المؤلفون: I. J. Frame, Myles H. Akabas, Yvett Sosa, Roman Deniskin

المصدر: International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 1, Pp 1-11 (2016)
International Journal for Parasitology: Drugs and Drug Resistance

مصطلحات موضوعية: WT, wild type, 0301 basic medicine, Purine, Single-nucleotide polymorphism (SNP), Adenosine, PvENT1, P. vivax ENT type 1, Plasmodium vivax, CQ, chloroquine, Protozoan Proteins, Pharmacology, Equilibrative nucleoside transporter 1, HTS, high throughput screen, PfENT1, P. falciparum ENT type 1, ACT, Artemisinin-based Combination Therapies, chemistry.chemical_compound, Drug Discovery, Pharmacology (medical), Nucleoside/nucleobase transport, Malaria, Falciparum, Hypoxanthine, 2. Zero hunger, Guanosine, biology, Dipyridamole, SNP, single nucleotide polymorphism, SDM, synthetic defined media, EC50, concentration causing 50% of maximal effect, 3. Good health, Parasite, Infectious Diseases, Biochemistry, IC50, concentration causing 50% inhibition, medicine.drug, Plasmodium falciparum, Drug development, Saccharomyces cerevisiae, Transporter, Polymorphism, Single Nucleotide, Article, WHO, World Health Organization, lcsh:Infectious and parasitic diseases, Equilibrative Nucleoside Transporter 1, Antimalarials, Inhibitory Concentration 50, 03 medical and health sciences, hENT1, human ENT type 1, NBMPR, 4-nitrobenzylthioinosine, parasitic diseases, Malaria, Vivax, medicine, Humans, lcsh:RC109-216, Inosine, Uridine, Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins, EV, empty vector, Equilibrative nucleoside transporter, biology.organism_classification, Malaria, Pyrimidines, 030104 developmental biology, chemistry, Purines, biology.protein, Parasitology, ENT, equilibrative nucleoside transporter, Nucleoside

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d369a70028fd3fb4d411b54bb547d0d
https://doi.org/10.1016/j.ijpddr.2015.11.003

المؤلفون: Deniskin R; Department of Physiology & Biophysics, Albert Einstein College of Medicine, Bronx, New York, USA., Frame IJ; Department of Physiology & Biophysics, Albert Einstein College of Medicine, Bronx, New York, USA., Sosa Y; Department of Physiology & Biophysics, Albert Einstein College of Medicine, Bronx, New York, USA., Akabas MH; Department of Physiology & Biophysics, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA. Electronic address: myles.akabas@einstein.yu.edu.

المصدر: International journal for parasitology. Drugs and drug resistance [Int J Parasitol Drugs Drug Resist] 2015 Nov 28; Vol. 6 (1), pp. 1-11. Date of Electronic Publication: 2015 Nov 28 (Print Publication: 2016).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101576715 Publication Model: eCollection Cited Medium: Internet ISSN: 2211-3207 (Electronic) Linking ISSN: 22113207 NLM ISO Abbreviation: Int J Parasitol Drugs Drug Resist Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, Antimalarials/*pharmacology , Equilibrative Nucleoside Transporter 1/*antagonists & inhibitors , Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins/*antagonists & inhibitors , Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins/*metabolism , Plasmodium falciparum/*drug effects , Plasmodium vivax/*drug effects , Protozoan Proteins/*antagonists & inhibitors , Protozoan Proteins/*metabolism, Adenosine/pharmacology ; Dipyridamole/pharmacology ; Equilibrative Nucleoside Transporter 1/genetics ; Guanosine/pharmacology ; Humans ; Inhibitory Concentration 50 ; Inosine/pharmacology ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/parasitology ; Malaria, Vivax/drug therapy ; Malaria, Vivax/parasitology ; Malaria, Vivax/prevention & control ; Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins/genetics ; Plasmodium falciparum/metabolism ; Plasmodium vivax/genetics ; Polymorphism, Single Nucleotide ; Protozoan Proteins/genetics ; Purines/metabolism ; Purines/pharmacology ; Pyrimidines/metabolism ; Saccharomyces cerevisiae/genetics ; Uridine/pharmacology