المؤلفون: Zu S; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Bio-systems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Molecular Medicine, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310013, China., Long Z; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Bio-systems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China., Zhang X; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Bio-systems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China., Sheng J; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Bio-systems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China., Xu Y; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Bio-systems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Molecular Medicine, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310013, China., Sun H; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Bio-systems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Molecular Medicine, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310013, China., Liu X; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Bio-systems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China., Shangguan D; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Bio-systems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Molecular Medicine, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310013, China.

المصدر: Journal of natural products [J Nat Prod] 2024 Sep 27; Vol. 87 (9), pp. 2170-2179. Date of Electronic Publication: 2024 Aug 30.

نوع المنشور: Journal Article; Comparative Study

بيانات الدورية: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE

مواضيع طبية MeSH: Benzophenanthridines*/pharmacology , Benzophenanthridines*/chemistry , Berberine Alkaloids*/pharmacology , Berberine Alkaloids*/chemistry , DNA*/drug effects, Humans ; G-Quadruplexes/drug effects ; Apoptosis/drug effects ; Molecular Structure ; Cell Line, Tumor ; Alkaloids/pharmacology ; Alkaloids/chemistry ; Cell Proliferation/drug effects ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry

المؤلفون: Lucier R; Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany., Kamileen MO; Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany., Nakamura Y; Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany; Research Group Biosynthesis and NMR, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany., Serediuk S; Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany., Barbole R; Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune 411008, Maharashtra, India., Wurlitzer J; Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany., Kunert M; Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany., Heinicke S; Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany., O'Connor SE; Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany. Electronic address: oconnor@ice.mpg.de., Sonawane PD; Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany. Electronic address: psonawane@ice.mpg.de.

المصدر: Molecular plant [Mol Plant] 2024 Aug 05; Vol. 17 (8), pp. 1236-1254. Date of Electronic Publication: 2024 Jun 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: England NLM ID: 101465514 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1752-9867 (Electronic) Linking ISSN: 16742052 NLM ISO Abbreviation: Mol Plant Subsets: MEDLINE

مواضيع طبية MeSH: Solanum*/metabolism , Alkaloids*/biosynthesis , Alkaloids*/chemistry , Alkaloids*/metabolism, Solanaceous Alkaloids/biosynthesis ; Solanaceous Alkaloids/metabolism ; Solanaceous Alkaloids/chemistry ; Steroids/biosynthesis ; Steroids/metabolism ; Nicotiana/metabolism ; Nicotiana/genetics ; Solanum nigrum/metabolism ; Solanum nigrum/chemistry

المؤلفون: Damiescu R; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55099, Germany., Dawood M; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55099, Germany., Elbadawi M; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55099, Germany., Klauck SM; Division of Cancer Genome Research, German Cancer Research Center (DKFZ) Heidelberg, National Center for Tumor Diseases (NCT), NCT Heidelberg, A Partnership between DKFZ and University Hospital Heidelberg, Heidelberg 69120, Germany., Bringmann G; Institute of Organic Chemistry, University of Würzburg, Am Hubland, Würzburg D-97074, Germany., Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55099, Germany.

المصدر: ACS chemical biology [ACS Chem Biol] 2024 Sep 20; Vol. 19 (9), pp. 1963-1981. Date of Electronic Publication: 2024 Aug 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Opioid, delta*/agonists , Receptors, Opioid, delta*/metabolism , Alkaloids*/pharmacology , Alkaloids*/chemistry , Azocines*/pharmacology , Azocines*/chemistry, Humans ; Drug Evaluation, Preclinical/methods ; Transcriptome/drug effects ; HEK293 Cells ; NF-kappa B/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Quinolizidine Alkaloids

المؤلفون: Wang WL; College of Pharmacy, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai Tibet Plateau, Southwest Minzu University, Chengdu, 610041, China; Research Center, Chengdu Medical College, Chengdu, 610500, China., Wu XY; Research Center, Chengdu Medical College, Chengdu, 610500, China., Luo XY; Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, China; Research Center, Chengdu Medical College, Chengdu, 610500, China., Tang YQ; Research Center, Chengdu Medical College, Chengdu, 610500, China., Cui J; College of Pharmacy, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai Tibet Plateau, Southwest Minzu University, Chengdu, 610041, China., Huang XY; College of Pharmacy, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai Tibet Plateau, Southwest Minzu University, Chengdu, 610041, China., Jiang YC; College of Pharmacy, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai Tibet Plateau, Southwest Minzu University, Chengdu, 610041, China., Liu Y; Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, China; Research Center, Chengdu Medical College, Chengdu, 610500, China. Electronic address: scunn519@gmail.com., Li LM; College of Pharmacy, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai Tibet Plateau, Southwest Minzu University, Chengdu, 610041, China. Electronic address: limeili@swun.edu.cn.

