المؤلفون: Gabler T; Department of Chemistry, Institute of Biochemistry, University of Natural Resources and Life Sciences, Vienna, Austria., Dali A; Department of Chemistry 'Ugo Schiff' (DICUS), University of Florence, Sesto Fiorentino, Italy., Bellei M; Department of Life Sciences, University of Modena and Reggio Emilia, Italy., Sebastiani F; Department of Chemistry 'Ugo Schiff' (DICUS), University of Florence, Sesto Fiorentino, Italy., Becucci M; Department of Chemistry 'Ugo Schiff' (DICUS), University of Florence, Sesto Fiorentino, Italy., Battistuzzi G; Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Modena, Italy., Furtmüller PG; Department of Chemistry, Institute of Biochemistry, University of Natural Resources and Life Sciences, Vienna, Austria., Smulevich G; Department of Chemistry 'Ugo Schiff' (DICUS), University of Florence, Sesto Fiorentino, Italy.; INSTM Research Unit of Firenze, Sesto Fiorentino, Italy., Hofbauer S; Department of Chemistry, Institute of Biochemistry, University of Natural Resources and Life Sciences, Vienna, Austria.

المصدر: The FEBS journal [FEBS J] 2024 May; Vol. 291 (10), pp. 2260-2272. Date of Electronic Publication: 2024 Feb 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-4658 (Electronic) Linking ISSN: 1742464X NLM ISO Abbreviation: FEBS J Subsets: MEDLINE

مواضيع طبية MeSH: Ferrochelatase*/metabolism , Ferrochelatase*/chemistry , Ferrochelatase*/genetics , Catalytic Domain* , Coproporphyrins*/metabolism , Coproporphyrins*/chemistry , Protoporphyrins*/metabolism , Protoporphyrins*/chemistry , Histidine*/metabolism , Histidine*/chemistry , Histidine*/genetics , Glutamic Acid*/metabolism , Glutamic Acid*/chemistry , Glutamic Acid*/genetics, Heme/metabolism ; Heme/chemistry ; Substrate Specificity ; Models, Molecular ; Oxidation-Reduction ; Kinetics ; Bacterial Proteins/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/chemistry ; Catalysis

المؤلفون: Piscitelli J; Pfizer Inc, San Diego, CA, USA., Reddy MB; Pfizer Inc, Boulder, CO, USA., Wollenberg L; Pfizer Inc, Boulder, CO, USA., Del Frari L; Pierre Fabre Medicament, Toulouse, France., Gong J; Pfizer Inc, New York, NY, USA., Wood L; Pfizer Inc, Groton, CT, USA., Zhang Y; Pfizer Inc, Groton, CT, USA., Matschke K; Pfizer Inc, Collegeville, PA, USA., Williams JH; Pfizer Inc, San Diego, CA, USA. jason.williams@pfizer.com.

المصدر: Clinical pharmacokinetics [Clin Pharmacokinet] 2024 Apr; Vol. 63 (4), pp. 483-496. Date of Electronic Publication: 2024 Feb 29.

نوع المنشور: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Country of Publication: Switzerland NLM ID: 7606849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1926 (Electronic) Linking ISSN: 03125963 NLM ISO Abbreviation: Clin Pharmacokinet Subsets: MEDLINE

مواضيع طبية MeSH: Bupropion*/administration & dosage , Bupropion*/pharmacokinetics , Carbamates*/administration & dosage , Carbamates*/pharmacokinetics , Coproporphyrins* , Drug Interactions* , Hydroxymethylglutaryl-CoA Reductase Inhibitors*/pharmacokinetics , Hydroxymethylglutaryl-CoA Reductase Inhibitors*/administration & dosage , Rosuvastatin Calcium*/pharmacokinetics , Rosuvastatin Calcium*/administration & dosage , Sulfonamides*/administration & dosage , Sulfonamides*/pharmacokinetics , Sulfonamides*/pharmacology, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; Liver-Specific Organic Anion Transporter 1/antagonists & inhibitors ; Liver-Specific Organic Anion Transporter 1/genetics ; Liver-Specific Organic Anion Transporter 1/metabolism ; Aged, 80 and over

المؤلفون: Kinzi J; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Hussner J; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Schäfer AM; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Treyer A; Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Seibert I; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Tillmann A; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Mueller V; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Gherardi C; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Vonwyl C; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Hamburger M; Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Meyer Zu Schwabedissen HE; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

المصدر: British journal of pharmacology [Br J Pharmacol] 2024 Jan; Vol. 181 (1), pp. 36-53. Date of Electronic Publication: 2023 Sep 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Coproporphyrins*/metabolism , Organic Anion Transporters*/genetics , Organic Anion Transporters*/metabolism, Animals ; Female ; Humans ; Rats ; Liver/metabolism ; Membrane Transport Proteins/metabolism

