المؤلفون: Hélène FE Gleitz, Ai Yin Liao, James R Cook, Samuel F Rowlston, Gabriella MA Forte, Zelpha D'Souza, Claire O'Leary, Rebecca J Holley, Brian W Bigger

المصدر: EMBO Molecular Medicine, Vol 10, Iss 7, Pp n/a-n/a (2018)

مصطلحات موضوعية: apolipoprotein E, blood–brain barrier, Hunter, mucopolysaccharidosis type II, stem cell gene therapy, Medicine (General), R5-920, Genetics, QH426-470

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

URL الوصول: https://doaj.org/article/7b790fd6101949a990e17c2cd9b2efa6

المؤلفون: Heeseog Kang, Audrey Kerloc’h, Maxime Rotival, Xiaoqing Xu, Qing Zhang, Zelpha D’Souza, Michael Kim, Jodi Carlson Scholz, Jeong-Hun Ko, Prashant K. Srivastava, Jonathan R. Genzen, Weiguo Cui, Timothy J. Aitman, Laurence Game, James E. Melvin, Adedayo Hanidu, Janice Dimock, Jie Zheng, Donald Souza, Aruna K. Behera, Gerald Nabozny, H. Terence Cook, J.H. Duncan Bassett, Graham R. Williams, Jun Li, Agnès Vignery, Enrico Petretto, Jacques Behmoaras

المصدر: Cell Reports, Vol 8, Iss 4, Pp 1210-1224 (2014)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124714006160; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/f6208b18c69045d9b837b050615cef3e

المؤلفون: Zelpha D’Souza, Stephen P. McAdoo, Jennifer Smith, Charles D. Pusey, H. Terence Cook, Jacques Behmoaras, Timothy J. Aitman

المصدر: Disease Models & Mechanisms, Vol 6, Iss 6, Pp 1477-1486 (2013)

مصطلحات موضوعية: Medicine, Pathology, RB1-214

وصف الملف: electronic resource

Relation: http://dmm.biologists.org/content/6/6/1477; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

URL الوصول: https://doaj.org/article/5122790028c74d6881addadf98d505fb

المؤلفون: R. Michael Linden, Els Henckaerts, Rebecca J. Holley, Antonette Bennett, Patrick Aldrin-Kirk, Robin R. Ali, Amir Saam Youshani, Carla Martins, Alexey V. Pshezhetsky, Mavis Agbandje-McKenna, Brian W. Bigger, André S L M Antunes, Thierry Levade, Julie Tordo, Helen Parker, Paul Rouse, Zelpha D'Souza, Larbi Dridi, Kevin B. Stacey, Ahad A. Rahim, Annie Godwin, Nathalie Clement, Claire O'Leary, Daniel M. Davis, Ai Yin Liao, Simon N. Waddington, Nuria Palomar, Mark Basche, Hélène F.E. Gleitz, Adam Dyer, Tomas Björklund

المصدر: Brain
Tordo, J, O'Leary, C, Antunes, A S L M, Palomar, N, Aldrin-Kirk, P, Basche, M, Bennett, A, D'Souza, Z, Gleitz, H, Godwin, A, Holley, R J, Parker, H, Liao, A Y, Rouse, P, Youshani, A S, Dridi, L, Martins, C, Levade, T, Stacey, K B, Davis, D M, Dyer, A, Clément, N, Björklund, T, Ali, R R, Agbandje-McKenna, M, Rahim, A A, Pshezhetsky, A, Waddington, S N, Linden, R M, Bigger, B W & Henckaerts, E 2018, ' A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency ', Brain, vol. 141, no. 7, pp. 2014-2031 . https://doi.org/10.1093/brain/awy126
Tordo, J, O'Leary, C, Antunes, A S L M, Palomar, N, Aldrin-Kirk, P, Basche, M, Bennett, A, D'Souza, Z, Gleitz, H, Godwin, A, Holley, R, Parker, H, Liao, A, Rouse, P, Youshani, A, Dridi, L, Martins, C, Levade, T, Stacey, K, Davis, D M, Dyer, A, Clement, N, Bjorklund, T, Ali, R R, Agbandje-McKenna, M, Rahim, A, Pshezhetsky, A V, Waddington, S N, Linden, R M, Bigger, B & Henckaerts, E 2018, ' A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency ', Brain, vol. 141, no. 7, pp. 2014-2031 . https://doi.org/10.1093/brain/awy126

