المؤلفون: Cui L; Ganzhou Key Laboratory of Greenhouse Vegetables, College of Life Sciences, Gannan Normal University, Ganzhou, Jiangxi, 341000, China.; National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University, Wuhan, 430070, China., Zheng F; Ganzhou Key Laboratory of Greenhouse Vegetables, College of Life Sciences, Gannan Normal University, Ganzhou, Jiangxi, 341000, China.; National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University, Wuhan, 430070, China., Li C; National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University, Wuhan, 430070, China., Li G; National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University, Wuhan, 430070, China., Ye J; National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University, Wuhan, 430070, China., Zhang Y; National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University, Wuhan, 430070, China., Wang T; National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University, Wuhan, 430070, China., Hong Z; Department of Plant Sciences, University of Idaho, Moscow, ID 83844, USA., Ye Z; National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University, Wuhan, 430070, China., Zhang J; National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University, Wuhan, 430070, China.

المصدر: Journal of experimental botany [J Exp Bot] 2024 Jun 07; Vol. 75 (11), pp. 3322-3336.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 9882906 Publication Model: Print Cited Medium: Internet ISSN: 1460-2431 (Electronic) Linking ISSN: 00220957 NLM ISO Abbreviation: J Exp Bot Subsets: MEDLINE

مواضيع طبية MeSH: Solanum lycopersicum*/genetics , Fruit*/genetics , Fruit*/growth & development , Plant Proteins*/genetics , Plant Proteins*/metabolism , Geranylgeranyl-Diphosphate Geranylgeranyltransferase*/genetics , Geranylgeranyl-Diphosphate Geranylgeranyltransferase*/metabolism , Alkyl and Aryl Transferases*/genetics , Alkyl and Aryl Transferases*/metabolism, Mutation ; Plants, Genetically Modified/genetics ; Gene Expression Regulation, Plant ; Transcription Factors/genetics ; Transcription Factors/metabolism

المؤلفون: Kulakova AV; Institute of Bioengineering, Federal Research Center 'Fundamentals of Biotechnology,' Russian Academy of Sciences, 119071, Moscow, Russia. kulakova_97@mail.ru., Shchennikova AV; Institute of Bioengineering, Federal Research Center 'Fundamentals of Biotechnology,' Russian Academy of Sciences, 119071, Moscow, Russia., Kochieva EZ; Institute of Bioengineering, Federal Research Center 'Fundamentals of Biotechnology,' Russian Academy of Sciences, 119071, Moscow, Russia.

المصدر: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections [Dokl Biol Sci] 2024 Jun; Vol. 516 (1), pp. 21-26. Date of Electronic Publication: 2024 Mar 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Consultants Bureau Country of Publication: United States NLM ID: 7505459 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1608-3105 (Electronic) Linking ISSN: 00124966 NLM ISO Abbreviation: Dokl Biol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Solanum tuberosum*/genetics , Solanum tuberosum*/enzymology , Geranylgeranyl-Diphosphate Geranylgeranyltransferase*/genetics , Geranylgeranyl-Diphosphate Geranylgeranyltransferase*/metabolism , Gene Expression Regulation, Plant*, Cold Temperature ; Cold-Shock Response/genetics ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Phylogeny ; Stress, Physiological/genetics

المؤلفون: Li CL; School of Marine Science and Fisheries, Jiangsu Ocean University, Lianyungang 222005, China.; Jiangsu Marine Fisheries Research Institute, Nantong 226007, China., Pu JQ; Jiangsu Marine Fisheries Research Institute, Nantong 226007, China.; College of Marine Sciences, Shanghai Ocean University, Shanghai 201306, China., Zhou W; Jiangsu Marine Fisheries Research Institute, Nantong 226007, China., Hu CM; Jiangsu Marine Fisheries Research Institute, Nantong 226007, China., Deng YY; Jiangsu Marine Fisheries Research Institute, Nantong 226007, China., Sun YY; School of Marine Science and Fisheries, Jiangsu Ocean University, Lianyungang 222005, China., Yang LE; School of Marine Science and Fisheries, Jiangsu Ocean University, Lianyungang 222005, China.; Jiangsu Marine Fisheries Research Institute, Nantong 226007, China.; College of Marine Sciences, Shanghai Ocean University, Shanghai 201306, China.

