المؤلفون: Gu X; Department of Oncology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China., Zhu Y; Department of Oncology, Shanghai Medical College of Fudan University, Shanghai 200032, China; Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai 200032, China., Su J; School of Medicine, Shihezi University, Shihezi 832002, China., Wang S; Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China., Su X; Department of Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China; School of Medicine, Southeast University, Nanjing 210009, China., Ding X; Department of Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China; School of Medicine, Southeast University, Nanjing 210009, China., Jiang L; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China. Electronic address: jiangleiem@aliyun.com., Fei X; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China. Electronic address: 387681863@qq.com., Zhang W; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China. Electronic address: dr_zhangwentian@163.com.

المصدر: Redox biology [Redox Biol] 2024 Aug; Vol. 74, pp. 103209. Date of Electronic Publication: 2024 May 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE

مواضيع طبية MeSH: Lung Neoplasms*/metabolism , Lung Neoplasms*/pathology , Lung Neoplasms*/genetics , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/pathology , Interleukin-8*/metabolism , Interleukin-8*/genetics , Tumor Microenvironment* , Macrophages*/metabolism , Macrophages*/immunology, Humans ; Mice ; Animals ; Lactic Acid/metabolism ; Disease Progression ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Tumor-Associated Macrophages/metabolism ; Tumor-Associated Macrophages/immunology

المؤلفون: Shimizu D; Department of Gastroenterology, Hiroshima University Hospital, Hiroshima 734-0037, Japan., Yuge R; Department of Gastroenterology, Hiroshima University Hospital, Hiroshima 734-0037, Japan., Kitadai Y; Department of Gastroenterology, Hiroshima University Hospital, Hiroshima 734-0037, Japan., Ariyoshi M; Department of Gastroenterology, Hiroshima University Hospital, Hiroshima 734-0037, Japan., Miyamoto R; Department of Gastroenterology, Hiroshima University Hospital, Hiroshima 734-0037, Japan., Hiyama Y; Department of Gastroenterology, Hiroshima University Hospital, Hiroshima 734-0037, Japan., Takigawa H; Department of Gastroenterology, Hiroshima University Hospital, Hiroshima 734-0037, Japan., Urabe Y; Department of Gastroenterology, Hiroshima University Hospital, Hiroshima 734-0037, Japan., Oka S; Department of Gastroenterology, Hiroshima University Hospital, Hiroshima 734-0037, Japan.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 26; Vol. 25 (13). Date of Electronic Publication: 2024 Jun 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/immunology , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/metabolism , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/drug effects , Cancer-Associated Fibroblasts*/immunology , Immune Checkpoint Inhibitors*/pharmacology , Immune Checkpoint Inhibitors*/therapeutic use , Cell Differentiation*/drug effects , Macrophages*/immunology , Macrophages*/metabolism , Macrophages*/drug effects , Tumor Microenvironment*/drug effects , Tumor Microenvironment*/immunology, Animals ; Mice ; Humans ; Aminopyridines/pharmacology ; Aminopyridines/therapeutic use ; Pyrrolidines/pharmacology ; Pyrrolidines/therapeutic use ; Cell Line, Tumor ; Tumor-Associated Macrophages/immunology ; Tumor-Associated Macrophages/drug effects ; Tumor-Associated Macrophages/metabolism ; Disease Models, Animal ; Pyrroles/pharmacology ; Pyrroles/therapeutic use ; Female ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/drug effects

المؤلفون: Kinamon T; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.; Oak Ridge Institute for Science and Education, United States Department of Energy, Oak Ridge, Tennessee, USA., Waack U; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA., Needles M; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA., Rubin D; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA., Collyar D; Patient Advocates in Research, Danville, California, USA., Doernberg SB; Department of Medicine, Division of Infectious Diseases, University of California San Francisco, San Francisco, California, USA., Evans SR; Biostatistics Center and Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, George Washington University, Washington D.C., USA.; Antibacterial Resistance Leadership Group, Durham, North Carolina, USA., Hamasaki T; Biostatistics Center and Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, George Washington University, Washington D.C., USA.; Antibacterial Resistance Leadership Group, Durham, North Carolina, USA., Holland TL; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA., Howard-Anderson J; Antibacterial Resistance Leadership Group, Durham, North Carolina, USA.; Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA., Chambers H; Department of Medicine, Division of Infectious Diseases, University of California San Francisco, San Francisco, California, USA.; Antibacterial Resistance Leadership Group, Durham, North Carolina, USA., Fowler VG Jr; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.; Antibacterial Resistance Leadership Group, Durham, North Carolina, USA., Nambiar S; Antibacterial Resistance Leadership Group, Durham, North Carolina, USA.; Johnson and Johnson, Raritan, New Jersey, USA., Kim P; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA., Boucher HW; Antibacterial Resistance Leadership Group, Durham, North Carolina, USA.; Tufts University School of Medicine and Tufts Medicine, Boston, Massachusetts, USA., Gopinath R; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.

