المؤلفون: Li N; Research Center for Differentiation and Development of TCM Basic Theory, Jiangxi Province Key Laboratory of TCM Etiopathogenesis, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, 330004, China. Electronic address: linanxin@jxutcm.edu.cn., Wang G; Department of Oncology, Affiliated Hospital of Jiangxi University of Chinese Medicine, No.445, Bayi Avenue, Nanchang, 330006, China. Electronic address: guojuan.wang@jxutcm.edu.cn., Guo M; Research Center for Differentiation and Development of TCM Basic Theory, Jiangxi Province Key Laboratory of TCM Etiopathogenesis, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, 330004, China. Electronic address: guomin1@jxutcm.edu.cn., Zhu N; Research Center for Differentiation and Development of TCM Basic Theory, Jiangxi Province Key Laboratory of TCM Etiopathogenesis, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, 330004, China. Electronic address: zhunaicheng@jxutcm.edu.cn., Yu W; Research Center for Differentiation and Development of TCM Basic Theory, Jiangxi Province Key Laboratory of TCM Etiopathogenesis, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, 330004, China. Electronic address: wenyan.yu@jxutcm.edu.cn.

المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Jul 30; Vol. 719, pp. 150046. Date of Electronic Publication: 2024 May 06.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms*/metabolism , Neoplasms*/pathology , Farnesyl-Diphosphate Farnesyltransferase*/metabolism , Farnesyl-Diphosphate Farnesyltransferase*/genetics, Humans ; Cholesterol/metabolism ; Animals ; Tumor Microenvironment

المؤلفون: Guan Z; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen9713 AV, The Netherlands., Song Y; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen9713 AV, The Netherlands.; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou510070, China., de Vries M; Interfaculty Mass Spectrometry Center, Groningen Research Institute of Pharmacy, University of Groningen, Groningen9713 AV, The Netherlands., Permentier H; Interfaculty Mass Spectrometry Center, Groningen Research Institute of Pharmacy, University of Groningen, Groningen9713 AV, The Netherlands., Tepper P; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen9713 AV, The Netherlands., van Merkerk R; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen9713 AV, The Netherlands., Setroikromo R; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen9713 AV, The Netherlands., Quax WJ; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen9713 AV, The Netherlands.

المصدر: Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Feb 14; Vol. 72 (6), pp. 3017-3024. Date of Electronic Publication: 2024 Feb 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

مواضيع طبية MeSH: Squalene*/*analogs & derivatives, Squalene*/metabolism , Farnesyl-Diphosphate Farnesyltransferase*/genetics , Farnesyl-Diphosphate Farnesyltransferase*/metabolism, Tandem Mass Spectrometry ; Terpenes/metabolism ; Nitric Oxide Synthase

المؤلفون: Avci D; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany; Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany. Electronic address: d.avci@uni-koeln.de., Heidasch R; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany., Costa M; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany; Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany., Lüchtenborg C; Biochemistry Center of Heidelberg University (BZH), Heidelberg, Germany., Kale D; Biochemistry Center of Heidelberg University (BZH), Heidelberg, Germany., Brügger B; Biochemistry Center of Heidelberg University (BZH), Heidelberg, Germany., Lemberg MK; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany; Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany. Electronic address: m.lemberg@uni-koeln.de.

المصدر: The Journal of biological chemistry [J Biol Chem] 2024 Feb; Vol. 300 (2), pp. 105644. Date of Electronic Publication: 2024 Jan 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Farnesyl-Diphosphate Farnesyltransferase*/genetics , Farnesyl-Diphosphate Farnesyltransferase*/metabolism , Mevalonic Acid*/metabolism, Aspartic Acid Endopeptidases ; Cholesterol/metabolism ; Terpenes ; HEK293 Cells ; Humans

المؤلفون: Kanmalar M; Department of Physics, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia., Kamal R; Department of Physics, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia., Abdul Sani SF; Department of Physics, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia. Electronic address: s.fairus@um.edu.my., Pathmanathan D; Department of Mathematic, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia., Bm Said NA; Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, University of Malaya, 50603, Kuala Lumpur, Malaysia., Paramanantham Y; School of Pharmacy, Monash University Malaysia, Selangor Darul Ehsan, 47500, Malaysia., Abd Jamil AH; Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, University of Malaya, 50603, Kuala Lumpur, Malaysia., Mun KS; Department of Pathology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia., Kuppusamy S; Department of Surgery, University of Malaya, 50603, Kuala Lumpur, Malaysia., Almugren KS; Department of Physics, College of Science, Princess Nourah bint Abdulrahman University, Saudi Arabia. Electronic address: ksalmogren@pnu.edu.sa., Almajid HF; Medicine College, Alfaisal University, Riyadh, Kingdom of Saudi Arabia., Bradley DA; Sunway University, Centre for Applied Physics and Radiation Technologies, Jalan Universiti, 46150, PJ, Malaysia; School of Mathematics and Physics, University of Surrey, Guildford, GU2 7XH, UK.