المصدر: Marine drugs [Mar Drugs] 2024 May 31; Vol. 22 (6). Date of Electronic Publication: 2024 May 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE

مواضيع طبية MeSH: Rhodophyta*/genetics , Rhodophyta*/enzymology , Phylogeny* , Geranylgeranyl-Diphosphate Geranylgeranyltransferase*/genetics , Geranylgeranyl-Diphosphate Geranylgeranyltransferase*/metabolism, Carotenoids/metabolism ; Escherichia coli/genetics ; Cloning, Molecular ; Edible Seaweeds ; Porphyra

SCR Organism: Nori and laver red algae

المؤلفون: Rao S; Robert W. Holley Center for Agriculture and Health, USDA-ARS, Cornell University, Ithaca, NY 14853, USA.; Plant Breeding and Genetics Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA., Cao H; Robert W. Holley Center for Agriculture and Health, USDA-ARS, Cornell University, Ithaca, NY 14853, USA.; College of Horticulture, Hebei Agricultural University, Baoding, Hebei 071000, China., O'Hanna FJ; Robert W. Holley Center for Agriculture and Health, USDA-ARS, Cornell University, Ithaca, NY 14853, USA., Zhou X; Robert W. Holley Center for Agriculture and Health, USDA-ARS, Cornell University, Ithaca, NY 14853, USA.; Plant Breeding and Genetics Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA., Lui A; Robert W. Holley Center for Agriculture and Health, USDA-ARS, Cornell University, Ithaca, NY 14853, USA.; Plant Breeding and Genetics Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA., Wrightstone E; Robert W. Holley Center for Agriculture and Health, USDA-ARS, Cornell University, Ithaca, NY 14853, USA.; Plant Breeding and Genetics Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA., Fish T; Robert W. Holley Center for Agriculture and Health, USDA-ARS, Cornell University, Ithaca, NY 14853, USA., Yang Y; Robert W. Holley Center for Agriculture and Health, USDA-ARS, Cornell University, Ithaca, NY 14853, USA., Thannhauser T; Robert W. Holley Center for Agriculture and Health, USDA-ARS, Cornell University, Ithaca, NY 14853, USA., Cheng L; Horticulture Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA., Dudareva N; Department of Biochemistry, Purdue University, West Lafayette, IN 47907-2063, USA.; Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA.; Purdue Center for Plant Biology, Purdue University, West Lafayette, IN 47907, USA., Li L; Robert W. Holley Center for Agriculture and Health, USDA-ARS, Cornell University, Ithaca, NY 14853, USA.; Plant Breeding and Genetics Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA.

المصدر: The Plant cell [Plant Cell] 2024 May 01; Vol. 36 (5), pp. 1868-1891.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 9208688 Publication Model: Print Cited Medium: Internet ISSN: 1532-298X (Electronic) Linking ISSN: 10404651 NLM ISO Abbreviation: Plant Cell Subsets: MEDLINE

مواضيع طبية MeSH: Carotenoids*/metabolism , Arabidopsis*/genetics , Arabidopsis*/metabolism , Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics , Gene Expression Regulation, Plant*, Nudix Hydrolases ; Chloroplasts/metabolism ; Geranylgeranyl-Diphosphate Geranylgeranyltransferase/metabolism ; Geranylgeranyl-Diphosphate Geranylgeranyltransferase/genetics ; Farnesyltranstransferase/metabolism ; Farnesyltranstransferase/genetics ; Pyrophosphatases/metabolism ; Pyrophosphatases/genetics ; Protein Processing, Post-Translational ; Plants, Genetically Modified ; Plant Leaves/metabolism ; Plant Leaves/genetics

