المؤلفون: Unlu, O, Erkan, D, Barbhaiya, M, Andrade, D, Nascimento, I, Rosa, R, Banzato, A, Pengo, V, Ugarte, A, Gerosa, M, Ji, L, Efthymiou, M, Branch, Dw, de Jesus GR, Tincani, A, Belmont, Hm, Fortin, Pr, Petri, M, Rodriguez, E, Pons-Estel, Gj, Knight, Js, Atsumi, T, Willis, R, Zuily, S, Tektonidou, Mg

مصطلحات موضوعية: Adult, Male, APS ACTION, Antiphospholipid Syndrome, Cardiovascular Disease, Hydroxychloroquine, Systemic Lupus Erythematosus, Internationality, Databases, Factual, Middle Aged, Article, Phenotype, immune system diseases, Pregnancy, Antibodies, Antiphospholipid, Humans, Lupus Erythematosus, Systemic, Female, Registries, skin and connective tissue diseases, neoplasms

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::73b4a214935a3d4d4670f12fe1845a5e
https://europepmc.org/articles/PMC6484425/

المؤلفون: Chighizola, CB, de Jesus, GR

المصدر: Lupus; Oct2014, Vol. 23 Issue 12, p1232-1238, 7p

مصطلحات موضوعية: ANTIPHOSPHOLIPID syndrome, RISK factors in infertility, TROPHOBLASTIC tumors, ANTICOAGULANTS, HUMAN in vitro fertilization, HEALTH outcome assessment, TUMOR risk factors, DISEASE risk factors

المؤلفون: de Jesus, GR, de Jesus, NR, Levy, RA, Klumb, EM

المصدر: Lupus; Oct2014, Vol. 23 Issue 12, p1299-1301, 3p

مصطلحات موضوعية: VASCULAR endothelial growth factors, DIFFERENTIAL diagnosis, PREECLAMPSIA diagnosis, ANTIPHOSPHOLIPID syndrome, KIDNEY disease diagnosis, LUPUS nephritis, SYSTEMIC lupus erythematosus diagnosis, DIAGNOSIS

المؤلفون: Barbhaiya M; Hospital for Special Surgery; Weill Cornell Medicine, New York, NY, USA., Zuily S; CHRU-Nancy, Nancy University Hospital; INSERM UMR-S 1116; University of Lorraine, F-54000, Nancy, France., Amigo MC; ABC Medical Center, Mexico DF, Mexico., Andrade D; University of Sao Paulo, Sao Paulo, Brazil., Avcin T; Rheumatology, and Clinical Immunology, Children's Hospital, University Medical Center, University of Ljubljana, Ljubljana, Slovenia., Bertolaccini ML; King's College London British Heart Foundation Centre of Excellence, School of Cardiovascular Medicine & Sciences, London, UK., Branch DW; University of Utah Health, Salt Lake City, UT, USA., Costedoat-Chalumeau N; APHP, Hopital Cochin; Université de Paris, Centre de recherche épidémiologie et biostatistiques de Sorbonne Paris Cité, F-75004, Paris, France., Crowther M; McMaster University, Canada., de Jesus GR; Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Devreese KMJ; Ghent University Hospital, Ghent University, Ghent, Belgium., Frances C; Tenon Hospital, Paris, France., Garcia D; University of Washington, Seattle, WA, USA., Gómez-Puerta JA; Hospital Clinic and IDIBAPS, Barcelona, Spain., Guillemin F; CHRU, Inserm, Université de Lorraine, and INSPIIRE, Université de Lorraine, Inserm, Nancy, France., Levine SR; State University of New York Downstate Health Sciences University; Kings County Hospital Center, and Maimonides Medical Center/Jaffe Stroke Center, Brooklyn, NY, USA., Levy RA; Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; and Glaxo Smith Kline, Upper Providence, PA, USA., Lockshin MD; Hospital for Special Surgery; Weill Cornell Medicine, New York, NY, USA., Ortel TL; Duke University School of Medicine, Durham, NC, USA., Petri M; Hopkins University School of Medicine, Baltimore, MD, USA., Sanna G; Guy's and St Thomas' NHS Foundation Trust, London, UK., Sciascia S; S. Giovanni Bosco Hospital, Turin, Italy., University of Turin, Torino, Italy., Seshan SV; Weill Cornell Medicine, New York, New York, USA., Tektonidou MG; National and Kapodistrian, University of Athens, Athens, Greece., Wahl D; CHRU-Nancy, Nancy University Hospital; INSERM UMR-S 1116; University of Lorraine, F-54000, Nancy, France., Willis R; Antiphospholipid Standardization Laboratory, University of Texas Medical Branch, Galveston, TX, USA., Yelnik C; Univ. Lille, CHU Lille, INSERM, UMR 1167, F-59000, Lille, France., Hendry A; Middlemore Hospital, Auckland, New Zealand., Naden R; Auckland City Hospital, Auckland, New Zealand., Costenbader K; Brigham and Women's Hospital, Boston, MA, USA., Erkan D; Hospital for Special Surgery; Weill Cornell Medicine, New York, NY, USA.