مصطلحات موضوعية: 0301 basic medicine, Male, Neurotropism, Mucopolysaccharidosis, Genetic enhancement, viruses, medicine.disease_cause, Protein Engineering, Rats, Sprague-Dawley, Transduction (genetics), Mice, Mucopolysaccharidosis III, Transduction, Genetic, GENE-THERAPY VECTOR, Lysosomal storage disease, Tissue Distribution, Adeno-associated virus, VIRAL VECTORS, neurotropism, mucopolysaccharidosis, MOUSE MODEL, HEPARAN-SULFATE PROTEOGLYCAN, Dependovirus, 3. Good health, Cell biology, Capsid, CONGENITAL AMAUROSIS, Female, Life Sciences & Biomedicine, lysosomal transmembrane enzyme, RECEPTOR FOOTPRINT, Genetic Vectors, Clinical Neurology, adeno-associated virus, Biology, SANFILIPPO-SYNDROME, Virus, Retina, capsid engineering, 03 medical and health sciences, medicine, Animals, Photoreceptor Cells, HIPPOCAMPAL-LESIONS, Science & Technology, MUCOPOLYSACCHARIDOSIS-IIIB, Neurosciences, Original Articles, Genetic Therapy, NEURONAL CEROID-LIPOFUSCINOSIS, medicine.disease, Rats, Mice, Inbred C57BL, 030104 developmental biology, Neurosciences & Neurology, Neurology (clinical)

وصف الملف: application/pdf; Print

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b17a7608215d5ccd1f1e0191c5e9330

المؤلفون: Alex Langford-Smith, Rebecca J. Holley, Aiyin Liao, Patricia I. Dickson, John H McDermott, Helen Parker, Hélène F.E. Gleitz, Nishanthi Senthivel, Shih hsin Kan, Claire O'Leary, Zelpha D'Souza, Brian W. Bigger, Fiona L. Wilkinson, Stuart M. Ellison, Samuel Rowlston, Daniel Fil

المصدر: Holley, R J, Ellison, S M, Fil, D, O'Leary, C, McDermott, J, Senthivel, N, Langford-Smith, A W W, Wilkinson, F L, D'Souza, Z, Parker, H, Liao, A, Rowlston, S, Gleitz, H F E, Kan, S H, Dickson, P I & Bigger, B W 2018, ' Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy ', Brain, vol. 141, no. 1, pp. 99-116 . https://doi.org/10.1093/brain/awx311

مصطلحات موضوعية: 0301 basic medicine, Male, Mucopolysaccharidosis, Genetic enhancement, Prednisolone, Clinical Neurology, microglia, Mice, Transgenic, 03 medical and health sciences, Mice, Mucopolysaccharidosis III, stem cells, Mucopolysaccharidosis I, medicine, Lysosomal storage disease, Animals, Humans, Gliosis, Glycosaminoglycans, Microglia, business.industry, Macrophages, Stem Cells, neurodegeneration, Brain, mucopolysaccharidosis, Genetic Therapy, medicine.disease, Mice, Inbred C57BL, Haematopoiesis, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, lysosomal storage disease, Liver, Immunology, Cytokines, Encephalitis, Female, Neurology (clinical), Bone marrow, Stem cell, Sulfatases, business, Spleen

وصف الملف: text

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac70cc8ffc5736a43bd0c0457864ff70
https://pubmed.ncbi.nlm.nih.gov/29186350

