المؤلفون: Aramburu IV; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK., Hoving D; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK., Vernardis SI; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, UK., Tin MCF; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK., Ioannou M; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK., Temkin MI; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK., De Vasconcelos NM; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK., Demichev V; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, UK., Helbig ET; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany., Lippert L; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany., Stahl K; Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Hannover, Germany., White M; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, UK., Radbruch H; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Neuropathology, Charitéplatz 1, 10117 Berlin, Germany., Ihlow J; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pathology, Charitéplatz 1, 10117 Berlin, Germany., Horst D; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pathology, Charitéplatz 1, 10117 Berlin, Germany., Chiesa ST; Institute of Cardiovascular Science, University College London, London, UK., Deanfield JE; Institute of Cardiovascular Science, University College London, London, UK., David S; Institute for Intensive Care Medicine, University Hospital Zurich, Zurich, Switzerland., Bode C; Department of Anaesthesiology and Critical Care, University Hospital Bonn, Bonn, Germany., Kurth F; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany., Ralser M; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, UK; Charité - Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany., Papayannopoulos V; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK. Electronic address: veni.p@crick.ac.uk.

المصدر: Immunity [Immunity] 2022 Dec 13; Vol. 55 (12), pp. 2436-2453.e5. Date of Electronic Publication: 2022 Nov 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19* , Sepsis*, Animals ; Mice ; Actins ; Chromatin ; Deoxyribonuclease I ; DNA ; Neutrophils ; Proteomics

المؤلفون: Ioannou M; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK., Hoving D; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK., Aramburu IV; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK., Temkin MI; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK., De Vasconcelos NM; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK., Tsourouktsoglou TD; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK., Wang Q; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK., Boeing S; The Francis Crick Institute, Bioinformatics and Biostatistics, London, UK., Goldstone R; The Francis Crick Institute, Advanced Sequencing, London, UK., Vernardis S; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, UK., Demichev V; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, UK., Ralser M; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, UK.; Charité Universitätsmedizin, Department of Biochemistry, 10117, Berlin, Germany., David S; Institute for Intensive Care Medicine, University Hospital Zurich, Zurich, Switzerland., Stahl K; Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Hannover, Germany., Bode C; Department of Anaesthesiology and Critical Care, University Hospital Bonn, Bonn, Germany., Papayannopoulos V; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK. veni.p@crick.ac.uk.

المصدر: Nature communications [Nat Commun] 2022 Aug 09; Vol. 13 (1), pp. 4658. Date of Electronic Publication: 2022 Aug 09.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Neutrophils* , Sepsis*, Granulocyte Colony-Stimulating Factor/metabolism ; Histones/metabolism ; Humans ; Longevity ; Macrophages/metabolism ; Peroxidase/metabolism ; T-Lymphocytes/metabolism

المؤلفون: de Vasconcelos NM; Department of Internal Medicine and Pediatrics, Ghent University, 9052 Ghent, Belgium; VIB Center for Inflammation Research, 9052 Ghent, Belgium., Van Opdenbosch N; Department of Internal Medicine and Pediatrics, Ghent University, 9052 Ghent, Belgium; VIB Center for Inflammation Research, 9052 Ghent, Belgium; Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, Beerse 2340, Belgium., Van Gorp H; Department of Internal Medicine and Pediatrics, Ghent University, 9052 Ghent, Belgium; VIB Center for Inflammation Research, 9052 Ghent, Belgium., Martín-Pérez R; Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, Beerse 2340, Belgium., Zecchin A; Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, Beerse 2340, Belgium., Vandenabeele P; VIB Center for Inflammation Research, 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent 9052, Belgium; Methusalem program, Ghent University, Ghent 9052, Belgium., Lamkanfi M; Department of Internal Medicine and Pediatrics, Ghent University, 9052 Ghent, Belgium; VIB Center for Inflammation Research, 9052 Ghent, Belgium; Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, Beerse 2340, Belgium. Electronic address: mohamed.lamkanfi@ugent.be.

