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1دورية أكاديمية
المؤلفون: Li, Zhen, Chen, Zhenyue, Chen, Jiayi, Liu, Zhutong, Li, Zehui, Sun, He, Wang, Xiaochao, Wei, Jinqiang, Cao, XueweiAff1, Aff4, IDs13020023007482_cor9, Zheng, DecaiAff1, Aff5, IDs13020023007482_cor10
المصدر: Chinese Medicine. 18(1)
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2دورية أكاديمية
المؤلفون: Zhen Li, Zhenyue Chen, Jiayi Chen, Zhutong Liu, Zehui Li, He Sun, Xiaochao Wang, Jinqiang Wei, Xuewei Cao, Decai Zheng
المصدر: Chinese Medicine, Vol 18, Iss 1, Pp 1-16 (2023)
مصطلحات موضوعية: Monotropein, Osteoarthritis, Cartilage matrix degradation, Apoptosis, Pyroptosis, Other systems of medicine, RZ201-999
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1749-8546
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3دورية أكاديمية
المصدر: ACS Biomaterials Science & Engineering. 2(2)
مصطلحات موضوعية: Control Engineering, Mechatronics and Robotics, Engineering, Biomedical Engineering, Aging, Arthritis, Osteoarthritis, Prevention, Bioengineering, Regenerative Medicine, Biotechnology, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Musculoskeletal, chondroitin sulfate, collagen type II, hyaluronan, intra-articular, resist proteases, cartilage matrix degradation, Chondroitin sulfate, Biomedical engineering
وصف الملف: application/pdf
URL الوصول: https://escholarship.org/uc/item/3899p6xr
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4دورية أكاديمية
المؤلفون: Ze-qin Wen, Di Liu, Yi Zhang, Zi-jun Cai, Wen-feng Xiao, Yu-sheng Li
المصدر: Frontiers in Cell and Developmental Biology, Vol 9 (2021)
مصطلحات موضوعية: G protein-coupled receptor, osteoarthritis, cartilage matrix degradation, synovitis, pathogenesis, treatment, Biology (General), QH301-705.5
وصف الملف: electronic resource
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5دورية أكاديمية
لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل. -
6دورية أكاديمية
المؤلفون: Z Hu, JHN Yik, DD Cissell, PV Michelier, KA Athanasiou, DR Haudenschild
المصدر: European Cells & Materials, Vol 30, Pp 200-209 (2012)
مصطلحات موضوعية: which promote chondrocyte apoptosis and degrade cartilage to potentiate PTOA development. Recent studies show that the rate-limiting step for transcriptional activation of injury response genes is controlled by cyclin-dependent kinase 9 (CDK9), and thus it is an attractive target for limiting the injury response. Here, we determined the effects of CDK9 inhibition in suppressing the injury response in mechanically-injured cartilage explants. Bovine cartilage explants were injured by a single compressive load of 30 % strain at 100 %/s, and then treated with the CDK9 inhibitor Flavopiridol. To assess acute injury responses, we measured the mRNA expression of pro-inflammatory cytokines, catabolic enzymes, and apoptotic genes by RT-PCR, and chondrocyte viability and apoptosis by TUNEL staining. For long-term outcome, cartilage matrix degradation was assessed by soluble glycosaminoglycan release, and by determining the mechanical properties with instantaneous and relaxation moduli. Our data showed CDK9 inhibitor markedly reduced injury-induced inflammatory cytokine and catabolic gene expression. CDK9 inhibitor also attenuated chondrocyte apoptosis and reduced cartilage matrix degradation. Lastly, the mechanical properties of the injured explants were preserved by CDK9 inhibitor. Our results provide a temporal profile connecting the chain of events from mechanical impact, acute injury responses, to the subsequent induction of chondrocyte apoptosis and cartilage matrix deterioration. Thus, CDK9, Flavopiridol, inflammatory cytokines, chondrocytes, Diseases of the musculoskeletal system, RC925-935, Orthopedic surgery, RD701-811
وصف الملف: electronic resource
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7كتاب إلكتروني
المساهمون: Beck, F., editorAff1, Clascá, F., editorAff2, Frotscher, M., editorAff3, Haines, D. E., editorAff4, Hirokawa, N., editorAff5, Kmiec, Z., editorAff6, Korf, H. -W., editorAff7, Marani, E., editorAff8, Putz, R., editorAff9, Sano, Y., editorAff10, Schiebler, T. H., editorAff11, Timmermans, J. -P., editorAff12, Mobasheri, AliAff13, Bondy, Carolyn A.Aff14, Moley, KelleAff15, Mendes, Alexandrina FerreiraAff16, Rosa, Susana CarvalhoAff16, Richardson, Stephen M.Aff17, Hoyland, Judith A.Aff17, Barrett-Jolley, RichardAff18, Shakibaei, MehdiAff19
المصدر: Facilitative Glucose Transporters in Articular Chondrocytes : Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytokines. 200:50-53
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8دورية أكاديمية
لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل. -
9كتاب إلكتروني
المؤلفون: Lark, Michael W.Aff3, Bayne, Ellen K.Aff4, Lohmander, L. StefanAff5
المساهمون: Parnham, Michael J., editorAff1, Bottomley, Kevin M. K., editorAff2, Bradshaw, David, editorAff2, Nixon, John S., editorAff2
المصدر: Metalloproteinases as Targets for Anti-Inflammatory Drugs. :59-83
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10دورية أكاديمية
المؤلفون: Houard, Xavier, Goldring, Mary B., Berenbaum, Francis
المصدر: Current Rheumatology Reports. November 2013 15(11):1-10