المؤلفون: Sherrard-Smith, E, Churcher, TS, Upton, LM, Sala, KA, Zakutansky, SE, Slater, HC, Blagborough, AM, Betancourt, M

المساهمون: Medical Research Council (MRC)

مصطلحات موضوعية: Science & Technology, HOST, Plasmodium berghei, MOSQUITO FEEDING ASSAYS, Transmission-blocking vaccines, Transmission-blocking drugs, Infectious Diseases, RELEVANCE, PROGRAMS, DESIGN, 1108 Medical Microbiology, Tropical Medicine, DISEASES, POPULATIONS, DRUGS, Parasitology, PLASMODIUM, Life Sciences & Biomedicine, Atovaquone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______1032::b653244411cee9ea28c81cbb08a8c48f
http://hdl.handle.net/10044/1/45695

المؤلفون: Paquet T; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Le Manach C; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Cabrera DG; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Younis Y; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Henrich PP; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA., Abraham TS; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.; Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1020 Locust Street, Suite 368, Philadelphia, PA 19107, USA., Lee MCS; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.; Malaria Programme, Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Basak R; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.; Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520-8114, USA., Ghidelli-Disse S; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Meyerhofstrasse 1, 69117 Heidelberg, Germany., Lafuente-Monasterio MJ; Malaria Disease Performance Unit, Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Bantscheff M; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Meyerhofstrasse 1, 69117 Heidelberg, Germany., Ruecker A; Department of Life Sciences, Imperial College, London SW7 2AZ, UK., Blagborough AM; Department of Life Sciences, Imperial College, London SW7 2AZ, UK., Zakutansky SE; Department of Life Sciences, Imperial College, London SW7 2AZ, UK., Zeeman AM; Department of Parasitology, Biomedical Primate Research Centre, 2280 GH Rijswijk, Netherlands., White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., Shackleford DM; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., Mannila J; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.; Admescope Ltd., Typpitie 1, 90620 Oulu, Finland., Morizzi J; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., Scheurer C; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland.; University of Basel, 4003 Basel, Switzerland., Angulo-Barturen I; Malaria Disease Performance Unit, Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Martínez MS; Malaria Disease Performance Unit, Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Ferrer S; Malaria Disease Performance Unit, Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Sanz LM; Malaria Disease Performance Unit, Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Gamo FJ; Malaria Disease Performance Unit, Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Reader J; Department of Biochemistry, Centre for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa., Botha M; Department of Biochemistry, Centre for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa., Dechering KJ; TropIQ Health Sciences, Transistorweg 5, 6534 AT Nijmegen, Netherlands., Sauerwein RW; TropIQ Health Sciences, Transistorweg 5, 6534 AT Nijmegen, Netherlands.; Radboud University Medical Center, Department of Medical Microbiology, 6500 HB Nijmegen, Netherlands., Tungtaeng A; Department of Veterinary Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand., Vanachayangkul P; Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand., Lim CS; Novartis Institute for Tropical Diseases Pte. Ltd., 10 Biopolis Road, #05-01 Chromos, Singapore 138670, Singapore., Burrows J; Medicines for Malaria Venture, International Center Cointrin, Route de Pré-Bois 20, 1215 Geneva, Switzerland., Witty MJ; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.; Medicines for Malaria Venture, International Center Cointrin, Route de Pré-Bois 20, 1215 Geneva, Switzerland., Marsh KC; AbbVie, 1 North Waukegan Road, North Chicago, IL 60064-6104, USA., Bodenreider C; Novartis Institute for Tropical Diseases Pte. Ltd., 10 Biopolis Road, #05-01 Chromos, Singapore 138670, Singapore., Rochford R; Departments of Immunology and Microbiology and Environmental and Occupational Health, University of Colorado Denver, Aurora, CO 80045, USA., Solapure SM; Nagarjuna Gardens, 60 Feet Road, Sahakaranagar, Bangalore 560092, India., Jiménez-Díaz MB; Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1020 Locust Street, Suite 368, Philadelphia, PA 19107, USA., Wittlin S; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland.; University of Basel, 4003 Basel, Switzerland., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., Donini C; Medicines for Malaria Venture, International Center Cointrin, Route de Pré-Bois 20, 1215 Geneva, Switzerland., Campo B; Medicines for Malaria Venture, International Center Cointrin, Route de Pré-Bois 20, 1215 Geneva, Switzerland., Birkholtz LM; Department of Biochemistry, Centre for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa., Hanson KK; Department of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX 78249, USA., Drewes G; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Meyerhofstrasse 1, 69117 Heidelberg, Germany., Kocken CHM; Department of Parasitology, Biomedical Primate Research Centre, 2280 GH Rijswijk, Netherlands., Delves MJ; Department of Life Sciences, Imperial College, London SW7 2AZ, UK., Leroy D; Medicines for Malaria Venture, International Center Cointrin, Route de Pré-Bois 20, 1215 Geneva, Switzerland., Fidock DA; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA., Waterson D; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.; Medicines for Malaria Venture, International Center Cointrin, Route de Pré-Bois 20, 1215 Geneva, Switzerland., Street LJ; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Chibale K; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa. kelly.chibale@uct.ac.za.; South African Medical Research Council Drug Discovery and Development Research Unit, and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa.