المصدر: Cell reports [Cell Rep] 2020 Jul 28; Vol. 32 (4), pp. 107959.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Caspases/*metabolism , Macrophages/*metabolism , Pyroptosis/*physiology, Animals ; Apoptosis/physiology ; Apoptosis Regulatory Proteins/metabolism ; Caspase 1/metabolism ; Caspase 1/physiology ; Caspase 3/metabolism ; Caspase 7/metabolism ; Caspase 8/metabolism ; Caspase 8/physiology ; Cell Death ; Cell Membrane/metabolism ; Female ; Inflammasomes/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Phosphate-Binding Proteins/metabolism

المؤلفون: de Vasconcelos NM; Department of Internal Medicine and Pediatrics, Ghent University, B-9000 Ghent, Belgium.; VIB-UGhent Center for Inflammation Research, VIB, B-9052 Ghent, Belgium., Lamkanfi M; Department of Internal Medicine and Pediatrics, Ghent University, B-9000 Ghent, Belgium.; Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, B-2340 Beerse, Belgium.

المصدر: Cold Spring Harbor perspectives in biology [Cold Spring Harb Perspect Biol] 2020 May 01; Vol. 12 (5). Date of Electronic Publication: 2020 May 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 101513680 Publication Model: Electronic Cited Medium: Internet ISSN: 1943-0264 (Electronic) Linking ISSN: 19430264 NLM ISO Abbreviation: Cold Spring Harb Perspect Biol Subsets: MEDLINE

مواضيع طبية MeSH: Caspases/*metabolism , Inflammasomes/*immunology , Intracellular Signaling Peptides and Proteins/*metabolism , Phosphate-Binding Proteins/*metabolism, Animals ; Apoptosis ; Caspase 1/metabolism ; Caspases, Initiator/metabolism ; Humans ; Inflammation ; Interleukin-1/metabolism ; Interleukin-1beta/metabolism ; Mice ; Pyroptosis

المؤلفون: de Vasconcelos NM; Programa de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil., Ribeiro M; Programa de Pós-Graduação em Medicina e Saúde, Faculdade de Medicina da Bahia, UFBA, Salvador, BA, Brazil., Reis D; Programa de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil., Couto I; Programa de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil., Sena C; Programa de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil., Botelho AC; Programa de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil., Bonavides D; Programa de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil., Hemanny C; Programa de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil., Seixas C; Programa de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil., Zeni CP; School of Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA., de Oliveira IR; Programa de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil.; Programa de Pós-Graduação em Medicina e Saúde, Faculdade de Medicina da Bahia, UFBA, Salvador, BA, Brazil.; School of Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.

المصدر: Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) [Braz J Psychiatry] 2020; Vol. 42 (3), pp. 250-257. Date of Electronic Publication: 2020 Jan 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Associação Brasileira de Psiquiatria Country of Publication: Brazil NLM ID: 100895975 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1809-452X (Electronic) Linking ISSN: 15164446 NLM ISO Abbreviation: Braz J Psychiatry Subsets: MEDLINE

مواضيع طبية MeSH: Adverse Childhood Experiences*/statistics & numerical data , Personal Satisfaction*, Child Abuse/*psychology , Depressive Disorder/*psychology, Adolescent ; Brazil ; Child ; Cross-Sectional Studies ; Depressive Disorder/etiology ; Female ; Humans ; Male ; Psychiatric Status Rating Scales ; Risk Factors ; Surveys and Questionnaires

المؤلفون: de Vasconcelos NM; Department of Internal Medicine, Ghent University, Ghent, Belgium.; VIB-UGhent Center for Inflammation Research, VIB, Ghent, Belgium., Vliegen G; Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium., Gonçalves A; VIB-UGhent Center for Inflammation Research, VIB, Ghent, Belgium.; VIB Bioimaging Core, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., De Hert E; Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium., Martín-Pérez R; Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, Beerse, Belgium., Van Opdenbosch N; Department of Internal Medicine, Ghent University, Ghent, Belgium.; VIB-UGhent Center for Inflammation Research, VIB, Ghent, Belgium.; Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, Beerse, Belgium., Jallapally A; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium., Geiss-Friedlander R; Institut für Molekularbiologie, Universitätsmedizin Göttingen, Göttingen, Germany., Lambeir AM; Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium., Augustyns K; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium., Van Der Veken P; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium., De Meester I; Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium., Lamkanfi M; Department of Internal Medicine, Ghent University, Ghent, Belgium mlamkanf@its.jnj.com.; VIB-UGhent Center for Inflammation Research, VIB, Ghent, Belgium.; Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, Beerse, Belgium.

