المؤلفون: Han Han, Hiroki J. Nakaoka, Line Hofmann, Jeff Jiajing Zhou, Clinton Yu, Lisha Zeng, Junyu Nan, Gayoung Seo, Rebecca Elizabeth Vargas, Bing Yang, Ruxi Qi, Lee Bardwell, Dmitry A. Fishman, Ken W. Y. Cho, Lan Huang, Ray Luo, Rahul Warrior, Wenqi Wang

المصدر: Nat Cell Biol
Nature cell biology, vol 24, iss 1

مصطلحات موضوعية: Transcription, Genetic, physiology [Metabolic], genetics [Protein Serine-Threonine Kinases], Protein Serine-Threonine Kinases, genetics [Gene Expression Regulation], Stress, Inactivation, Article, Cell Line, genetics [Homeostasis], genetics [Tumor Suppressor Proteins], Stress, Physiological, Cell Line, Tumor, Homeostasis, Humans, metabolism [Transcription Factors], Hippo Signaling Pathway, Phosphorylation, metabolism [Cadmium], Tumor, genetics [Genetic], physiology [Physiological], Tumor Suppressor Proteins, toxicity, Cell Biology, metabolism [Zinc], DNA-Binding Proteins, Zinc, HEK293 Cells, Gene Expression Regulation, Inactivation, Metabolic, physiology [Hippo Signaling Pathway], metabolism [DNA-Binding Proteins], metabolism, Transcription, Cadmium, HeLa Cells, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc72fa5595c58c2af5bb74b636342fb0
https://europepmc.org/articles/PMC9022944/

المؤلفون: von Spreckelsen, Niklas, Waldt, Natalie, Poetschke, Rebecca, Kesseler, Christoph, Dohmen, Hildegard, Jiao, Hui-Ke, Nemeth, Attila, Schob, Stefan, Scherlach, Cordula, Sandalcioglu, Ibrahim Erol, Deckert, Martina, Angenstein, Frank, Krischek, Boris, Stavrinou, Pantelis, Timmer, Marco, Remke, Marc, Kirches, Elmar, Goldbrunner, Roland, Chiocca, E. Antonio, Huettelmaier, Stefan, Acker, Till, Mawrin, Christian

المصدر: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-11 (2020)
Acta Neuropathologica Communications 8(1), 41 (2020). doi:10.1186/s40478-020-00912-x
Acta Neuropathologica Communications

مصطلحات موضوعية: pharmacology [Protein Kinase Inhibitors], drug effects [Gene Expression Regulation, Neoplastic], analogs & derivatives [Sirolimus], genetics [Gene Expression Regulation, Neoplastic], lcsh:RC346-429, drug effects [Kruppel-Like Transcription Factors], Mice, Meningeal Neoplasms, Edema, RNA-Seq, Hypoxia, antagonists & inhibitors [Mechanistic Target of Rapamycin Complex 1], genetics [Meningeal Neoplasms], Reverse Transcriptase Polymerase Chain Reaction, genetics [Meningioma], KLF4, genetics [Tumor Hypoxia], Up-Regulation, Gene Expression Regulation, Neoplastic, K409Q, Meningioma, Signal Transduction, Kruppel-Like Transcription Factors, pharmacology [Sirolimus], Mice, Nude, Mechanistic Target of Rapamycin Complex 1, genetics [Hypoxia], Skull Base Neoplasms, Prolyl Hydroxylases, Kruppel-Like Factor 4, metabolism [Meningeal Neoplasms], Cell Line, Tumor, genetics [Hypoxia-Inducible Factor 1, alpha Subunit], otorhinolaryngologic diseases, Animals, Humans, HIF, ddc:610, neoplasms, Protein Kinase Inhibitors, lcsh:Neurology. Diseases of the nervous system, Cell Proliferation, Sirolimus, Research, metabolism [Hypoxia-Inducible Factor 1, alpha Subunit], genetics [Kruppel-Like Transcription Factors], Hypoxia-Inducible Factor 1, alpha Subunit, metabolism [Hypoxia], nervous system diseases, metabolism [Meningioma], Mutation, Tumor Hypoxia, drug effects [Hypoxia-Inducible Factor 1, alpha Subunit], Neoplasm Transplantation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::306ca425261f423e431772a1a39f2e78
http://link.springer.com/article/10.1186/s40478-020-00912-x

