المؤلفون: Hanitrarimalala V; Department of Translational Medicine, Lund University, Malmö, S-214 28, Sweden., Bednarska I; Department of Translational Medicine, Lund University, Malmö, S-214 28, Sweden., Murakami T; Department of Microbiology, Saitama Medical University, Saitama, 350-0495, Japan., Papadakos KS; Department of Translational Medicine, Lund University, Malmö, S-214 28, Sweden. konstantinos.papadakos@med.lu.se., Blom AM; Department of Translational Medicine, Lund University, Malmö, S-214 28, Sweden.

المصدر: Cell death & disease [Cell Death Dis] 2024 Jul 04; Vol. 15 (7), pp. 480. Date of Electronic Publication: 2024 Jul 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms*/drug therapy , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology , Breast Neoplasms*/genetics , Drug Resistance, Neoplasm*/drug effects , Cartilage Oligomeric Matrix Protein*/metabolism , Cartilage Oligomeric Matrix Protein*/genetics , Apoptosis*/drug effects , Calpain*/metabolism, Humans ; Female ; Cell Line, Tumor ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum/drug effects

المؤلفون: Rosas S; Department of Orthopedic Surgery, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC 27101, USA., Kwok A; Department of Radiation Oncology, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC 27101, USA., Moore J; Department of Radiation Oncology, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC 27101, USA., Shi L; Department of Cancer Biology, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC 27101, USA., Smith TL; Department of Orthopedic Surgery, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC 27101, USA., Tallant EA; Department of Hypertension, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC 27101, USA., Kerr BA; Department of Orthopedic Surgery, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC 27101, USA.; Department of Cancer Biology, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC 27101, USA., Willey JS; Department of Radiation Oncology, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC 27101, USA.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 May 30; Vol. 25 (11). Date of Electronic Publication: 2024 May 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Prostatic Neoplasms*/metabolism , Prostatic Neoplasms*/pathology , Cell Proliferation* , Cartilage Oligomeric Matrix Protein*/metabolism , Cartilage Oligomeric Matrix Protein*/genetics , Osteoarthritis*/metabolism , Osteoarthritis*/pathology , Osteoarthritis*/etiology, Male ; Animals ; Mice ; Cell Line, Tumor ; Cell Movement/drug effects ; Humans ; Disease Models, Animal ; Interleukin-1alpha/metabolism

المؤلفون: Lambova SN; Department of Propaedeutics of Internal Diseases 'Prof Dr Anton Mitov', Faculty of Medicine, Medical University-Plovdiv, 4000 Plovdiv, Bulgaria.; Department of Rheumatology, MHAT 'Sveti Mina', 4000 Plovdiv, Bulgaria., Batsalova T; Department of Developmental Biology, Paisii Hilendarski University of Plovdiv, 4000 Plovdiv, Bulgaria., Moten D; Department of Developmental Biology, Paisii Hilendarski University of Plovdiv, 4000 Plovdiv, Bulgaria., Dzhambazov B; Department of Developmental Biology, Paisii Hilendarski University of Plovdiv, 4000 Plovdiv, Bulgaria.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 May 12; Vol. 25 (10). Date of Electronic Publication: 2024 May 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Cartilage Oligomeric Matrix Protein*/blood , Cartilage Oligomeric Matrix Protein*/metabolism , Obesity*/metabolism , Obesity*/complications , Osteoarthritis, Knee*/metabolism, Humans ; Female ; Male ; Middle Aged ; Aged ; Body Mass Index ; Biomarkers/blood ; Cartilage, Articular/metabolism ; Cartilage, Articular/pathology ; Case-Control Studies

المؤلفون: Hay AM; Department of Exercise Sciences, Brigham Young University, Provo, Utah., Rhoades MJ; Department of Exercise Sciences, Brigham Young University, Provo, Utah., Bangerter S; Department of Exercise Sciences, Brigham Young University, Provo, Utah., Ferguson SA; Department of Exercise Sciences, Brigham Young University, Provo, Utah., Lee H; Department of Exercise Sciences, Brigham Young University, Provo, Utah., T Gill M; Department of Exercise Sciences, Brigham Young University, Provo, Utah., Page GL; Department of Statistics, Brigham Young University, Provo, Utah., Pope A; Department of Statistics, Brigham Young University, Provo, Utah., Measom GJ; Department of Nursing, Utah Valley University, Orem, Utah., Hager RL; Department of Exercise Sciences, Brigham Young University, Provo, Utah., Seeley MK; Department of Exercise Sciences, Brigham Young University, Provo, Utah.