المؤلفون: Hou X; ARC Training Centre for Accelerated Future Crops Development, Research School of Biology, College of Science, The Australian National University, Canberra, ACT 2601, Australia., Alagoz Y; Hawkesbury Institute for the Environment, Western Sydney University, Locked Bag 1797, Penrith, NSW, 2751, Australia., Welsch R; Faculty of Biology II, University of Freiburg, D-79104 Freiburg, Germany., Mortimer MD; ARC Training Centre for Accelerated Future Crops Development, Research School of Biology, College of Science, The Australian National University, Canberra, ACT 2601, Australia., Pogson BJ; ARC Training Centre for Accelerated Future Crops Development, Research School of Biology, College of Science, The Australian National University, Canberra, ACT 2601, Australia., Cazzonelli CI; Hawkesbury Institute for the Environment, Western Sydney University, Locked Bag 1797, Penrith, NSW, 2751, Australia.

المصدر: Journal of experimental botany [J Exp Bot] 2024 Feb 12; Vol. 75 (4), pp. 1187-1204.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 9882906 Publication Model: Print Cited Medium: Internet ISSN: 1460-2431 (Electronic) Linking ISSN: 00220957 NLM ISO Abbreviation: J Exp Bot Subsets: MEDLINE

مواضيع طبية MeSH: Arabidopsis*/metabolism , Arabidopsis Proteins*/genetics , Arabidopsis Proteins*/metabolism, Geranylgeranyl-Diphosphate Geranylgeranyltransferase/genetics ; Carotenoids/metabolism ; Plastids/genetics ; Plastids/metabolism ; Chlorophyll/metabolism ; Basic-Leucine Zipper Transcription Factors/metabolism ; Basic Helix-Loop-Helix Transcription Factors/metabolism

المؤلفون: Ezquerro M; Institute for Plant Molecular and Cell Biology (IBMCP), CSIC-Universitat Politècnica de València, Valencia 46022, Spain.; Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Barcelona 08193, Spain., Burbano-Erazo E; Institute for Plant Molecular and Cell Biology (IBMCP), CSIC-Universitat Politècnica de València, Valencia 46022, Spain., Rodriguez-Concepcion M; Institute for Plant Molecular and Cell Biology (IBMCP), CSIC-Universitat Politècnica de València, Valencia 46022, Spain.

المصدر: Plant physiology [Plant Physiol] 2023 Oct 26; Vol. 193 (3), pp. 2021-2036.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society of Plant Biologists Country of Publication: United States NLM ID: 0401224 Publication Model: Print Cited Medium: Internet ISSN: 1532-2548 (Electronic) Linking ISSN: 00320889 NLM ISO Abbreviation: Plant Physiol Subsets: MEDLINE

مواضيع طبية MeSH: Abscisic Acid*/metabolism , Solanum lycopersicum*/genetics, Geranylgeranyl-Diphosphate Geranylgeranyltransferase/genetics ; Geranylgeranyl-Diphosphate Geranylgeranyltransferase/metabolism ; Carotenoids/metabolism ; Fruit/genetics ; Fruit/metabolism ; Protein Isoforms/metabolism ; Gene Expression Regulation, Plant

المؤلفون: Ezquerro M; Institute for Plant Molecular and Cell Biology (IBMCP), CSIC-Universitat Politècnica de València, Valencia, 46022, Spain.; Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Campus UAB Bellaterra, Barcelona, 08193, Spain., Li C; Plant Hormone Biology Group, Green Life Sciences Cluster, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, Amsterdam, 1098 XH, the Netherlands., Pérez-Pérez J; Institute for Plant Molecular and Cell Biology (IBMCP), CSIC-Universitat Politècnica de València, Valencia, 46022, Spain., Burbano-Erazo E; Institute for Plant Molecular and Cell Biology (IBMCP), CSIC-Universitat Politècnica de València, Valencia, 46022, Spain., Barja MV; Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Campus UAB Bellaterra, Barcelona, 08193, Spain., Wang Y; Plant Hormone Biology Group, Green Life Sciences Cluster, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, Amsterdam, 1098 XH, the Netherlands., Dong L; Plant Hormone Biology Group, Green Life Sciences Cluster, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, Amsterdam, 1098 XH, the Netherlands., Lisón P; Institute for Plant Molecular and Cell Biology (IBMCP), CSIC-Universitat Politècnica de València, Valencia, 46022, Spain., López-Gresa MP; Institute for Plant Molecular and Cell Biology (IBMCP), CSIC-Universitat Politècnica de València, Valencia, 46022, Spain., Bouwmeester HJ; Plant Hormone Biology Group, Green Life Sciences Cluster, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, Amsterdam, 1098 XH, the Netherlands., Rodríguez-Concepción M; Institute for Plant Molecular and Cell Biology (IBMCP), CSIC-Universitat Politècnica de València, Valencia, 46022, Spain.

