يعرض 1 - 10 نتائج من 516 نتيجة بحث عن '"brain-penetration"', وقت الاستعلام: 0.97s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Solubility-Permeability Interplay in Facilitating the Prediction of Drug Disposition Routes, Extent of Absorption, Food Effects, Brain Penetration and Drug Induced Liver Injury Potential

    المؤلفون: Benet, Leslie Z

    المصدر: Journal of Pharmaceutical Sciences. 112(9)

    مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Orphan Drug, Rare Diseases, Humans, Solubility, Permeability, Biopharmaceutics, Chemical and Drug Induced Liver Injury, Brain, Pharmaceutical Preparations, Permeability rate, BDDCS, ECCS, BCS, Food effects, Brain penetration, DILI, Pharmacology & Pharmacy, Pharmacology and pharmaceutical sciences

    وصف الملف: application/pdf

    URL الوصول: https://escholarship.org/uc/item/8pt21240

    أضف إلى المفضلة
  2. 2
    دورية أكاديمية
    Unraveling the drug distribution in brain enabled by MALDI MS imaging with laser-assisted chemical transfer

    المؤلفون: Shuai Guo, Kening Li, Yanwen Chen, Bin Li

    المصدر: Acta Pharmaceutica Sinica B, Vol 12, Iss 4, Pp 2120-2126 (2022)

    مصطلحات موضوعية: Pharmaceutical analysis, Laser-assisted chemical transfer, Mass spectrometry imaging, Drug distribution, Brain penetration, Therapeutics. Pharmacology, RM1-950

    وصف الملف: electronic resource

    Relation: http://www.sciencedirect.com/science/article/pii/S2211383521004408; https://doaj.org/toc/2211-3835

    URL الوصول: https://doaj.org/article/b799497645594301b8dce2d6d43b6ffe

    View record from ScienceDirect Full Text Finder
    أضف إلى المفضلة
  3. 3
    دورية أكاديمية
    Panobinostat penetrates the blood–brain barrier and achieves effective brain concentrations in a murine model

    المؤلفون: Homan, Morgan J., Franson, Andrea, Ravi, Karthik, Roberts, Holly, Pai, Manjunath P., Liu, Cai, He, Miao, Matvekas, Aleksas, Koschmann, Carl, Marini, Bernard L.Aff4

    المصدر: Cancer Chemotherapy and Pharmacology. 88(3):555-562

    Find this article in full text from Springer Verlag. Find this article in full text from ProQuest Full Text Finder
    أضف إلى المفضلة
  4. 4
    دورية أكاديمية
    Targeting the Brain with Single-Domain Antibodies: Greater Potential Than Stated So Far?

    المؤلفون: Mireille Elodie Tsitokana, Pierre-André Lafon, Laurent Prézeau, Jean-Philippe Pin, Philippe Rondard

    المصدر: International Journal of Molecular Sciences, Vol 24, Iss 3, p 2632 (2023)

    مصطلحات موضوعية: camelid nanobody, VHH, blood-brain barrier, immunotherapy, brain penetration, Biology (General), QH301-705.5, Chemistry, QD1-999

    وصف الملف: electronic resource

    Relation: https://www.mdpi.com/1422-0067/24/3/2632; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067

    URL الوصول: https://doaj.org/article/5b6cddb357dd419e97960d36725e317d

    Find this article in full text from ProQuest Full Text Finder
    أضف إلى المفضلة
  5. 5
    دورية أكاديمية
    Diosgenin content is a novel criterion to assess memory enhancement effect of yam extracts

    المؤلفون: Yang, Ximeng, Nomoto, Kaori, Tohda, ChihiroAff1

    المصدر: Journal of Natural Medicines. 75(1):207-216

    Find this article in full text from Springer Verlag. Full Text Finder
    أضف إلى المفضلة
  6. 6
    دورية أكاديمية
    Pamiparib is a potent and selective PARP inhibitor with unique potential for the treatment of brain tumor

    المؤلفون: Yao Xiong, Yin Guo, Ye Liu, Hexiang Wang, Wenfeng Gong, Yong Liu, Xing Wang, Yajuan Gao, Fenglong Yu, Dan Su, Fan Wang, Yutong Zhu, Yuan Zhao, Yiyuan Wu, Zhen Qin, Xuebing Sun, Bo Ren, Bin Jiang, Wei Jin, Zhirong Shen, Zhiyu Tang, Xiaomin Song, Lai Wang, Xuesong Liu, Changyou Zhou, Beibei Jiang

