المؤلفون: Bate-Eya LT; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands., den Hartog IJ; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands., van der Ploeg I; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands., Schild L; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands., Koster J; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands., Santo EE; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands., Westerhout EM; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands., Versteeg R; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands., Caron HN; Department of Pediatric Oncology, Emma Kinderziekenhuis, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Molenaar JJ; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands., Dolman ME; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands.

المصدر: Oncotarget [Oncotarget] 2016 May 10; Vol. 7 (19), pp. 27946-58.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: Print Cited Medium: Internet ISSN: 1949-2553 (Electronic) Linking ISSN: 19492553 NLM ISO Abbreviation: Oncotarget Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Bridged Bicyclo Compounds, Heterocyclic/*therapeutic use , Myeloid Cell Leukemia Sequence 1 Protein/*metabolism , Neuroblastoma/*drug therapy , Proto-Oncogene Proteins c-bcl-2/*antagonists & inhibitors , Proto-Oncogene Proteins c-bcl-2/*metabolism , Sulfonamides/*therapeutic use, Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Apoptosis/drug effects ; Bcl-2-Like Protein 11/metabolism ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Cell Line, Tumor ; Cell Survival/drug effects ; Cytochromes c/metabolism ; Drug Evaluation, Preclinical ; Female ; Humans ; Inhibitory Concentration 50 ; Mice ; Mitochondria/metabolism ; Myeloid Cell Leukemia Sequence 1 Protein/antagonists & inhibitors ; Neuroblastoma/pathology ; Sulfonamides/pharmacology ; Treatment Outcome ; Xenograft Model Antitumor Assays

المؤلفون: Dolman ME; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. memdolman@gmail.com., Poon E; Division of Clinical Studies, The Institute of Cancer Research, London, England., Ebus ME; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., den Hartog IJ; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., van Noesel CJ; Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Jamin Y; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, England., Hallsworth A; Division of Clinical Studies, The Institute of Cancer Research, London, England., Robinson SP; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, England., Petrie K; Division of Clinical Studies, The Institute of Cancer Research, London, England., Sparidans RW; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, the Netherlands., Kok RJ; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, Utrecht, the Netherlands., Versteeg R; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Caron HN; Department of Pediatric Oncology, Emma Kinderziekenhuis, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Chesler L; Division of Clinical Studies, The Institute of Cancer Research, London, England., Molenaar JJ; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2015 Nov 15; Vol. 21 (22), pp. 5100-9. Date of Electronic Publication: 2015 Jul 22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Neuroblastoma/*drug therapy , Nuclear Proteins/*genetics , Oncogene Proteins/*genetics , Piperidines/*administration & dosage , Protein Kinase Inhibitors/*administration & dosage , Pyrazoles/*administration & dosage, Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclin-Dependent Kinase 2/biosynthesis ; Cyclin-Dependent Kinase 2/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; N-Myc Proto-Oncogene Protein ; Neuroblastoma/genetics ; Neuroblastoma/pathology ; Nuclear Proteins/biosynthesis ; Oncogene Proteins/biosynthesis ; Xenograft Model Antitumor Assays

المؤلفون: Dolman ME; Amsterdam Medical Center, University of Amsterdam, Department of Oncogenomics, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands., den Hartog IJ; Amsterdam Medical Center, University of Amsterdam, Department of Oncogenomics, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands., Molenaar JJ; Amsterdam Medical Center, University of Amsterdam, Department of Oncogenomics, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands., Schellens JH; Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology & Clinical Pharmacology, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands; The Netherlands Cancer Institute, Department of Clinical Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands., Beijnen JH; Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology & Clinical Pharmacology, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands; The Netherlands Cancer Institute, Department of Clinical Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands; Slotervaart Hospital, Department of Pharmacy & Pharmacology, Louwesweg 6, 1066 EC Amsterdam, The Netherlands., Sparidans RW; Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology & Clinical Pharmacology, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands. Electronic address: R.W.Sparidans@uu.nl.