المصدر: Phytochemistry [Phytochemistry] 2024 Sep; Vol. 225, pp. 114198. Date of Electronic Publication: 2024 Jun 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE

مواضيع طبية MeSH: Narcissus*/chemistry , Alkaloids*/pharmacology , Alkaloids*/chemistry , Alkaloids*/isolation & purification , Immunosuppressive Agents*/pharmacology , Immunosuppressive Agents*/chemistry , Immunosuppressive Agents*/isolation & purification , Cell Proliferation*/drug effects, Humans ; Animals ; Mice ; T-Lymphocytes/drug effects ; Molecular Structure ; NF-kappa B/metabolism ; NF-kappa B/antagonists & inhibitors ; Benzophenanthridines/pharmacology ; Benzophenanthridines/chemistry ; Benzophenanthridines/isolation & purification ; Structure-Activity Relationship ; Dose-Response Relationship, Drug ; Stereoisomerism ; Signal Transduction/drug effects ; Phenanthridines ; Amaryllidaceae Alkaloids

المؤلفون: Reddy KP; Medical Practice Evaluation Center, Mongan Institute, Massachusetts General Hospital, Boston.; Tobacco Research and Treatment Center, Mongan Institute, Massachusetts General Hospital, Boston.; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston.; Harvard Medical School, Boston, Massachusetts., Paltiel AD; Public Health Modeling Unit, Yale School of Public Health, New Haven, Connecticut., Freedberg KA; Medical Practice Evaluation Center, Mongan Institute, Massachusetts General Hospital, Boston.; Harvard Medical School, Boston, Massachusetts.; Division of General Internal Medicine, Massachusetts General Hospital, Boston.; Division of Infectious Diseases, Massachusetts General Hospital, Boston.; Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Rigotti NA; Tobacco Research and Treatment Center, Mongan Institute, Massachusetts General Hospital, Boston.; Harvard Medical School, Boston, Massachusetts.; Division of General Internal Medicine, Massachusetts General Hospital, Boston.

المصدر: JAMA health forum [JAMA Health Forum] 2024 Aug 02; Vol. 5 (8), pp. e242647. Date of Electronic Publication: 2024 Aug 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Medical Association Country of Publication: United States NLM ID: 101769500 Publication Model: Electronic Cited Medium: Internet ISSN: 2689-0186 (Electronic) Linking ISSN: 26890186 NLM ISO Abbreviation: JAMA Health Forum Subsets: MEDLINE

مواضيع طبية MeSH: Azocines*/therapeutic use , Azocines*/adverse effects , Quinolizines*/therapeutic use , Quinolizines*/adverse effects , Alkaloids*/adverse effects , Alkaloids*/therapeutic use , United States Food and Drug Administration* , Smoking Cessation*/methods , Public Health*, Humans ; United States ; Adult ; Middle Aged ; Adolescent ; Aged ; Young Adult ; Aged, 80 and over ; Female ; Male ; Life Expectancy ; Smoking Cessation Agents/therapeutic use ; Smoking Cessation Agents/adverse effects ; Quinolizidine Alkaloids

المؤلفون: Li Y; Key Laboratory of Ethnomedicine of Ministry of Education, School of Pharmacy, Center on Translational Neuroscience, Minzu University of China, 100081, Beijing, China., Fan F; Key Laboratory of Ethnomedicine of Ministry of Education, School of Pharmacy, Center on Translational Neuroscience, Minzu University of China, 100081, Beijing, China., Liu Q; Key Laboratory of Ethnomedicine of Ministry of Education, School of Pharmacy, Center on Translational Neuroscience, Minzu University of China, 100081, Beijing, China. Electronic address: nlqsh@163.com.

المصدر: European journal of pharmacology [Eur J Pharmacol] 2024 Jul 05; Vol. 974, pp. 176512. Date of Electronic Publication: 2024 Mar 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Oxidative Stress*/drug effects , Brain-Derived Neurotrophic Factor*/metabolism , Proto-Oncogene Proteins c-akt*/metabolism , Ischemic Stroke*/drug therapy , Ischemic Stroke*/metabolism , Ischemic Stroke*/complications , Ischemic Stroke*/pathology , Signal Transduction*/drug effects , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use , Alkaloids*/pharmacology , Alkaloids*/therapeutic use , Receptor, trkB*/metabolism, Animals ; Mice ; Male ; Isoflavones/pharmacology ; Isoflavones/therapeutic use ; Quinolizines/pharmacology ; Quinolizines/therapeutic use ; Azocines/pharmacology ; Disease Models, Animal ; Brain/drug effects ; Brain/metabolism ; Brain/pathology ; Quinolizidine Alkaloids

المؤلفون: Qin JX; Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Hong Y; Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Zhao LY; Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Wang CQ; Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Fang X; Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Liang S; Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

المصدر: Journal of Asian natural products research [J Asian Nat Prod Res] 2024 Jun; Vol. 26 (6), pp. 765-771. Date of Electronic Publication: 2024 Feb 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 100888334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2213 (Electronic) Linking ISSN: 10286020 NLM ISO Abbreviation: J Asian Nat Prod Res Subsets: MEDLINE