    المصدر: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 9, Pp 431-440 (2020)

    مصطلحات موضوعية: Pamiparib, PARP, TMZ, Brain penetration, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

    وصف الملف: electronic resource

    Relation: http://www.sciencedirect.com/science/article/pii/S1476558620301317; https://doaj.org/toc/1476-5586

    URL الوصول: https://doaj.org/article/7890b74952de41b5ab145b51032217fe

    View record from ScienceDirect Full Text via ClinicalKey Full Text Finder
    أضف إلى المفضلة
  7. 7
    دورية أكاديمية
    Lasmiditan mechanism of action – review of a selective 5-HT1F agonist

    المؤلفون: David B. Clemow, Kirk W. Johnson, Helen M. Hochstetler, Michael H. Ossipov, Ann M. Hake, Andrew M. Blumenfeld

    المصدر: The Journal of Headache and Pain, Vol 21, Iss 1, Pp 1-13 (2020)

    مصطلحات موضوعية: Migraine, Lasmiditan, Lipophilicity, Brain penetration, 5-HT1F, CGRP, Medicine

    وصف الملف: electronic resource

    Relation: http://link.springer.com/article/10.1186/s10194-020-01132-3; https://doaj.org/toc/1129-2369; https://doaj.org/toc/1129-2377

    URL الوصول: https://doaj.org/article/2862c682cbcd488db55c7f0c23bb485b

    Find this article in full text from Springer Verlag. Find this article in full text from ProQuest Full Text Finder
    أضف إلى المفضلة
  8. 8
    دورية أكاديمية
    An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent

    المؤلفون: Nicky J. Willis, Elliott D. Bayle, George Papageorgiou, David Steadman, Benjamin N. Atkinson, William Mahy, Paul V. Fish

    المصدر: Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2790-2797 (2019)

    مصطلحات موضوعية: brain penetration, 1-chloro-1,2-benziodoxol-3-one, electrophilic chlorination, lp-922056, notum inhibitor, Science, Organic chemistry, QD241-441

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/1860-5397

    URL الوصول: https://doaj.org/article/0e99894a7cf64cf9a6e14cd7a002f112

    Find this article in full text from ProQuest Full Text Finder
    أضف إلى المفضلة
  9. 9
    دورية أكاديمية
    D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II

    المؤلفون: Sadakatali S. Gori, Ajit G. Thomas, Arindom Pal, Robyn Wiseman, Dana V. Ferraris, Run-duo Gao, Ying Wu, Jesse Alt, Takashi Tsukamoto, Barbara S. Slusher, Rana Rais

    المصدر: Pharmaceutics, Vol 14, Iss 10, p 2018 (2022)

    مصطلحات موضوعية: catechol, glutamate carboxypeptidase II, CNS, D-DOPA, pharmacokinetics, brain penetration, Pharmacy and materia medica, RS1-441

    وصف الملف: electronic resource

    Relation: https://www.mdpi.com/1999-4923/14/10/2018; https://doaj.org/toc/1999-4923

    URL الوصول: https://doaj.org/article/8dd66acf64054ef395a30b21fda30f08

    Find this article in full text from ProQuest Full Text Finder
    أضف إلى المفضلة
  10. 10
    كتاب إلكتروني
    Integrated Lead Optimization: Translational Models as We Advance Toward the Clinic

    المؤلفون: Liederer, Bianca M.Aff7, Liu, XingrongAff7, Wong, SimonAff7, Mudra, Daniel R.Aff8

    المساهمون: Crommelin, Daan J. A., Editor-in-chiefAff1, Lipper, Robert A., Editor-in-chiefAff2, Bhattachar, Shobha N., editorAff3, Morrison, John S., editorAff4, Mudra, Daniel R., editorAff5, Bender, David M., editorAff6

    المصدر: Translating Molecules into Medicines : Cross-Functional Integration at the Drug Discovery-Development Interface. 25:165-230

    أضف إلى المفضلة
أدوات البحث: أحصل على تغذية RSS – أرسل هذا البحث بالبريد الإلكتروني – حفظ البحث – جدول التنبيهات: لا شيء