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المؤلفون: Amir Zeb, Seok Ju Park, Minky Son, Sanghwa Yoon, Ju Hyun Kim, Keun Woo Lee
المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 579-590 (2019)مصطلحات موضوعية: Structure-based pharmacophore modeling, MD, Molecular dynamics, ASP, Astex statistical potential, H-bond, Hydrogen bond, NVT, Number of particles, volume, and temperature, Biochemistry, PD, Parkinson's disease, HBA, Hydrogen bond acceptor, PME, Particle mesh ewald, chemistry.chemical_compound, 0302 clinical medicine, Structural Biology, HYP, Hydrophobic, PLP, Piecewise linear potential, 0303 health sciences, biology, Hydrogen bond, IBS, InterBioScreen, P5, A 24-residues mimetic peptide of p35, EF, Enrichment factor, BBB, Blood-brain barrier, female genital diseases and pregnancy complications, ZNPD, Zinc Natural Product Database, Computer Science Applications, 030220 oncology & carcinogenesis, TIP3P, Transferable intermolecular potential with 3 points, Molecular docking, ROF, Rule of five, Cdks, Cyclin-dependent kinases, AD, Alzheimer's disease, GOLD, Genetic optimization of ligand docking, GA, Genetic algorithm, Pharmacophore, Decoy, Biotechnology, Research Article, CGMC, Cyclin-dependent kinases, mitogen-activated protein kinases, glycogen synthase kinases, and Cdk-like kinases, GH, Guner-Henry, lcsh:Biotechnology, Tau protein, Biophysics, MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, HBD, Hydrogen bond donor, Computational biology, K, kelvin, RMSD, Root mean square deviation, 03 medical and health sciences, ADMET, Absorption, distribution, metabolism, excretion, and toxicity, lcsh:TP248.13-248.65, Molecular dynamics simulation, Genetics, Aβ, Amyloid beta, DS, Discovery Studio, Molecule, NPT, Number particle, pressure, and temperature, GROMACS, Groningen Machine for Chemical Simulation, GFA, Genetic Function Approximation, 030304 developmental biology, 2D, Two-dimentional, Natural product, Cdk5/p25 inhibitors, Tau-pathogenesis, Chemical space, eye diseases, TAT, Twin-arginine targeting, chemistry, nervous system, Docking (molecular), PDB, Protein databank, biology.protein, 3D, Three-dimentional, Cdk5, Cyclin-dependent kinase 5, HD, Hungtington's disease
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المؤلفون: Chang Qu, Siu-Po Ip, Qiao-Ping Li, Qiuju Yuan, Yan-Feng Huang, Zi-Ren Su, You-Liang Xie, Zhi-Xiu Lin, Qing-Qing Xu, Yan-Fang Xian, Wen Yang
المصدر: Journal of Advanced Research
Journal of Advanced Research, Vol 35, Iss, Pp 231-243 (2022)مصطلحات موضوعية: 0301 basic medicine, Honokiol, Male, WT, wild type, Medicine (General), Science (General), Aβ, β-amyloid, Morris water navigation task, Pharmaceutical Science, MWMT, Morris Water Maze test, PDI, poly-dispersity index, PS-1, presenilin-1, Pharmacology, NEP, neprilysin, NFTs, neurofibrillary tangles, chemistry.chemical_compound, Q1-390, Mice, IL-1β, interleukin 1β, 0302 clinical medicine, Cognition, Neuroinflammation, Amyloid precursor protein, Neprilysin, GSK-3β, glycogen synthase kinase 3β, Multidisciplinary, Microglia, biology, Cognitive deficits, TEM, transmission electron microscope, IL-6, interleukin 6, medicine.anatomical_structure, Tau protein hyperphosphorylation, HPLC, high performance liquid chromatography, 030220 oncology & carcinogenesis, JNK, c-Jun N-terminal