المصدر: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2014 Apr; Vol. 92, pp. 144-8. Date of Electronic Publication: 2014 Jan 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

مواضيع طبية MeSH: Chromatography, Liquid/*methods , Imidazoles/*chemistry , Inhibitor of Apoptosis Proteins/*antagonists & inhibitors , Naphthoquinones/*chemistry , Repressor Proteins/*antagonists & inhibitors , Tandem Mass Spectrometry/*methods, Animals ; Calibration ; Female ; Light ; Mice ; Reproducibility of Results ; Survivin

المؤلفون: Bate-Eya LT; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands., Ebus ME; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands., Koster J; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands., den Hartog IJ; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands., Zwijnenburg DA; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands., Schild L; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands., van der Ploeg I; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands., Dolman ME; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands., Caron HN; Department of Paediatric Oncology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands., Versteeg R; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands., Molenaar JJ; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands. Electronic address: j.j.molenaar@amc.uva.nl.

المصدر: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2014 Feb; Vol. 50 (3), pp. 628-37. Date of Electronic Publication: 2013 Dec 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Cell Line, Tumor*, Neuroblastoma/*genetics , Neuroblastoma/*pathology, Animals ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Child ; Child, Preschool ; Culture Media, Serum-Free ; Genotype ; Humans ; Infant ; Mice ; Mice, Nude ; Neuroblastoma/metabolism ; Phenotype ; RNA, Messenger/genetics ; RNA, Messenger/metabolism

المؤلفون: Dolman ME; Amsterdam Medical Center, University of Amsterdam, Department of Oncogenomics, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands., den Hartog IJ, Molenaar JJ, Schellens JH, Beijnen JH, Sparidans RW

المصدر: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2014 Jan; Vol. 88, pp. 216-20. Date of Electronic Publication: 2013 Sep 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

مواضيع طبية MeSH: Cyclin-Dependent Kinases/*antagonists & inhibitors , Piperidines/*blood , Protein Kinase Inhibitors/*blood , Pyrazoles/*blood, Animals ; Calibration ; Chromatography, Liquid ; Female ; Indoles/analysis ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Neuroblastoma/drug therapy ; Reproducibility of Results ; Spectrometry, Mass, Electrospray Ionization ; Tandem Mass Spectrometry

المؤلفون: Lamers F; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands., Schild L, den Hartog IJ, Ebus ME, Westerhout EM, Ora I, Koster J, Versteeg R, Caron HN, Molenaar JJ

المصدر: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2012 Nov; Vol. 48 (16), pp. 3093-103. Date of Electronic Publication: 2012 Feb 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Targeted Therapy*, Aniline Compounds/*pharmacology , Antineoplastic Agents/*pharmacology , Neuroblastoma/*drug therapy , Proto-Oncogene Proteins c-bcl-2/*antagonists & inhibitors , Sulfonamides/*pharmacology, Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Drug Synergism ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic ; HEK293 Cells ; Humans ; Mice ; Mice, Nude ; Neuroblastoma/genetics ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Oligonucleotide Array Sequence Analysis ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA Interference ; RNA, Messenger/metabolism ; Time Factors ; Transfection ; Tumor Burden/drug effects ; Up-Regulation ; Xenograft Model Antitumor Assays

المؤلفون: Eijkelkamp N; Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands., Heijnen CJ, Willemen HL, Deumens R, Joosten EA, Kleibeuker W, den Hartog IJ, van Velthoven CT, Nijboer C, Nassar MA, Dorn GW 2nd, Wood JN, Kavelaars A

المصدر: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2010 Feb 10; Vol. 30 (6), pp. 2138-49.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: G-Protein-Coupled Receptor Kinase 2/*physiology , Pain/*enzymology , Pain/*physiopathology, Animals ; Astrocytes/metabolism ; Cells, Cultured ; Chemokine CCL3/pharmacology ; Chemokine CCL3/physiology ; Female ; G-Protein-Coupled Receptor Kinase 2/genetics ; Hyperalgesia/enzymology ; Hyperalgesia/physiopathology ; Inflammation/enzymology ; Inflammation/physiopathology ; Macrophages/enzymology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microglia/enzymology ; Pain/immunology ; Peripheral Nervous System Diseases/enzymology ; Peripheral Nervous System Diseases/immunology ; Peripheral Nervous System Diseases/physiopathology ; Rats ; Rats, Sprague-Dawley ; Sensory Receptor Cells/enzymology ; Spinal Cord/enzymology ; TRPV Cation Channels/physiology ; Tumor Necrosis Factor-alpha/physiology ; p38 Mitogen-Activated Protein Kinases/physiology