المصدر: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2024 Aug; Vol. 210, pp. 111372. Date of Electronic Publication: 2024 May 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 9306253 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9800 (Electronic) Linking ISSN: 09698043 NLM ISO Abbreviation: Appl Radiat Isot Subsets: MEDLINE

مواضيع طبية MeSH: Cisplatin*/pharmacology , Cisplatin*/therapeutic use , Drug Resistance, Neoplasm* , Spectrum Analysis, Raman*/methods , Urinary Bladder Neoplasms*/drug therapy , Urinary Bladder Neoplasms*/metabolism , Urinary Bladder Neoplasms*/pathology, Humans ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Farnesyltranstransferase/metabolism ; X-Ray Diffraction ; Farnesyl-Diphosphate Farnesyltransferase/metabolism

المؤلفون: Matralis AN; Department of Medicinal Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece; Bio-innovation Institute, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Athens, Greece. Electronic address: matralis@fleming.gr., Kaklamanis L; Onassis Cardiac Surgery Center, Department of Pathology, Athens, Greece., Perrea D; Laboratory of Experimental Surgery and Surgical Research 'N.S. Christeas', National and Kapodistrian University of Athens, Medical School, Athens, Greece., Kourounakis AP; Department of Medicinal Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece. Electronic address: angeliki@pharm.uoa.gr.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2023 Jul 15; Vol. 90, pp. 117378. Date of Electronic Publication: 2023 Jun 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Farnesyl-Diphosphate Farnesyltransferase* , Atherosclerosis*/drug therapy, Mice ; Animals ; Squalene ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Apolipoproteins E/genetics ; Mice, Transgenic ; Antioxidants/pharmacology ; Mice, Knockout

المؤلفون: Yamada R; Department of Chemical Engineering, Osaka Metropolitan University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka, 599-8531, Japan. ryamada@omu.ac.jp., Ando K; Department of Chemical Engineering, Osaka Metropolitan University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka, 599-8531, Japan., Sakaguchi R; Department of Chemical Engineering, Osaka Metropolitan University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka, 599-8531, Japan., Matsumoto T; Department of Chemical Engineering, Osaka Metropolitan University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka, 599-8531, Japan., Ogino H; Department of Chemical Engineering, Osaka Metropolitan University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka, 599-8531, Japan.

المصدر: World journal of microbiology & biotechnology [World J Microbiol Biotechnol] 2024 Jun 03; Vol. 40 (7), pp. 230. Date of Electronic Publication: 2024 Jun 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9012472 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-0972 (Electronic) Linking ISSN: 09593993 NLM ISO Abbreviation: World J Microbiol Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Saccharomyces cerevisiae*/genetics , Saccharomyces cerevisiae*/metabolism , beta Carotene*/biosynthesis , beta Carotene*/metabolism , Metabolic Engineering*/methods , Saccharomyces cerevisiae Proteins*/genetics , Saccharomyces cerevisiae Proteins*/metabolism, Mutation ; Gene Expression Regulation, Fungal ; Carotenoids/metabolism ; Mutagenesis ; Point Mutation ; Mevalonic Acid/metabolism ; Biosynthetic Pathways/genetics ; Farnesyl-Diphosphate Farnesyltransferase

المؤلفون: Haginoya N; Daiichi Sankyo RD Novare Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, 134-8630 Tokyo, Japan., Suzuki M; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, 140-8710 Tokyo, Japan., Suzuki M; Daiichi Sankyo RD Novare Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, 134-8630 Tokyo, Japan., Ishigai Y; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, 140-8710 Tokyo, Japan., Terayama K; Daiichi Sankyo RD Novare Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, 134-8630 Tokyo, Japan., Kanda A; Daiichi Sankyo RD Novare Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, 134-8630 Tokyo, Japan., Sugita K; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, 140-8710 Tokyo, Japan.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Apr 11; Vol. 67 (7), pp. 5305-5314. Date of Electronic Publication: 2024 Mar 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Anticholesteremic Agents*/chemistry, Cricetinae ; Animals ; Farnesyl-Diphosphate Farnesyltransferase ; Enzyme Inhibitors/chemistry ; Cholesterol ; Liver

المؤلفون: Park SC; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA., Steffan BN; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA., Yun Lim F; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Gupta R; Department of Chemistry, Northwestern University, Evanston, IL, USA., Ayaloglu Butun F; Department of Chemistry, Northwestern University, Evanston, IL, USA., Chen H; Intact Genomics Inc., St. Louis, MO, USA., Ye R; Intact Genomics Inc., St. Louis, MO, USA., Decker T; Intact Genomics Inc., St. Louis, MO, USA., Wu CC; Intact Genomics Inc., St. Louis, MO, USA., Kelleher NL; Department of Chemistry, Northwestern University, Evanston, IL, USA., Woo Bok J; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA., Keller NP; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.; Department of Plant Pathology, University of Wisconsin-Madison, Madison, WI, USA.