المصدر: The New phytologist [New Phytol] 2023 Sep; Vol. 239 (6), pp. 2292-2306. Date of Electronic Publication: 2023 Jun 28.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley on behalf of New Phytologist Trust Country of Publication: England NLM ID: 9882884 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8137 (Electronic) Linking ISSN: 0028646X NLM ISO Abbreviation: New Phytol Subsets: MEDLINE

مواضيع طبية MeSH: Solanum lycopersicum*/genetics , Diterpenes*, Geranylgeranyl-Diphosphate Geranylgeranyltransferase/genetics ; Geranylgeranyl-Diphosphate Geranylgeranyltransferase/metabolism ; Farnesyltranstransferase ; Carotenoids/metabolism ; Protein Isoforms ; Plant Leaves/metabolism

المؤلفون: Lee HF; Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada., Lacbay CM; Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada., Boutin R; Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada., Matralis AN; Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada., Park J; Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada.; Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada., Waller DD; Department of Medicine, McGill University, Montreal, Quebec H3A 1A1, Canada.; Division of Hematology, McGill University Health Center, Montreal, Quebec H4A 3J1, Canada., Guan TL; Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada., Sebag M; Department of Medicine, McGill University, Montreal, Quebec H3A 1A1, Canada.; Division of Hematology, McGill University Health Center, Montreal, Quebec H4A 3J1, Canada., Tsantrizos YS; Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada.; Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Feb 10; Vol. 65 (3), pp. 2471-2496. Date of Electronic Publication: 2022 Jan 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*therapeutic use , Enzyme Inhibitors/*therapeutic use , Geranylgeranyl-Diphosphate Geranylgeranyltransferase/*antagonists & inhibitors , Multiple Myeloma/*drug therapy , Pyrimidines/*therapeutic use , Thiophenes/*therapeutic use, Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/toxicity ; Bone Marrow Cells/drug effects ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/toxicity ; Female ; Fungal Proteins/antagonists & inhibitors ; Fungal Proteins/metabolism ; Geranylgeranyl-Diphosphate Geranylgeranyltransferase/metabolism ; Humans ; Liver/drug effects ; Male ; Mice, Inbred C57BL ; Molecular Structure ; Protein Binding ; Pyrimidines/chemical synthesis ; Pyrimidines/metabolism ; Pyrimidines/toxicity ; Rats ; Saccharomyces cerevisiae/enzymology ; Structure-Activity Relationship ; Thiophenes/chemical synthesis ; Thiophenes/metabolism ; Thiophenes/toxicity ; Mice