kinase, Bcl-2, B cell lymphoma-2, CMC-Na, sodium carboxymethylcellulose, PBS, phosphate-buffered saline, Honokiol nanoscale drug delivery system, Gut microbiota, AD, Alzheimer’s disease, Neuroprotection, Lignans, 03 medical and health sciences, MCT, Medium-chain triglycerides, R5-920, HO, Honokiol, ROS, reactive oxygen species, Alzheimer Disease, APP, amyloid precursor protein, medicine, Animals, IDE, insulin degrading enzyme, Cognitive Dysfunction, ZP, zeta potential, ComputingMethodologies_COMPUTERGRAPHICS, Glycogen Synthase Kinase 3 beta, Biphenyl Compounds, CDK5, cyclin-dependent kinase 5, Nano-HO, honokiol nanoscale drug delivery system, TgCRND8 mice, Bioavailability, Gastrointestinal Microbiome, APH-1, anterior pharynx-defective-1, TNF-α, tumor necrosis factor, 030104 developmental biology, chemistry, BACE-1, β-site APP cleaving enzyme-1, Neuroinflammatory Diseases, biology.protein
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المؤلفون: Measho Abreha, Allan I. Levey, Shamsideen A. Ojelade, Duc M. Duong, Zachary T. McEachin, Gary J. Bassell, Eric B. Dammer, Nicholas T. Seyfried, James J. Lah, Joshua M. Shulman, Marla Gearing
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Male, 0301 basic medicine, FTD, frontotemporal dementia, Alzheimer’s disease (AD), Biochemistry, Frontotemporal dementia and parkinsonism linked to chromosome 17, IMAC, immobilized metal affinity chromatography, TANK-binding kinase 1, neurofibrillary tangles (NFTs), posttranslational modification (PTM), CDK5, cyclin dependent kinase 5, Corticobasal degeneration, Protein Interaction Maps, co-IP, co-immunoprecipitation, ERG, electroretinogram, FTDP-17, familial frontotemporal dementia and parkinsonism linked to chromosome 17, FA, formic acid, Gene knockdown, Kinase, LFQ, label-free quantitation, Neurodegeneration, IP, immunoprecipitation, ALS, amyotrophic lateral sclerosis, CAMK, calcium/calmodulin-dependent protein kinase, Cell biology, Tauopathies, co-immunoprecipitation (co-IP), Mitogen-activated protein kinase, Phosphorylation, Drosophila, Female, Tauopathy, Research Article, CBD, corticobasal degeneration, FDR, false discovery rate, tau Proteins, Protein Serine-Threonine Kinases, Biology, AD, Alzheimer’s disease, TFA, trifluoroacetic acid, 03 medical and health sciences, Alzheimer Disease, GSK3β, glycogen synthase kinase 3β, medicine, Animals, Humans, mass spectrometry (MS), IκB kinase (IKK), Molecular Biology, TANK-binding kinase 1 (TBK1), NFT, neurofibrillary tangle, microtubule-associated protein tau (MAPT), GO, gene ontology, familial frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), 030102 biochemistry & molecular biology, Cyclin-dependent kinase 5, Neurofibrillary tangle, Cell Biology, Aβ, amyloid-β, medicine.disease, In vitro, HCD, higher-energy collision dissociation, HEK293 Cells, 030104 developmental biology, MS, mass spectrometry, DTT, dithiothreitol, TBK1, TANK-binding kinase 1, biology.protein, PTM, posttranslational modification, IAA, iodoacetamide, MAPK, mitogen-activated protein kinase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f79bdc687578d84246e18e1f234fa5
https://doi.org/10.1101/2020.06.17.157552 -
