المؤلفون: Brian S. J. Blagg, Michael A. Serwetnyk

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1446-1468 (2021)

مصطلحات موضوعية: MD, middle domain, Review, SUMO, small ubiquitin-like modifier, TPR2A, tetratricopeptide-containing repeat 2A, chemistry.chemical_compound, 0302 clinical medicine, Immunophilins, polycyclic compounds, General Pharmacology, Toxicology and Pharmaceutics, Natural products, 0303 health sciences, biology, Small molecules, HIF-1α, hypoxia-inducing factor-1α, HSQC, heteronuclear single quantum coherence, Geldanamycin, Hsp90, CTD, C-terminal domain, Radicicol, Cell biology, 030220 oncology & carcinogenesis, HOP, Hsp70‒Hsp90 organizing protein, SAHA, suberoylanilide hydroxamic acid, Protein folding, ATP, adenosine triphosphate, Cdc37, cell division cycle 37, RM1-950, Protein–protein interaction, 03 medical and health sciences, TROSY, transverse relaxation-optimized spectroscopy, Heat shock protein, SAR, structure–activity relationship, NTD, N-terminal domain, Heat shock, 030304 developmental biology, Disruptors, TRAP1, Hsp75tumor necrosis factor receptor associated protein 1, Hsp90, 90-kD heat shock protein, Her-2, human epidermal growth factor receptor-2, Aha1, activator of Hsp90 ATPase homologue 1, HIP, Hsp70-interaction protein, hERG, human ether-à-go-go-related gene, PPI, protein−protein interaction, ADP, adenosine diphosphate, chemistry, Grp94, 94-kD glucose-regulated protein, biology.protein, Protein−protein interactions, Therapeutics. Pharmacology, Peptidomimetics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d551031a93c74226093f0f0844e22506
https://doi.org/10.1016/j.apsb.2020.11.015

المؤلفون: Wenfu Tan, Huaqian Ding, Xiaohua Liu, Chunyong Ding, Juan Wang, Yalei Li, Ao Zhang, Yu Zhang, Hongchun Liu, Wenjing Huang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 488-504 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: SAR, structure−activity relationship, Hedgehog signaling pathway, BRD4, p.o., per os, medicine.medical_treatment, WNT, wingless, PK, pharmacokinetic, Targeted therapy, BRD4, bromodomain-containing protein 4, 03 medical and health sciences, 0302 clinical medicine, medicine, General Pharmacology, Toxicology and Pharmaceutics, BET, bromo and extra C-terminal bromodomain proteins, Hedgehog, BCC, basal cell carcinoma, 030304 developmental biology, Medulloblastoma, 0303 health sciences, MB, medulloblastoma, TGI, tumor growth inhibition, Oncogene, SHH, Sonic hedgehog, Chemistry, lcsh:RM1-950, medicine.disease, HH, hedgehog, Bromodomain, lcsh:Therapeutics. Pharmacology, Drug resistance, 030220 oncology & carcinogenesis, PTCH, patched, Cancer research, Original Article, i.v., intravenous injection, Smoothened, HTRF, homogeneous time-resolved fluorescence, hERG, human ether-a-go-go-related gene, SMO, smoothened, GLI

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301cde2b3eb755a22e93dd5c8eb925b1
https://doi.org/10.1016/j.apsb.2020.07.007

المؤلفون: Ankur Gupta, Ashutosh Yadav, Sourabh Agstam, Praveen Kumar-M

المصدر: Indian Pacing and Electrophysiology Journal, Vol 21, Iss 1, Pp 36-43 (2021)
Indian Pacing and Electrophysiology Journal

مصطلحات موضوعية: medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, ECG, Electrocardiography, COVID-19, Coronavirus disease2019, Torsades de pointes, Subgroup analysis, 030204 cardiovascular system & hematology, Azithromycin, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, QT interval, Article, 03 medical and health sciences, 0302 clinical medicine, Aminoquinoline, Physiology (medical), Internal medicine, HCQ, Hydroxychloroquine, medicine, CQ, Chloroquine, 030212 general & internal medicine, TdP, Torsades de pointes, EAD, Early afterdepolarization, VT, Ventricular tachycardia, WHO, World Health organization, business.industry, SARS-CoV-2, SA, Sinoatrial, COVID-19, Hydroxychloroquine, Chloroquine, RR, Risk ratio, medicine.disease, RCT, Randomized control trial, Coronavirus, ICU, Intensive care unit, Regimen, HERG, human ether-a-go-go-related gene, lcsh:RC666-701, Meta-analysis, Relative risk, QTc prolongation, Cardiology and Cardiovascular Medicine, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb67cbd258e36c9417eda8c9a426b21a
http://www.sciencedirect.com/science/article/pii/S0972629220301169

