splicing, Animals, Humans, Tissue Distribution, RNA, Messenger, In Vitro Techniques, Azo Compounds
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::4530dce338c940f32f354504129eb183
https://pubmed.ncbi.nlm.nih.gov/34620695 -
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المؤلفون: Leon Aarons, Heidemarie Kletzl, Yumi Cleary, Michael Gertz, Andreas Günther, Katja Heinig, Aleksandra Galetin, Kayode Ogungbenro, Paul Grimsey
المصدر: Fukushima (Cleary), Y, Gertz, M, Grimsey, P, Günther, A, Heinig, K, Ogungbenro, K, Aarons, L, Galetin, A & Kletzl, H 2021, ' Model-based drug-drug interaction extrapolation strategy from adults to children – risdiplam in pediatric patients with spinal muscular atrophy ', Clinical Pharmacology & Therapeutics . https://doi.org/10.1002/cpt.2384
مصطلحات موضوعية: Adult, Male, Oncology, Physiologically based pharmacokinetic modelling, medicine.medical_specialty, Adolescent, CYP3A, Midazolam, Models, Biological, Muscular Atrophy, Spinal, Young Adult, Pharmacokinetics, In vivo, Internal medicine, Humans, Medicine, Drug Interactions, Pharmacology (medical), Child, Pharmacology, business.industry, Infant, Newborn, Area under the curve, Infant, Spinal muscular atrophy, SMA, medicine.disease, Pyrimidines, Neuromuscular Agents, Child, Preschool, Cytochrome P-450 CYP3A Inhibitors, Female, business, Azo Compounds, medicine.drug
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d9913e9af5e9910daa01792db02396
https://www.research.manchester.ac.uk/portal/en/publications/modelbased-drugdrug-interaction-extrapolation-strategy-from-adults-to-children--risdiplam-in-pediatric-patients-with-spinal-muscular-atrophy(c85742c4-c14d-419d-9311-c599b740e7f5).html -
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المؤلفون: Yumi Cleary, Peter N. Morcos, Markus Abt, Elena Guerini, Massimiliano Donzelli, Bogdana Balas, Faye Vazvaei, Carolina Sturm-Pellanda, Li Yu, Neil Parrott
المصدر: Journal of Clinical Pharmacology
مصطلحات موضوعية: Adult, Male, Alectinib, PBPK, medicine.medical_specialty, hepatic impairment, Population, Carbazoles, 030226 pharmacology & pharmacy, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Piperidines, Pharmacokinetics, Carcinoma, Non-Small-Cell Lung, Internal medicine, medicine, Humans, Anaplastic lymphoma kinase, alectinib, Pharmacology (medical), education, Protein Kinase Inhibitors, Active metabolite, Pharmacology, education.field_of_study, business.industry, Liver Diseases, Hepatic impairment, PK Parameters, Middle Aged, Confidence interval, Special Populations, Liver, Area Under Curve, Case-Control Studies, 030220 oncology & carcinogenesis, physiologically based pharmacokinetic modeling, Female, business, pharmacokinetics, Half-Life
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المؤلفون: Yumi Cleary, Katja Heinig, Lutz Müller, Hasane Ratni, Omar Khwaja, Nicolas Frances, Paul Jordan, Agnès Poirier, Birgit Jaber, Tobias Bergauer, Heidemarie Kletzl, Nada Al Kotbi, Stefan Sturm, Anne Marquet, Andreas Günther, Christian Czech, Nikhat Parkar
المصدر: British journal of clinical pharmacology. 85(1)
مصطلحات موضوعية: Adult, Male, Adolescent, CYP3A, Itraconazole, RNA Splicing, Administration, Oral, Pharmacology, Placebo, 030226 pharmacology & pharmacy, Muscular Atrophy, Spinal, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Pharmacokinetics, Double-Blind Method, Medicine, Humans, Pharmacology (medical), Drug Interactions, 030212 general & internal medicine, RNA, Messenger, Volunteer, business.industry, Original Articles, Middle Aged, Confidence interval, Healthy Volunteers, Survival of Motor Neuron 2 Protein, Pyrimidines, Tolerability, Neuromuscular Agents, Pharmacodynamics, Area Under Curve, Cytochrome P-450 CYP3A Inhibitors, business, Azo Compounds, medicine.drug