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المؤلفون: Ettcheto Arriola, Miren, Sánchez-López, E. (Elena), Pons, Laura, Busquets Figueras, Oriol, Olloquequi González, Jordi, Beas Zárate, Carlos, Pallàs i Llibería, Mercè, 1964, García López, María Luisa, Auladell i Costa, M. Carme, Folch, Jaume, Camins Espuny, Antoni
المساهمون: Universitat de Barcelona
المصدر: Redox Biology, Vol 13, Iss C, Pp 345-352 (2017)
Redox Biology
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelonaمصطلحات موضوعية: GFAP, Glial Fibrillary Acidic Protein, ADAM10, Disintegrin and metalloproteinase domain-containing protein 10, MAPK, Mitogen-activated protein kinase, BACE1, β-secretase 1, CDK5, Cyclin-dependent kinase 5, Ibuprofen, IBU, Ibuprofen, Hippocampus, Mitocondris, PFA, Paraformaldehide, PPARγ, Peroxisome proliferator-activated receptor-γ, Amyloid beta-Protein Precursor, Mice, Cognition, DXI, Dexibuprofen, APPSwe/PS1dE9, Aspartic Acid Endopeptidases, Proto-Oncogene Proteins c-abl, PKA, Protein kinase A, lcsh:QH301-705.5, lcsh:R5-920, DI, Discrimination index, Brain, Drugs, COX-1, Cyclooxygenase-1, NORT, Novel object recognition test, IDE, Insulin-degrading enzyme, Memory impairment, Alzheimer's disease, Mitochondria, TNF-α, Tumor necrosis factor, Neuroprotective Agents, pTAU, Phospho-TAU, SYP, Synaptophysin, Female, AD, Alzheimer's disease, lcsh:Medicine (General), Hippocampus (Brain), Medicaments, Research Paper, Signal Transduction, APP/PS1, APPswe/PS1dE9, NSAIDs, Non-steroidal anti-inflammatory drugs, Hipocamp (Cervell), NFĸβ, Nuclear factor kappa beta, c-ABL, Abelson non-receptor tyrosine kinase, tau Proteins, COX-2, Cyclooxygenase-2, Alzheimer Disease, Cyclins, GSK3β, Glycogen synthase kinase 3β, Aβ, Amyloid beta, Presenilin-1, Animals, Insulin receptors, Tumor Necrosis Factor-alpha, Cyclin-Dependent Kinase 5, Receptors d'insulina, Phosphoproteins, iNOS, Inducible nitric oxide synthase, Mice, Inbred C57BL, Dexibuprofen, MWM, Morris water maze, Malaltia d'Alzheimer, lcsh:Biology (General), nNOS, Neuronal Nitric Oxide Synthase, Amyloid Precursor Protein Secretases, TAU, Carrier Proteins, APP, Amyloid precursor protein, NFTs, Neurofibrillary tangles, WT, Wild type, Insulin receptor
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::eeb03ed861896c8e278a922a0d33b70d
http://hdl.handle.net/2445/118847 -
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المؤلفون: Miran Jo, Mi Hee Park, Chong-Kil Lee, Yu Ri Kim, Jin Tae Hong
المصدر: Pharmacology & Therapeutics
مصطلحات موضوعية: 0301 basic medicine, Transcription, Genetic, EAE, Experimental autoimmune encephalomyelitis, MCAO, Middle cerebral artery occlusion, VEGF, Vascular endothelial growth factor, Regulator, cdk5, Cyclin-dependent kinase 5, iPLA2, Calcium-independent Phospholipase A2, H2O2, Hydrogen peroxide, Inflammatory diseases, medicine.disease_cause, Antioxidants, GST, Glutathione S-transferase, Neoplasms, Therapeutic approaches, Pharmacology (medical), SOD, Superoxide Dismutase, LPS, Lipopolysaccharide, Cancer, chemistry.chemical_classification, Trx, Thioredoxin, RA, Rheumatoid arthritis, Neurodegenerative diseases, Srx, Sulfiredoxin, Cell biology, Biochemistry, FOXO, Forkhead box O3, JNK, c-Jun N-terminal kinase, NF-κB, Nuclear factor kappa B, medicine.symptom, Signal transduction, TCA, Tricarboxylic acid, Oxidation-Reduction, PI3K, phosphoinositide 3-kinase, Signal Transduction, TLR, Toll-like receptor, Cell signaling, PRDX, Peroxiredoxin, PDGF, Platelet-derived