مواضيع طبية MeSH: Uncaria*/chemistry , Alkaloids*/pharmacology , Alkaloids*/chemistry , Nitric Oxide*/antagonists & inhibitors , Nitric Oxide*/biosynthesis , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , Lipopolysaccharides*/pharmacology , Microglia*/drug effects , Indole Alkaloids*, Molecular Structure ; Animals ; Mice ; Chromatography, High Pressure Liquid ; Secologanin Tryptamine Alkaloids/pharmacology ; Secologanin Tryptamine Alkaloids/chemistry

المؤلفون: Vera-Baquero FL; Departamento de Tecnología Química y Ambiental, E.S.C.E.T, Universidad Rey Juan Carlos, C/Tulipán s/n, 28933 Móstoles, Madrid, Spain. Electronic address: fernando.vera@urjc.es., Casado N; Departamento de Tecnología Química y Ambiental, E.S.C.E.T, Universidad Rey Juan Carlos, C/Tulipán s/n, 28933 Móstoles, Madrid, Spain. Electronic address: natalia.casado@urjc.es., Morante-Zarcero S; Departamento de Tecnología Química y Ambiental, E.S.C.E.T, Universidad Rey Juan Carlos, C/Tulipán s/n, 28933 Móstoles, Madrid, Spain. Electronic address: sonia.morante@urjc.es., Sierra I; Departamento de Tecnología Química y Ambiental, E.S.C.E.T, Universidad Rey Juan Carlos, C/Tulipán s/n, 28933 Móstoles, Madrid, Spain; Instituto de Investigación de Tecnologías para la Sostenibilidad, Universidad Rey Juan Carlos, Spain. Electronic address: isabel.sierra@urjc.es.

المصدر: Food chemistry [Food Chem] 2024 Dec 01; Vol. 460 (Pt 3), pp. 140769. Date of Electronic Publication: 2024 Aug 05.

نوع المنشور: Journal Article; Evaluation Study

بيانات الدورية: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

مواضيع طبية MeSH: Food Contamination*/analysis , Pyrrolizidine Alkaloids*/analysis , Pyrrolizidine Alkaloids*/chemistry , Food Safety* , Tropanes*/analysis , Tropanes*/chemistry, Opium/analysis ; Opium/chemistry ; Bread/analysis ; Chromatography, High Pressure Liquid ; Alkaloids/analysis ; Alkaloids/chemistry

المؤلفون: He Q; College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, P. R. China., Zhang HR; College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, P. R. China., Zou Y; College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, P. R. China.

المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 May 27; Vol. 63 (22), pp. e202404000. Date of Electronic Publication: 2024 Apr 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

مواضيع طبية MeSH: Alkaloids*/chemical synthesis , Alkaloids*/metabolism , Cytochrome P-450 Enzyme System*/metabolism , Cytochrome P-450 Enzyme System*/chemistry , Insecticides*/chemical synthesis , Insecticides*/chemistry , Piperazines*/chemistry, Animals ; Biocatalysis ; Dimerization ; Indole Alkaloids/chemistry ; Indole Alkaloids/metabolism ; Molecular Structure ; Oxidation-Reduction

المؤلفون: Rubaiya Talukder S; National Drug and Alcohol Research Centre, University of New South Wales, 22-32 King St, Randwick, New South Wales 2031, Australia. Electronic address: s.talukder@unsw.edu.au., Lappin J; National Drug and Alcohol Research Centre, University of New South Wales, 22-32 King St, Randwick, New South Wales 2031, Australia; Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney 2200, Australia., Clare Boland V; National Drug and Alcohol Research Centre, University of New South Wales, 22-32 King St, Randwick, New South Wales 2031, Australia., Weaver N; School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, 2308, Australia., McRobbie H; National Drug and Alcohol Research Centre, University of New South Wales, 22-32 King St, Randwick, New South Wales 2031, Australia., James Courtney R; National Drug and Alcohol Research Centre, University of New South Wales, 22-32 King St, Randwick, New South Wales 2031, Australia.

المصدر: Addictive behaviors [Addict Behav] 2024 Dec; Vol. 159, pp. 108148. Date of Electronic Publication: 2024 Aug 29.

نوع المنشور: Journal Article; Randomized Controlled Trial

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 7603486 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6327 (Electronic) Linking ISSN: 03064603 NLM ISO Abbreviation: Addict Behav Subsets: MEDLINE

مواضيع طبية MeSH: Varenicline*/therapeutic use , Varenicline*/adverse effects , Quinolizines*/therapeutic use , Quinolizines*/adverse effects , Azocines*/therapeutic use , Azocines*/adverse effects , Alkaloids*/adverse effects , Alkaloids*/therapeutic use , Smoking Cessation*/methods , Smoking Cessation Agents*/therapeutic use , Smoking Cessation Agents*/adverse effects , Mental Disorders*/drug therapy , Mental Disorders*/epidemiology, Humans ; Male ; Female ; Middle Aged ; Adult ; Australia/epidemiology ; Quinolizidine Alkaloids