المؤلفون: Vivek Y. Reddy, Anuradha Lala, Jonathan L. Halperin, Hillary A. Johnston-Cox, Gennaro Giustino, Sean Pinney, Jeffrey I. Mechanick, Valentin Fuster

المصدر: Journal of the American College of Cardiology

مصطلحات موضوعية: Disease, 030204 cardiovascular system & hematology, medicine.disease_cause, ADAM-17, a disintegrin and metalloproteinase domain 17, 0302 clinical medicine, CMR, cardiac magnetic resonance, myocardial injury, 030212 general & internal medicine, COVID-19, coronavirus disease 2019, Coronavirus, TNF, tumor necrosis factor, hERG, human ether-a-go-go related gene, Thrombosis, Cardiovascular Diseases, DVT, deep venous thrombosis, Ang, angiotensin, MI, myocardial infarction, CYP, cytochrome P450, medicine.symptom, STEMI, ST-segment elevation acute myocardial infarction, Coronavirus Infections, Cardiology and Cardiovascular Medicine, Pneumonia, Viral, Inflammation, Context (language use), CVD, cardiovascular disease, JACC Focus Seminar: Coronavirus Disease 2019 in 2020, arrhythmia, ACE2, angiotensin-converting enzyme 2, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, Endothelial activation, Betacoronavirus, 03 medical and health sciences, Immune system, medicine, Humans, SARS, severe acute respiratory syndrome, Pandemics, thrombosis, ARDS, acute respiratory distress syndrome, JACC Focus Seminar, SARS-CoV-2, business.industry, COVID-19, HCQ, hydroxychloroquine, medicine.disease, IL, interleukin, CI, confidence interval, OR, odds ratio, Immunology, RNA, ribonucleic acid, TMPRSS2, transmembrane serine protease 2, Cardiovascular Injury, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::894e3f800b9b7614f467ee277943fbe9
https://doi.org/10.1016/j.jacc.2020.08.059

المؤلفون: Jiang Wang, Hualiang Jiang, Hong Liu, Chenglin Wu, Zhao Jing, Wang Yiping, Junhua Tong, Xi Cong

المصدر: Acta Pharmaceutica Sinica B, Vol 9, Iss 6, Pp 1216-1230 (2019)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Tetrahydroprotoberberine derivatives, HFD, high-fat diet, POCl3, phosphoryl trichloride, Pharmacology, CHD, coronary heart disease, DiI-LDL, low-density lipoprotein, labeled with 1,1′-dioctadecyl-3,3,3′,3′-tetramethyl-indocarbocyanine perchlorate, PCSK9, t1/2, half-life, chemistry.chemical_compound, 0302 clinical medicine, Berberine, Hyperlipidemia, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, hERG, human ether-à-go-go related gene, LDLR, low-density lipoprotein receptor, 030220 oncology & carcinogenesis, Low-density lipoprotein, AUC, area under the plasma concentration−time curve, Kexin, lipids (amino acids, peptides, and proteins), MRT, mean residence time, CVDs, cardiovascular diseases, mAbs, monoclonal antibodies, Original article, PK, pharmacokinetic, 03 medical and health sciences, medicine, Cmax, maximum concentration, Low-density lipoprotein cholesterol, LDL-C, low-density lipoprotein-cholesterol, Low-density lipoprotein receptor, Total cholesterol, THPBs, tetrahydroprotoberberine derivatives, ADH, autosomal dominant hypercholesterolemia, 030304 developmental biology, Lipid-lowering, Hyperlipidemia hamster, lcsh:RM1-950, Proprotein convertase, medicine.disease, PCSK9 expression, TC, total cholesterol, lcsh:Therapeutics. Pharmacology, FDA, food and drug administration, chemistry, LDL receptor, BBR, berberine, PCSK9, proprotein convertase subtilisin/kexin type 9, CL, clearance, F, oral bioavailability, Lipoprotein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320ead47ecd96b8853bf0cb6e07e3c6f
https://doi.org/10.1016/j.apsb.2019.06.006