growth factor, RCMD, Refractory cytopenia with multilineage dysplasia, MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, TNF-α, tumor necrosis factor (TNF)-α, Inflammation, Biology, AD, Alzheimer’s disease, Article, 03 medical and health sciences, COX-2, Cyclooxygenase-2, ER, Endoplasmic reticulum, ICAM-1, Intercellular adhesion molecule-1, 4-HNE, 4-hydroxynonenal, medicine, Animals, Humans, VCAM-1, Vascular cell adhesion molecule-1, ARE/EpRE, Antioxidant/electrophile responsive element, PD, Parkinson’s disease, TrxR, Thioredoxin reductase, Pharmacology, Reactive oxygen species, MPP(+), 1-methyl-4-phenylpyridinium, PTEN, Phosphatase and tensin homolog, SMCs, Smooth muscle cells, TRAIL, TNF-related apoptosis-inducing ligand, Cell growth, Hydrogen Peroxide, Peroxiredoxins, Review article, Oxidative Stress, 030104 developmental biology, chemistry, HIF-1, Hypoxia inducible factor-1, AML, Acute myeloid leukemia, Carcinogens, ApoE, Apolipoprotein, Oxidative stress, ROS, Reactive oxygen species
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المؤلفون: Carol MacKintosh, David G. Campbell, Sandra Crowther, Margaret J. Stafford, Rachel Toth, Catherine Johnson
المصدر: Biochemical Journal
مصطلحات موضوعية: CaMK, Ca2+/calmodulin-dependent protein kinase, HDAC, histone deacetylase, disrupted-in-schizophrenia 1 (DISC1), AGC, protein kinase A/protein kinase G/protein kinase C family kinase, Kidney, DSTT, Division of Signal Transduction Therapy, Biochemistry, AANAT, serotonin acetyltransferase, GST, glutathione transferase, PP2A, protein phosphatase 2A, Phosphorylation, Cells, Cultured, Calcium-Calmodulin-Dependent Protein Kinases, HA, haemagglutinin, HAP1A, Huntingtin-associated protein 1A, Reverse Transcriptase Polymerase Chain Reaction, Kinase, DISC1, disrupted-in-schizophrenia 1, RSK, ribosomal S6 kinase, PI4K, phosphoinositide 4-kinase, EST, expressed sequence tag, Dimerization, Research Article, Protein Binding, PKB, protein kinase B, Protein family, Blotting, Western, Nerve Tissue Proteins, KLC, kinesin light chain, Biology, HEK, human embryonic kidney, Ca2+/calmodulin-dependent protein kinase, evolution, PKC, protein kinase C, Humans, Immunoprecipitation, RNA, Messenger, Protein kinase A, Molecular Biology, Protein kinase C, GLUT4, glucose transporter 4, MARK, microtubule affinity-regulating kinase, YAP1, yes-associated protein 1, Binding Sites, NDEL1, AGC protein kinase, CDK5, cyclin-dependent kinase 5, Computational Biology, 14-3-3 protein, Cell Biology, FOXO, Forkhead box O, AMPK, AMP-activated protein kinase, 14-3-3 Proteins, Phosphoprotein, BAD, Bcl-XL/Bcl-2-associated death promoter, Carrier Proteins, DIG, digoxigenin, Protein Kinases, cGMP-dependent protein kinase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233aa1db83f31d992236e3066a26f892
https://doi.org/10.1042/bj20091834 -
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المؤلفون: Limei, Wang, Birgit, Waltenberger, Eva-Maria, Pferschy-Wenzig, Martina, Blunder, Xin, Liu, Clemens, Malainer, Tina, Blazevic, Stefan, Schwaiger, Judith M, Rollinger, Elke H, Heiss, Daniela, Schuster, Brigitte, Kopp, Rudolf, Bauer, Hermann, Stuppner, Verena M, Dirsch, Atanas G, Atanasov
المصدر: Biochemical Pharmacology
