نتائج البحث - "drug effects [Cell Proliferation]"

1

AKT1 E17K ‐mutated meningioma cell lines respond to treatment with the AKT inhibitor AZD5363

المؤلفون: Stefan Schnabel, Christian Mawrin, Felix Sahm, Natalie Waldt, Christoph Kesseler, Josephine Liebich, Peter John, C. Scherlach, Frank Angenstein, I. Erol Sandalcioglu, Elmar Kirches

المصدر: Neuropathology & applied neurobiology 48(2), e12780 (2022). doi:10.1111/nan.12780

مصطلحات موضوعية: Histology, pathology [Meningeal Neoplasms], Cell, pharmacology [Enzyme Inhibitors], AKT1, Biology, medicine.disease_cause, meningioma, Pathology and Forensic Medicine, pharmacology [Pyrimidines], Meningioma, Mice, capivasertib, In vivo, Cell Line, Tumor, antagonists & inhibitors [Proto-Oncogene Proteins c-akt], pathology [Skull Base Neoplasms], Physiology (medical), otorhinolaryngologic diseases, medicine, Animals, Humans, Pyrroles, ddc:610, Enzyme Inhibitors, neoplasms, drug effects [Cell Proliferation], Mutation, genetics [Meningeal Neoplasms], Akt inhibitor AZD5363, Cell growth, genetics [Meningioma], targeted therapy, medicine.disease, nervous system diseases, Pyrimidines, medicine.anatomical_structure, Neurology, Cell culture, Cancer research, pharmacology [Pyrroles], genetics [Proto-Oncogene Proteins c-akt], genetics [Skull Base Neoplasms], Neurology (clinical), Proto-Oncogene Proteins c-akt, pathology [Meningioma]

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cca490852d8aecdd9a5e8a3886f1d3a
https://doi.org/10.1111/nan.12780

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2

Propionic Acid Rescues High-Fat Diet Enhanced Immunopathology in Autoimmunity via Effects on Th17 Responses

المؤلفون: Linker, Ralf A., Haase, Stefanie, Mäurer, Jonas, Duscha, Alexander, Lee, De-Hyung, Balogh, Andras, Gold, Ralf, Müller, Dominik N., Haghikia, Aiden

المصدر: Frontiers in Immunology
Frontiers in immunology 12, 701626 (2021). doi:10.3389/fimmu.2021.701626

مصطلحات موضوعية: pharmacology [Propionates], Male, propionic acid, metabolism [Encephalomyelitis, Autoimmune, Experimental], 610 Medizin, Autoimmunity, multiple sclerosis, T-Lymphocytes, Regulatory, Mice, metabolism [Spleen], Immunology and Allergy, Original Research, metabolism [Inflammation], ddc:610, immunosuppression, EAE, metabolism [Multiple Sclerosis], high-fat diet, Spinal Cord, Cytokines, Female, Signal Transduction, drug effects [Autoimmunity], drug effects [Signal Transduction], metabolism [Spinal Cord], Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, drug effects [Spleen], Immunology, drug effects [Spinal Cord], Diet, High-Fat, Animals, Humans, drug therapy [Multiple Sclerosis], drug effects [T-Lymphocytes, Regulatory], Cell Proliferation, Inflammation, drug effects [Cell Proliferation], metabolism [T-Lymphocytes, Regulatory], metabolism [Cytokines], drug therapy [Inflammation], drug effects [Th17 Cells], Mice, Inbred C57BL, Cardiovascular and Metabolic Diseases, drug therapy [Encephalomyelitis, Autoimmune, Experimental], Th17 Cells, metabolism [Th17 Cells], Propionates, adverse effects [Diet, High-Fat], Spleen

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90fbddd7246d55093ed5a91778f609d
http://europepmc.org/articles/PMC8204048

3

Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation

المؤلفون: S Cantilena, Stefanie Meier, Darren Hargrave, David Michod, John Anderson, Jasper de Boer, Maria Victoria Niklison Chirou, Paolo Salomoni

