نتائج البحث - "Zheming Ruan"

1

Ligand Enabled Pd(II)-Catalyzed γ-C(sp(3))─H Lactamization of Native Amides

المؤلفون: Shuang Liu, Zhe Zhuang, Jennifer X. Qiao, Kap-Sun Yeung, Shun Su, Emily C. Cherney, Zheming Ruan, William R. Ewing, Michael A. Poss, Jin-Quan Yu

المصدر: J Am Chem Soc

مصطلحات موضوعية: Colloid and Surface Chemistry, Lactams, Molecular Structure, General Chemistry, Biochemistry, Amides, Article, Catalysis, Palladium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e435084c43e9a77b57719fbe46530c
https://europepmc.org/articles/PMC9116424/

2

Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists

المصدر: Bioorganicmedicinal chemistry letters. 30(12)

مصطلحات موضوعية: Agonist, Drug, medicine.drug_class, Receptors, Retinoic Acid, media_common.quotation_subject, Clinical Biochemistry, Retinoic acid, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, RAR-related orphan receptor gamma, Heterocyclic Compounds, Drug Discovery, Benzyl Compounds, medicine, Animals, Molecular Biology, media_common, Orphan receptor, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, chemistry, Pharmacodynamics, Molecular Medicine, Female, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28391368dbe9fe0275182d85ed69ba6
https://pubmed.ncbi.nlm.nih.gov/32334911

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3

Abstract 1140: A novel MTA non-competitive PRMT5 inhibitor

المصدر: Cancer Research. 81:1140-1140

مصطلحات موضوعية: Cancer Research, Gene knockdown, Chemistry, Protein arginine methyltransferase 5, Cancer, medicine.disease, Molecular biology, In vitro, law.invention, Oncology, CDKN2A, In vivo, law, Cancer cell, medicine, Suppressor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::769a298e5dedd6469a5cf85008a3a619
https://doi.org/10.1158/1538-7445.am2021-1140

4

Substituted diaryl ether compounds as retinoic acid-related orphan Receptor-γt (RORγt) agonists

المصدر: Bioorganic & Medicinal Chemistry Letters. 35:127778

مصطلحات موضوعية: Models, Molecular, Agonist, medicine.drug_class, Clinical Biochemistry, Retinoic acid, Pharmaceutical Science, Tretinoin, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, RAR-related orphan receptor gamma, Drug Discovery, medicine, Animals, Humans, Potency, Molecular Biology, Orphan receptor, Diaryl ether, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Nuclear Receptor Subfamily 1, Group F, Member 3, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Th17 Cells, Molecular Medicine, Lead compound, Ethers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6bcbeb08e68c5a36002135e73f0931e
https://doi.org/10.1016/j.bmcl.2021.127778

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5

Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:855-861

مصطلحات موضوعية: 0301 basic medicine, Class I Phosphatidylinositol 3-Kinases, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Biochemistry, Piperazines, Autoimmune Diseases, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immune system, In vivo, Drug Discovery, Animals, Humans, Protein Isoforms, Amines, Piperazine, Protein Kinase Inhibitors, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, Amine derivatives, Binding Sites, Triazines, Organic Chemistry, Alternative treatment, Molecular Docking Simulation, Disease Models, Animal, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Microsomes, Liver, Molecular Medicine, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62fd58c8612f99a2829596d8b0690e5
https://doi.org/10.1016/j.bmcl.2017.01.016

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6

Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors

المؤلفون: Carolyn A. Weigelt, Xiaomei Gu, Lan-Ying Qin, Christine B. Goldstine, Sylwia Stachura, Jenny Xie, Zheming Ruan, T. G. Murali Dhar, Donna L. Pedicord, Michael A. Poss, Luisa Salter-Cid, Rajeev S. Bhide, Percy H. Carter, James Neels, John S. Sack, Stefan Ruepp, Kevin Stefanski, Paul Davies, Stacey Skala

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:4256-4260

مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, chemical and pharmacologic phenomena, Phosphatidylinositol 3-Kinases, Biochemistry, PI3K signaling, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Animals, Protein Isoforms, Structure–activity relationship, Amines, Protein Kinase Inhibitors, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, Binding Sites, biology, Triazines, Chemistry, Arthritis, Organic Chemistry, Protein Structure, Tertiary, Molecular Docking Simulation, Disease Models, Animal, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Keyhole limpet hemocyanin, Protein Binding, Collagen-induced arthritis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdaa3a62c46009198cffe25f36688ef7
https://doi.org/10.1016/j.bmcl.2016.07.047