المؤلفون: Enrico Petretto, Prashant K. Srivastava, James E. Melvin, Xiaoqing Xu, Michael Kim, Aruna K Behera, Adedayo Hanidu, Graham R. Williams, Jacques Behmoaras, Audrey Kerloc'h, Jie Zheng, Heeseog Kang, Janice Dimock, J. H. Duncan Bassett, Jeong-Hun Ko, Donald Souza, Zelpha D’Souza, Qing-qing Zhang, H. Terence Cook, Jodi A Carlson Scholz, Timothy J. Aitman, Gerald Nabozny, Jonathan R. Genzen, Agnès Vignery, Weiguo Cui, Laurence Game, Maxime Rotival, Jun-Jun Li

المصدر: Cell Reports, Vol 8, Iss 4, Pp 1210-1224 (2014)
Cell Reports

مصطلحات موضوعية: Arthritis, Inflammation, Biology, Rats, Inbred WKY, General Biochemistry, Genetics and Molecular Biology, Bone resorption, Article, Bone and Bones, 03 medical and health sciences, 0302 clinical medicine, Immune system, Glomerulonephritis, Osteoclast, medicine, Macrophage, Animals, Homeostasis, Humans, Gene Regulatory Networks, Calcium Signaling, Bone Resorption, Receptors, Immunologic, lcsh:QH301-705.5, Cells, Cultured, 030304 developmental biology, Cell Nucleus, Mice, Knockout, 0303 health sciences, Macrophages, medicine.disease, Intermediate-Conductance Calcium-Activated Potassium Channels, 3. Good health, medicine.anatomical_structure, lcsh:Biology (General), Giant cell, Rats, Inbred Lew, Immunology, Cancer research, medicine.symptom, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e8ff7b45b5b6029f993ee3f3c8a6d0
http://www.sciencedirect.com/science/article/pii/S2211124714006160

المؤلفون: Jacques Behmoaras, H. Terence Cook, Theresa H. Page, Timothy J. Aitman, S Nakanishi, Zelpha D’Souza, Charles D. Pusey, Tadao Serikawa

المصدر: The Journal of Biological Chemistry
Journal of Biological Chemistry
Page, T H, D'Souza, Z, Nakanishi, S, Serikawa, T, Pusey, C D, Aitman, T J, Cook, H T & Behmoaras, J 2012, ' Role of novel rat-specific Fc receptor in macrophage activation associated with crescentic glomerulonephritis ', Journal of Biological Chemistry, vol. 287, no. 8, pp. 5710-9 . https://doi.org/10.1074/jbc.M111.260695

مصطلحات موضوعية: Cytoplasm, Phagocytosis, Interleukin-1beta, Molecular Sequence Data, Fc receptor, Receptor Regulation, Biology, Gene delivery, Biochemistry, Fc receptor-mediated Signaling, Mice, 03 medical and health sciences, Glomerulonephritis, 0302 clinical medicine, Species Specificity, Cell Line, Tumor, Gene Duplication, Animals, Humans, Macrophage, Gene Regulation, Amino Acid Sequence, Receptor, Molecular Biology, Phylogeny, 030304 developmental biology, 0303 health sciences, Tumor Necrosis Factor-alpha, Macrophages, Receptors, IgG, Exons, Cell Biology, Molecular biology, Protein Structure, Tertiary, Rats, Toll-Like Receptor 4, biology.protein, Rat, Cattle, Antibody, Signal transduction, Cell activation, Gene Deletion, Signal Transduction, 030215 immunology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f30803e6e30a02f94b3c470a7956cd
https://doi.org/10.1074/jbc.m111.260695

المؤلفون: Chris Fewings, Laurence Game, Klio Maratou, Jennifer A. Smith, Prashant K. Srivastava, Zelpha D’Souza, Terence Cook, Jacques Behmoaras, Timothy J. Aitman