مؤلفون مشاركون: New APS Classification Criteria Collaborators

المصدر: Arthritis care & research [Arthritis Care Res (Hoboken)] 2024 Aug 12. Date of Electronic Publication: 2024 Aug 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101518086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2151-4658 (Electronic) Linking ISSN: 2151464X NLM ISO Abbreviation: Arthritis Care Res (Hoboken) Subsets: MEDLINE

المؤلفون: Chen ATC; Department of Radiation Oncology, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil. Electronic address: andre.chen@hc.fm.usp.br., Serante AR; Department of Radiation Oncology, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil., Ayres AS; Department of Radiology, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da FMUSP, Sao Paulo, Brazil., Tonaki JO; Division of Psychology, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da FMUSP, Sao Paulo, Brazil., Moreno RA; Department of Radiology, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da FMUSP, Sao Paulo, Brazil., Shih H; Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts., Gattás GS; Department of Radiology, Institute of Radiology, Hospital das Clínicas da FMUSP, Sao Paulo, Brazil., Lopez RVM; Oncology Translational Research Center, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da FMUSP, Sao Paulo, Brazil., Dos Santos de Jesus GR; Department of Radiation Oncology, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil., de Carvalho IT; Department of Radiation Oncology, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil., Marotta RC; Department of Radiation Oncology, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil., Marta GN; Department of Radiation Oncology, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil., Feher O; Department of Clinical Oncology, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da FMUSP, Sao Paulo, Brazil., Neto HS; Department of Neurosurgery, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da FMUSP, Sao Paulo, Brazil., Ribeiro ISN; Department of Neurosurgery, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da FMUSP, Sao Paulo, Brazil., Vasconcelos KGMDC; Department of Radiation Oncology, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil., Figueiredo EG; Department of Neurosurgery, Hospital das Clínicas da FMUSP, Sao Paulo, Brazil., Weltman E; Department of Radiation Oncology, FMUSP, São Paulo, Brazil.

المصدر: International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2024 Jul 15; Vol. 119 (4), pp. 1122-1132. Date of Electronic Publication: 2024 Jan 15.

نوع المنشور: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Comparative Study

بيانات الدورية: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 7603616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-355X (Electronic) Linking ISSN: 03603016 NLM ISO Abbreviation: Int J Radiat Oncol Biol Phys Subsets: MEDLINE

مواضيع طبية MeSH: Glioblastoma*/radiotherapy , Glioblastoma*/mortality , Glioblastoma*/surgery , Glioblastoma*/pathology , Radiation Dose Hypofractionation* , Re-Irradiation*/adverse effects , Radiosurgery*/adverse effects , Radiosurgery*/methods , Neoplasm Recurrence, Local*/radiotherapy , Progression-Free Survival* , Brain Neoplasms*/radiotherapy , Brain Neoplasms*/mortality , Brain Neoplasms*/pathology , Brain Neoplasms*/surgery, Humans ; Middle Aged ; Aged ; Male ; Female ; Adult ; Prospective Studies ; Dose Fractionation, Radiation ; Necrosis

المؤلفون: Arruda Correia ML; IFF/Fiocruz, Rio de Janeio, Brazil., Peixoto Filho FM; Department of Fetal Medicine, IFF/Fiocruz, Rio de Janeio, Brazil., Gomes Júnior SC; Department of Clinical Research, IFF/Fiocruz, Rio de Janeio, Brazil., de Jesus GR; Department of Obstetrics, IFF/Fiocruz, Rio de Janeio, Brazil.

المصدر: PloS one [PLoS One] 2024 Mar 20; Vol. 19 (3), pp. e0300514. Date of Electronic Publication: 2024 Mar 20 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Pregnant Women* , Manipulation, Osteopathic*, Female ; Pregnancy ; Humans ; Adolescent ; Adult ; Pregnancy Trimester, Third ; Prospective Studies ; Hemodynamics/physiology