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7

Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders

المؤلفون: Dezhi Xing, Carolyn A. Weigelt, Luisa Salter-Cid, Pirama Nayagam Arunachalam, Rodney B.W. Smith, Ling Li, Melissa Yarde, Jodi K. Muckelbauer, Jonathan Lippy, Mary Ellen Cvijic, Sidney Pitt, John S. Sack, Thatipamula Rp, Michael A. Poss, Paul Levesque, Robert J. Cherney, Ipsit Kundu, David Marcoux, Gary L. Schieven, Arvind Mathur, Qingjie Liu, Zheming Ruan, Rosemary Zhang, R M Fancher, Shweta Padmanabhan, Scott H. Watterson, Qing Shi, Mary T. Obermeier, Anurag S. Srivastava, Anuradha Gupta, Douglas G. Batt, James Neels, Joseph A. Tino, Kevin Stefanski, Percy H. Carter, Macor John E, John Hynes, Myra Beaudoin-Bertrand, Hao Lu, Kim W. McIntyre, Stacey Skala, Aberra Fura, Lan-Ying Qin, Cornelius Lyndon A M, James Hennan, Richard Rampulla, Bogdan Sleczka, Jenny Xie, Kallem Rajareddy, Jie Pan, Christine B. Goldstine, Hua Gong, Qian Ruan, Kathleen M. Gillooly, Donna L. Pedicord, Jingsong Fan, Rajeev S. Bhide, Stefan Ruepp

المصدر: Journal of medicinal chemistry. 60(12)

مصطلحات موضوعية: 0301 basic medicine, Antigens, Differentiation, T-Lymphocyte, Male, ERG1 Potassium Channel, hERG, Drug Evaluation, Preclinical, Phosphatidylinositol 3-Kinases, Pharmacology, Pyrazole, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Antigens, CD, Drug Discovery, Structure–activity relationship, Potency, Animals, Humans, Lectins, C-Type, Phosphatidylinositol, Enzyme Inhibitors, Phosphoinositide-3 Kinase Inhibitors, Mice, Inbred BALB C, biology, Kinase, Arthritis, Experimental, Isoenzymes, 030104 developmental biology, chemistry, Immune System Diseases, biology.protein, Molecular Medicine, Pyrazoles, Female, Efflux, Rabbits, Caco-2 Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67ea5386a71d40a3c8aca591866f2ab
https://pubmed.ncbi.nlm.nih.gov/28541707

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8

Identification of highly potent and selective PI3Kδ inhibitors

المؤلفون: Rajeev S. Bhide, Carolyn A. Weigelt, David Marcoux, Zheming Ruan, Joseph A. Tino, Lan-Ying Qin, Qian Ruan, John Hynes, Qing Shi, Michael A. Poss, Hongchen Qiu, Gary L. Schieven

المصدر: Bioorganicmedicinal chemistry letters. 27(13)

مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Phosphatidylinositol 3-Kinases, Pharmacology, Biochemistry, 03 medical and health sciences, Mice, Structure-Activity Relationship, 0302 clinical medicine, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Kinome, Molecular Biology, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Highly selective, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, Rheumatoid arthritis, Molecular Medicine, Identification (biology)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa6e633769aca402bfa7c285b9d57d2
https://pubmed.ncbi.nlm.nih.gov/28209465

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9

Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:7516-7521

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bb84aabdb3a646b55d279059af6aab
https://doi.org/10.1016/j.bmcl.2011.06.098

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10

Solid-phase synthesis of a library based on biphenyl-containing trypsin-like serine protease inhibitors

المؤلفون: Ramesh Kakarla, James C. Sutton, Shirong Zhu, Robert D. Hutchins, Samuel Gerritz, Bogumila Rachwal, Zheming Ruan, Daniel L. Cheney, Michael J. Sofia, Shuhao Shi

المصدر: Bioorganic & Medicinal Chemistry Letters. 19:6477-6480

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2287529f3595663e6f1ca28ba0600c
https://doi.org/10.1016/j.bmcl.2009.08.100

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