المصدر: Science translational medicine [Sci Transl Med] 2017 Apr 26; Vol. 9 (387).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: 1-Phosphatidylinositol 4-Kinase/*antagonists & inhibitors , Aminopyridines/*therapeutic use , Antimalarials/*therapeutic use , Sulfones/*therapeutic use, Aminopyridines/pharmacology ; Animals ; Antimalarials/pharmacology ; Female ; Malaria/drug therapy ; Malaria/enzymology ; Male ; Mice ; Mice, SCID ; Parasitic Sensitivity Tests ; Plasmodium/drug effects ; Plasmodium/pathogenicity ; Sulfones/pharmacology

المؤلفون: Sherrard-Smith E; MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London, W2 1PG, UK. e.sherrard-smith@imperial.ac.uk., Churcher TS; MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London, W2 1PG, UK., Upton LM; Department of Life Sciences, Imperial College London, South Kensington, London, SW7 2AZ, UK., Sala KA; Department of Life Sciences, Imperial College London, South Kensington, London, SW7 2AZ, UK., Zakutansky SE; Department of Life Sciences, Imperial College London, South Kensington, London, SW7 2AZ, UK., Slater HC; MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London, W2 1PG, UK., Blagborough AM; Department of Life Sciences, Imperial College London, South Kensington, London, SW7 2AZ, UK., Betancourt M; Department of Statistics, University of Warwick, Warwick, UK.

المصدر: Malaria journal [Malar J] 2017 Apr 04; Vol. 16 (1), pp. 137. Date of Electronic Publication: 2017 Apr 04.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE

مواضيع طبية MeSH: Anopheles/*parasitology , Disease Transmission, Infectious/*prevention & control , Drug Evaluation, Preclinical/*methods , Malaria/*parasitology , Malaria/*prevention & control , Plasmodium berghei/*isolation & purification, Animals ; Female ; Humans ; Malaria/transmission ; Mice ; Models, Statistical

المؤلفون: Churcher TS; MRC Centre for Outbreak Analysis and Modelling, Infectious Disease Epidemiology, Imperial College London, London, United Kingdom., Sinden RE; Department of Life Sciences, Imperial College London, South Kensington, London, United Kingdom.; The Jenner Institute, University of Oxford, Roosevelt Drive, Oxford, United Kingdom., Edwards NJ; The Jenner Institute, University of Oxford, Roosevelt Drive, Oxford, United Kingdom., Poulton ID; The Jenner Institute, University of Oxford, Roosevelt Drive, Oxford, United Kingdom., Rampling TW; The Jenner Institute, University of Oxford, Roosevelt Drive, Oxford, United Kingdom., Brock PM; MRC Centre for Outbreak Analysis and Modelling, Infectious Disease Epidemiology, Imperial College London, London, United Kingdom.; Institute of Biodiversity Animal Health and Comparative Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Griffin JT; MRC Centre for Outbreak Analysis and Modelling, Infectious Disease Epidemiology, Imperial College London, London, United Kingdom., Upton LM; Department of Life Sciences, Imperial College London, South Kensington, London, United Kingdom., Zakutansky SE; Department of Life Sciences, Imperial College London, South Kensington, London, United Kingdom., Sala KA; Department of Life Sciences, Imperial College London, South Kensington, London, United Kingdom., Angrisano F; Department of Life Sciences, Imperial College London, South Kensington, London, United Kingdom., Hill AV; The Jenner Institute, University of Oxford, Roosevelt Drive, Oxford, United Kingdom., Blagborough AM; Department of Life Sciences, Imperial College London, South Kensington, London, United Kingdom.