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المؤلفون: Bruno Reigner, Stephen Toovey, Neil Parrott, Trevor N. Johnson, Yumi Cleary, James R. Smith
المصدر: British journal of clinical pharmacology. 85(1)
مصطلحات موضوعية: Adult, Physiologically based pharmacokinetic modelling, Pediatrics, medicine.medical_specialty, Population, 030226 pharmacology & pharmacy, Models, Biological, White People, 03 medical and health sciences, Antimalarials, Young Adult, 0302 clinical medicine, Pharmacokinetics, Medicine, Humans, Pharmacology (medical), Drug Dosage Calculations, Drug Interactions, 030212 general & internal medicine, education, Child, Pharmacology, education.field_of_study, business.industry, Mefloquine, Age Factors, Infant, Original Articles, Middle Aged, medicine.disease, Malaria, Clinical trial, Ketoconazole, Treatment Outcome, Pharmacodynamics, Child, Preschool, Chemoprophylaxis, Female, Rifampin, business, medicine.drug
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المؤلفون: Edgar Schuck, Yang Xu, Arian Emami Riedmaier, Haojing Rong, Rangaraj Narayanan, Pradeep Sharma, Felix Huth, Maud Beneton, Jing Lin, Ming Zheng, Iain Gardner, Yuan Chen, Masoud Jamei, Venkatesh Pilla Reddy, Christiane Collins, Mohamad Shebley, Jun Chen, Punam Sandhu, Shinji Yamazaki, Loeckie de Zwart, Malcolm Rowland, Nassim Djebli, Faraz Kazmi, Sheila Annie Peters, Yumi Cleary, Aarti Patel, Shu Pei Wu, Chirag Patel, Francois Bouzom, Aleksandrs Odinecs, Feras Khalil, Gemma L. Dickinson, Heidi J. Einolf, Kenta Yoshida
المصدر: Shebley, M, Sandhu, P, Emami Riedmaier, A, Jamei, M, Narayanan, R, Patel, A, Peters, S A, Reddy, V P, Zheng, M, de Zwart, L, Beneton, M, Bouzom, F, Chen, J, Chen, Y, Cleary, Y, Collins, C, Dickinson, G L, Djebli, N, Einolf, H J, Gardner, I, Huth, F, Kazmi, F, Khalil, F, Lin, J, Odinecs, A, Patel, C, Rong, H, Schuck, E, Sharma, P, Wu, S P, Xu, Y, Yamazaki, S, Yoshida, K & Rowland, M 2018, ' Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions : A Consortium Perspective ', Clinical Pharmacology and Therapeutics . https://doi.org/10.1002/cpt.1013
Clinical Pharmacology and Therapeuticsمصطلحات موضوعية: Pharmacology, Physiologically based pharmacokinetic modelling, United States Food and Drug Administration, Computer science, Reviews, Review, Models, Biological, 030226 pharmacology & pharmacy, Regulatory Submission, United States, Europe, Food and drug administration, 03 medical and health sciences, Engineering management, 0302 clinical medicine, 030220 oncology & carcinogenesis, Humans, Computer Simulation, Pharmacokinetics, Pharmacology (medical), Drug Approval
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4695aa7ee7d1f810eac77f151fe62bd
https://doi.org/10.1002/cpt.1013 -
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المؤلفون: Michael Gertz, Peter N. Morcos, Li Yu, Kuresh Youdim, Alex Phipps, Yumi Cleary, Neil Parrott, Stephen Fowler
المصدر: Clinical pharmacology and therapeutics. 104(3)
مصطلحات موضوعية: Alectinib, Physiologically based pharmacokinetic modelling, Breakthrough therapy, Carbazoles, Pharmacology, 030226 pharmacology & pharmacy, Models, Biological, Risk Assessment, Substrate Specificity, Activation, Metabolic, Cytochrome P-450 CYP2C8, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Drug Development, Piperidines, Anaplastic lymphoma kinase, Medicine, Cytochrome P-450 CYP3A, Humans, heterocyclic compounds, Pharmacology (medical), Computer Simulation, Drug Interactions, Drug Approval, Protein Kinase Inhibitors, Active metabolite, CYP3A4, business.industry, United States Food and Drug Administration, virus diseases, United States, Clinical trial, Cytochrome P-450 CYP2C8 Inhibitors, 030220 oncology & carcinogenesis, Cytochrome P-450 CYP3A Inhibitors, Patient Safety, business
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