المؤلفون: Kikuchi R; Quantitative, Translational and ADME Sciences, AbbVie Inc., North Chicago, Illinois, USA., Chothe PP; Global Drug Metabolism and Pharmacokinetics, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts, USA., Chu X; ADME and Discovery Toxicology, Merck & Co., Inc., Rahway, New Jersey, USA., Huth F; PK Sciences, Novartis Pharma AG, Basel, Switzerland., Ishida K; Drug Metabolism, Gilead Sciences Inc., Foster City, California, USA., Ishiguro N; Pharmacokinetics and Non-Clinical Safety Department, Nippon Boehringer Ingelheim Co., Ltd., Kobe, Japan., Jiang R; Drug Metabolism and Pharmacokinetics, Eisai Inc., Cambridge, Massachusetts, USA., Shen H; Departments of Drug Metabolism and Pharmacokinetics, Bristol Myers Squibb Research and Development, Princeton, New Jersey, USA., Stahl SH; CVRM Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Varma MVS; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Inc., Groton, Connecticut, USA., Willemin ME; Drug Metabolism and Pharmacokinetics, Janssen Research and Development, a Division of Janssen Pharmaceutica NV, Beerse, Belgium., Morse BL; Department of Drug Disposition, Eli Lilly, Indianapolis, Indiana, USA.

المصدر: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2023 Dec; Vol. 114 (6), pp. 1170-1183. Date of Electronic Publication: 2023 Oct 11.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Coproporphyrins*/metabolism , Organic Anion Transporters*, Humans ; Liver-Specific Organic Anion Transporter 1 ; Drug Interactions ; Biomarkers ; Drug Industry

المؤلفون: Gabler T; Department of Chemistry, Institute of Biochemistry, University of Natural Resources and Life Sciences, Vienna, Austria., Dali A; Dipartimento di Chimica 'Ugo Schiff'-DICUS, Università di Firenze, Sesto Fiorentino, Italy., Sebastiani F; Dipartimento di Chimica 'Ugo Schiff'-DICUS, Università di Firenze, Sesto Fiorentino, Italy., Furtmüller PG; Department of Chemistry, Institute of Biochemistry, University of Natural Resources and Life Sciences, Vienna, Austria., Becucci M; Dipartimento di Chimica 'Ugo Schiff'-DICUS, Università di Firenze, Sesto Fiorentino, Italy., Hofbauer S; Department of Chemistry, Institute of Biochemistry, University of Natural Resources and Life Sciences, Vienna, Austria., Smulevich G; Dipartimento di Chimica 'Ugo Schiff'-DICUS, Università di Firenze, Sesto Fiorentino, Italy.; INSTM Research Unit of Firenze, Sesto Fiorentino, Italy.

المصدر: Protein science : a publication of the Protein Society [Protein Sci] 2023 Nov; Vol. 32 (11), pp. e4788.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

مواضيع طبية MeSH: Coproporphyrins*/metabolism , Iron*/metabolism, Ferrochelatase/chemistry ; Ferrochelatase/metabolism ; Propionates/chemistry ; Catalysis

المؤلفون: Lai Y; Drug Metabolism, Gilead Sciences Inc., Foster City, California yurong.lai@gilead.com.

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2023 Aug; Vol. 51 (8), pp. 950-961. Date of Electronic Publication: 2023 Jul 05.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Coproporphyrins*/metabolism , Organic Anion Transporters*/genetics, Humans ; Biomarkers ; Drug Interactions ; Rifampin/therapeutic use

المؤلفون: Bechtold BJ; Department of Pharmaceutical Sciences, Washington State University, 412 E. Spokane Falls Blvd., Spokane, Washington 99202, United States., Lynch KD; Department of Pharmaceutical Sciences, Washington State University, 412 E. Spokane Falls Blvd., Spokane, Washington 99202, United States., Oyanna VO; Department of Pharmaceutical Sciences, Washington State University, 412 E. Spokane Falls Blvd., Spokane, Washington 99202, United States., Call MR; Department of Pharmaceutical Sciences, Washington State University, 412 E. Spokane Falls Blvd., Spokane, Washington 99202, United States., Graf TN; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27412, United States., Oberlies NH; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27412, United States., Clarke JD; Department of Pharmaceutical Sciences, Washington State University, 412 E. Spokane Falls Blvd., Spokane, Washington 99202, United States.