المصدر: Genes and immunity
Maratou, K, Behmoaras, J, Fewings, C, Srivastava, P, D'Souza, Z, Smith, J, Game, L, Cook, T & Aitman, T 2011, ' Characterization of the macrophage transcriptome in glomerulonephritis-susceptible and-resistant rat strains ', Genes and Immunity, vol. 12, no. 2, pp. 78-89 . https://doi.org/10.1038/gene.2010.61

مصطلحات موضوعية: Kidney Glomerulus, Immunology, Gene Expression, macrophage, Biology, Quantitative trait locus, Rats, Inbred WKY, Article, Transcriptome, Glomerulonephritis, Crescentic glomerulonephritis, Gene expression, Genetics, medicine, Animals, Genetic Predisposition to Disease, rat, Gene, Genetics (clinical), Effector, Microarray analysis techniques, Gene Expression Profiling, Macrophages, medicine.disease, Molecular biology, Immunity, Innate, Rats, Gene expression profiling, Rats, Inbred Lew, microarray

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63043330fc8a2741989b122019a9be66
https://doi.org/10.1038/gene.2010.61

المؤلفون: H. Terence Cook, Santosh S. Atanur, Timothy J. Aitman, Enrico Petretto, Laurence Game, Prashant K. Srivastava, Richard P Hull, Jacques Behmoaras, Fatima Mechta-Grigoriou, Zelpha D’Souza

المصدر: Hull, R P, Srivastava, P K, D'Souza, Z, Atanur, S S, Mechta-Grigoriou, F, Game, L, Petretto, E, Cook, H T, Aitman, T J & Behmoaras, J 2013, ' Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1β synthesis in macrophages ', BMC Genomics, vol. 14, pp. 92 . https://doi.org/10.1186/1471-2164-14-92
BMC Genomics

مصطلحات موضوعية: Lipopolysaccharides, Proto-Oncogene Proteins c-jun, Interleukin-1beta, Primary Cell Culture, Gene Expression, Biology, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Glomerulonephritis, RNA interference, Gene expression, Genetics, Gene silencing, Animals, Transcription factor, 030304 developmental biology, 0303 health sciences, Binding Sites, integumentary system, Microarray analysis techniques, Gene Expression Profiling, Macrophages, Molecular biology, Respiratory burst, Rats, Gene expression profiling, Transcription Factor AP-1, Oxidative Stress, 030217 neurology & neurosurgery, Research Article, Biotechnology, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866021cb393dd11a5049f6ca6f175e77
https://www.pure.ed.ac.uk/ws/files/17263797/Combined_ChIP_Seq_and_transcriptome_analysis_identifies_AP_1_JunD_as_a_primary_regulator_of_oxidative_stress_and_IL_1_synthesis_in_macrophages.pdf

المؤلفون: Frederick W.K. Tam, Jennifer A. Smith, Gurjeet Bhangal, Zelpha D’Souza, Charles D. Pusey, Jacques Behmoaras, H. Terence Cook, Timothy J. Aitman, Ratana Chawanasuntoropoj

المصدر: Journal of the American Society of Nephrology : JASN. 21(7)

مصطلحات موضوعية: Male, medicine.medical_specialty, Renal glomerulus, Nitric Oxide Synthase Type II, Rats, Inbred WKY, Glomerulonephritis, Internal medicine, Matrix Metalloproteinase 12, medicine, Genetic predisposition, Macrophage, Animals, Genetic Predisposition to Disease, Cells, Cultured, Bone Marrow Transplantation, Kidney, biology, Tumor Necrosis Factor-alpha, Macrophages, Glomerular mesangium, General Medicine, medicine.disease, Kidney Transplantation, Glomerular Mesangium, Rats, Nitric oxide synthase, Disease Models, Animal, medicine.anatomical_structure, Endocrinology, Basic Research, Nephrology, Genetic Loci, Rats, Inbred Lew, biology.protein, Nephritis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506395215f25cc9cfa870c760f4410ee
https://pubmed.ncbi.nlm.nih.gov/20488952