المؤلفون: Giovanni Morrone, Fabrizio Bianchi, Bruna Codispoti, Enrico De Smaele, Heather M. Bond, Valeria Lucchino, Pietro Zoppoli, Annamaria Aloisio, Valentina Melocchi, Stefania Scicchitano, Emanuela Chiarella, Ylenia Montalcini, Marco Giordano, Maria Mesuraca

المساهمون: Scicchitano, S., Giordano, M., Lucchino, V., Montalcini, Y., Chiarella, E., Aloisio, A., Codispoti, B., Zoppoli, P., Melocchi, V., Bianchi, F., De Smaele, E., Mesuraca, M., Morrone, G., Bond, H. M.

المصدر: Cell Death and Disease, Vol 10, Iss 10, Pp 1-16 (2019)
Cell Death & Disease
Cell death & disease 10(10), 715 (2019). doi:10.1038/s41419-019-1946-x

مصطلحات موضوعية: Cancer Research, Gli2, Gli1, antagonists & inhibitors [Zinc Finger Protein Gli2], metabolism [Cerebellar Neoplasms], genetics [Gene Expression Regulation], genetics [Hedgehog Proteins], metabolism [Zinc Finger Protein GLI1], Biochemistry, genetics [Histone Deacetylases], Mice, Databases, Genetic, antagonists & inhibitors [Zinc Finger Protein GLI1], Nuclear Protein, biology, Chemistry, lcsh:Cytology, Nuclear Proteins, genetics [Nuclear Proteins], genetics [Zinc Finger Protein Gli2], Hedgehog signaling pathway, Cell biology, Up-Regulation, DNA-Binding Proteins, genetics [Chromatin Assembly and Disassembly], ZNF521, medulloblastoma, Hedgehog, Multigene Family, metabolism [Hedgehog Proteins], metabolism [DNA-Binding Proteins], Hedgehog Protein, metabolism [Nuclear Proteins], Human, Protein Binding, Signal Transduction, Chromatin Immunoprecipitation, animal structures, DNA-Binding Protein, Immunology, genetics [DNA-Binding Proteins], Zinc Finger Protein Gli2, genetics [Signal Transduction], Zinc Finger Protein GLI1, Article, Histone Deacetylases, Cell Line, Cellular and Molecular Neuroscience, GLI1, Histone Deacetylase, ddc:570, metabolism [Medulloblastoma], GLI2, Transcription factors, Animals, Humans, genetics [Cerebellar Neoplasms], Hedgehog Proteins, lcsh:QH573-671, Cerebellar Neoplasms, Transcription factor, genetics [Zinc Finger Protein GLI1], metabolism [Histone Deacetylases], genetics [Medulloblastoma], Animal, Cerebellar Neoplasm, Gene Expression Profiling, agonists [Hedgehog Proteins], Promoter, Cell Biology, Chromatin Assembly and Disassembly, Mi-2/NuRD complex, Gene Expression Regulation, antagonists & inhibitors [Nuclear Proteins], biology.protein, Histone deacetylase, metabolism [Zinc Finger Protein Gli2], Medulloblastoma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20cd354fb1d1cac69c0b4dd53e2a6f3
http://link.springer.com/article/10.1038/s41419-019-1946-x

المؤلفون: Jakob von Engelhardt, Kenji Sakimura, Eric Jacobi, Michaela Kerstin Müller, Roberto Malinow

المصدر: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-20 (2018)
Acta Neuropathologica Communications
Acta Neuropathologica Communications 6(1), 110 (2018). doi:10.1186/s40478-018-0611-4