المصدر: PLoS pathogens [PLoS Pathog] 2017 Jan 12; Vol. 13 (1), pp. e1006108. Date of Electronic Publication: 2017 Jan 12 (Print Publication: 2017).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

مواضيع طبية MeSH: Anopheles/*parasitology , Insect Vectors/*parasitology , Malaria/*prevention & control , Malaria Vaccines/*administration & dosage , Plasmodium/*immunology, Animals ; Antibodies, Protozoan ; Disease Models, Animal ; Humans ; Malaria/parasitology ; Malaria/transmission ; Mice ; Plasmodium/growth & development ; Population Dynamics ; Protozoan Proteins/immunology ; Salivary Glands/parasitology ; Sporozoites/immunology ; Vaccination

المؤلفون: Baragaña B, Hallyburton I, Lee MC, Norcross NR, Grimaldi R, Otto TD, Proto WR, Blagborough AM, Meister S, Wirjanata G, Ruecker A, Upton LM, Abraham TS, Almeida MJ, Pradhan A, Porzelle A, Martínez MS, Bolscher JM, Woodland A, Luksch T, Norval S, Zuccotto F, Thomas J, Simeons F, Stojanovski L, Osuna-Cabello M, Brock PM, Churcher TS, Sala KA, Zakutansky SE, Jiménez-Díaz MB, Sanz LM, Riley J, Basak R, Campbell M, Avery VM, Sauerwein RW, Dechering KJ, Noviyanti R, Campo B, Frearson JA, Angulo-Barturen I, Ferrer-Bazaga S, Gamo FJ, Wyatt PG, Leroy D, Siegl P, Delves MJ, Kyle DE, Wittlin S, Marfurt J, Price RN, Sinden RE, Winzeler EA, Charman SA, Bebrevska L, Gray DW, Campbell S, Fairlamb AH, Willis PA, Rayner JC, Fidock DA, Read KD, Gilbert IH

المصدر: Nature [Nature] 2016 Sep 01; Vol. 537 (7618), pp. 122. Date of Electronic Publication: 2016 May 25.

نوع المنشور: Journal Article; Published Erratum

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: PubMed not MEDLINE

المؤلفون: Blagborough AM; Department of Life Sciences, Sir Alexander Fleming Building, Imperial College London, Imperial College Road, South Kensington, London SW7 2AZ, UK. Electronic address: andrew.blagborough@imperial.ac.uk., Musiychuk K; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA., Bi H; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA., Jones RM; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA., Chichester JA; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA., Streatfield S; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA., Sala KA; Department of Life Sciences, Sir Alexander Fleming Building, Imperial College London, Imperial College Road, South Kensington, London SW7 2AZ, UK., Zakutansky SE; Department of Life Sciences, Sir Alexander Fleming Building, Imperial College London, Imperial College Road, South Kensington, London SW7 2AZ, UK., Upton LM; Department of Life Sciences, Sir Alexander Fleming Building, Imperial College London, Imperial College Road, South Kensington, London SW7 2AZ, UK., Sinden RE; Jenner Institute, The University of Oxford, Roosevelt Road, Oxford OX9 2PP, UK., Brian I; Jenner Institute, The University of Oxford, Roosevelt Road, Oxford OX9 2PP, UK., Biswas S; Jenner Institute, The University of Oxford, Roosevelt Road, Oxford OX9 2PP, UK., Sattabonkot J; Department of Entomology, Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand., Yusibov V; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA.

