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1Human Cerebral Organoids Reveal Early Spatiotemporal Dynamics and Pharmacological Responses of UBE3A
المؤلفون: Albert J. Keung, Alexis Voulgaropoulos, Zuzana Drobná, Dilara Sen
المصدر: Stem Cell Reports
مصطلحات موضوعية: 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Ataxia, Time Factors, Topoisomerase Inhibitors, Ubiquitin-Protein Ligases, autism, Biology, Biochemistry, cerebral organoid, Cell Line, 03 medical and health sciences, Genomic Imprinting, 0302 clinical medicine, Neurodevelopmental disorder, Angelman syndrome, Report, Genetics, medicine, UBE3A, Humans, pluripotent stem cell, Epigenetics, Induced pluripotent stem cell, Cerebrum, Cell Nucleus, Neurons, neurodevelopment, Cell Biology, medicine.disease, Ubiquitin ligase, Organoids, neurogenesis, 030104 developmental biology, biology.protein, medicine.symptom, imprinting, Neuroscience, 030217 neurology & neurosurgery, epigenetic, Developmental Biology, Cerebral organoid
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المؤلفون: Dilara Sen, Zuzana Drobná, Albert J. Keung
المصدر: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)مصطلحات موضوعية: 0301 basic medicine, Pluripotent Stem Cells, congenital, hereditary, and neonatal diseases and abnormalities, Science, Ubiquitin-Protein Ligases, Immunofluorescence, Article, Antibodies, 03 medical and health sciences, Genomic Imprinting, Mice, 0302 clinical medicine, Western blot, Neural Stem Cells, Cerebellum, medicine, UBE3A, Organoid, Animals, Humans, Autistic Disorder, Induced pluripotent stem cell, Biological models, Neurons, Multidisciplinary, medicine.diagnostic_test, biology, Molecular biology, Organoids, Disease Models, Animal, 030104 developmental biology, biology.protein, Medicine, Experimental organisms, Antibody, Angelman Syndrome, Genomic imprinting, 030217 neurology & neurosurgery, Cerebral organoid
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المؤلفون: Jodi A. Flaws, Emilie F. Rissman, Anne D Henriksen, Joshua W. Irvin, Rachel Stevenson, Jessica A. Goldsby, Jennifer T. Wolstenholme, Zuzana Drobná
المصدر: Endocrinology
مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Offspring, Nerve Tissue Proteins, Biology, Mice, 03 medical and health sciences, Fetus, 0302 clinical medicine, Endocrinology, Phenols, Postsynaptic potential, Internal medicine, Gene expression, medicine, Animals, Benzhydryl Compounds, Social Behavior, Gene, Research Articles, Brain, Post-Synaptic Density, Mice, Inbred C57BL, Paternal Exposure, 030104 developmental biology, Excitatory postsynaptic potential, Female, Neural development, Postsynaptic density, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857174052b06b4e2b13624d7745cbf4e
https://doi.org/10.1210/en.2019-00196 -
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المؤلفون: Emilie F. Rissman, Timothy R. Fennell, Alzbeta Talarovicova, Hannah E. Schrader, Rodney W. Snyder, Zuzana Drobná
المصدر: Toxicology
مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Bisphenol A, Time Factors, Bisphenol F, Bisphenol, Endocrine Disruptors, Weight Gain, Toxicology, Article, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Phenols, Endocrine disrupting compound, 3T3-L1 Cells, Diabetes mellitus, Internal medicine, Adipocytes, medicine, Animals, Sulfones, Benzhydryl Compounds, Mice, Inbred ICR, Adipogenesis, Dose-Response Relationship, Drug, Chemistry, Metabolism, medicine.disease, 030104 developmental biology, Endocrinology, Gene Expression Regulation, Bisphenol S, medicine.symptom, Weight gain, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery
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المؤلفون: Mazhar Adli, Erin P. Harris, Jennifer T. Wolstenholme, Changqing Zhou, Philip S. Lambeth, Stephen Shang, Anne D Henriksen, Jodi A. Flaws, Catalina Montiel, Emilie F. Rissman, Zuzana Drobná
المصدر: Endocrinology. 159:132-144
مصطلحات موضوعية: Male, 0301 basic medicine, endocrine system, medicine.medical_specialty, Mice, Inbred Strains, Endocrine Disruptors, Biology, Epigenesis, Genetic, Fetal Development, Random Allocation, 03 medical and health sciences, Endocrinology, Phenols, Endocrine disrupting compound, Pregnancy, Internal medicine, Gene expression, medicine, Animals, Lactation, Benzhydryl Compounds, Gene, Crosses, Genetic, Research Articles, Neurons, MEG3, Genetics, Regulation of gene expression, Sex Characteristics, urogenital system, Brain, Gene Expression Regulation, Developmental, DNA Methylation, Preoptic Area, 030104 developmental biology, Differentially methylated regions, Hypothalamus, Anterior, Maternal Exposure, DNA methylation, Female, RNA, Long Noncoding, Septal Nuclei, Genomic imprinting, hormones, hormone substitutes, and hormone antagonists