المصدر: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2024 Jul 19; Vol. 79 (1), pp. 60-69.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Pneumonia, Ventilator-Associated*/drug therapy , Pneumonia, Ventilator-Associated*/microbiology , Anti-Bacterial Agents*/therapeutic use , Pneumonia, Bacterial*/drug therapy , Pneumonia, Bacterial*/microbiology, Humans ; Male ; Healthcare-Associated Pneumonia/drug therapy ; Healthcare-Associated Pneumonia/microbiology ; Female ; United States ; Clinical Trials as Topic ; Cross Infection/drug therapy ; Treatment Outcome ; Middle Aged ; United States Food and Drug Administration ; Aged

المؤلفون: Klompas M; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts; and Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts mklompas@bwh.harvard.edu.

المصدر: Respiratory care [Respir Care] 2024 Jun 28; Vol. 69 (7), pp. 854-868. Date of Electronic Publication: 2024 Jun 28.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Daedalus Enterprises for the American Association for Respiratory Therapy Country of Publication: United States NLM ID: 7510357 Publication Model: Electronic Cited Medium: Internet ISSN: 1943-3654 (Electronic) Linking ISSN: 00201324 NLM ISO Abbreviation: Respir Care Subsets: MEDLINE

مواضيع طبية MeSH: Pneumonia, Ventilator-Associated*/epidemiology , Pneumonia, Ventilator-Associated*/prevention & control , COVID-19*/complications , COVID-19*/epidemiology , Cross Infection*/epidemiology , Cross Infection*/prevention & control, Humans ; SARS-CoV-2 ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Pneumonia, Viral/complications ; Healthcare-Associated Pneumonia/epidemiology

المؤلفون: Chen CL; Division of Pulmonary and Critical Care, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan., Tseng HY; Division of Pulmonary and Critical Care, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan., Chen WC; Division of Pulmonary and Critical Care, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan; Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; Department of Education, China Medical University Hospital, Taichung, Taiwan., Liang SJ; Division of Pulmonary and Critical Care, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan., Tu CY; Division of Pulmonary and Critical Care, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan., Lin YC; Division of Pulmonary and Critical Care, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan. Electronic address: cmchlyc@yahoo.com.tw., Hsueh PR; Departments of Laboratory Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan; Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan; Department of Laboratory Medicine, School of Medicine, China Medical University, Taichung, Taiwan. Electronic address: hsporen@gmail.com.

المصدر: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi [J Microbiol Immunol Infect] 2024 Jun; Vol. 57 (3), pp. 480-489. Date of Electronic Publication: 2024 Mar 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: published by Elsevier for the Taiwan Society of Microbiology Country of Publication: England NLM ID: 100956211 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1995-9133 (Electronic) Linking ISSN: 16841182 NLM ISO Abbreviation: J Microbiol Immunol Infect Subsets: MEDLINE

مواضيع طبية MeSH: Antimicrobial Stewardship* , Pneumonia, Ventilator-Associated*/drug therapy , Pneumonia, Ventilator-Associated*/microbiology , Pneumonia, Ventilator-Associated*/diagnosis , Intensive Care Units* , Anti-Bacterial Agents*/therapeutic use, Humans ; Male ; Female ; Retrospective Studies ; Middle Aged ; Aged ; Taiwan ; Healthcare-Associated Pneumonia/drug therapy ; Healthcare-Associated Pneumonia/microbiology ; Cross Infection/drug therapy ; Cross Infection/microbiology ; Adult ; Bacteria/isolation & purification ; Bacteria/classification ; Bacteria/drug effects ; Bacteria/genetics

المؤلفون: Yang X; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China. Electronic address: 2020207038@stu.njau.edu.cn., Wang Z; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China., Xie S; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China., Liang Z; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China., Wei N; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China., Pan J; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China., Zhao Y; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China., Cao R; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China. Electronic address: crb@njau.edu.cn.