مصطلحات موضوعية: Male, 0301 basic medicine, Action Potentials, genetics [Alzheimer Disease], drug effects [Synapses], drug effects [Gene Expression Regulation], Hippocampal formation, genetics [Gene Expression Regulation], lcsh:RC346-429, genetics [Calcium-Calmodulin-Dependent Protein Kinase Type 2], Synapse, pathology [Alzheimer Disease], Amyloid beta-Protein Precursor, Mice, genetics [Excitatory Postsynaptic Potentials], 0302 clinical medicine, Conditional gene knockout, genetics [Amyloid beta-Peptides], cytology [Dentate Gyrus], Receptor, ultrastructure [Neurons], Neurons, biology, Chemistry, musculoskeletal, neural, and ocular physiology, genetics [Presenilin-1], physiology [Neurons], genetics [Amyloid beta-Protein Precursor], NMDA receptor, Female, Alzheimer’s disease, drug effects [Excitatory Postsynaptic Potentials], Amyloid beta, Dendritic Spines, Protein subunit, metabolism [Amyloid beta-Peptides], genetics [Mutation], Mice, Transgenic, genetics [Action Potentials], Receptors, N-Methyl-D-Aspartate, Pathology and Forensic Medicine, PSEN1 protein, human, 03 medical and health sciences, Cellular and Molecular Neuroscience, Alzheimer Disease, genetics [Receptors, N-Methyl-D-Aspartate], mental disorders, Presenilin-1, drug effects [Neurons], Animals, Humans, ddc:610, Excitatory Amino Acid Agents, metabolism [Receptors, N-Methyl-D-Aspartate], lcsh:Neurology. Diseases of the nervous system, Amyloid beta-Peptides, drug effects [Action Potentials], pharmacology [Excitatory Amino Acid Agents], Research, Dentate gyrus, metabolism [Calcium-Calmodulin-Dependent Protein Kinase Type 2], Excitatory Postsynaptic Potentials, Mice, Inbred C57BL, GluN2B, Disease Models, Animal, GluN2A, HEK293 Cells, 030104 developmental biology, Gene Expression Regulation, nervous system, Amyloid Beta, pharmacology [Amyloid beta-Peptides], Dentate Gyrus, Mutation, Synapses, biology.protein, chemistry [Amyloid beta-Peptides], Neurology (clinical), physiology [Synapses], pathology [Dendritic Spines], Calcium-Calmodulin-Dependent Protein Kinase Type 2, Neuroscience, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18abc6835f7da525a487705c26d9d75e
http://link.springer.com/article/10.1186/s40478-018-0611-4

المؤلفون: Paul Flicek, Raffaele Teperino, Lydia Teboul, Thomas Werner, Marie-France Champy, Christopher J. Lelliott, Graham R. Williams, Jacqueline K. White, Gregor Miller, Mary E. Dickinson, Ann M Flenniken, Radislav Sedlacek, Martin Hrabé de Angelis, John R. Seavitt, Peter I. Croucher, Maria del Mar Muniz Moreno, Sara Wells, Jan Rozman, Terrence F. Meehan, Kristian F Odfalk, Juan Gallegos, J. H. Duncan Bassett, Mohammed Selloum, John G. Logan, Sylvie Jacquot, Elena J. Ghirardello, Robert Braun, Frantisek Spoutil, Kevin C K Lloyd, Lore Becker, Stephen A. Murray, Jan Prochazka, Elif F. Acar, Taylor S Vales, Michelle Simon, Helmut Fuchs, Nadine Spielmann, Mark Griffiths, Piia Keskivali-Bond, Valerie Gailus-Durner, Tania Sorg, Christine Schütt, Jeremy Mason, Helen Parkinson, Karen L. Svenson, Abdel Ayadi, Anna L Swan, Jason D. Heaney, Colin McKerlie, Wolfgang Wurst, Ann-Marie Mallon, Heather Cater, Stefanie Leuchtenberger, Harald Grallert, Steve D.M. Brown, Stefan Brandmaier, Yann Herault, Philipp Mayer-Kuckuk, Corey L. Reynolds, Ala Moshiri, Robert Brommage, Derek D. Cissell, Lauryl M J Nutter, Connor Lally