المصدر: Molecular pharmaceutics [Mol Pharm] 2024 May 06; Vol. 21 (5), pp. 2284-2297. Date of Electronic Publication: 2024 Mar 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

مواضيع طبية MeSH: Rifampin*/pharmacokinetics , Liver-Specific Organic Anion Transporter 1*/genetics , Liver-Specific Organic Anion Transporter 1*/metabolism , Mice, Transgenic* , Silymarin*/pharmacokinetics , Pravastatin*/pharmacokinetics , Pravastatin*/administration & dosage , Solute Carrier Organic Anion Transporter Family Member 1B3*/genetics , Solute Carrier Organic Anion Transporter Family Member 1B3*/metabolism , Drug Interactions*, Animals ; Mice ; Humans ; Quinolines/pharmacokinetics ; Coproporphyrins/metabolism ; Male ; Organic Anion Transporters/genetics ; Organic Anion Transporters/metabolism

المؤلفون: Watari R; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd, Japan. Electronic address: ryosuke.watari@shionogi.co.jp., Sawada H; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd, Japan., Hashimoto H; Department of ADMET and Analytical Chemistry II, Shionogi TechnoAdvance Research & Co., Ltd, Japan., Kasai Y; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd, Japan., Oka R; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd, Japan., Shimizu R; Clinical Pharmacology & Pharmacokinetics, Shionogi & Co., Ltd, Japan., Matsuzaki T; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd, Japan.

المصدر: Journal of pharmaceutical sciences [J Pharm Sci] 2024 Mar; Vol. 113 (3), pp. 798-805. Date of Electronic Publication: 2023 Sep 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19* , Anti-Infective Agents* , Indazoles* , Triazines* , Triazoles*, Humans ; ATP Binding Cassette Transporter, Subfamily G, Member 2 ; SARS-CoV-2 ; Protease Inhibitors ; Coproporphyrins/metabolism ; Coproporphyrins/pharmacology ; Liver-Specific Organic Anion Transporter 1/metabolism ; Neoplasm Proteins/metabolism ; Enzyme Inhibitors ; Antiviral Agents/pharmacology ; Drug Interactions