المصدر: Cell Death & Disease
Cell death & disease 12(8), 785 (2021). doi:10.1038/s41419-021-04078-9
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)

مصطلحات موضوعية: Cancer Research, genetics [Glioma], metabolism [Myeloid-Lymphoid Leukemia Protein], metabolism [Histones], Transcription, Genetic, drug effects [Gene Expression Regulation, Neoplastic], metabolism [Glioma], Histones, drug effects [Methylation], Disulfiram, drug effects [Protein Processing, Post-Translational], Child, media_common, Drug Synergism, Glioma, metabolism [Lysine], Gene Expression Regulation, Neoplastic, Alcoholism, therapeutic use [Auranofin], metabolism [Histone-Lysine N-Methyltransferase], medicine.symptom, Stem cell, drug effects [Transcription, Genetic], Myeloid-Lymphoid Leukemia Protein, medicine.drug, Drug, media_common.quotation_subject, Immunology, Down-Regulation, Drug development, Methylation, Article, Cellular and Molecular Neuroscience, Downregulation and upregulation, ddc:570, Auranofin, Cell Line, Tumor, pharmacology [Disulfiram], drug therapy [Glioma], medicine, drug therapy [Alcoholism], Humans, Adverse effect, neoplasms, Cell Proliferation, drug effects [Cell Proliferation], QH573-671, business.industry, Lysine, drug effects [Proteolysis], Drug Repositioning, Cancer, Cell Biology, pharmacology [Auranofin], Histone-Lysine N-Methyltransferase, medicine.disease, CNS cancer, Mechanism of action, drug effects [Down-Regulation], Proteolysis, Cancer research, Neoplasm Grading, Cytology, business, therapeutic use [Disulfiram], genetics [Down-Regulation], Protein Processing, Post-Translational, pathology [Glioma]

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352d109b5f0dbec2fa754da507bbd703
https://pubmed.ncbi.nlm.nih.gov/34381018

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4

Small organic molecules accelerate the expansion of regulatory T cells

المؤلفون: Xiaoming Zhang, Shafiullah Khan, Muhammad Waqar Hameed, Saifullah Afridi, Abdul Wajid Khalil, Musarrat Adnan, Jamshed Iqbal, M. A. Shahid, Daniel C. Hoessli, Zhiyuan Wu, Zafar Iqbal

المصدر: Bioorganic chemistry 111, 104908-(2021). doi:10.1016/j.bioorg.2021.104908

مصطلحات موضوعية: chemistry [Phenols], pharmacology [Small Molecule Libraries], 01 natural sciences, Biochemistry, T-Lymphocytes, Regulatory, chemistry.chemical_compound, Mice, pharmacology [Alkaloids], chemistry [Alkaloids], Drug Discovery, Receptor, Cytotoxicity, Mice, Inbred BALB C, Molecular Structure, Chemistry, Small molecules, FOXP3, hemic and immune systems, Regulatory T cells, Small molecule, Cell biology, Molecular Docking Simulation, ddc:540, T(reg) cells proliferators, chemistry [Small Molecule Libraries], FOXP3(+), chemical and pharmacologic phenomena, Small Molecule Libraries, Structure-Activity Relationship, Alkaloids, Phenols, Animals, Humans, Propidium iodide, drug effects [T-Lymphocytes, Regulatory], Molecular Biology, PI3K/AKT/mTOR pathway, Cell Proliferation, T(reg) cells receptors, drug effects [Cell Proliferation], Dose-Response Relationship, Drug, pharmacology [Phenols], 010405 organic chemistry, Organic Chemistry, T-cell receptor, In vitro, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, NIH 3T3 Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac5b1c329494176c9b4d583a1757389
https://pub.dzne.de/record/155992

