المؤلفون: Li, Zhen, Chen, Zhenyue, Chen, Jiayi, Liu, Zhutong, Li, Zehui, Sun, He, Wang, Xiaochao, Wei, Jinqiang, Cao, Xuewei^{Aff1, Aff4, IDs13020023007482_cor9}, Zheng, Decai^{Aff1, Aff5, IDs13020023007482_cor10}

المصدر: Chinese Medicine. 18(1)

المؤلفون: Zhen Li, Zhenyue Chen, Jiayi Chen, Zhutong Liu, Zehui Li, He Sun, Xiaochao Wang, Jinqiang Wei, Xuewei Cao, Decai Zheng

المصدر: Chinese Medicine, Vol 18, Iss 1, Pp 1-16 (2023)

مصطلحات موضوعية: Monotropein, Osteoarthritis, Cartilage matrix degradation, Apoptosis, Pyroptosis, Other systems of medicine, RZ201-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1749-8546

URL الوصول: https://doaj.org/article/a09ad9f558d549f295fcf18220e6f8a4

المؤلفون: Sharma, Shaili, Vazquez-Portalatin, Nelda, Calve, Sarah, Panitch, Alyssa

المصدر: ACS Biomaterials Science & Engineering. 2(2)

مصطلحات موضوعية: Control Engineering, Mechatronics and Robotics, Engineering, Biomedical Engineering, Aging, Arthritis, Osteoarthritis, Prevention, Bioengineering, Regenerative Medicine, Biotechnology, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Musculoskeletal, chondroitin sulfate, collagen type II, hyaluronan, intra-articular, resist proteases, cartilage matrix degradation, Chondroitin sulfate, Biomedical engineering

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3899p6xr

المؤلفون: Ze-qin Wen, Di Liu, Yi Zhang, Zi-jun Cai, Wen-feng Xiao, Yu-sheng Li

المصدر: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

مصطلحات موضوعية: G protein-coupled receptor, osteoarthritis, cartilage matrix degradation, synovitis, pathogenesis, treatment, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.758220/full; https://doaj.org/toc/2296-634X

URL الوصول: https://doaj.org/article/836d4bea52994a4c9fe9e4166b00fe9e

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المؤلفون: Z Hu, JHN Yik, DD Cissell, PV Michelier, KA Athanasiou, DR Haudenschild

المصدر: European Cells & Materials, Vol 30, Pp 200-209 (2012)

مصطلحات موضوعية: which promote chondrocyte apoptosis and degrade cartilage to potentiate PTOA development. Recent studies show that the rate-limiting step for transcriptional activation of injury response genes is controlled by cyclin-dependent kinase 9 (CDK9), and thus it is an attractive target for limiting the injury response. Here, we determined the effects of CDK9 inhibition in suppressing the injury response in mechanically-injured cartilage explants. Bovine cartilage explants were injured by a single compressive load of 30 % strain at 100 %/s, and then treated with the CDK9 inhibitor Flavopiridol. To assess acute injury responses, we measured the mRNA expression of pro-inflammatory cytokines, catabolic enzymes, and apoptotic genes by RT-PCR, and chondrocyte viability and apoptosis by TUNEL staining. For long-term outcome, cartilage matrix degradation was assessed by soluble glycosaminoglycan release, and by determining the mechanical properties with instantaneous and relaxation moduli. Our data showed CDK9 inhibitor markedly reduced injury-induced inflammatory cytokine and catabolic gene expression. CDK9 inhibitor also attenuated chondrocyte apoptosis and reduced cartilage matrix degradation. Lastly, the mechanical properties of the injured explants were preserved by CDK9 inhibitor. Our results provide a temporal profile connecting the chain of events from mechanical impact, acute injury responses, to the subsequent induction of chondrocyte apoptosis and cartilage matrix deterioration. Thus, CDK9, Flavopiridol, inflammatory cytokines, chondrocytes, Diseases of the musculoskeletal system, RC925-935, Orthopedic surgery, RD701-811

وصف الملف: electronic resource

Relation: http://www.ecmjournal.org/papers/vol030/pdf/v030a14.pdf; https://doaj.org/toc/1473-2262

URL الوصول: https://doaj.org/article/8a17de5451f7492ab62cbade472e0cb0

المساهمون: Beck, F., editor^Aff1, Clascá, F., editor^Aff2, Frotscher, M., editor^Aff3, Haines, D. E., editor^Aff4, Hirokawa, N., editor^Aff5, Kmiec, Z., editor^Aff6, Korf, H. -W., editor^Aff7, Marani, E., editor^Aff8, Putz, R., editor^Aff9, Sano, Y., editor^Aff10, Schiebler, T. H., editor^Aff11, Timmermans, J. -P., editor^Aff12, Mobasheri, Ali^Aff13, Bondy, Carolyn A.^Aff14, Moley, Kelle^Aff15, Mendes, Alexandrina Ferreira^Aff16, Rosa, Susana Carvalho^Aff16, Richardson, Stephen M.^Aff17, Hoyland, Judith A.^Aff17, Barrett-Jolley, Richard^Aff18, Shakibaei, Mehdi^Aff19

المصدر: Facilitative Glucose Transporters in Articular Chondrocytes : Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytokines. 200:50-53

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المؤلفون: Lark, Michael W.^Aff3, Bayne, Ellen K.^Aff4, Lohmander, L. Stefan^Aff5

المساهمون: Parnham, Michael J., editor^Aff1, Bottomley, Kevin M. K., editor^Aff2, Bradshaw, David, editor^Aff2, Nixon, John S., editor^Aff2

المصدر: Metalloproteinases as Targets for Anti-Inflammatory Drugs. :59-83

المؤلفون: Houard, Xavier, Goldring, Mary B., Berenbaum, Francis

المصدر: Current Rheumatology Reports. November 2013 15(11):1-10