المؤلفون: Zuo Y; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor., Navaz S; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor., Tsodikov A; School of Public Health, University of Michigan, Ann Arbor., Kmetova K; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, and Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia., Kluge L; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor., Ambati A; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor., Hoy CK; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor., Yalavarthi S; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor., de Andrade D; University of São Paulo, São Paulo, Brazil., Tektonidou MG; National and Kapodistrian University of Athens, Athens, Greece., Sciascia S; University of Turin, Turin, Italy., Pengo V; Padova University Hospital, Padova, Italy., Ruiz-Irastorza G; Hospital Universitario Cruces, University of the Basque Country, Bizkaia, Spain., Belmont HM; New York University Langone Medical Center, New York., Gerosa M; University of Milan, Milan, Italy., Fortin PR; CHU de Québec- Université Laval, Quebec, Canada., de Jesus GR; Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Branch DW; University of Utah and Intermountain Healthcare, Salt Lake City., Andreoli L; University of Brescia, Brescia, Italy., Rodriguez-Almaraz E; Hospital Universitario 12 de Octubre, Madrid, Spain., Petri M; Johns Hopkins University School of Medicine, Baltimore, Maryland., Cervera R; Hospital Clinic de Barcelona, Barcelona, Spain., Willis R; University of Texas Medical Branch, Galveston., Karp DR; Department of Internal Medicine, Division of Rheumatic Disease, University of Texas Southwestern Medical Center, Dallas., Li QZ; Department of Immunology, Immune Phenotyping Core Facility, University of Texas Southwestern Medical Center, Dallas., Cohen H; Haemostasis Research Unit, Department of Haematology, University College London, London, UK., Bertolaccini ML; King's College London British Heart Foundation Centre of Excellence, London, UK., Erkan D; Barbara Volcker Center for Women and Rheumatic Disease, Hospital for Special Surgery, Weill Cornell Medicine, New York, New York., Knight JS; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor.

مؤلفون مشاركون: Antiphospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking

المصدر: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2023 Aug; Vol. 75 (8), pp. 1407-1414. Date of Electronic Publication: 2023 May 18.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101623795 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2326-5205 (Electronic) Linking ISSN: 23265191 NLM ISO Abbreviation: Arthritis Rheumatol Subsets: MEDLINE

مواضيع طبية MeSH: Antiphospholipid Syndrome* , Extracellular Traps*, Humans ; Antibodies, Antiphospholipid ; Autoantibodies ; Immunoglobulin G ; Immunoglobulin M

المؤلفون: Sevim E; Hospital for Special Surgery, New York, New York, and Montefiore Medical Center, Bronx, New York., Zisa D; Hospital for Special Surgery and Weill Cornell Medicine, New York, New York., Andrade D; University of Sao Paulo, Sao Paulo, Brazil., Sciascia S; University of Turin, Turin, Italy., Pengo V; University Hospital Padova, Padova, Italy., Tektonidou MG; National and Kapodistrian University of Athens, Athens, Greece., Ugarte A; Hospital Universitario Cruces, Barakaldo, País Vasco, Spain., Gerosa M; University of Milan, Milan, Italy., Belmont HM; New York University Langone Medical Center, New York, New York., Zamorano MAA; Maimonides Institute for Biomedical Research of Cordoba, Cordoba, Spain., Fortin PR; CHU de Québec and Université Laval, Quebec City, Canada., Ji L; Peking University First Hospital, Beijing, China., Efthymiou M; University College London, London, UK., Cohen H; University College London, London, UK., Branch DW; University of Utah and Intermountain Healthcare, Salt Lake City, Utah., de Jesus GR; Rio de Janeiro State University, Rio de Janeiro, Brazil., Andreoli L; University of Brescia, Brescia, Italy., Petri M; Johns Hopkins University School of Medicine, Baltimore, Maryland., Rodriguez E; Hospital Universitario 12 de Octubre, Madrid, Spain., Cervera R; Hospital Clínic Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain., Knight JS; University of Michigan, Ann Arbor., Atsumi T; Hokkaido University Hospital, Sapporo, Japan., Willis R; University of Texas Medical Branch, Galveston., Roubey R; University of North Carolina, Chapel Hill., Bertolaccini ML; St Thomas' Hospital, London, UK., Erkan D; Hospital for Special Surgery and Weill Cornell Medicine, New York, New York., Barbhaiya M; Hospital for Special Surgery and Weill Cornell Medicine, New York, New York.

مؤلفون مشاركون: APS ACTION Investigators

المصدر: Arthritis care & research [Arthritis Care Res (Hoboken)] 2022 Feb; Vol. 74 (2), pp. 324-335.

نوع المنشور: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101518086 Publication Model: Print Cited Medium: Internet ISSN: 2151-4658 (Electronic) Linking ISSN: 2151464X NLM ISO Abbreviation: Arthritis Care Res (Hoboken) Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Antiphospholipid* , Registries*, Adult ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged

عنوان ترانسليتريتد: Assistência a vítimas de violência sexual em um serviço de referência: Uma experiência de 10 Anos.