المصدر: Sports health [Sports Health] 2024 Jul-Aug; Vol. 16 (4), pp. 534-541. Date of Electronic Publication: 2023 Sep 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 101518422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-0921 (Electronic) Linking ISSN: 19410921 NLM ISO Abbreviation: Sports Health Subsets: MEDLINE

مواضيع طبية MeSH: Swimming*/physiology , Cartilage Oligomeric Matrix Protein*/blood , Running*/physiology , Biomarkers*/blood, Humans ; Cross-Sectional Studies ; Male ; Female ; Aged ; Osteoarthritis, Knee/blood ; Osteoarthritis, Knee/physiopathology ; Cartilage, Articular ; Middle Aged ; Knee Joint/physiology

المؤلفون: Ivanochko NK; Department of Kinesiology and Health Sciences, University of Waterloo, Room 1036 Burt Matthews Hall, 200 University Avenue, Waterloo, ON, N2L 3G1, Canada., Gatti AA; Department of Radiology, Stanford University, Stanford, USA.; NeuralSeg Ltd., Hamilton, Canada., Stratford PW; School of Rehabilitation Science, McMaster University, Hamilton, Canada., Maly MR; Department of Kinesiology and Health Sciences, University of Waterloo, Room 1036 Burt Matthews Hall, 200 University Avenue, Waterloo, ON, N2L 3G1, Canada. mrmaly@uwaterloo.ca.

المصدر: Clinical rheumatology [Clin Rheumatol] 2024 Jul; Vol. 43 (7), pp. 2317-2327. Date of Electronic Publication: 2024 May 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 8211469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1434-9949 (Electronic) Linking ISSN: 07703198 NLM ISO Abbreviation: Clin Rheumatol Subsets: MEDLINE

مواضيع طبية MeSH: Osteoarthritis, Knee*/metabolism , Cartilage, Articular*/diagnostic imaging , Cartilage, Articular*/metabolism , Cartilage, Articular*/pathology , Biomarkers*/blood , Cartilage Oligomeric Matrix Protein*/blood , Magnetic Resonance Imaging* , Knee Joint*/diagnostic imaging , Collagen Type II*/blood, Humans ; Middle Aged ; Female ; Male ; Aged ; Disease Progression ; Weight-Bearing ; Body Mass Index

المؤلفون: Chrisman M; University of Missouri-Kansas City, School of Nursing and Health Studies, 2464 Charlotte St., Kansas City, MO 64108, USA. Electronic address: chrismanms@umkc.edu., White-Lewis S; University of Missouri-Kansas City, School of Nursing and Health Studies, 2464 Charlotte St., Kansas City, MO 64108, USA., Lasiter S; University of Missouri-Kansas City, School of Nursing and Health Studies, 2464 Charlotte St., Kansas City, MO 64108, USA., Chesnut SR; University of Missouri-Kansas City, School of Nursing and Health Studies, 2464 Charlotte St., Kansas City, MO 64108, USA., Russell CL; University of Missouri-Kansas City, School of Nursing and Health Studies, 2464 Charlotte St., Kansas City, MO 64108, USA.

المصدر: Complementary therapies in medicine [Complement Ther Med] 2024 Jun; Vol. 82, pp. 103047. Date of Electronic Publication: 2024 May 01.

نوع المنشور: Journal Article; Randomized Controlled Trial

بيانات الدورية: Publisher: Elsevier Country of Publication: Scotland NLM ID: 9308777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6963 (Electronic) Linking ISSN: 09652299 NLM ISO Abbreviation: Complement Ther Med Subsets: MEDLINE

مواضيع طبية MeSH: Biomarkers*/blood , Cartilage Oligomeric Matrix Protein*/blood , Equine-Assisted Therapy*/methods, Humans ; Middle Aged ; Pilot Projects ; Female ; Male ; Aged ; Horses ; Arthritis/therapy ; Animals ; Cartilage/metabolism

المؤلفون: Zhou L; Department of Medical Genetics, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, China., Chen J; Department of Medical Genetics, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, China., Liu Q; Medical Department, Zhejiang Biosan Biochemical Technologies Co. Ltd, Hangzhou, Zhejiang, China., Yang S; Department of Medical Genetics, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, China., Xie W; National Health Commission Key Laboratory of Birth Defects for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, China., Peng Y; Department of Medical Genetics, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, China.

المصدر: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2023 Nov 23; Vol. 14, pp. 1267946. Date of Electronic Publication: 2023 Nov 23 (Print Publication: 2023).

