المؤلفون: Lu Feng, Kai Zhang, Bo Liu, Tingting Jiang, Liang Ouyang, Guan Wang, Jiamei Li, Shiou Zhu, Junping Pei

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3015-3034 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Target, ONRs, orphan nuclear receptors, Parkinson's disease, Small-molecule compound, MPP+, 1-methyl-4-phenylpyridinium, Autolysosome, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, GBA, glucocerebrosidase β acid, Review, MPTP, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, Disease, mTORC1, mTOR, the mammalian target of rapamycin, PD, Parkinson's disease, 0302 clinical medicine, CL, clearance rate, DAT, dopamine transporter, HDAC6, histone deacetylase 6, PD therapy, A2A, adenosine 2A, MYCBP2, MYC-binding protein 2, TFEB, transcription factor EB, AUTAC, autophagy targeting chimera, General Pharmacology, Toxicology and Pharmaceutics, SAS, solvent accessible surface, 0303 health sciences, α-syn, α-synuclein, ALP, autophagy-lysosomal pathway, AADC, aromatic amino acid decarboxylase, DJ-1, Parkinson protein 7, PI3K, phosphatidylinositol 3-kinase, COMT, catechol-O-methyltransferase, LUHMES, lund human mesencephalic, LRRK2, CMA, chaperone-mediated autophagy, KI, knockin, 030220 oncology & carcinogenesis, LRS, leucyl-tRNA synthetase, BBB, blood−brain barrier, SN, substantia nigra, IMPase, inositol monophosphatase, IPPase, inositol polyphosphate 1-phosphatase, HSPA8, heat shock 70 kDa protein 8, MAO-B, monoamine oxidase B, PREP, prolyl oligopeptidase, Parkinson's disease (PD), DR, dopamine receptor, PDE4, phosphodiesterase 4, AMPK, 5ʹAMP-activated protein kinase, 5-HT2C, serotonin 2C, SNCA, α-synuclein gene, TSC2, tuberous sclerosis complex 2, RM1-950, LIMP-2, lysosomal integrated membrane protein-2, CNS, central nervous system, 5-HT2A, Serotonin 2A, ER, endoplasmic reticulum, ATG, autophagy related protein, 03 medical and health sciences, PLC, phospholipase C, ROS, reactive oxygen species, ERRα, estrogen-related receptor alpha, SAR, structure–activity relationship, ULK1, UNC-51-like kinase 1, medicine, Autophagy, NMDA, N-methyl-d-aspartic acid, mAChR, muscarinic acetylcholine receptor, GWAS, genome-wide association study, LAMP2A, lysosome-associated membrane protein 2 A, Lamp2a, type 2A lysosomal-associated membrane protein, 030304 developmental biology, Parkin, parkin RBR E3 ubiquitin−protein ligase, PINK1, PTEN-induced kinase 1, ATTEC, autophagosome-tethering compound, ATP13A2, ATPase cation transporting 13A2, business.industry, ULK1, medicine.disease, LC3, light chain 3, PI3P, phosphatidylinositol 3-phosphate, SYT11, synaptotagmin 11, AUC, the area under the curve, UPS, ubiquitin−proteasome system, TFEB, DA, dopamine, Therapeutics. Pharmacology, business, BAF, bafilomycinA1, HSC70, heat shock cognate 71 kDa protein, Neuroscience, 3-MA, 3-methyladenine, F, oral bioavailability, LRRK2, leucine-rich repeat sequence kinase 2

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12dab43aca56bfd6a912c2aa71297ff
http://www.sciencedirect.com/science/article/pii/S2211383521000642

المؤلفون: Andrew Dickson, Benjamin R. Stromberg, Christine Insinna, Matthew K. Summers, Yosup Rhee, Adrian E. Torres, Debjani Pal, Christopher J. Westlake, Mayank Singh, Amy C. Burrows