المؤلفون: Normi D. Gajjar, Tejas M. Dhameliya, Prinsa R. Nagar

المصدر: Journal of Molecular Structure

مصطلحات موضوعية: RdRp, NSPs, non-structural proteins, Molecular model, BBB, blood-brain barrier, In silico, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), LOAEL, oral rat chronic toxicity, Druggability, RNA-dependent RNA polymerase, SARS CoV-2, FDA, food and drugs administration, Computational biology, medicine.disease_cause, ssRNA, single stranded ribonucleic acid, Article, Analytical Chemistry, Autodock vina, Inorganic Chemistry, E, envelope protein, RdRp, RNA dependent RNA polymerase, BOILED, brain or intestinal estimated permeation method, medicine, HBD, hydrogen bond donor, Spectroscopy, Coronavirus, Virtual screening, MD simulations, ACE2, angiotensin converting enzyme 2, S, spike glycoprotein, Chemistry, Organic Chemistry, COVID-19, ADMET assay, ADMET, absorption, distribution, metabolism, excretion and toxicity, COVID-19, corona virus disease 2019, MD, molecular dynamics, N, nucleocapsid protein, UTR, untranslated region, HERG, human ether-a-go-go-related gene, M, membrane protein, HBA, hydrogen bond acceptor, Molecular docking, WHO, world health organization, pp1a/b, polyproteins, SARS CoV-2, severe acute respiratory syndrome 2

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abed05e0c722916ff1e29ed7cf4000e
https://pubmed.ncbi.nlm.nih.gov/34334813

المؤلفون: Meng Yan, Pan Fan, Yanhui Shi, Lifang Feng, Junnan Wang, Ge Zhan, Baoxin Li

المصدر: International Journal of Molecular Sciences, Vol 17, Iss 10, p 1648 (2016)

مصطلحات موضوعية: quinidine, quinine, hERG (human ether-a-go-go-related gene), stereoselectivity, pharmacological rescue, Biology (General), QH301-705.5, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1422-0067/17/10/1648; https://doaj.org/toc/1422-0067

URL الوصول: https://doaj.org/article/e1c902b858554061b78ae36cb9102a4e

المؤلفون: Stephanie M. Soohoo, Tinatin I. Brelidze, Purushottam B. Tiwari, Yuichiro J. Suzuki

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: ERG1 Potassium Channel, Mutant, hERG, HCN, hyperpolarization-activated cyclic nucleotide-gated, SPR, surface plasmon resonance, Protein Serine-Threonine Kinases, Biochemistry, Homology (biology), TEV, tobacco etch virus, Protein Domains, hERG, human ether-á-go-go-related gene, PAS domain, PAS, Per-Arnt-Sim, KCNH4, LQTS, long-QT syndrome, Humans, KCNH1, KCNH2, Surface plasmon resonance, Molecular Biology, chemistry.chemical_classification, biology, EAG, Cell Biology, Surface Plasmon Resonance, Ligand (biochemistry), KCNH, Potassium channel, Amino acid, Long QT Syndrome, CNBH, C-terminal cyclic nucleotide-binding homology, chemistry, Mutation, biology.protein, Biophysics, LQTS, Kv11.1 channels, Protein Binding, Research Article, ELK, potassium channel

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529b9a2ffbf79bd667b162aa48200da0
https://doi.org/10.1016/j.jbc.2021.101433

المؤلفون: Xiao-Feng Xiong, Yang Sun, Xue Ping Chen, Zhendong Song, Ziyang Xu, Yang Ge, Meijing Wang

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 13-29 (2021)