5

Apple Peel and Flesh Contain Pro-neurogenic Compounds

المؤلفون: Jutta Ludwig-Müller, Tara L. Walker, Zeina Nicola, Merve Bulut, Gerd Kempermann, Alex M. Sykes, Leonardo Ortiz-López, Rupert W. Overall, Muhammad Ichwan, Vijay S. Adusumilli, Gerardo Ramírez-Rodríguez, Christoph Böttcher, Norbert Hubner, Enrique A. Lugo-Hernández

المصدر: Stem cell reports 16(3), 548-565 (2021). doi:10.1016/j.stemcr.2021.01.005
Stem Cell Reports

مصطلحات موضوعية: 0301 basic medicine, Male, Neural precursor cell proliferation, drug effects [Cell Cycle], pharmacology [Quercetin], drug effects [Hippocampus], hippocampus, metabolism [Receptors, G-Protein-Coupled], Apple peel, drug effects [Neurogenesis], Hippocampal formation, Biochemistry, Antioxidants, Receptors, G-Protein-Coupled, quercetin, chemistry.chemical_compound, Mice, 0302 clinical medicine, Hydroxybenzoates, chemistry [Fruit], dentate gyrus, pharmacology [Resorcinols], drug effects [Cell Differentiation], Cell Cycle, Neurogenesis, Cell Differentiation, pharmacology [Flavonoids], Cell biology, adult neurogenesis, Malus, metabolism [Proto-Oncogene Proteins c-akt], Female, chemistry [Malus], Quercetin, Signal Transduction, Cell Survival, drug effects [Cell Survival], Biology, pharmacology [Hydroxybenzoates], Article, 03 medical and health sciences, Precursor cell, Genetics, pharmacology [Antioxidants], Animals, ddc:610, mouse, Cell Proliferation, Flavonoids, drug effects [Cell Proliferation], Dentate gyrus, Flesh, fungi, Resorcinols, Cell Biology, Mice, Inbred C57BL, 030104 developmental biology, chemistry, Cardiovascular and Metabolic Diseases, Fruit, Proto-Oncogene Proteins c-akt, 3,5-dihydroxybenzoic acid, 030217 neurology & neurosurgery, neural precursor cells, Developmental Biology

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e15b0ea64c8d6286e334014b640ae6b
https://pub.dzne.de/record/157719

6

Norepinephrine is a negative regulator of the adult periventricular neural stem cell niche

المؤلفون: Mareike Fauser, Moritz D. Brandt, Christoph Redecker, Manfred Gerlach, Julia Müller, Grit Weselek, Silke Keiner, Alexander Storch, Barbara Kaltschmidt, Andreas Hermann, Lisa Wagenführ

المصدر: Stem cells 38(9), 1188–1201 (2020). doi:10.1002/stem.3232

مصطلحات موضوعية: drug effects [Signal Transduction], metabolism [Receptors, Adrenergic, beta], drug effects [Neural Stem Cells], Neurogenesis, Subventricular zone, Hippocampus, drug effects [Neurogenesis], Biology, Midbrain, cytology [Olfactory Bulb], Lateral ventricles, Norepinephrine, Neurochemical, Neural Stem Cells, Mesencephalon, Lateral Ventricles, Receptors, Adrenergic, beta, medicine, otorhinolaryngologic diseases, Animals, ddc:610, cytology [Neural Stem Cells], Stem Cell Niche, Cell Proliferation, cytology [Mesencephalon], drug effects [Cell Proliferation], Cell Biology, Olfactory Bulb, Neural stem cell, Cell biology, Mice, Inbred C57BL, stomatognathic diseases, medicine.anatomical_structure, Phenotype, nervous system, Hypothalamus, cytology [Hippocampus], pharmacology [Norepinephrine], Molecular Medicine, cytology [Lateral Ventricles], Signal Transduction, Developmental Biology

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43bdb3622839b7f3f271c955a5ab8d94
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/21825

7

Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways

المؤلفون: Sai-Yang Zhang, Yu-Hui Hou, Ping Li, Ying-Chao Liu, Cheng-Yun Jin, Ruo-Han Zhao, Hong-Min Liu, Xiaolin Zi, Ruo-Wang Mao, Dong-Jun Fu, Jia-Jia Yang, Jian Song, Yan-Bing Zhang, Zhang Li, Jia-Huan Li