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: SCFβTRCP, SKP1–CUL1–F-box in complex with the β-transducing repeat–containing protein, DNA damage response, Biochemistry, Deubiquitinating enzyme, S Phase, Histones, Enzyme Stability, HDAC6, histone deacetylase 6, checkpoint control, deubiquitination, Ub, ubiquitin, βTRCP, β-transducing repeat–containing protein, biology, Chemistry, Cell cycle, Cell biology, USP37, DUB, deubiquitinating enzyme, ATR, ataxia telangiectasia and Rad3-related, MCF-7 Cells, cell cycle, PBST, PBS with Tween-20, Research Article, DNA Replication, CHK1, CHK1, checkpoint kinase 1, ubiquitination, APH, aphidicolin, DDR, DNA damage response, Genomic Instability, CHX, cycloheximide, APC/CCDH1, cyclosome in complex with the activator CDH1, GST, glutathione-S-transferase, Endopeptidases, Humans, CHEK1, APC/C, anaphase-promoting complex/Cyclosome, TBST, Tris-buffered saline with Tween-20, Molecular Biology, Mitosis, Cell growth, DNA replication, Cell Biology, SCF, SKP1–CUL1–F-box, HDAC6, HCT116 Cells, Checkpoint Kinase 1, biology.protein, BSA, bovine serum albumin, Ataxia telangiectasia and Rad3 related, HU, hydroxyurea, DNA Damage, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eedf7a343128548aa738f8cb79c88d9
http://europepmc.org/articles/PMC8487067

المؤلفون: Toshifumi Fukuda, Saho Kato, Shohei Okuda, Mariko Sato, Ryoko Inatome, Shigeru Yanagi, Shun Nagashima

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: CAMDI, coiled-coil protein associated with MRLC IIa and DISC1, Cdc20 Proteins, CAMDI-sh, shRNA against mouse Ccdc141 gene that encodes CAMDI, autism, Cell Cycle Proteins, Nerve Tissue Proteins, CDC20, migration, Biochemistry, APC/C, anaphase-promoting complex/cyclosome, Anaphase-Promoting Complex-Cyclosome, Dilation (metric space), Mice, Cell Movement, medicine, HDAC6, histone deacetylase 6, Animals, Humans, Molecular Biology, Cells, Cultured, Centrosome, Cerebral Cortex, Neurons, D-box, destruction box, E, embryonic day, neurodevelopment, Chemistry, Mental Disorders, Brain, Cell migration, Cell Biology, HDAC6, EGFP, enhanced green fluorescent protein, neuron, Cell biology, medicine.anatomical_structure, Gene Knockdown Techniques, Models, Animal, CAMDI, Cdc20, cell division cycle protein 20, Female, Neuron, Degron, Nucleus, Research Article, Cdc20–APC

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed46172359dc9ac7681697efc07a5e3
https://pubmed.ncbi.nlm.nih.gov/34298015

المؤلفون: Semir Vranic, Maha Al-Asmakh, Ishita Gupta, Ahmed H. Amarah, Muhammad Umar Sohail, Ala-Eddin Al Moustafa, Khaled E. Elzawawi

المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 1654-1660 (2021)

مصطلحات موضوعية: RAS, renin-angiotensin, ERK, extracellular signal-regulated kinases, TJP3, tight junction protein 3, ALCAM, activated leukocyte cell adhesion molecule, RR, relative risk, Review, medicine.disease_cause, Biochemistry, Lung Disease, 0302 clinical medicine, ACEIs, Angiotensin‐converting enzyme inhibitors, IFN, Interferons, Structural Biology, ARBs, angiotensin receptor blockers, Pandemic, HDAC6, histone deacetylase 6, Coronavirus, COVID-19, coronavirus disease 2019, 0303 health sciences, Smoking, Oral disease, Computer Science Applications, CTNNB1, catenin beta 1, 030220 oncology & carcinogenesis, Ang, angiotensin, JNK, c-Jun N-terminal kinase, HIV-1, human immunodeficiency virus 1, CLDN7, claudin 7, R0, R-nought, Biotechnology, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), MCN, mucin, Biophysics, MERS, middle-East respiratory syndrome, TMPRSS2, 03 medical and health sciences, ACE2, angiotensin-converting enzyme-2, Genetics, medicine, ADAM17, ADAM metallopeptidase domain 17, IR, Ionizing radiation, BatCoV, bat coronavirus, nAChR, α7 nicotinic acetylcholine receptor, Oral Disease, ARDS, acute respiratory distress syndrome, 030304 developmental biology, ComputingMethodologies_COMPUTERGRAPHICS, NO, nitric oxide, business.industry, IPF, Idiopathic pulmonary fibrosis, SARS-CoV-2, TMPRSS, transmembrane serine protease, COVID-19, medicine.disease, COPD, chronic obstructive pulmonary disease, SARS-CoV-2, severe acute respiratory syndrome coronavirus, Infectious disease (medical specialty), Lung disease, Immunology, Middle East respiratory syndrome, Cytokine storm, business, hrsACE2, human recombinant soluble ACE-2, TP248.13-248.65

