المؤلفون: Alexey Osipov, Yuri Utkin

المصدر: International Journal of Molecular Sciences, Vol 24, Iss 3, p 2919 (2023)

مصطلحات موضوعية: azemiopsin, cysteine-rich secretory protein, hemotoxic venom, nervous system, nicotinic acetylcholine receptor, phospholipase A2, Biology (General), QH301-705.5, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1422-0067/24/3/2919; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067

URL الوصول: https://doaj.org/article/52f7821bebe24948871364ad566c8906

المؤلفون: Igor E. Kasheverov, Alexey I. Kuzmenkov, Denis S. Kudryavtsev, Ivan S. Chudetskiy, Irina V. Shelukhina, Evgeny P. Barykin, Igor A. Ivanov, Andrei E. Siniavin, Rustam H. Ziganshin, Mikhail S. Baranov, Victor I. Tsetlin, Alexander A. Vassilevski, Yuri N. Utkin

المصدر: Frontiers in Molecular Biosciences, Vol 8 (2021)

مصطلحات موضوعية: nicotinic acetylcholine receptor, acetylcholine-binding protein, α-cobratoxin, azemiopsin, fluorescent protein, fluorescent toxin, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2021.753283/full; https://doaj.org/toc/2296-889X

URL الوصول: https://doaj.org/article/8df2465348d643aa93dc27978d775e2c

المؤلفون: Kasheverov, Igor E.^Aff4, Tsetlin, Victor I.^Aff4

المساهمون: Gopalakrishnakone, P., Editor-in-chief^Aff1, Cruz, Lourdes J., editor^Aff2, Luo, Sulan, editor^Aff3

المصدر: Toxins and Drug Discovery. :103-128

المؤلفون: Irina V. Shelukhina, Maxim N. Zhmak, Alexander V. Lobanov, Igor A. Ivanov, Alexandra I. Garifulina, Irina N. Kravchenko, Ekaterina A. Rasskazova, Margarita A. Salmova, Elena A. Tukhovskaya, Vladimir A. Rykov, Gulsara A. Slashcheva, Natalya S. Egorova, Inessa S. Muzyka, Victor I. Tsetlin, Yuri N. Utkin

المصدر: Toxins, Vol 10, Iss 1, p 34 (2018)

مصطلحات موضوعية: nicotinic acetylcholine receptor, azemiopsin, preclinical studies, toxicity, pharmacokinetics, myorelaxant, Key Contribution, Investigation of the preclinical profile of azemiopsin demonstrated its high affinity and specificity for muscle type nicotinic acetylcholine receptor as well as good muscle relaxant capacity. Toxicology studies in mice indicated that azemiopsin was well tolerated during chronic dosing and showed no immunotoxicity, allergenic or mutagenic activity, which made it a good candidate for application as a local muscle relaxant., Medicine

وصف الملف: electronic resource

Relation: http://www.mdpi.com/2072-6651/10/1/34; https://doaj.org/toc/2072-6651

URL الوصول: https://doaj.org/article/1c3a1a5152d349a28255839e22ecb2e9

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المؤلفون: Margarita A Salmova, A. V. Lobanov, Natalya S. Egorova, G. A. Slashcheva, Victor I. Tsetlin, Maxim N. Zhmak, Elena A Tukhovskaya, Inessa S. Muzyka, Igor Ivanov, I. N. Kravchenko, Irina V. Shelukhina, Alexandra I. Garifulina, Ekaterina A Rasskazova, Yuri N. Utkin, V. A. Rykov

المصدر: Toxins
Toxins; Volume 10; Issue 1; Pages: 34
Toxins, Vol 10, Iss 1, p 34 (2018)

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.drug_class, Health, Toxicology and Mutagenesis, Xenopus, lcsh:Medicine, Investigation of the preclinical profile of azemiopsin demonstrated its high affinity and specificity for muscle type nicotinic acetylcholine receptor as well as good muscle relaxant capacity. Toxicology studies in mice indicated that azemiopsin was well tolerated during chronic dosing and showed no immunotoxicity, allergenic or mutagenic activity, which made it a good candidate for application as a local muscle relaxant, CHO Cells, Nicotinic Antagonists, Viper Venoms, Pharmacology, Receptors, Nicotinic, Toxicology, Article, nicotinic acetylcholine receptor, azemiopsin, preclinical studies, toxicity, pharmacokinetics, myorelaxant, Key Contribution, Rats, Sprague-Dawley, 03 medical and health sciences, Cricetulus, Cell Line, Tumor, Toxicity Tests, medicine, Animals, Humans, Receptor, Mice, Inbred ICR, GABAA receptor, Chemistry, lcsh:R, Antagonist, Muscle relaxant, Effective dose (pharmacology), Nicotinic acetylcholine receptor, 030104 developmental biology, Neuromuscular Agents, Toxicity, Oocytes, Female, Peptides, Acetylcholine, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780d44beb0594fcc42b84be1ef3ab48d
https://pubmed.ncbi.nlm.nih.gov/29316656

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