المصدر: Vaccine [Vaccine] 2016 Jun 14; Vol. 34 (28), pp. 3252-9. Date of Electronic Publication: 2016 May 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE

مواضيع طبية MeSH: Malaria Vaccines/*immunology , Malaria, Vivax/*prevention & control , Protozoan Proteins/*immunology, Adjuvants, Immunologic/administration & dosage ; Animals ; Chromobox Protein Homolog 5 ; Female ; Immunization, Secondary ; Mice, Inbred BALB C ; Plants, Genetically Modified ; Plasmodium vivax ; Recombinant Proteins/immunology ; Nicotiana ; Vaccines, Subunit/immunology ; Vaccines, Synthetic/immunology

المؤلفون: Li Y; Jenner Institute, University of Oxford, Oxford, OX3 7DQ, UK., Leneghan DB; Jenner Institute, University of Oxford, Oxford, OX3 7DQ, UK., Miura K; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious. Disease/National Institutes of Health, Rockville, Maryland, USA., Nikolaeva D; Jenner Institute, University of Oxford, Oxford, OX3 7DQ, UK.; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious. Disease/National Institutes of Health, Rockville, Maryland, USA., Brian IJ; Jenner Institute, University of Oxford, Oxford, OX3 7DQ, UK., Dicks MD; Jenner Institute, University of Oxford, Oxford, OX3 7DQ, UK., Fyfe AJ; Jenner Institute, University of Oxford, Oxford, OX3 7DQ, UK., Zakutansky SE; Jenner Institute, University of Oxford, Oxford, OX3 7DQ, UK., de Cassan S; Jenner Institute, University of Oxford, Oxford, OX3 7DQ, UK., Long CA; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious. Disease/National Institutes of Health, Rockville, Maryland, USA., Draper SJ; Jenner Institute, University of Oxford, Oxford, OX3 7DQ, UK., Hill AV; Jenner Institute, University of Oxford, Oxford, OX3 7DQ, UK., Hill F; IMAXIO, 69007 Lyon, France., Biswas S; Jenner Institute, University of Oxford, Oxford, OX3 7DQ, UK.

المصدر: Scientific reports [Sci Rep] 2016 Jan 08; Vol. 6, pp. 18848. Date of Electronic Publication: 2016 Jan 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Immunogenicity, Vaccine*, Adjuvants, Immunologic/*genetics , Antibodies, Protozoan/*biosynthesis , Malaria Vaccines/*immunology , Malaria, Falciparum/*prevention & control , Plasmodium falciparum/*drug effects , Protozoan Proteins/*immunology, Adenoviridae/genetics ; Adenoviridae/immunology ; Adjuvants, Immunologic/administration & dosage ; Adjuvants, Immunologic/chemistry ; Animals ; Antigens, Protozoan/genetics ; Antigens, Protozoan/immunology ; Culicidae/drug effects ; Culicidae/parasitology ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/immunology ; Germinal Center/drug effects ; Germinal Center/immunology ; Humans ; Insect Vectors/drug effects ; Insect Vectors/parasitology ; Life Cycle Stages/drug effects ; Life Cycle Stages/immunology ; Malaria Vaccines/administration & dosage ; Malaria Vaccines/genetics ; Malaria, Falciparum/immunology ; Malaria, Falciparum/parasitology ; Mice ; Mice, Inbred BALB C ; Pichia/genetics ; Pichia/metabolism ; Plasmids/chemistry ; Plasmids/immunology ; Plasmodium falciparum/growth & development ; Plasmodium falciparum/immunology ; Protozoan Proteins/administration & dosage ; Protozoan Proteins/genetics ; Recombinant Fusion Proteins/administration & dosage ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/immunology ; Vaccination ; Vaccines, Synthetic