المصدر: Life science alliance [Life Sci Alliance] 2019 Feb 04; Vol. 2 (1). Date of Electronic Publication: 2019 Feb 04 (Print Publication: 2019).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2575-1077 (Electronic) Linking ISSN: 25751077 NLM ISO Abbreviation: Life Sci Alliance Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis Regulatory Proteins/*metabolism , Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/*antagonists & inhibitors , Inflammasomes/*metabolism , Macrophages/*metabolism, Alleles ; Animals ; Antigens, Bacterial ; Apoptosis/drug effects ; Bacterial Toxins ; Boronic Acids/administration & dosage ; Boronic Acids/pharmacology ; CARD Signaling Adaptor Proteins/genetics ; Caspase 1/metabolism ; Cell Line ; Dipeptides/administration & dosage ; Dipeptides/pharmacology ; Interleukin-18/metabolism ; Interleukin-1beta/metabolism ; Mice ; Mice, Inbred C57BL ; Pyroptosis/drug effects

المؤلفون: de Vasconcelos NM; Department of Internal Medicine, Ghent University, Ghent, B-9000, Belgium.; VIB-UGhent Center for Inflammation Research, VIB, Ghent, B-9000, Belgium., Van Opdenbosch N; Department of Internal Medicine, Ghent University, Ghent, B-9000, Belgium.; VIB-UGhent Center for Inflammation Research, VIB, Ghent, B-9000, Belgium., Van Gorp H; Department of Internal Medicine, Ghent University, Ghent, B-9000, Belgium.; VIB-UGhent Center for Inflammation Research, VIB, Ghent, B-9000, Belgium., Parthoens E; VIB-UGhent Center for Inflammation Research, VIB, Ghent, B-9000, Belgium.; VIB Bioimaging Core, VIB, Ghent, B-9000, Belgium., Lamkanfi M; Department of Internal Medicine, Ghent University, Ghent, B-9000, Belgium. mlamkanf@its.jnj.com.; VIB-UGhent Center for Inflammation Research, VIB, Ghent, B-9000, Belgium. mlamkanf@its.jnj.com.; Janssen Immunosciences, World Without Disease Accelerator, Janssen Pharmaceutical Companies of Johnson and Johnson, Beerse, B-2340, Belgium. mlamkanf@its.jnj.com.

المصدر: Cell death and differentiation [Cell Death Differ] 2019 Jan; Vol. 26 (1), pp. 146-161. Date of Electronic Publication: 2018 Apr 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE

مواضيع طبية MeSH: Intracellular Signaling Peptides and Proteins/*metabolism , Macrophages/*cytology , Phosphate-Binding Proteins/*metabolism , Pyroptosis/*immunology, Animals ; Apoptosis Regulatory Proteins/metabolism ; Cell Membrane/metabolism ; Inflammasomes/metabolism ; Lysosomes/metabolism ; Macrophages/drug effects ; Macrophages/metabolism ; Mice ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Mitochondria/metabolism ; Necroptosis ; Necrosis/metabolism ; Phosphatidylserines/metabolism ; Pyroptosis/genetics ; Single-Cell Analysis