المصدر: Veterinary microbiology [Vet Microbiol] 2024 Aug; Vol. 295, pp. 110150. Date of Electronic Publication: 2024 Jun 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Scientific Pub. Co Country of Publication: Netherlands NLM ID: 7705469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2542 (Electronic) Linking ISSN: 03781135 NLM ISO Abbreviation: Vet Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Lysosomes*/metabolism , Autophagy* , Encephalitis Virus, Japanese*/physiology , Lysosomal-Associated Membrane Protein 2*/genetics , Lysosomal-Associated Membrane Protein 2*/metabolism , Down-Regulation*, Animals ; Swine ; Lysosomal-Associated Membrane Protein 1/metabolism ; Lysosomal-Associated Membrane Protein 1/genetics ; Encephalitis, Japanese/virology ; Encephalitis, Japanese/veterinary ; Cell Line ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/metabolism ; Lysosomal Membrane Proteins/metabolism ; Lysosomal Membrane Proteins/genetics

المؤلفون: Reginato G; Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), 6500, Bellinzona, Switzerland., Dello Stritto MR; Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), 6500, Bellinzona, Switzerland., Wang Y; Department of Biophysics & Biophysical Chemistry, Johns Hopkins University, Baltimore, MD, 21205, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Hao J; Department of Biophysics, Johns Hopkins University, Baltimore, MD21218, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA., Pavani R; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Schmitz M; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zürich, Switzerland., Halder S; Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), 6500, Bellinzona, Switzerland.; Biological Systems Engineering, Plaksha University, Mohali, Punjab, 140306, India., Morin V; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France., Cannavo E; Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), 6500, Bellinzona, Switzerland., Ceppi I; Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), 6500, Bellinzona, Switzerland., Braunshier S; Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), 6500, Bellinzona, Switzerland., Acharya A; Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), 6500, Bellinzona, Switzerland., Ropars V; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France., Charbonnier JB; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France., Jinek M; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zürich, Switzerland., Nussenzweig A; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Ha T; Department of Biophysics & Biophysical Chemistry, Johns Hopkins University, Baltimore, MD, 21205, USA.; Department of Biophysics, Johns Hopkins University, Baltimore, MD21218, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA.; Howard Hughes Medical Institute, Boston, MA, 02115, USA., Cejka P; Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), 6500, Bellinzona, Switzerland. petr.cejka@irb.usi.ch.

المصدر: Nature communications [Nat Commun] 2024 Jul 10; Vol. 15 (1), pp. 5789. Date of Electronic Publication: 2024 Jul 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: DNA Breaks, Double-Stranded* , CRISPR-Cas Systems* , CRISPR-Associated Protein 9*/metabolism , CRISPR-Associated Protein 9*/genetics , DNA*/metabolism , DNA*/genetics, Humans ; MRE11 Homologue Protein/metabolism ; MRE11 Homologue Protein/genetics ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/genetics ; CRISPR-Associated Proteins/metabolism ; CRISPR-Associated Proteins/genetics ; Gene Editing ; Endonucleases/metabolism ; Endonucleases/genetics ; Bacterial Proteins/metabolism ; Bacterial Proteins/genetics ; Endodeoxyribonucleases/metabolism ; Endodeoxyribonucleases/genetics ; DNA End-Joining Repair ; DNA Cleavage ; Transcription Factors/metabolism ; Transcription Factors/genetics

المؤلفون: Anandhan S; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Herbrich S; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Goswami S; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Guan B; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chen Y; Immunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Macaluso MD; Immunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Jindal S; Immunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Natarajan SM; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Andrewes SW; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Xiong L; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Nagarajan A; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Basu S; Immunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tang DN; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liu J; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Min J; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Sheikh Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Maitra A; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Sheikh Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sharma P; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. PadSharma@mdanderson.org.; The James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. PadSharma@mdanderson.org.; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. PadSharma@mdanderson.org.; Immunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. PadSharma@mdanderson.org.

المصدر: Nature communications [Nat Commun] 2024 Jul 10; Vol. 15 (1), pp. 5291. Date of Electronic Publication: 2024 Jul 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Pancreatic Neoplasms*/immunology , Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/metabolism , Tumor Microenvironment*/immunology , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/drug effects , Immune Checkpoint Inhibitors*/pharmacology , Immune Checkpoint Inhibitors*/therapeutic use , Cell Adhesion Molecules*/metabolism , Cell Adhesion Molecules*/genetics, Animals ; Humans ; Mice ; Cell Line, Tumor ; Myeloid Cells/metabolism ; Myeloid Cells/immunology ; Tumor-Associated Macrophages/metabolism ; Tumor-Associated Macrophages/immunology ; Tumor-Associated Macrophages/drug effects ; Mice, Inbred C57BL ; Female ; Drug Resistance, Neoplasm ; Macrophages/immunology ; Macrophages/metabolism ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism

المؤلفون: Owaki T; Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Iida T; Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan. iidatyuw@med.nagoya-u.ac.jp.; Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan. iidatyuw@med.nagoya-u.ac.jp., Miyai Y; Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Kato K; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Hase T; Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan., Ishii M; Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan., Ando R; Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Hinohara K; Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Institute for Advanced Research, Nagoya University, Nagoya, Japan., Akashi T; Division of Systems Biology, Graduate School of Medicine, Nagoya University, Nagoya, Japan., Mizutani Y; Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Ishikawa T; Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Mii S; Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Shiraki Y; Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Esaki N; Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Yamamoto M; Laboratory of Physiological Pathology, Nippon Veterinary and Life Science University, Tokyo, Japan., Tsukamoto T; Division of Analytical Pathology, Oncology Innovation Center, Fujita Health University, Toyoake, Japan., Nomura S; Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Clinical Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo, Japan., Murakami T; Department of Microbiology, Saitama Medical University, Saitama, Japan., Takahashi M; Department of Pathology, Fujita Health University, Toyoake, Japan.; International Center for Cell and Gene Therapy, Fujita Health University, Toyoake, Japan., Yuguchi Y; Department of Urology, Chukyo Hospital, Nagoya, Japan., Maeda M; Department of Urology, Chukyo Hospital, Nagoya, Japan., Sano T; Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Sassa N; Department of Urology, Aichi Medical University, Nagakute, Japan., Matsukawa Y; Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Kawashima H; Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Akamatsu S; Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Enomoto A; Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan. enomoto@iar.nagoya-u.ac.jp.; Center for One Medicine Innovative Translational Research, Gifu University Institute for Advanced Study, Gifu, Japan. enomoto@iar.nagoya-u.ac.jp.

المصدر: British journal of cancer [Br J Cancer] 2024 Jul; Vol. 131 (2), pp. 372-386. Date of Electronic Publication: 2024 Jun 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Cancer-Associated Fibroblasts*/drug effects , Cancer-Associated Fibroblasts*/metabolism , Immune Checkpoint Inhibitors*/pharmacology , Immune Checkpoint Inhibitors*/therapeutic use , Tumor Microenvironment*/drug effects , Tumor Microenvironment*/immunology , Macrophages*/immunology , Macrophages*/drug effects , Macrophages*/metabolism, Animals ; Mice ; Humans ; Tetrahydronaphthalenes/pharmacology ; Retinoids/pharmacology ; Retinoids/therapeutic use ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/immunology ; Carcinoma, Renal Cell/pathology ; Tumor-Associated Macrophages/drug effects ; Tumor-Associated Macrophages/immunology ; Tumor-Associated Macrophages/metabolism ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/immunology ; Kidney Neoplasms/pathology ; Female ; Cell Line, Tumor ; Benzoates

المؤلفون: Madugula SS; Department of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, Texas 76107, United States., Pujar P; Department of Industrial, Manufacturing and Systems Engineering, University of Texas at Arlington, 701 South Nedderman Drive, Arlington, Texas 76019, United States., Nammi B; Department of Industrial, Manufacturing and Systems Engineering, University of Texas at Arlington, 701 South Nedderman Drive, Arlington, Texas 76019, United States., Wang S; Department of Industrial, Manufacturing and Systems Engineering, University of Texas at Arlington, 701 South Nedderman Drive, Arlington, Texas 76019, United States., Jayasinghe-Arachchige VM; Department of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, Texas 76107, United States., Pham T; School of Biomedical Sciences, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, Texas 76107, United States., Mashburn D; Department of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, Texas 76107, United States., Artiles M; School of Biomedical Sciences, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, Texas 76107, United States., Liu J; Department of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, Texas 76107, United States.; School of Biomedical Sciences, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, Texas 76107, United States.

المصدر: Journal of chemical information and modeling [J Chem Inf Model] 2024 Jun 24; Vol. 64 (12), pp. 4897-4911. Date of Electronic Publication: 2024 Jun 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101230060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-960X (Electronic) Linking ISSN: 15499596 NLM ISO Abbreviation: J Chem Inf Model Subsets: MEDLINE

مواضيع طبية MeSH: Machine Learning* , CRISPR-Associated Protein 9*/chemistry , CRISPR-Associated Protein 9*/metabolism , CRISPR-Associated Protein 9*/genetics, CRISPR-Associated Proteins/chemistry ; CRISPR-Associated Proteins/metabolism ; CRISPR-Cas Systems