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fce205d35bae79eb29d825fbfe8d236
https://pubmed.ncbi.nlm.nih.gov/33777332

المؤلفون: Yuan Li, Yang Shen, Xihua Wang, Baobiao Zhuo, Shixian Li, Rong Wang, Jiayong Li

المصدر: Journal of Bone Oncology
Journal of Bone Oncology, Vol 31, Iss, Pp 100403-(2021)

مصطلحات موضوعية: musculoskeletal diseases, CSCs, cancer stem cells, Short Communication, Notch signaling pathway, JNK, c-Jun N-terminal kinase (JNK, Diseases of the musculoskeletal system, NS, nucleostemin, Metastasis, bFGF, basic fibroblast growth factor, Nude mouse, Cancer stem cell, IL-24, Interleukin 24, HDAC6, histone deacetylase 6, Medicine, neoplasms, RC254-282, Notch signaling, Osteosarcoma, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT, biology, business.industry, IL-24, interleukin-24, fungi, Wnt signaling pathway, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, food and beverages, biology.organism_classification, medicine.disease, EGF, Epidermal Growth Factor, RC925-935, Oncology, Cancer cell, Cancer research, business, Wnt/β-catenin signaling

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c099090d80f9f8c1e72cfef3f20d2c8
https://doi.org/10.1016/j.jbo.2021.100403

المؤلفون: Hong-Min Ni, Wen-Xing Ding, Xiaojuan Chao

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 885-886 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: HFD, high-fat diet, S100A11, S100 calcium binding protein A11, Datasets as Topic, CIDEC, cell death-inducing DFFA-like effector c, Mice, RFP, red fluorescent protein, HFHC, high-fat and high-cholesterol diet, Non-alcoholic Fatty Liver Disease, LDL-c, low-density lipoprotein c, HDAC6, histone deacetylase 6, TBA, tubastatin A, Medicine, co-IP, co-immunoprecipitation, Original Research, TG, triglyceride, Forkhead Box Protein O1, Liver Diseases, FOXO1, S100 Proteins, Fatty liver, Gastroenterology, ATG7, autophagy related 7, mRNA, messenger RNA, Up-Regulation, Gene Expression Regulation, Neoplastic, HFLC, high-fat low-cholesterol, Editorial, Liver, LD, lipid droplets, CON, control, Ac-FOXO1, acetylated forkhead box O1, LC3-II, LC3-phosphatidylethanolamine conjugate, qPCR, quantitative polymerase chain reaction, SILAC, stable isotope labeling technology of amino acids in cell culture, Signal Transduction, SDS, sodium dodecyl sulfate, PBS, phosphate-buffered saline, Mice, Transgenic, Diet, High-Fat, FOXO1, forkhead box O1, CE, cholesterol ester, SIRT1, Sirtuin 1, Text mining, Cell Line, Tumor, NAFLD, Autophagy, Animals, Humans, lcsh:RC799-869, DGAT2, diacylglycerol O-acyltransferase 2, GRB2, growth factor receptor-bound protein 2, Hepatology, business.industry, Lipogenesis, Tupaiidae, OA, oleic acid, Lipid Metabolism, medicine.disease, WT, wild-type, Disease Models, Animal, MS, mass spectrometry, S100A11, CRISPR/Cas9, clustered regularly interspaced short palindromic repeats/cas9, Hepatocytes, Cancer research, lcsh:Diseases of the digestive system. Gastroenterology, NAFLD, nonalcoholic fatty liver disease, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1287515fb220d00a7c882d49e29bf5ca
http://www.sciencedirect.com/science/article/pii/S2352345X20301922