المؤلفون: Van Opdenbosch N; Department of Internal Medicine, Ghent University, 9052 Ghent, Belgium; VIB-UGent Center for Inflammation Research, VIB, 9052 Ghent, Belgium., Van Gorp H; Department of Internal Medicine, Ghent University, 9052 Ghent, Belgium; VIB-UGent Center for Inflammation Research, VIB, 9052 Ghent, Belgium., Verdonckt M; Department of Internal Medicine, Ghent University, 9052 Ghent, Belgium; VIB-UGent Center for Inflammation Research, VIB, 9052 Ghent, Belgium., Saavedra PHV; Department of Internal Medicine, Ghent University, 9052 Ghent, Belgium; VIB-UGent Center for Inflammation Research, VIB, 9052 Ghent, Belgium., de Vasconcelos NM; Department of Internal Medicine, Ghent University, 9052 Ghent, Belgium; VIB-UGent Center for Inflammation Research, VIB, 9052 Ghent, Belgium., Gonçalves A; VIB-UGent Center for Inflammation Research, VIB, 9052 Ghent, Belgium; VIB Bioimaging Core, VIB, 9000 Ghent, Belgium., Vande Walle L; Department of Internal Medicine, Ghent University, 9052 Ghent, Belgium; VIB-UGent Center for Inflammation Research, VIB, 9052 Ghent, Belgium., Demon D; Department of Internal Medicine, Ghent University, 9052 Ghent, Belgium; VIB-UGent Center for Inflammation Research, VIB, 9052 Ghent, Belgium., Matusiak M; Department of Internal Medicine, Ghent University, 9052 Ghent, Belgium; VIB-UGent Center for Inflammation Research, VIB, 9052 Ghent, Belgium., Van Hauwermeiren F; Department of Internal Medicine, Ghent University, 9052 Ghent, Belgium; VIB-UGent Center for Inflammation Research, VIB, 9052 Ghent, Belgium., D'Hont J; VIB-UGent Center for Inflammation Research, VIB, 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium., Hochepied T; VIB-UGent Center for Inflammation Research, VIB, 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium., Krautwald S; Department of Nephrology and Hypertension, University Hospital Schleswig-Holstein, 24105 Kiel, Germany., Kanneganti TD; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA., Lamkanfi M; Department of Internal Medicine, Ghent University, 9052 Ghent, Belgium; VIB-UGent Center for Inflammation Research, VIB, 9052 Ghent, Belgium. Electronic address: mohamed.lamkanfi@irc.vib-ugent.be.

المصدر: Cell reports [Cell Rep] 2017 Dec 19; Vol. 21 (12), pp. 3427-3444.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Pyroptosis*, Apoptosis Regulatory Proteins/*metabolism , CASP8 and FADD-Like Apoptosis Regulating Protein/*metabolism , Calcium-Binding Proteins/*metabolism , Caspase 1/*metabolism , Inflammasomes/*metabolism, Animals ; Caspase 8/metabolism ; Enterocytes/metabolism ; Macrophages/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Toll-Like Receptors/metabolism