نوع المنشور: Case Reports; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE

مواضيع طبية MeSH: Achondroplasia*/genetics , Cartilage Oligomeric Matrix Protein*/genetics , Osteochondrodysplasias*/genetics, Humans ; Exome Sequencing ; Matrilin Proteins/genetics

SCR Disease Name: Pseudoachondroplasia

المؤلفون: Wang Y; Department of Digestive Diseases, 900TH Hospital of Joint Logistics Support Force, Fujian University of Traditional Chinese Medicine, Fuzhou, China; College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China., Li HT; Department of Digestive Diseases, 900TH Hospital of Joint Logistics Support Force, Fujian University of Traditional Chinese Medicine, Fuzhou, China; College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China; Department of Digestive Diseases, Fuzong Clinical Medical College, Fujian Medical University, Fuzhou, China; Department of Digestive Diseases, Dongfang Hospital, Xiamen University, Fuzhou, China., Liu G; Department of Digestive Diseases, 900TH Hospital of Joint Logistics Support Force, Fujian University of Traditional Chinese Medicine, Fuzhou, China; College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China; Department of Digestive Diseases, Fuzong Clinical Medical College, Fujian Medical University, Fuzhou, China; Department of Digestive Diseases, Dongfang Hospital, Xiamen University, Fuzhou, China., Jiang CS; Department of Digestive Diseases, 900TH Hospital of Joint Logistics Support Force, Fujian University of Traditional Chinese Medicine, Fuzhou, China; College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China; Department of Digestive Diseases, Fuzong Clinical Medical College, Fujian Medical University, Fuzhou, China; Department of Digestive Diseases, Dongfang Hospital, Xiamen University, Fuzhou, China., Ni YH; Department of Digestive Diseases, 900TH Hospital of Joint Logistics Support Force, Fujian University of Traditional Chinese Medicine, Fuzhou, China; College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China., Zeng JH; Department of Presbyatrics, 900TH Hospital of Joint Logistics Support Force, Fujian University of Traditional Chinese Medicine, Fuzhou, China., Lin X; Department of Digestive Diseases, Fuzong Clinical Medical College, Fujian Medical University, Fuzhou, China., Wang QY; Department of Digestive Diseases, Dongfang Hospital, Xiamen University, Fuzhou, China., Li DZ; Department of Digestive Diseases, 900TH Hospital of Joint Logistics Support Force, Fujian University of Traditional Chinese Medicine, Fuzhou, China; College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China; Department of Digestive Diseases, Fuzong Clinical Medical College, Fujian Medical University, Fuzhou, China; Department of Digestive Diseases, Dongfang Hospital, Xiamen University, Fuzhou, China. Electronic address: lidazhou@fjmu.edu.cn., Wang W; Department of Digestive Diseases, 900TH Hospital of Joint Logistics Support Force, Fujian University of Traditional Chinese Medicine, Fuzhou, China; College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China; Department of Digestive Diseases, Fuzong Clinical Medical College, Fujian Medical University, Fuzhou, China; Department of Digestive Diseases, Dongfang Hospital, Xiamen University, Fuzhou, China. Electronic address: wangwen@fjmu.edu.cn., Zeng XP; Department of Digestive Diseases, 900TH Hospital of Joint Logistics Support Force, Fujian University of Traditional Chinese Medicine, Fuzhou, China; College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China; Department of Digestive Diseases, Fuzong Clinical Medical College, Fujian Medical University, Fuzhou, China; Department of Digestive Diseases, Dongfang Hospital, Xiamen University, Fuzhou, China. Electronic address: doctorzxp@fjmu.edu.cn.

المصدر: Cellular signalling [Cell Signal] 2024 Jun; Vol. 118, pp. 111135. Date of Electronic Publication: 2024 Mar 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

مواضيع طبية MeSH: Pancreatic Diseases*/metabolism , Pancreatitis, Chronic*/drug therapy , Pancreatitis, Chronic*/metabolism , Pancreatitis, Chronic*/pathology, Animals ; Humans ; Mice ; Cartilage Oligomeric Matrix Protein/metabolism ; Cartilage Oligomeric Matrix Protein/pharmacology ; Cartilage Oligomeric Matrix Protein/therapeutic use ; Cells, Cultured ; Collagen Type I/metabolism ; Fibronectins/metabolism ; Fibrosis ; Pancreatic Stellate Cells/metabolism ; Pancreatic Stellate Cells/pathology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction

المؤلفون: Kronenberg J; Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York 11201, United States., Jung Y; Advanced Science Research Center (ASRC) at the Graduate Center, City University of New York, New York, New York 10031, United States.; Department of Chemical Engineering, City College of New York, New York, New York 10031, United States., Chen J; Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York 11201, United States., Kulapurathazhe MJ; Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York 11201, United States., Britton D; Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York 11201, United States., Kim S; Advanced Science Research Center (ASRC) at the Graduate Center, City University of New York, New York, New York 10031, United States.; Department of Chemical Engineering, City College of New York, New York, New York 10031, United States., Chen X; Advanced Science Research Center (ASRC) at the Graduate Center, City University of New York, New York, New York 10031, United States.; Department of Chemical Engineering, City College of New York, New York, New York 10031, United States.; PhD Programs in Chemistry and Physics at the Graduate Center, City University of New York, New York, New York 10016, United States., Tu RS; Department of Chemical Engineering, City College of New York, New York, New York 10031, United States., Montclare JK; Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York 11201, United States.; Department of Chemistry, New York University, New York, New York 10031, United States.; Department of Biomaterials, New York University College of Dentistry, New York, New York 10010, United States.; Department of Radiology, New York University Grossman School of Medicine, New York, New York 10016, United States.; Department of Biomedical Engineering, New York University Tandon School of Engineering, Brooklyn, New York 11203, United States.

المصدر: ACS applied bio materials [ACS Appl Bio Mater] 2024 Jun 17; Vol. 7 (6), pp. 3714-3720. Date of Electronic Publication: 2024 May 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101729147 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2576-6422 (Electronic) Linking ISSN: 25766422 NLM ISO Abbreviation: ACS Appl Bio Mater Subsets: MEDLINE

مواضيع طبية MeSH: Water*/chemistry , Biocompatible Materials*/chemistry , Materials Testing*, Polymers/chemistry ; Particle Size ; Cartilage Oligomeric Matrix Protein/chemistry ; Cartilage Oligomeric Matrix Protein/metabolism ; Elastin/chemistry ; Elastin/metabolism

المؤلفون: Britton D; Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA. montclare@nyu.edu., Katsara O; Department of Microbiology, New York University School of Medicine, New York, New York, 10016, USA., Mishkit O; Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, New York, 10016, USA.; Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, 10016, USA., Wang A; Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA. montclare@nyu.edu.; Department of Biomedical Engineering, State University of New York Downstate Medical Center, Brooklyn, New York, 11203, USA.; College of Medicine, State University of New York Downstate Medical Center, Brooklyn, New York, 11203, USA., Pandya N; Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, New York, 10016, USA.; Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, 10016, USA., Liu C; Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA. montclare@nyu.edu., Mao H; Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA. montclare@nyu.edu.; Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, New York, 10016, USA.; Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, 10016, USA., Legocki J; Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA. montclare@nyu.edu., Jia S; Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA. montclare@nyu.edu., Xiao Y; Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA. montclare@nyu.edu., Aristizabal O; Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, New York, 10016, USA.; Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, 10016, USA., Paul D; Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA. montclare@nyu.edu., Deng Y; Microscopy Laboratory, New York University Langone Health, New York, NY, 10016, USA., Schneider R; Department of Microbiology, New York University School of Medicine, New York, New York, 10016, USA.; Department of Radiation Oncology, New York University School of Medicine, New York, New York, 10016, USA., Wadghiri YZ; Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, New York, 10016, USA.; Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, 10016, USA., Montclare JK; Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA. montclare@nyu.edu.; Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, New York, 10016, USA.; Department of Chemistry, New York University, New York, New York, 10012, USA.; Department of Biomaterials, New York University College of Dentistry, New York, New York, 10010, USA.; Department of Biomedical Engineering, New York University, New York, NY, 11201, USA.

المصدر: Biomaterials science [Biomater Sci] 2024 May 28; Vol. 12 (11), pp. 2951-2959. Date of Electronic Publication: 2024 May 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101593571 Publication Model: Electronic Cited Medium: Internet ISSN: 2047-4849 (Electronic) Linking ISSN: 20474830 NLM ISO Abbreviation: Biomater Sci Subsets: MEDLINE

مواضيع طبية MeSH: Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Hypoxia-Inducible Factor 1, alpha Subunit*/chemistry , Protein Engineering*, Humans ; Animals ; Protein Domains ; Mice ; Cell Line, Tumor ; Cartilage Oligomeric Matrix Protein/chemistry ; Cartilage Oligomeric Matrix Protein/metabolism ; Tumor Microenvironment ; E1A-Associated p300 Protein/metabolism ; E1A-Associated p300 Protein/chemistry