المؤلفون: Liu S; Key Laboratory of Biology and Genetic Improvement of Horticulture Crops (Northeast Region), Ministry of Agriculture and Rural Affairs, Northeast Agricultural University, Harbin, 150030, China. shiliu@neau.edu.cn.; Horticulture and Landscape Architecture College, Northeast Agricultural University, Harbin, 150030, China. shiliu@neau.edu.cn., Gao Z; Key Laboratory of Biology and Genetic Improvement of Horticulture Crops (Northeast Region), Ministry of Agriculture and Rural Affairs, Northeast Agricultural University, Harbin, 150030, China.; Horticulture and Landscape Architecture College, Northeast Agricultural University, Harbin, 150030, China., Wang X; Key Laboratory of Biology and Genetic Improvement of Horticulture Crops (Northeast Region), Ministry of Agriculture and Rural Affairs, Northeast Agricultural University, Harbin, 150030, China. xz6206815@163.com.; Horticulture and Landscape Architecture College, Northeast Agricultural University, Harbin, 150030, China. xz6206815@163.com., Luan F; Key Laboratory of Biology and Genetic Improvement of Horticulture Crops (Northeast Region), Ministry of Agriculture and Rural Affairs, Northeast Agricultural University, Harbin, 150030, China.; Horticulture and Landscape Architecture College, Northeast Agricultural University, Harbin, 150030, China., Dai Z; Anhui Jianghuai Horticulture Technology Co., Ltd., Hefei, 230031, China., Yang Z; Anhui Jianghuai Horticulture Technology Co., Ltd., Hefei, 230031, China., Zhang Q; Horticulture Institute, Anhui Academy of Agricultural Science, Hefei, 230031, China.

المصدر: TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik [Theor Appl Genet] 2022 Jan; Vol. 135 (1), pp. 185-200. Date of Electronic Publication: 2021 Oct 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 0145600 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2242 (Electronic) Linking ISSN: 00405752 NLM ISO Abbreviation: Theor Appl Genet Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Variation*, Citrullus/*genetics , Geranylgeranyl-Diphosphate Geranylgeranyltransferase/*genetics , Pigmentation/*genetics, Citrullus/metabolism ; Gene Expression Regulation, Plant ; Genes, Plant ; Genes, Recessive ; Genetic Association Studies ; Genetic Linkage ; Genetic Markers ; Geranylgeranyl-Diphosphate Geranylgeranyltransferase/metabolism ; Inheritance Patterns ; Nucleotides ; Promoter Regions, Genetic ; RNA-Seq

المؤلفون: Boutin R; Department of Chemistry, McGill University, Montreal, Québec H3A 0B8, Canada., Lee HF; Department of Chemistry, McGill University, Montreal, Québec H3A 0B8, Canada., Guan TL; Department of Chemistry, McGill University, Montreal, Québec H3A 0B8, Canada.; Department of Biochemistry, McGill University, Montreal, Québec H3G 1Y6, Canada., Nguyen TT; Department of Medicine, McGill University, Montreal, Québec H3A 1A1, Canada., Huang XF; Department of Medicine, McGill University, Montreal, Québec H3A 1A1, Canada., Waller DD; Terry Fox Laboratory, BC Cancer Research Institute, Vancouver, British Columbia V5Z 1L3, Canada., Lu J; Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, New York 10032, United States., Christine Chio II; Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, New York 10032, United States.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York 10032, United States., Michel RP; Department of Pathology, McGill University, Montréal, Québec H3A 1A1, Canada., Sebag M; Department of Medicine, McGill University, Montreal, Québec H3A 1A1, Canada.; Division of Hematology, McGill University Health Center, Montreal, Québec H4A 3J1, Canada., Tsantrizos YS; Department of Chemistry, McGill University, Montreal, Québec H3A 0B8, Canada.; Department of Biochemistry, McGill University, Montreal, Québec H3G 1Y6, Canada.

المصدر: Journal of medicinal chemistry [J Med Chem] 2023 Dec 14; Vol. 66 (23), pp. 15776-15800. Date of Electronic Publication: 2023 Nov 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Multiple Myeloma* , Pancreatic Neoplasms*/pathology , Carcinoma, Pancreatic Ductal* , Colorectal Neoplasms*/drug therapy, Humans ; Mice ; Rats ; Animals ; Geranylgeranyl-Diphosphate Geranylgeranyltransferase ; Diphosphonates/pharmacology ; Diphosphonates/therapeutic use ; Apoptosis ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use ; Cell Line, Tumor ; Cell Proliferation ; Xenograft Model Antitumor Assays