المؤلفون: Van Gorp H; Inflammation Research Center, VIB, Zwijnaarde, B-9052, Belgium.; Department of Internal Medicine, Ghent University, Ghent, B-9000, Belgium., Saavedra PH; Inflammation Research Center, VIB, Zwijnaarde, B-9052, Belgium.; Department of Internal Medicine, Ghent University, Ghent, B-9000, Belgium., de Vasconcelos NM; Inflammation Research Center, VIB, Zwijnaarde, B-9052, Belgium.; Department of Internal Medicine, Ghent University, Ghent, B-9000, Belgium., Van Opdenbosch N; Inflammation Research Center, VIB, Zwijnaarde, B-9052, Belgium.; Department of Internal Medicine, Ghent University, Ghent, B-9000, Belgium., Vande Walle L; Inflammation Research Center, VIB, Zwijnaarde, B-9052, Belgium.; Department of Internal Medicine, Ghent University, Ghent, B-9000, Belgium., Matusiak M; Inflammation Research Center, VIB, Zwijnaarde, B-9052, Belgium.; Department of Internal Medicine, Ghent University, Ghent, B-9000, Belgium., Prencipe G; Rheumatology Unit, Bambino Gesù Children's Hospital, Rome, I-00146, Italy., Insalaco A; Rheumatology Unit, Bambino Gesù Children's Hospital, Rome, I-00146, Italy., Van Hauwermeiren F; Inflammation Research Center, VIB, Zwijnaarde, B-9052, Belgium.; Department of Internal Medicine, Ghent University, Ghent, B-9000, Belgium., Demon D; Inflammation Research Center, VIB, Zwijnaarde, B-9052, Belgium.; Department of Internal Medicine, Ghent University, Ghent, B-9000, Belgium., Bogaert DJ; Clinical Immunology Research Laboratory, Centre for Primary Immunodeficiency Ghent, Ghent University Hospital, Ghent, B-9000, Belgium.; Department of Pediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent, Ghent University Hospital, Ghent, B-9000, Belgium.; Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, B-9000, Belgium., Dullaers M; Clinical Immunology Research Laboratory, Centre for Primary Immunodeficiency Ghent, Ghent University Hospital, Ghent, B-9000, Belgium.; Laboratory of Immunoregulation, Inflammation Research Center, VIB, Zwijnaarde, B-9052, Belgium., De Baere E; Center for Medical Genetics Ghent, Ghent University, Ghent, B-9000, Belgium., Hochepied T; Inflammation Research Center, VIB, Zwijnaarde, B-9052, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, B-9000, Belgium., Dehoorne J; Department of Pediatric Rheumatology, Ghent University Hospital, Ghent, B-9000, Belgium., Vermaelen KY; Department of Internal Medicine, Ghent University, Ghent, B-9000, Belgium.; Tumor Immunology Laboratory, Department of Pulmonary Medicine, Ghent University Hospital, Ghent, B-9000, Belgium., Haerynck F; Clinical Immunology Research Laboratory, Centre for Primary Immunodeficiency Ghent, Ghent University Hospital, Ghent, B-9000, Belgium.; Department of Pediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent, Ghent University Hospital, Ghent, B-9000, Belgium.; Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, B-9000, Belgium., De Benedetti F; Rheumatology Unit, Bambino Gesù Children's Hospital, Rome, I-00146, Italy., Lamkanfi M; Inflammation Research Center, VIB, Zwijnaarde, B-9052, Belgium; mohamed.lamkanfi@irc.vib-ugent.be.; Department of Internal Medicine, Ghent University, Ghent, B-9000, Belgium.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Dec 13; Vol. 113 (50), pp. 14384-14389. Date of Electronic Publication: 2016 Nov 22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Mutation*, Familial Mediterranean Fever/*genetics , Familial Mediterranean Fever/*metabolism , Inflammasomes/*metabolism , Pyrin/*genetics , Pyrin/*metabolism, Animals ; Bacterial Toxins/toxicity ; CARD Signaling Adaptor Proteins/metabolism ; Clostridium Infections/immunology ; Clostridium Infections/metabolism ; Enterotoxins/toxicity ; Familial Mediterranean Fever/immunology ; HEK293 Cells ; Humans ; Inflammasomes/drug effects ; Inflammasomes/immunology ; Lipopolysaccharides/toxicity ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microtubules/drug effects ; Microtubules/immunology ; Microtubules/metabolism ; Pyrin/immunology ; Tubulin/metabolism

المؤلفون: de Vasconcelos NM; NOD-like Receptor and Inflammasome Laboratory, Inflammation Research Center, VIB, Technologiepark 927, B-9052, Zwijnaarde, Belgium.; Department of Internal Medicine, Ghent University, B-9000, Ghent, Belgium., Van Opdenbosch N; NOD-like Receptor and Inflammasome Laboratory, Inflammation Research Center, VIB, Technologiepark 927, B-9052, Zwijnaarde, Belgium.; Department of Internal Medicine, Ghent University, B-9000, Ghent, Belgium., Lamkanfi M; NOD-like Receptor and Inflammasome Laboratory, Inflammation Research Center, VIB, Technologiepark 927, B-9052, Zwijnaarde, Belgium. mohamed.lamkanfi@irc.vib-ugent.be.; Department of Internal Medicine, Ghent University, B-9000, Ghent, Belgium. mohamed.lamkanfi@irc.vib-ugent.be.

المصدر: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2016 Jun; Vol. 73 (11-12), pp. 2335-47. Date of Electronic Publication: 2016 Apr 05.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis/*physiology , Caspase 1/*metabolism , Gram-Negative Bacteria/*immunology , Inflammasomes/*metabolism , Pyroptosis/*physiology, Alarmins/metabolism ; Animals ; Caspases/metabolism ; Caspases, Initiator ; Humans ; Inflammation/pathology ; Interleukin-18/metabolism ; Interleukin-1beta/metabolism ; Mice ; Mice, Knockout ; Signal Transduction