المؤلفون: Zhang Y; Drug Metabolism and Pharmacokinetics (Y.Z., C.C, E.M.J., Z.Y., H.S.), Discovery Toxicology (S.-J.C., L.A.), Discovery Pharmaceutics (X.-Q.C.), and Veterinary Sciences (D.J.S., H.D.), Bristol Myers Squibb Company, Princeton, New Jersey; and Drug Metabolism and Pharmacokinetics (S.-J.C.), Biocon Bristol Myers Squibb R&D Centre, Syngene International Ltd., Bangalore, India., Chen SJ; Drug Metabolism and Pharmacokinetics (Y.Z., C.C, E.M.J., Z.Y., H.S.), Discovery Toxicology (S.-J.C., L.A.), Discovery Pharmaceutics (X.-Q.C.), and Veterinary Sciences (D.J.S., H.D.), Bristol Myers Squibb Company, Princeton, New Jersey; and Drug Metabolism and Pharmacokinetics (S.-J.C.), Biocon Bristol Myers Squibb R&D Centre, Syngene International Ltd., Bangalore, India., Chen C; Drug Metabolism and Pharmacokinetics (Y.Z., C.C, E.M.J., Z.Y., H.S.), Discovery Toxicology (S.-J.C., L.A.), Discovery Pharmaceutics (X.-Q.C.), and Veterinary Sciences (D.J.S., H.D.), Bristol Myers Squibb Company, Princeton, New Jersey; and Drug Metabolism and Pharmacokinetics (S.-J.C.), Biocon Bristol Myers Squibb R&D Centre, Syngene International Ltd., Bangalore, India., Chen XQ; Drug Metabolism and Pharmacokinetics (Y.Z., C.C, E.M.J., Z.Y., H.S.), Discovery Toxicology (S.-J.C., L.A.), Discovery Pharmaceutics (X.-Q.C.), and Veterinary Sciences (D.J.S., H.D.), Bristol Myers Squibb Company, Princeton, New Jersey; and Drug Metabolism and Pharmacokinetics (S.-J.C.), Biocon Bristol Myers Squibb R&D Centre, Syngene International Ltd., Bangalore, India., Chatterjee S; Drug Metabolism and Pharmacokinetics (Y.Z., C.C, E.M.J., Z.Y., H.S.), Discovery Toxicology (S.-J.C., L.A.), Discovery Pharmaceutics (X.-Q.C.), and Veterinary Sciences (D.J.S., H.D.), Bristol Myers Squibb Company, Princeton, New Jersey; and Drug Metabolism and Pharmacokinetics (S.-J.C.), Biocon Bristol Myers Squibb R&D Centre, Syngene International Ltd., Bangalore, India., Shuster DJ; Drug Metabolism and Pharmacokinetics (Y.Z., C.C, E.M.J., Z.Y., H.S.), Discovery Toxicology (S.-J.C., L.A.), Discovery Pharmaceutics (X.-Q.C.), and Veterinary Sciences (D.J.S., H.D.), Bristol Myers Squibb Company, Princeton, New Jersey; and Drug Metabolism and Pharmacokinetics (S.-J.C.), Biocon Bristol Myers Squibb R&D Centre, Syngene International Ltd., Bangalore, India., Dexter H; Drug Metabolism and Pharmacokinetics (Y.Z., C.C, E.M.J., Z.Y., H.S.), Discovery Toxicology (S.-J.C., L.A.), Discovery Pharmaceutics (X.-Q.C.), and Veterinary Sciences (D.J.S., H.D.), Bristol Myers Squibb Company, Princeton, New Jersey; and Drug Metabolism and Pharmacokinetics (S.-J.C.), Biocon Bristol Myers Squibb R&D Centre, Syngene International Ltd., Bangalore, India., Armstrong L; Drug Metabolism and Pharmacokinetics (Y.Z., C.C, E.M.J., Z.Y., H.S.), Discovery Toxicology (S.-J.C., L.A.), Discovery Pharmaceutics (X.-Q.C.), and Veterinary Sciences (D.J.S., H.D.), Bristol Myers Squibb Company, Princeton, New Jersey; and Drug Metabolism and Pharmacokinetics (S.-J.C.), Biocon Bristol Myers Squibb R&D Centre, Syngene International Ltd., Bangalore, India., Joshi EM; Drug Metabolism and Pharmacokinetics (Y.Z., C.C, E.M.J., Z.Y., H.S.), Discovery Toxicology (S.-J.C., L.A.), Discovery Pharmaceutics (X.-Q.C.), and Veterinary Sciences (D.J.S., H.D.), Bristol Myers Squibb Company, Princeton, New Jersey; and Drug Metabolism and Pharmacokinetics (S.-J.C.), Biocon Bristol Myers Squibb R&D Centre, Syngene International Ltd., Bangalore, India., Yang Z; Drug Metabolism and Pharmacokinetics (Y.Z., C.C, E.M.J., Z.Y., H.S.), Discovery Toxicology (S.-J.C., L.A.), Discovery Pharmaceutics (X.-Q.C.), and Veterinary Sciences (D.J.S., H.D.), Bristol Myers Squibb Company, Princeton, New Jersey; and Drug Metabolism and Pharmacokinetics (S.-J.C.), Biocon Bristol Myers Squibb R&D Centre, Syngene International Ltd., Bangalore, India., Shen H; Drug Metabolism and Pharmacokinetics (Y.Z., C.C, E.M.J., Z.Y., H.S.), Discovery Toxicology (S.-J.C., L.A.), Discovery Pharmaceutics (X.-Q.C.), and Veterinary Sciences (D.J.S., H.D.), Bristol Myers Squibb Company, Princeton, New Jersey; and Drug Metabolism and Pharmacokinetics (S.-J.C.), Biocon Bristol Myers Squibb R&D Centre, Syngene International Ltd., Bangalore, India hong.shen1@bms.com.

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2022 Aug; Vol. 50 (8), pp. 1077-1086. Date of Electronic Publication: 2022 May 30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Chenodeoxycholic Acid*/metabolism , Chenodeoxycholic Acid*/pharmacology , Coproporphyrins*/blood , Coproporphyrins*/metabolism , Liver-Specific Organic Anion Transporter 1*/genetics , Liver-Specific Organic Anion Transporter 1*/metabolism, Animals ; Bile Acids and Salts ; Biomarkers/metabolism ; Down-Regulation ; Drug Interactions ; Humans ; Macaca fascicularis/metabolism ; Organic Anion Transporters/genetics ; Organic Anion Transporters/metabolism ; RNA, Messenger

المؤلفون: Dailey HA; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.; Department of Microbiology, University of Georgia, Athens, GA, USA., Medlock AE; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA. medlock@uga.edu.; Augusta University/University of Georgia Medical Partnership, Athens, GA, USA. medlock@uga.edu.

المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2839, pp. 243-247.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Ferrochelatase*/metabolism , Ferrochelatase*/chemistry , Ferrochelatase*/genetics , Protoporphyrins*/chemistry , Protoporphyrins*/metabolism , Enzyme Assays*/methods, Coproporphyrins/metabolism ; Coproporphyrins/chemistry ; Spectrum Analysis/methods ; Humans