المساهمون: MRC Harwell Institute [UK], German Research Center for Environmental Health - Helmholtz Center München (GmbH), German Center for Diabetes Research - Deutsches Zentrum für Diabetesforschung [Neuherberg] (DZD), Institute of Molecular Genetics of the Czech Academy of Sciences (IMG / CAS), Czech Academy of Sciences [Prague] (CAS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Helmholtz-Zentrum München (HZM), The Wellcome Trust Sanger Institute [Cambridge], University of Michigan [Ann Arbor], University of Michigan System, University of California [Davis] (UC Davis), University of California, Baylor College of Medicine (BCM), Baylor University, European Molecular Biology Laboratory [Hinxton], University of Toronto, University of Manitoba [Winnipeg], Lunenfeld-Tanenbaum Research Institute [Toronto, Canada], French National Infrastructure for Mouse Phenogenomics (PHENOMIN), The Jackson Laboratory [Bar Harbor] (JAX), European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Imperial College London, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Deutsches Zentrum für Neurodegenerative Erkrankungen [Ulm] (DZNE), German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich Cluster for systems neurology [Munich] (SyNergy), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM)-Ludwig-Maximilians-Universität München (LMU), Garvan Institute of Medical Research [Sydney, Australia], St. Vincent’s Clinical School [Sydney, Australia], UNSW Faculty of Medicine [Sydney], University of New South Wales [Sydney] (UNSW)-University of New South Wales [Sydney] (UNSW), Université de Nouvelle-Galles du Sud - UNSW [Sydney, Australia], Mundlos, Stefan, Wellcome Trust, Commission of the European Communities, European Commission, Herault, Yann, Helmholtz Zentrum München = German Research Center for Environmental Health, University of California (UC), Garvan Institute of medical research, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Technische Universität München [München] (TUM), Technische Universität München [München] (TUM)-Ludwig-Maximilians-Universität München (LMU), Swan, Anna L [0000-0003-1810-3756], Rozman, Jan [0000-0002-8035-8904], Del Mar Muñiz Moreno, Maria [0000-0002-2662-890X], Leuchtenberger, Stefanie [0000-0003-2475-0810], Brommage, Robert [0000-0002-9947-3822], Grallert, Harald [0000-0002-6876-9655], Werner, Thomas [0000-0003-0402-4539], Teperino, Raffaele [0000-0001-8815-1409], Becker, Lore [0000-0002-6890-4984], Miller, Gregor [0000-0002-4281-4905], Seavitt, John R [0000-0003-3209-3187], Cissell, Derek D [0000-0002-6450-422X], Acar, Elif F [0000-0003-2908-7691], Lelliott, Christopher J [0000-0001-8087-4530], Braun, Robert E [0000-0003-3856-9465], Cater, Heather [0000-0002-8696-6070], Flicek, Paul [0000-0002-3897-7955], Ghirardello, Elena J [0000-0002-1100-9217], Heaney, Jason D [0000-0001-8475-8828], Lally, Connor [0000-0002-3801-1966], Logan, John G [0000-0003-2801-700X], Mason, Jeremy [0000-0002-2796-5123], Nutter, Lauryl MJ [0000-0001-9619-146X], Odfalk, Kristian F [0000-0003-4152-4583], Prochazka, Jan [0000-0003-4675-8995], Selloum, Mohammed [0000-0003-4057-3519], Spoutil, Frantisek [0000-0002-7310-3487], Svenson, Karen L [0000-0002-7928-1911], Vales, Taylor S [0000-0001-9751-5681], Wells, Sara E [0000-0002-0572-0600], White, Jacqueline K [0000-0001-6268-2826], Sedlacek, Radislav [0000-0002-3352-392X], Wurst, Wolfgang [0000-0003-4422-7410], Lloyd, KC Kent [0000-0002-5318-4144], Williams, Graham R [0000-0002-8555-8219], Herault, Yann [0000-0001-7049-6900], Brown, Steve DM [0000-0002-0617-4824], Hrabe de Angelis, Martin [0000-0002-7898-2353], Apollo - University of Cambridge Repository