مصطلحات موضوعية: PDAC, pancreatic ductal adenocarcinoma, STAT, signal transducers and activators of transcription, RAS, rat sarcoma protein, Protein tyrosine phosphatase, Review, TIGIT, T-cell immunoglobulin and ITIM domain protein, SCC, squamous cell carcinoma, B-ALL, B-cell acute lymphoblastic leukemia, SCNA, somatic copy number change, 0302 clinical medicine, KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, Selectivity, CTLA-4, cytotoxic T lymphocyte-associated antigen-4, General Pharmacology, Toxicology and Pharmaceutics, Tyrosine, GAB2, Grb2-associated binding protein-2, PD-1/PDL-1, programmed cell death protein-1/programmed death ligand-1, AML, acute myeloid leukemia, 0303 health sciences, PTK, protein tyrosine kinase, Chemistry, SHP2, Src homology containing protein tyrosine phosphatase 2, TKIs, tyrosine kinase inhibitors, 030220 oncology & carcinogenesis, Tumor therapy, JAK, Janus kinase, BTLA, B and T lymphocyte attenuator, PTP, protein tyrosine phosphatase, RTKs, receptor tyrosine kinase inhibitors, Proto-oncogene tyrosine-protein kinase Src, Allosteric inhibitor, Phosphatase, Allosteric regulation, CSF-1, colony stimulating factor-1, Tumor targeted, 03 medical and health sciences, PI3K, phosphatidylinositol 3 kinase, TYROSINE PHOSPHATASE SHP2, SAR, structure–activity relationship, ERK1/2, extracelluar signal-regulated kinase 1/2, SBDD, structure-based drug design, GRB2, growth factor receptor-bound protein 2, PDX, patient-derived xenograft, 030304 developmental biology, FLT3, Fms-like tyrosine kinase-3, ALK, anaplastic lymphoma kinase, lcsh:RM1-950, Bioavailability, EGFR, epidermal growth factor receptor, CADD, computer aided drug design, lcsh:Therapeutics. Pharmacology, HGF/SF, hepatocyte growth factor/scatter factor, NLRP3, NLR family, pyrin domain containing protein 3, HER2, human epidermal growth factor receptor-2, Cancer research, SHP2, MAPK, mitogen-activated protein kinase, hERG, human ether-a-go-go-related gene

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377d61b2602a59fd7130cd6ded70715c
https://pubmed.ncbi.nlm.nih.gov/33532178

المؤلفون: Jin Zhai, Mary Jo Wildey, Elisa Passini, John Imredy, Frederick Sannajust, Kevin Fitzgerald, Anne Chain, Sebastian Polak, Christopher P. Regan, Pierre Morissette, Patrick Fanelli, Jeffrey Travis, Blanca Rodriguez

المصدر: Toxicology and Applied Pharmacology

مصطلحات موضوعية: 0301 basic medicine, ICH, The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use, TN, True Negative, PPV, Positive Predictive Value, Pharmacology, TdP, Torsade de Pointes, Toxicology, Membrane Potentials, 0302 clinical medicine, HTS, High Throughput Screening, QTcVdW, Van de Water's Heart Rate QT-corrected Interval, In Silico modeling, Medicine, Translational PKPD modeling, NCEs, New Chemical Entities, CTD90, Ca2+-Transient Duration at 90% repolarization, education.field_of_study, Anesthetized Cardiovascular Guinea Pig, HR, Heart Rate, PNV, Predictive Negative Value, Safety pharmacology, ECG, Electrocardiogram, FIH, First in Human, IKr, rapidly-activating delayed rectifier potassium current, AP, Action Potential, QTc, Heart Rate corrected QT Interval, PX, PatchXpress®, 030220 oncology & carcinogenesis, Electrophysiologic Techniques, Cardiac, FP, False Positive, LVP, Left Ventricular Pressure, Anti-Arrhythmia Agents, In silico, Population, Guinea Pigs, QT interval, Models, Biological, Article, Ventricular action potential, Cell Line, CVGP, Cardiovascular Anesthetized Guinea Pig, GP, Guinea Pig, 03 medical and health sciences, hERG, Human Ether-a-go-go Related Gene, Pharmacokinetics, In vivo, Animals, Humans, Computer Simulation, education, QT corrected interval, BP, Blood Pressure, business.industry, M5P, M5 trees automated pruning model, tPKPD, thranslational pharmacokinetic/pharmacodynamic, FLIPR, Fluorescent Imaging Plate Reader, Arrhythmias, Cardiac, ORd, O'Hara Rudy model, Electrophysiological Phenomena, 030104 developmental biology, HEK293 Cells, Models, Chemical, Pharmacodynamics, Torsade de Pointes, EMw, Electromechanical window, FN, False Negative, TP, True Positive, Calcium, Calcium Channels, LOO, Leave-One-Out, business, APD90, Action Potential Duration at 90% repolarization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291b9744f97d46ac0f6fd500ad2e1c0f
http://europepmc.org/articles/PMC7322544