المؤلفون: Bartolomeo Augello, Giuseppe Merla, Marco Castori, Rita Fischetto, Tommaso Mazza, Antonio Petracca, Matteo Della Monica, Silvia Maitz, Daniela Melis, Angelo Selicorni, Marilena Carmela Di Giacomo, Paolo Prontera, Matteo Aldo Russo, Natascia Malerba, Elisabetta Di Fede, Cristina Gervasini, Maria Accadia, Valentina Massa, Elisa Colombo, Gabriella Maria Squeo, Maria Piccione, Stefano Castellana, Sabrina Giglio, Donatella Milani

المساهمون: Squeo G.M., Augello B., Massa V., Milani D., Colombo E.A., Mazza T., Castellana S., Piccione M., Maitz S., Petracca A., Prontera P., Accadia M., Della Monica M., Di Giacomo M.C., Melis D., Selicorni A., Giglio S., Fischetto R., Di Fede E., Malerba N., Russo M., Castori M., Gervasini C., Merla G., Squeo, G. M., Augello, B., Massa, V., Milani, D., Colombo, E. A., Mazza, T., Castellana, S., Piccione, M., Maitz, S., Petracca, A., Prontera, P., Accadia, M., Della Monica, M., Di Giacomo, M. C., Melis, D., Selicorni, A., Giglio, S., Fischetto, R., Di Fede, E., Malerba, N., Russo, M., Castori, M., Gervasini, C., Merla, G.

مصطلحات موضوعية: Adenosine Triphosphatase, Adult, Male, CCCTC-Binding Factor, Transcription Factor, DNA-Binding Protein, chromatin disorder, Computational biology, Biology, DNA Helicase, DNA sequencing, Epigenesis, Genetic, Mendelian chromatin disorders, Locus heterogeneity, De Lange Syndrome, Genetics, medicine, Coffin-Lowry Syndrome, Humans, Genetic Predisposition to Disease, Epigenetics, Genetic Testing, Child, Gene, Genetics (clinical), Adenosine Triphosphatases, next generation sequencing, epigenetics, Genetic heterogeneity, DNA Helicases, Mendelian chromatin disorder, Histone-Lysine N-Methyltransferase, medicine.disease, Chromatin, DNA-Binding Proteins, Cohort, Mutation, Related disorder, Female, Myeloid-Lymphoid Leukemia Protein, epigenetic, Transcription Factors, Human

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccc452b2f5398e3deac068ca07982db
http://hdl.handle.net/10447/472474

المؤلفون: Della Ragione F, Vacca M, Fioriniello S, Pepe G, D'Esposito M.

المصدر: Briefings in functional genomics
(2016).
info:cnr-pdr/source/autori:Della Ragione F, Vacca M, Fioriniello S, Pepe G, D'Esposito M./titolo:MECP2, a multi-talented modulator of chromatin architecture/doi:/rivista:Briefings in functional genomics (Print)/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume

مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, the year of the discovery of MECP2, we can firmly attest that MeCP2 is a player with 'a great future behind it'*.*V. Gassmann 'Un grande avvenire dietro le spalle'. TEA Eds, It has been a long trip from 1992, which is caused by MECP2 mutations, moving from the 'classical' CpG doublet to the more complex view addressed by the non-CpG methylation, is considered a paradigmatic example of a 'chromatin disorder'. Even if the hunt for bona-fide MECP2 target genes is far from concluded today, the role of MeCP2 in the maintenance of chromatin architecture appears to be clearly established. Taking a cue from the non-scientific literature, nervous system diseases, Rett syndrome, MeCP2 performs many more functions. MeCP2 is a reader of epigenetic information contained in methylated (and hydroxymethylated) DNA, to the present day. What is surprising is that some of the pivotal roles of MeCP2 were already postulated at that time, although when it forms complexes with the appropriate molecules, mental disorders, which is a feature of the postnatal brain. MECP2 is a transcriptional repressor, it can become a transcriptional activator. For all of these aspects, such as repression of inappropriate expression from repetitive elements and the regulation of pericentric heterochromatin condensation. However

URL الوصول: https://explore.openaire.eu/search/publication?articleId=cnr_________::2a5f6c0ff484f525eed1c53d43b9dc5d
http://www.cnr.it/prodotto/i/356238