المصدر: PLoS Genetics
PLoS Genetics, Public Library of Science, 2020, 16 (12), pp.e1009190. ⟨10.1371/journal.pgen.1009190⟩
PLoS genetics, vol 16, iss 12
PLoS Genet. 16:e1009190 (2021)
PLoS Genetics 16(12), e1009190 (2020). doi:10.1371/journal.pgen.1009190
PLOS Genetics
PLoS Genetics, 2020, 16 (12), pp.e1009190. ⟨10.1371/journal.pgen.1009190⟩
PLoS Genetics, Vol 16, Iss 12, p e1009190 (2020)

مصطلحات موضوعية: Male, Osteoporosis, genetics [Gene Expression Regulation], Transgenic, Transcriptome, Mice, 0302 clinical medicine, Animal Cells, Aetiology, Musculoskeletal System, Connective Tissue Cells, Genetics & Heredity, 0303 health sciences, Genomics, 3. Good health, Cellular Types, musculoskeletal diseases, Genotype, In silico, 1.1 Normal biological development and functioning, 03 medical and health sciences, genetics [Osteoporosis], Rheumatology, pathology [Osteoblasts], Genetic, Genome-Wide Association Studies, Genetics, GENOME-WIDE ASSOCIATION, Molecular Biology, Skeleton, Ecology, Evolution, Behavior and Systematics, METAANALYSIS, metabolism [Osteoblasts], 0604 Genetics, [SDV.GEN]Life Sciences [q-bio]/Genetics, Science & Technology, Osteoblasts, IDENTIFICATION, Biology and Life Sciences, Computational Biology, medicine.disease, COLLAGEN, Biological Tissue, OSTEOGENESIS IMPERFECTA, DISCOVERY, IMPC Consortium, Mutation, Animal Studies, Developmental Biology, Candidate gene, Cancer Research, Bone density, Gene Expression, Osteoclasts, [SDV.GEN] Life Sciences [q-bio]/Genetics, QH426-470, Bone remodeling, Bone Density, Medicine and Health Sciences, 2.1 Biological and endogenous factors, Protein Interaction Maps, Connective Tissue Diseases, Promoter Regions, Genetic, Genetics (clinical), Bone mineral, Sex Characteristics, genetics [Bone Density], metabolism [Osteoclasts], Genetic Pleiotropy, Animal Models, pathology [Osteoclasts], Phenotype, DIFFERENTIATION, Experimental Organism Systems, ANIMAL-MODELS, Connective Tissue, SEX, Female, Anatomy, Technology Platforms, Life Sciences & Biomedicine, Research Article, metabolism [Osteoporosis], Mouse Models, 030209 endocrinology & metabolism, Mice, Transgenic, Biology, Research and Analysis Methods, Promoter Regions, Model Organisms, Underpinning research, medicine, Animals, ddc:610, Bone, 030304 developmental biology, Human Genetics, Cell Biology, Genome Analysis, Gene Ontology, Gene Expression Regulation, Musculoskeletal, Genome-Wide Association Study

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd75524d05346ddd91358167446ef7f4

المؤلفون: Marijke P. Baltissen, Palma Rico Lastres, Valerie Gailus-Durner, Martin Hrabé de Angelis, Kayla Borland, Oana V. Amarie, Adrián Sanz-Moreno, Robert H. Schneider, Tobias H. Gustafsson, Sebastian Bultmann, Lillian Garrett, Lore Becker, Erik van de Logt, Magdalena Valenta, Helmut Fuchs, Steffen Kaiser, Oliver J. Rando, Markus J. Kraiger, Julia Calzada-Wack, Sabine M. Hölter, Wolfgang Wurst, Antonio Aguilar-Pimentel, Stefanie Kellner, Tanja Klein-Rodewald, Claudia Seisenberger, Pascal W.T.C. Jansen, Yi-Li Cho, Valentina V. Ignatova, Susan Marschall, Michiel Vermeulen, Paul Stolz