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ae821441afc694c7782bf8c8d6b2f1
https://doi.org/10.1210/en.2017-00730 -
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المؤلفون: Jessica E. Laine, Wimal Pathmasiri, Susan Sumner, Susan McRitchie, Lisa Smeester, Kathryn A. Bailey, Rebecca C. Fry, Gonzalo G. García-Vargas, Zuzana Drobná, Christelle Douillet, Marisela Rubio-Andrade, Andrew F. Olshan, Miroslav Stýblo
المصدر: Environmental Science & Technology. 51:625-633
مصطلحات موضوعية: 0301 basic medicine, Cord, Urinary system, Physiology, 010501 environmental sciences, 01 natural sciences, Arsenicals, Article, Arsenic, 03 medical and health sciences, Metabolomics, Pregnancy, MD Multidisciplinary, Metabolome, medicine, Humans, Environmental Chemistry, Mexico, 0105 earth and related environmental sciences, Chemistry, Infant, Newborn, Environmental Exposure, General Chemistry, Environmental exposure, medicine.disease, Metabolic pathway, 030104 developmental biology, In utero, Environmental chemistry, Female, Environmental Sciences
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المؤلفون: Ana Navas Acien, Frederick W. Miller, Maria Grau Perez, Angela D. Liese, Richard F. Hamman, Chongben Zang, Michelle A. Mendez, Robin C. Puett, Chin-Chi Kuo, Miroslav Styblo, Kristina A. Thayer, Miranda Spratlen, Dana Dabelea, William C. Knowler, Christelle Douillet, Zuzana Drobná, Ronny A. Bell, Elizabeth J. Mayer-Davis, John L. Adgate
المصدر: Diabetes Care
مصطلحات موضوعية: inorganic chemicals, Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Physiology, chemistry.chemical_element, Type 2 diabetes, 010501 environmental sciences, 01 natural sciences, Gastroenterology, Arsenic, Young Adult, 03 medical and health sciences, Folic Acid, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Vitamin B12, Epidemiology/Health Services Research, ARSENIC EXPOSURE, General Environmental Science, 0105 earth and related environmental sciences, Advanced and Specialized Nursing, Type 1 diabetes, integumentary system, business.industry, Case-control study, Environmental Exposure, Environmental exposure, Odds ratio, medicine.disease, Vitamin B 12, Diabetes Mellitus, Type 1, 030104 developmental biology, Diabetes Mellitus, Type 2, chemistry, Case-Control Studies, General Earth and Planetary Sciences, Female, business, Biomarkers
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788b5109ddb23f4cf1ec52de5cadbb61
https://doi.org/10.2337/dc16-0810 -
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المؤلفون: Miroslav Stýblo, Jenna M. Currier, Christelle Douillet, Zuzana Drobná
المصدر: Journal of Environmental Sciences. 49:104-112
مصطلحات موضوعية: Male, 0301 basic medicine, Environmental Engineering, Methyltransferase, Adipose tissue, chemistry.chemical_element, 010501 environmental sciences, 01 natural sciences, Article, Arsenicals, Arsenic, Mice, 03 medical and health sciences, chemistry.chemical_compound, medicine, Animals, Environmental Chemistry, 0105 earth and related environmental sciences, General Environmental Science, Arsenite, Kidney, Chemistry, business.industry, Wild type, Methyltransferases, General Medicine, Methylation, Molecular biology, Biotechnology, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Knockout mouse, business, Oxidation-Reduction, Water Pollutants, Chemical
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المؤلفون: Alexis Voulgaropoulos, Albert J. Keung, Zuzana Drobná, Dilara Sen
مصطلحات موضوعية: 0303 health sciences, Computer science, Disease, medicine.disease, Disease etiology, 03 medical and health sciences, 0302 clinical medicine, Time windows, Autism spectrum disorder, Angelman syndrome, UBE3A, medicine, Screening tool, Neuroscience, 030217 neurology & neurosurgery, 030304 developmental biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785cbc2d241f8e503d66b20a72b7cadb
https://doi.org/10.1101/742213 -
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المؤلفون: Zuzana Drobná
المصدر: Toxicology and Applied Pharmacology. 408:115278
مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Arsenites, Substantia nigra, Striatum, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Toxicology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Slice preparation, Cerebellum, Internal medicine, Arsenic Poisoning, medicine, Animals, Neurotoxin, Muscle Strength, Phosphorylation, Arsenite, Pharmacology, Chemistry, Neurodegeneration, Environmental exposure, medicine.disease, Corpus Striatum, nervous system diseases, Mice, Inbred C57BL, Substantia Nigra, 030104 developmental biology, Endocrinology, nervous system, 030220 oncology & carcinogenesis, alpha-Synuclein, Transcriptome