المصدر: Science advances [Sci Adv] 2024 Feb 23; Vol. 10 (8), pp. eadk7416. Date of Electronic Publication: 2024 Feb 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

مواضيع طبية MeSH: Aspergillus nidulans*/genetics , Aspergillus nidulans*/metabolism , Polyisoprenyl Phosphates* , Sesquiterpenes*, Farnesyl-Diphosphate Farnesyltransferase/genetics ; Farnesyl-Diphosphate Farnesyltransferase/metabolism ; Squalene ; Terpenes/metabolism

المؤلفون: Jiang H; Department of General Surgery, School of Medicine, Yangpu Hospital, Tongji University, Shanghai, China.; Institute of Gastrointestinal Surgery and Translational Medicine, School of Medicine, Tongji University, Shanghai, China., Tang E; Institute of Gastrointestinal Surgery and Translational Medicine, School of Medicine, Tongji University, Shanghai, China.; Center for Clinical Research and Translational Medicine, School of Medicine, Yangpu Hospital, Tongji University, Shanghai, China., Chen Y; Institute of Gastrointestinal Surgery and Translational Medicine, School of Medicine, Tongji University, Shanghai, China.; Center for Clinical Research and Translational Medicine, School of Medicine, Yangpu Hospital, Tongji University, Shanghai, China., Liu H; Department of General Surgery, School of Medicine, Yangpu Hospital, Tongji University, Shanghai, China.; Institute of Gastrointestinal Surgery and Translational Medicine, School of Medicine, Tongji University, Shanghai, China., Zhao Y; Hangzhou Institute for Advanced Study, School of Life Science, University of Chinese Academy of Sciences, Hangzhou, China.; The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Lin M; Department of General Surgery, School of Medicine, Yangpu Hospital, Tongji University, Shanghai, China.; Institute of Gastrointestinal Surgery and Translational Medicine, School of Medicine, Tongji University, Shanghai, China.; Center for Clinical Research and Translational Medicine, School of Medicine, Yangpu Hospital, Tongji University, Shanghai, China., He L; Institute of Gastrointestinal Surgery and Translational Medicine, School of Medicine, Tongji University, Shanghai, China.; Center for Clinical Research and Translational Medicine, School of Medicine, Yangpu Hospital, Tongji University, Shanghai, China.

المصدر: Cancer science [Cancer Sci] 2022 Mar; Vol. 113 (3), pp. 971-985. Date of Electronic Publication: 2022 Jan 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Publishing on behalf of the Japanese Cancer Association Country of Publication: England NLM ID: 101168776 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7006 (Electronic) Linking ISSN: 13479032 NLM ISO Abbreviation: Cancer Sci Subsets: MEDLINE

مواضيع طبية MeSH: Colonic Neoplasms/*enzymology , Farnesyl-Diphosphate Farnesyltransferase/*metabolism , Squalene Monooxygenase/*metabolism, Acetyltransferases/metabolism ; Aged ; Aged, 80 and over ; Animals ; Cell Line, Tumor ; Cell Proliferation ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; Farnesyl-Diphosphate Farnesyltransferase/deficiency ; Female ; Humans ; Male ; Mice ; Middle Aged ; Neoplasm Staging ; Pantetheine/analogs & derivatives ; Pantetheine/metabolism ; Prognosis ; Reactive Oxygen Species/metabolism ; Squalene Monooxygenase/deficiency ; Xenograft Model Antitumor Assays

المؤلفون: Vijayakumar K; Centre of Advanced Study in Marine Biology, Annamalai University, Parangipettai, Tamil Nadu, 608 502, India. Vijaybiotech92@gmail.com.; PAR Life Sciences and Research Private Limited, Woraiyur, Trichy, Tamil Nadu, 620003, India. Vijaybiotech92@gmail.com., Muhilvannan S; PAR Life Sciences and Research Private Limited, Woraiyur, Trichy, Tamil Nadu, 620003, India., Arun Vignesh M; PAR Life Sciences and Research Private Limited, Woraiyur, Trichy, Tamil Nadu, 620003, India.

المصدر: World journal of microbiology & biotechnology [World J Microbiol Biotechnol] 2022 Jan 22; Vol. 38 (3), pp. 44. Date of Electronic Publication: 2022 Jan 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9012472 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-0972 (Electronic) Linking ISSN: 09593993 NLM ISO Abbreviation: World J Microbiol Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Bacterial Proteins/*metabolism , Biofilms/*drug effects , Farnesyl-Diphosphate Farnesyltransferase/*metabolism , Hesperidin/*pharmacology , Methicillin-Resistant Staphylococcus aureus/*drug effects , Methicillin-Resistant Staphylococcus aureus/*physiology , Trans-Activators/*metabolism , Xanthophylls/*metabolism, Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/chemistry ; Farnesyl-Diphosphate Farnesyltransferase/chemistry ; Gene Expression Regulation, Bacterial ; Hesperidin/chemistry ; Humans ; Methicillin-Resistant Staphylococcus aureus/chemistry ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology ; Trans-Activators/chemistry ; Virulence/drug effects ; Virulence Factors/metabolism