المصدر: Genes & Development, 34, 9-10, pp. 715-729
Genes & Development, 34, 715-729
Genes Dev. 34, 715-729 (2020)
Genes & development 34(9-10), 715-729 (2020). doi:10.1101/gad.333369.119

مصطلحات موضوعية: Methyltransferase, metabolism [Pluripotent Stem Cells], metabolism [RNA, Ribosomal, 18S], cytology [Mouse Embryonic Stem Cells], Biology, 18S ribosomal RNA, 03 medical and health sciences, Mice, 0302 clinical medicine, ddc:570, Genetics, Animals, genetics [Gene Expression Regulation, Developmental], 030304 developmental biology, genetics [Protein Biosynthesis], chemistry.chemical_classification, analogs & derivatives [Adenosine], 0303 health sciences, Messenger RNA, genetics [Cell Differentiation], cytology [Pluripotent Stem Cells], Proteomics and Chromatin Biology, RNA, Translation (biology), Ribosomal RNA, enzymology [Mouse Embryonic Stem Cells], Embryonic stem cell, Cell biology, Enzyme, chemistry, 030220 oncology & carcinogenesis, M6a, Pluripotency, metabolism [Adenosine], Mutation, Developmental Biology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ed29f70b50fee3d80942789e9882ce
https://hdl.handle.net/2066/219165

المؤلفون: Ivan Lazarevich, Maiya A. Rozhnova, Sergey V. Stasenko, Alexander Dityatev, Victor B. Kazantsev, Evgeniya V. Pankratova

المصدر: PLoS ONE
PLOS ONE 15(1), e0227917 (2020). doi:10.1371/journal.pone.0227917
PLoS ONE, Vol 15, Iss 1, p e0227917 (2020)

مصطلحات موضوعية: 0301 basic medicine, Physiology, Action Potentials, Neural Homeostasis, genetics [Neuronal Plasticity], genetics [Gene Expression Regulation], Biochemistry, Systems Science, Extracellular matrix, 0302 clinical medicine, Animal Cells, Medicine and Health Sciences, Premovement neuronal activity, metabolism [Nerve Net], Neurons, Multidisciplinary, Neuronal Plasticity, Chemistry, Brain, Proteases, Cell biology, Enzymes, Extracellular Matrix, genetics [Synapses], Electrophysiology, genetics [Neurogenesis], metabolism [Neurons], genetics [Receptors, Cell Surface], Physical Sciences, Excitatory postsynaptic potential, Medicine, Cellular Types, Cellular Structures and Organelles, Neural development, Research Article, Nervous System Physiology, genetics [Peptide Hydrolases], Computer and Information Sciences, Neural Networks, Science, Neurogenesis, Neurophysiology, Receptors, Cell Surface, genetics [Action Potentials], Inhibitory postsynaptic potential, Membrane Potential, 03 medical and health sciences, Extracellular, Animals, Humans, ddc:610, System Stability, Biology and Life Sciences, Proteins, Cell Biology, Models, Theoretical, 030104 developmental biology, Gene Expression Regulation, metabolism [Brain], extracellular matrix receptor, Cellular Neuroscience, Synaptic plasticity, Synapses, genetics [Extracellular Matrix], Enzymology, Nerve Net, 030217 neurology & neurosurgery, Mathematics, Neuroscience, Peptide Hydrolases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a361477749efae12290d15a1669ccb
http://europepmc.org/articles/PMC6980407

المؤلفون: Gregor Toporowski, Jan N. Hansen, Ramona Lundt, Anne-Caroline Schmöle, Annett Halle, Andreas Zimmer, Eva Beins