مصطلحات موضوعية: Models, Molecular, CAP, c-Cbl-associated protein, RXR, retinoid X receptor, HDL, high-density lipoprotein, PPAR, peroxisome proliferator-activated receptor, Natural product, AF-2, activation function-2, LBD, ligand-binding domain, NF-κB, nuclear factor-kappaB, Cdk5, cyclin-dependent kinase 5, DPP-4, dipeptidylpeptidase 4, LDL, low-density lipoprotein, HUVEC, human umbilical vein endothelial cells, Humans, TNF-α, tumor necrosis factor alpha, PDB, protein data bank, ComputingMethodologies_COMPUTERGRAPHICS, Nutrition, PPRE, peroxisome proliferator response element, Biological Products, Molecular Structure, Diabetes, DIO, diet-induced obesity, Part of the Special Issue: Metabolism 2014 – Alterations of metabolic pathways as therapeutic targets, SPPARMs, selective PPARγ modulators, FDA, Food and Drug Administration, DCM, dichloromethane, PPAR gamma, 9-(S)-HODE, (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid, Glut4, glucose transporter type 4, Nuclear receptor, EMA, European Medicines Agency, TCM, traditional Chinese medicine, Energy Metabolism, MeOH, methanol, MAPK, mitogen-activated protein kinase, Protein Binding
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المصدر: ASN NEURO
ASN Neuro, Vol 6 (2014)مصطلحات موضوعية: Male, striatum, KA, kainate, Long-Term Potentiation, Ca, calcium, Synaptic Transmission, DARPP-32, dopamine and cAMP-regulated phosphoprotein of 32 kDa, chemistry.chemical_compound, Mice, LTP, long-term potentiation, Cdk5, cyclin-dependent kinase 5, Neural Pathways, LTP induction, PKA, Neurotransmitter, Cerebral Cortex, education.field_of_study, General Neuroscience, Long-term potentiation, S11, 3. Good health, PP1, protein phosphatase 1, PPR, pair pulse ratio, HFS, high-frequency stimulation, Excitatory postsynaptic potential, NMDA receptor, LFS, low-frequency stimulation, dopamine, Research Article, S1, LTD, long-term depression, Calcium Channels, L-Type, Cdk5, Population, Glutamic Acid, MSN, medium spiny neurons, Neurotransmission, Biology, EPSC, excitatory postsynaptic currents, Receptors, N-Methyl-D-Aspartate, lcsh:RC321-571, Glutamatergic, AMPA, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid, Roscovitine, Animals, education, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Protein Kinase Inhibitors, SP, substance P, NMDA, N-methyl-D-aspartate, Receptors, Dopamine D2, Long-Term Synaptic Depression, Receptors, Dopamine D1, Excitatory Postsynaptic Potentials, Cyclin-Dependent Kinase 5, Cyclic AMP-Dependent Protein Kinases, Corpus Striatum, Mice, Inbred C57BL, chemistry, nervous system, Purines, plasticity, ACSF, artificial cerebrospinal fluid, PKA, protein kinase A, Neurology (clinical), DA, dopamine, Neuroscience
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المؤلفون: Helen Walden, Donald E. Spratt, Gary S. Shaw
المصدر: Biochemical Journal
مصطلحات موضوعية: CCCP, carbonyl cyanide m-chlorophenylhydrazone, CK1, casein kinase 1, SH3, Src homology 3, DNA Repair, Protein Conformation, PINK1, PTEN-induced putative kinase 1, TRAF6, tumour-necrosis-factor-receptor-associated factor 6, HOIP, HOIL-1-interacting protein, HDAC, histone deacetylase, Review Article, RWD, RING finger and WD repeat-containing, Ubiquitin-conjugating enzyme, Biochemistry, Parkin, RBR, RING-BetweenRING-RING/RING1-BRcat-Rcat, 0302 clinical medicine, Protein structure, Ubiquitin, ANKIB1, ankyrin repeat- and