المؤلفون: Baragaña B; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Hallyburton I; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Lee MC; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA., Norcross NR; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Grimaldi R; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Otto TD; Malaria Programme, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK., Proto WR; Malaria Programme, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK., Blagborough AM; Department of Life Sciences, Imperial College, London SW7 2AZ, UK., Meister S; University of California, San Diego, School of Medicine, 9500 Gilman Drive 0760, La Jolla, California 92093, USA., Wirjanata G; Global Health and Tropical Medicine Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, Darwin, Northern Territory 0811, Australia., Ruecker A; Department of Life Sciences, Imperial College, London SW7 2AZ, UK., Upton LM; Department of Life Sciences, Imperial College, London SW7 2AZ, UK., Abraham TS; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA., Almeida MJ; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA., Pradhan A; Department of Global Health, College of Public Health University of South Florida, 3720 Spectrum Boulevard, Suite 304, Tampa, Florida 33612, USA., Porzelle A; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Luksch, Martínez MS; GlaxoSmithKline, Tres Cantos Medicines Development Campus-Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain., Luksch T, Bolscher JM; TropIQ Health Sciences, Geert Grooteplein 28, Huispost 268, 6525 GA Nijmegen, The Netherlands., Woodland A; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Norval S; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Zuccotto F; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Thomas J; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Simeons F; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Stojanovski L; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Osuna-Cabello M; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Brock PM; Department of Life Sciences, Imperial College, London SW7 2AZ, UK., Churcher TS; Department of Life Sciences, Imperial College, London SW7 2AZ, UK., Sala KA; Department of Life Sciences, Imperial College, London SW7 2AZ, UK., Zakutansky SE; Department of Life Sciences, Imperial College, London SW7 2AZ, UK., Jiménez-Díaz MB; GlaxoSmithKline, Tres Cantos Medicines Development Campus-Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain., Sanz LM; GlaxoSmithKline, Tres Cantos Medicines Development Campus-Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain., Riley J; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Basak R; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA., Campbell M; Centre for Drug Candidate Optimisation, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., Avery VM; Eskitis Institute, Brisbane Innovation Park, Nathan Campus, Griffith University, Queensland 4111, Australia., Sauerwein RW; TropIQ Health Sciences, Geert Grooteplein 28, Huispost 268, 6525 GA Nijmegen, The Netherlands., Dechering KJ; TropIQ Health Sciences, Geert Grooteplein 28, Huispost 268, 6525 GA Nijmegen, The Netherlands., Noviyanti R; Malaria Pathogenesis Laboratory, Eijkman Institute for Molecular Biology, Jalan Diponegoro 69, 10430 Jakarta, Indonesia., Campo B; Medicines for Malaria Venture, PO Box 1826, 20 route de Pre-Bois, 1215 Geneva 15, Switzerland., Frearson JA; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Angulo-Barturen I; GlaxoSmithKline, Tres Cantos Medicines Development Campus-Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain., Ferrer-Bazaga S; GlaxoSmithKline, Tres Cantos Medicines Development Campus-Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain., Gamo FJ; GlaxoSmithKline, Tres Cantos Medicines Development Campus-Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain., Wyatt PG; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Leroy D; Medicines for Malaria Venture, PO Box 1826, 20 route de Pre-Bois, 1215 Geneva 15, Switzerland., Siegl P; Medicines for Malaria Venture, PO Box 1826, 20 route de Pre-Bois, 1215 Geneva 15, Switzerland., Delves MJ; Department of Life Sciences, Imperial College, London SW7 2AZ, UK., Kyle DE; Department of Global Health, College of Public Health University of South Florida, 3720 Spectrum Boulevard, Suite 304, Tampa, Florida 33612, USA., Wittlin S; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland., Marfurt J; Global Health and Tropical Medicine Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, Darwin, Northern Territory 0811, Australia., Price RN; 1] Global Health and Tropical Medicine Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, Darwin, Northern Territory 0811, Australia [2] Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7LJ, UK., Sinden RE; Department of Life Sciences, Imperial College, London SW7 2AZ, UK., Winzeler EA; University of California, San Diego, School of Medicine, 9500 Gilman Drive 0760, La Jolla, California 92093, USA., Charman SA; Centre for Drug Candidate Optimisation, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., Bebrevska L; Medicines for Malaria Venture, PO Box 1826, 20 route de Pre-Bois, 1215 Geneva 15, Switzerland., Gray DW; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Campbell S; Medicines for Malaria Venture, PO Box 1826, 20 route de Pre-Bois, 1215 Geneva 15, Switzerland., Fairlamb AH; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Willis PA; Medicines for Malaria Venture, PO Box 1826, 20 route de Pre-Bois, 1215 Geneva 15, Switzerland., Rayner JC; Malaria Programme, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK., Fidock DA; 1] Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA [2] Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA., Read KD; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Gilbert IH; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