المصدر: Journal of Alzheimer's disease 64(2), 379-392 (2018). doi:10.3233/JAD-180230

مصطلحات موضوعية: 0301 basic medicine, genetics [Alzheimer Disease], Plaque, Amyloid, Disease, metabolism [Microglia], genetics [Gene Expression Regulation], Receptor, Cannabinoid, CB2, pathology [Alzheimer Disease], Amyloid beta-Protein Precursor, Mice, 0302 clinical medicine, Cannabinoid receptor type 2, Amyloid precursor protein, pathology [Neurons], Neurons, chemistry.chemical_classification, Microglia, General Neuroscience, Age Factors, pathology [Microglia], genetics [Presenilin-1], General Medicine, etiology [Plaque, Amyloid], deficiency [Receptor, Cannabinoid, CB2], metabolism [Endocannabinoids], Endocannabinoid system, Psychiatry and Mental health, Clinical Psychology, medicine.anatomical_structure, genetics [Amyloid beta-Protein Precursor], metabolism [Neurons], Cnr2 protein, mouse, lipids (amino acids, peptides, and proteins), Signal Transduction, Genetically modified mouse, medicine.medical_specialty, metabolism [Amyloid beta-Peptides], Mice, Transgenic, genetics [Receptor, Cannabinoid, CB2], Biology, physiopathology [Alzheimer Disease], 03 medical and health sciences, physiology [Maze Learning], Alzheimer Disease, Internal medicine, physiology [Signal Transduction], mental disorders, Presenilin-1, medicine, Animals, Humans, ddc:610, pathology [Plaque, Amyloid], Maze Learning, Neuroinflammation, Amyloid beta-Peptides, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Endocrinology, Enzyme, Gene Expression Regulation, chemistry, biology.protein, Geriatrics and Gerontology, 030217 neurology & neurosurgery, Endocannabinoids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b17966391d56e597750ac81f66d97246
https://doi.org/10.3233/jad-180230

المؤلفون: Giulia Soldà, Michela Deleidi, Stefano Goldwurm, Valeria Rimoldi, Rosanna Asselta, Maura Samarani, Massimo Aureli, Alessio Di Fonzo, Letizia Straniero, Rejko Krüger, Stefano Duga

المصدر: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific reports, 7(1), 12702. England (2017).
Scientific Reports
Scientific reports 7(1), 12702 (2017). doi:10.1038/s41598-017-12973-5

مصطلحات موضوعية: Male, 0301 basic medicine, Untranslated region, genetics [RNA Stability], lysosomal glucocerebrosidase, RNA Stability, Neurology [D14] [Human health sciences], lcsh:Medicine, genetics [Gene Expression Regulation], genetics [Glucosylceramidase], genetics [Parkinson Disease], Gene Regulatory Networks, genetics [MicroRNAs], genetics [RNA], lcsh:Science, Genetics, Multidisciplinary, genetics [Cell Differentiation], Cell Differentiation, Parkinson Disease, pathology [Induced Pluripotent Stem Cells], metabolism [Induced Pluripotent Stem Cells], Codon, Nonsense, genetics [Gene Regulatory Networks], RNA splicing, genetics [RNA Splicing], Glucosylceramidase, Female, Pseudogenes, Mutations, RNA Splicing, Pseudogene, Induced Pluripotent Stem Cells, MIRN22 microRNA, human, Biology, Article, 03 medical and health sciences, microRNA, Humans, Gene, genetics [Codon, Nonsense], genetics [Pseudogenes], Messenger RNA, Neurologie [D14] [Sciences de la santé humaine], GBA-Gene, Competing endogenous RNA, lcsh:R, pathology [Parkinson Disease], MicroRNAs, 030104 developmental biology, Gene Expression Regulation, RNA, lcsh:Q, ddc:600, Glucocerebrosidase, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b578116239757fa0851e0f9df3a6242
http://link.springer.com/article/10.1038/s41598-017-12973-5