المصدر: Fu, Dong-Jun; Zhang, Li; Song, Jian; Mao, Ruo-Wang; Zhao, Ruo-Han; Liu, Ying-Chao; et al.(2017). Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways.. European journal of medicinal chemistry, 127, 87-99. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/2jw7m037

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, chemical synthesis, chemistry, pharmacology [Antineoplastic Agents], MAP Kinase Signaling System, drug effects [G1 Phase Cell Cycle Checkpoints], Thio, Antineoplastic Agents, Apoptosis, Chemistry Techniques, Synthetic, drug effects [Apoptosis], 01 natural sciences, Article, drug effects [MAP Kinase Signaling System], Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Cell Movement, Thiocarbamates, Cell Line, Tumor, Drug Discovery, Medicine and Health Sciences, Humans, Structure–activity relationship, Formononetin, Wnt Signaling Pathway, drug effects [Cell Movement], Cell Proliferation, Pharmacology, drug effects [Cell Proliferation], Dose-Response Relationship, Drug, 010405 organic chemistry, Chemistry, Cell growth, Organic Chemistry, Wnt signaling pathway, Drug Synergism, drug effects [Wnt Signaling Pathway], General Medicine, Cell cycle, G1 Phase Cell Cycle Checkpoints, Isoflavones, pharmacology [Isoflavones], 0104 chemical sciences, 030104 developmental biology, Biochemistry, Drug Design, Drug Screening Assays, Antitumor, chemistry [Thiocarbamates]

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c7cb2bc7ec5dbad4016e58ecc17c96
https://doi.org/10.1016/j.ejmech.2016.12.027

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8

Pharmacological treatment options for mast cell activation disease

المؤلفون: Lawrence B. Afrin, Britta Haenisch, Gerhard J. Molderings, Stefan Brettner, Franz Ludwig Dumoulin, Jürgen Homann, Jens Panse, Joseph H. Butterfield, Markus Menzen

المصدر: Naunyn-Schmiedeberg's Archives of Pharmacology
Naunyn-Schmiedeberg's archives of pharmacology 389(7), 671-694 (2016). doi:10.1007/s00210-016-1247-1

مصطلحات موضوعية: Apoptosis, Leukemia, Mast-Cell, Disease, Review, Systemic mast cell activation syndrome, Cell Degranulation, 0302 clinical medicine, Mutant protein, therapeutic use [Antineoplastic Agents], pathology [Mastocytosis, Systemic], Mast Cells, Molecular Targeted Therapy, Systemic mastocytosis, drug effects [Cell Degranulation], Kinase, pathology [Leukemia, Mast-Cell], General Medicine, therapeutic use [Histamine Antagonists], Mast cell, Leukemia, medicine.anatomical_structure, Treatment Outcome, 030220 oncology & carcinogenesis, drug effects [Mast Cells], immunology [Mast Cells], Immunosuppressive Agents, drug therapy [Leukemia, Mast-Cell], pathology [Mast Cells], Histamine Antagonists, Antineoplastic Agents, metabolism [Mast Cells], adverse effects [Antineoplastic Agents], 03 medical and health sciences, Antigen, Mastocytosis, Systemic, adverse effects [Histamine Antagonists], medicine, Animals, Humans, immunology [Mastocytosis, Systemic], ddc:610, Cell Proliferation, Pharmacology, drug effects [Cell Proliferation], business.industry, metabolism [Mastocytosis, Systemic], Mast cell activation disease, medicine.disease, therapeutic use [Immunosuppressive Agents], metabolism [Leukemia, Mast-Cell], immunology [Leukemia, Mast-Cell], Immunology, drug therapy [Mastocytosis, Systemic], Therapy, business, adverse effects [Immunosuppressive Agents], 030215 immunology