IBR domain-containing 1, Cdk5, cyclin-dependent kinase 5, HOIL-1, haem-oxidized IRP2 ubiquitin ligase 1, Protein Interaction Maps, 0303 health sciences, biology, UBA, ubiquitin-associated, CRL, Cul-RING-ligase, SUMO, small ubiquitin-related modifier, ZNF, zinc finger, TRIAD, two RING fingers and a DRIL (double RING finger linked), MIRO, mitochondrial Rho GTPase, RNF, RING finger protein, Ubiquitin ligase, Cul, cullin, BRcat, benign-catalytic, Ubl, ubiquitin-like, NF-κB, nuclear factor κB, cIAP2, cellular inhibitor of apoptosis 2, NZF, Npl4 ZNF, Eps15, epidermal growth factor receptor pathway substrate 15, Ubiquitin-Protein Ligases, SHARPIN, SHANK-associated RH domain interactor, Computational biology, NEDD, neural-precursor-cell-expressed developmentally down-regulated, ubiquitination, ubiquitin ligase, Catalysis, 03 medical and health sciences, Enzyme activator, PKC, protein kinase C, Animals, Humans, structure, Molecular Biology, 030304 developmental biology, FANCL, Fanconi anaemia, complementation group L, MDM2, murine double minute 2, NEMO, NF-κB essential modulator, TOMM70A, translocase of outer mitochondrial membrane 70 homologue A, Membrane Proteins, Cell Biology, UBE2L, ubiquitin-conjugating enzyme E2L, Parc, parkin-like cytoplasmic p53-binding protein, Enzyme Activation, RanBP2, RAN-binding protein 2, Rcat, required-for-catalysis, HECT, homologous with E6-associated protein C-terminus, IBR, InBetweenRING, biology.protein, RNA, LUBAC, linear ubiquitin chain assembly complex, SILAC, stable isotope labelling by amino acids in cell culture, 030217 neurology & neurosurgery, Cysteine, CPH, Cul7, Parc and HERC2 proteins, UIM, ubiquitin-interacting motif
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cedff32799050efc0f1ef4664dad485
https://pubmed.ncbi.nlm.nih.gov/24576094 -
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المؤلفون: Özlem Karalay, Rupert W. Overall, D. Chichung Lie, Fred H. Gage, Sebastian Jessberger, Gerd Kempermann, Nicolas Toni, Gregory D. Clemenson, Stefan Aigner
المصدر: PLoS Biology
PLoS Biol. 6, 2465-2475:e272 (2008)
PLoS Biology, Vol 6, Iss 11, p e272 (2008)
PLoS Biology, Vol 6, Iss 11, p e291 (2008)
PLoS Biology, 6 (11)مصطلحات موضوعية: Cellular differentiation, BrdU, bromo-deoxy-uridine, Developmental cognitive neuroscience, Hippocampus, Hippocampal formation, RFP, red fluorescent protein, Mice, shRNA, small hairpin RNA, Biology (General), cdk5, cyclin-dependent kinase 5, GFP, green fluorescent protein, Neurons, General Neuroscience, DCX, doublecortin, Neurogenesis, Gene Expression Regulation, Developmental, Cell Differentiation, Cell migration, Cell biology, Adult Stem Cells, Synopsis, Female, Dendrite extension, GCL, granule cell layer, General Agricultural and Biological Sciences, Adult stem cell, Research Article, Neurite, QH301-705.5, ML, molecular layer, NPC, neural stem and progenitor cell, Biology, General Biochemistry, Genetics and Molecular Biology, Animals, Humans, Dendritic spike, General Immunology and Microbiology, Cyclin-dependent kinase 5, Dentate gyrus, Cyclin-Dependent Kinase 5, Dendrites, Rats, Mice, Inbred C57BL, Electrophysiology, Retroviridae, nervous system, Dentate Gyrus, Synapses, Neuroscience
وصف الملف: application/pdf; application/application/pdf
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