المؤلفون: Orr Shormoni, Inga Zerr, Katrin Thüne, Eirini Kanata, Juan Carlos Espinosa, Franc Llorens, Matthias Schmitz, Olivier Andreoletti, Athanasios Dimitriadis, Vincenzo Capece, Nikolaos Bekas, Stefan Bonn, Dimitra Dafou, Alba Marín-Moreno, Juan María Torres, Isidre Ferrer, Konstantinos Xanthopoulos, Theodoros Sklaviadis

المساهمون: Aristotle University of Thessaloniki, Neurodegenerative Diseases Research Group, Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki-Aristotle University of Thessaloniki-School of Health Sciences, Aristotle University of Thessaloniki-Aristotle University of Thessaloniki, Institute of Health Carlos III, Network Center for Biomedical Research of Neurodegenerative Diseases, University Medical Center Göttingen (UMG), Department of Genetics, Development and Molecular Biology, School of Biology, Faculty of Sciences, German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Laboratory of Pharmacology, Department of Pharmaceutical Sciences, School of Health Sciences, Centro de Investigacion en Sanidad Animal (INIA-CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (INIA), Institute Developmental Biochemistry, Microarray and Deep-Sequencing Core Facility, University Medical Center Göttingen (UMG)-University Medical Center Göttingen (UMG), Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Department of Pathology and Experimental Therapeutics, Universitat de Barcelona (UB), This study was supported by the Research Funding program ARISTEIA II (Grant RNA edit 3739), cofinanced by the European Union (European Social Fund-ESF) and Greek national funds through the Operational Program 'Education and Lifelong Learning' of the National Strategic Reference Framework (to T.S.), the Alliance BioSecure Foundation project 'RNA editing in CJD' (T.S. and I.Z.), Federal Ministry of Education and Research grants within the German Network for Degenerative Dementia (to I.Z.), the Red Nacional de Priones AGL2015-71764-REDT-MINECO (to F.L., I.Z., J.M.T., and I.F.), the Spanish Ministry of Health-Instituto Carlos III/Fondo Social Europeo CP16/00041 (to F.L.), by the IKYDA Greek-German collaboration Project 57260006 (to F.L., I.Z., D.D., and T.S.), and in part by Grant AGL2016-78054-R (AEI/FEDER, UE).

المصدر: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (39), pp.19727-19735. ⟨10.1073/pnas.1803521116⟩
Proceedings of the National Academy of Sciences of the United States of America 116(39), 19727-19735 (2019). doi:10.1073/pnas.1803521116

مصطلحات موضوعية: RNA editing, genetics [Transcriptome], Disease, genetics [Gene Expression Regulation], Creutzfeldt-Jakob Syndrome, Transcriptome, Mice, [SPI]Engineering Sciences [physics], 0302 clinical medicine, Pathogen, 0303 health sciences, Multidisciplinary, Brain, genetics [Creutzfeldt-Jakob Syndrome], Biological Sciences, 3. Good health, medicine.anatomical_structure, PNAS Plus, Disease Progression, ER-stress, Neuropathogenesis, ddc:500, metabolism [Prion Diseases], Genotype, Prions, physiology [RNA Editing], RNA-sequencing, sporadic Creutzfeldt-Jakob disease, Context (language use), Biology, Prion Proteins, 03 medical and health sciences, Lysosome, genetics [Prion Diseases], medicine, Animals, Humans, 030304 developmental biology, Gene Expression Profiling, sporadic Creutzfeldt–Jakob disease, genetics [RNA Editing], prion diseases, Disease Models, Animal, Gene Expression Regulation, metabolism [Brain], Immunology, metabolism [Prions], Unfolded protein response, genetics [Prion Proteins], 030217 neurology & neurosurgery, methods [Gene Expression Profiling], Neuroscience

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https://hal.inrae.fr/hal-03199348/file/pnas-09-2019.pdf