المصدر: Nature [Nature] 2015 Jun 18; Vol. 522 (7556), pp. 315-20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Antimalarials/*pharmacology , Gene Expression Regulation/*drug effects , Malaria/*parasitology , Plasmodium/*drug effects , Plasmodium/*metabolism , Protein Biosynthesis/*drug effects , Quinolines/*pharmacology, Animals ; Antimalarials/administration & dosage ; Antimalarials/adverse effects ; Antimalarials/pharmacokinetics ; Drug Discovery ; Female ; Life Cycle Stages/drug effects ; Liver/drug effects ; Liver/parasitology ; Malaria/drug therapy ; Male ; Models, Molecular ; Peptide Elongation Factor 2/antagonists & inhibitors ; Peptide Elongation Factor 2/metabolism ; Plasmodium/genetics ; Plasmodium/growth & development ; Plasmodium berghei/drug effects ; Plasmodium berghei/physiology ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/metabolism ; Plasmodium vivax/drug effects ; Plasmodium vivax/metabolism ; Quinolines/administration & dosage ; Quinolines/chemistry ; Quinolines/pharmacokinetics

المؤلفون: Sala KA; Department of Life Sciences, Sir Alexander Fleming Building, Imperial College London, Imperial College Road, South Kensington, London SW7 2AZ, UK., Nishiura H; Laboratory of Vaccinology and Applied Immunology, School of Pharmacy, Kanazawa University, Ishikawa, Japan., Upton LM; Department of Life Sciences, Sir Alexander Fleming Building, Imperial College London, Imperial College Road, South Kensington, London SW7 2AZ, UK., Zakutansky SE; Department of Life Sciences, Sir Alexander Fleming Building, Imperial College London, Imperial College Road, South Kensington, London SW7 2AZ, UK., Delves MJ; Department of Life Sciences, Sir Alexander Fleming Building, Imperial College London, Imperial College Road, South Kensington, London SW7 2AZ, UK., Iyori M; Laboratory of Vaccinology and Applied Immunology, School of Pharmacy, Kanazawa University, Ishikawa, Japan., Mizutani M; Laboratory of Vaccinology and Applied Immunology, School of Pharmacy, Kanazawa University, Ishikawa, Japan., Sinden RE; Department of Life Sciences, Sir Alexander Fleming Building, Imperial College London, Imperial College Road, South Kensington, London SW7 2AZ, UK; Jenner Institute, The University of Oxford, Roosevelt Road, Oxford OX9 2PP, UK., Yoshida S; Laboratory of Vaccinology and Applied Immunology, School of Pharmacy, Kanazawa University, Ishikawa, Japan., Blagborough AM; Department of Life Sciences, Sir Alexander Fleming Building, Imperial College London, Imperial College Road, South Kensington, London SW7 2AZ, UK. Electronic address: andrew.blagborough@imperial.ac.uk.

المصدر: Vaccine [Vaccine] 2015 Jan 09; Vol. 33 (3), pp. 437-45. Date of Electronic Publication: 2014 Nov 30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE

مواضيع طبية MeSH: Antigens, Protozoan/*immunology , Disease Transmission, Infectious/*prevention & control , Malaria/*immunology , Malaria/*transmission , Malaria Vaccines/*immunology , Plasmodium berghei/*immunology, Animals ; Baculoviridae/genetics ; Baculoviridae/growth & development ; Cell Surface Display Techniques ; Drug Carriers ; Female ; Malaria Vaccines/administration & dosage ; Malaria Vaccines/genetics ; Male ; Mice, Inbred BALB C

المؤلفون: Douglas AD; Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom;, Williams AR, Knuepfer E, Illingworth JJ, Furze JM, Crosnier C, Choudhary P, Bustamante LY, Zakutansky SE, Awuah DK, Alanine DG, Theron M, Worth A, Shimkets R, Rayner JC, Holder AA, Wright GJ, Draper SJ

المصدر: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2014 Jan 01; Vol. 192 (1), pp. 245-58. Date of Electronic Publication: 2013 Nov 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Neutralizing/*immunology , Antibodies, Protozoan/*immunology , Carrier Proteins/*immunology , Merozoites/*immunology , Plasmodium falciparum/*immunology, Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/metabolism ; Antibodies, Neutralizing/metabolism ; Antibodies, Protozoan/metabolism ; Carrier Proteins/metabolism ; Epitope Mapping ; Epitopes/chemistry ; Epitopes/immunology ; Erythrocytes/immunology ; Erythrocytes/parasitology ; Humans ; Kinetics ; Malaria Vaccines/immunology ; Malaria, Falciparum/immunology ; Mice ; Neutralization Tests ; Plasmodium falciparum/growth & development ; Protein Binding/immunology ; Rabbits