المؤلفون: Haifeng Tang, Zack Zhiqiang Guo, Lee-Yuh Pai, Adam B. Weinglass, Xin Gu, Shuzhi Dong, Alexander Pasternak, Yang Yu, Kathleen A. Sullivan, Mengwei Hu, Kelsey VanGelder, Gloria J. Zingaro, Sophie Roy, Jessica Liu, Qinghong Fu, Birgit T. Priest, Michael Margulis, Brande Thomas-Fowlkes, Pierre Morissette, Robin E. Haimbach, Zhicai Wu, Juliann Ehrhart, Karen Owens, Caryn Hampton, Zhi-Cai Shi, Jessica Frie, Ron Ferguson, Shiyao Xu, Vincent Tong

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:2559-2566

مصطلحات موضوعية: 0301 basic medicine, ERG1 Potassium Channel, Scaffold, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, Dogs, 0302 clinical medicine, Thiadiazoles, In vivo, Rats, Inbred SHR, Drug Discovery, Potassium Channel Blockers, medicine, Animals, Structure–activity relationship, Spiro Compounds, Potassium Channels, Inwardly Rectifying, Molecular Biology, biology, Chemistry, Organic Chemistry, Potassium channel blocker, Rats, Disease Models, Animal, Pyrimidines, 030104 developmental biology, 030220 oncology & carcinogenesis, Hypertension, ROMK, biology.protein, Molecular Medicine, Pharmacophore, Half-Life, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2dc6104dc29c3168c501b413896773
https://doi.org/10.1016/j.bmcl.2017.03.086

المؤلفون: Zack Zhiqiang Guo, Keun-Joong Lee, Gino Salituro, Timothy Rhodes, Christopher W. Boyce, Lina Liu, Dennis Leung, Annette Bak

المصدر: International Journal of Pharmaceutics. 592:120026

مصطلحات موضوعية: Materials science, Drug Compounding, Pharmaceutical Science, 02 engineering and technology, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, medicine, Animals, Solubility, Fusion, Supersaturation, Hot Melt Extrusion Technology, Kolliphor EL, Acoustics, 021001 nanoscience & nanotechnology, Rats, Amorphous solid, Chemical engineering, Spray drying, Extrusion, Itraconazole, 0210 nano-technology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e754d102147031d3d8eb5f6299fc8175
https://doi.org/10.1016/j.ijpharm.2020.120026