المؤلفون: de Jesus GR; Gynecology And Obstetrics Department, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil., Rodrigues NP; Gynecology And Obstetrics Department, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil., Braga GC; Gynecology And Obstetrics Department, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil., Abduch R; Gynecology And Obstetrics Department, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil., Melli PPDS; Gynecology And Obstetrics Department, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil., Duarte G; Gynecology And Obstetrics Department, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil., Quintana SM; Gynecology And Obstetrics Department, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

المصدر: Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia [Rev Bras Ginecol Obstet] 2022 Jan; Vol. 44 (1), pp. 47-54. Date of Electronic Publication: 2022 Jan 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Federação das Sociedades de Ginecologia e Obstetrícia Country of Publication: Brazil NLM ID: 9214757 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1806-9339 (Electronic) Linking ISSN: 01007203 NLM ISO Abbreviation: Rev Bras Ginecol Obstet Subsets: MEDLINE

مواضيع طبية MeSH: Domestic Violence* , Sex Offenses*, Adolescent ; Adult ; Aged ; Child ; Female ; Humans ; Male ; Middle Aged ; Pregnancy ; Referral and Consultation ; Retrospective Studies ; Sexual Behavior ; Young Adult

المؤلفون: Gkrouzman E; E. Gkrouzman, MD, MS, Hospital for Special Surgery, New York, New York, USA; egkrouzman@gmail.com., Sevim E; E. Sevim, MD, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, New York, USA., Finik J; J. Finik, MPH, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Andrade D; D. Andrade, MD, PhD, University of São Paulo, São Paulo, Brazil., Pengo V; V. Pengo, MD, University Hospital Padova, Padova, Italy., Sciascia S; S. Sciascia, MD, PhD, Center of Research of Immunopathology and Rare Diseases, University of Turin, Turin, Italy., Tektonidou MG; M.G. Tektonidou, MD, PhD, National and Kapodistrian University of Athens, Athens, Greece., Ugarte A; A. Ugarte, MD, Hospital Universitario Cruces, Barakaldo, País Vasco, Spain., Chighizola CB; C.B. Chighizola, MD, PhD, Clinical Immunology & Rheumatology Unit, IRCCS Istituto Auxologico Italiano, Milan, Italy., Belmont HM; H.M. Belmont, MD, Hospital for Joint Diseases, New York University, New York, New York, USA., Lopez-Pedrera C; C. Lopez-Pedrera, PhD, Rheumatology Service, IMIBIC/Reina Sofia Hospital, University of Cordoba, Cordoba, Spain., Ji L; L. Ji, MD, Rheumatology and Immunology Department, Peking University First Hospital, Beijing, China., Fortin P; P. Fortin, MD, CHU de Québec-Université Laval, Québec City, Québec, Canada., Efthymiou M; M. Efthymiou, PhD, H. Cohen, MD, Haemostasis Research Unit, Department of Haematology, University College London, London, UK., de Jesus GR; G. Ramires de Jesus, MD, MSc, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Branch DW; D.W. Branch, MD, University of Utah and Intermountain Healthcare, Salt Lake City, Utah, USA., Nalli C; C. Nalli, MD, Rheumatology and Immunology Unit, ASST Spedali Civili of Brescia, Brescia, Italy., Petri M; M. Petri, MD, MPH, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Rodriguez E; E. Rodriguez, MD, Hospital Universitario 12 de Octubre, Madrid, Spain., Cervera R; R. Cervera, MD, PhD, FRCP, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain., Knight JS; J.S. Knight, MD, PhD, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA., Atsumi T; T. Atsumi, MD, PhD, Hokkaido University Hospital, Sapporo, Japan., Willis R; R. Willis, MD, Antiphospholipid Standardization Laboratory, University of Texas Medical Branch, Galveston, Texas, USA., Bertolaccini ML; M.L. Bertolaccini, PhD, Academic Department of Vascular Surgery, King's College London British Heart Foundation Centre of Excellence, School of Cardiovascular Medicine & Sciences, London, UK., Cohen H; M. Efthymiou, PhD, H. Cohen, MD, Haemostasis Research Unit, Department of Haematology, University College London, London, UK., Rand J; J. Rand, MD, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA., Erkan D; D. Erkan, MD, MPH, Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, Weill Cornell Medicine, New York, New York, USA.

مؤلفون مشاركون: APS ACTION+

المصدر: The Journal of rheumatology [J Rheumatol] 2021 Apr; Vol. 48 (4), pp. 541-547. Date of Electronic Publication: 2020 Sep 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Journal Of Rheumatology Publishing Co Country of Publication: Canada NLM ID: 7501984 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1499-2752 (Electronic) Linking ISSN: 0315162X NLM ISO Abbreviation: J Rheumatol Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Antiphospholipid* , Antiphospholipid Syndrome*, Cohort Studies ; Humans ; Prospective Studies ; beta 2-Glycoprotein I