المؤلفون: Hyundong Cho, Dong Gyu Kim, Soo Young Choi, Gi Soo Youn, Jinseu Park

المصدر: Redox Biology, Vol 12, Iss, Pp 978-986 (2017)
REDOX BIOLOGY(12)
Redox Biology

مصطلحات موضوعية: 0301 basic medicine, Chemokine, Indoles, Clinical Biochemistry, Histone Deacetylase 6, Hydroxamic Acids, Biochemistry, Mice, Transactivation, chemistry.chemical_compound, 0302 clinical medicine, Nox2, NADPH oxidase enzyme 2, HDAC6, histone deacetylase 6, lcsh:QH301-705.5, chemistry.chemical_classification, Gene knockdown, lcsh:R5-920, NADPH oxidase, biology, virus diseases, ROS, 3. Good health, Gene Knockdown Techniques, NADPH Oxidase 2, tat Gene Products, Human Immunodeficiency Virus, Chemokines, lcsh:Medicine (General), Research Paper, CNS, central nervous system, Cell Line, Tat, transactivator of transcription, 03 medical and health sciences, ROS, reactive oxygen species, Animals, Humans, HIV-1 Tat, Inflammation, Reactive oxygen species, Organic Chemistry, HDAC6, Molecular biology, 030104 developmental biology, chemistry, lcsh:Biology (General), Astrocytes, Apocynin, HIV-1, biology.protein, P22phox, Reactive Oxygen Species, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8267f6a083589af069e639a42a879b70
http://www.sciencedirect.com/science/article/pii/S2213231717302975

المؤلفون: Maria Dominguez, Issidora S. Papassideri, Aimilia D. Sklirou, Marianna Ralli, Ioannis P. Trougakos, Alexios-Leandros Skaltsounis

المصدر: Redox Biology
Redox Biology, Vol 5, Iss, Pp 205-215 (2015)

مصطلحات موضوعية: Antioxidant responses, Sqstm1, sequestosome 1, Clinical Biochemistry, Cell, PDR, proteome damage responses, Chaperone, hdac6, histone deacetylase 6, Biochemistry, Antioxidants, Cell Movement, hsf1, heat shock transcription factor-1, lcsh:QH301-705.5, Cellular Senescence, lcsh:R5-920, BECN1, Keap1, Kelch-like ECH-associated protein 1, medicine.anatomical_structure, ctsd, cathepsin-D, HDFs, human diploid fibroblasts, Matrix Metalloproteinase 9, Nqo1, NAD(P)H dehydrogenase, quinone 1, Matrix Metalloproteinase 2, lcsh:Medicine (General), Oligopeptides, Nrf2, NF-E2-related factor 2, Research Paper, ALS, autophagy lysosome system, Senescence, Proteasome Endopeptidase Complex, Cell Survival, NF-E2-Related Factor 2, Human fibroblasts, Biology, Hexapeptide-11, Cell Line, ER, endoplasmic reticulum, ROS, reactive oxygen species, UPS, ubiquitin proteasome system, Extracellular, medicine, Autophagy, CLU, apolipoprotein J/Clusterin, Humans, Viability assay, ctsl, cathepsin-L, Txnrd1, thioredoxin reductase 1, hsp, heat shock protein, Proteasome, Organic Chemistry, PN, proteostasis network, Fibroblasts, KEAP1, Diploidy, Oxidative Stress, Proteostasis, lcsh:Biology (General), becn1, beclin-1, Molecular Chaperones

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21d891c4db690600e8c356f78ea8f22
https://pubmed.ncbi.nlm.nih.gov/25974626

المؤلفون: Zhuo B; Department of Surgery, Affiliated Xuzhou Children's Hospital of Xuzhou Medical University, 221002 Xuzhou, Jiangsu, China., Wang X; Department of Surgery, Affiliated Xuzhou Children's Hospital of Xuzhou Medical University, 221002 Xuzhou, Jiangsu, China., Shen Y; Department of Surgery, Affiliated Xuzhou Children's Hospital of Xuzhou Medical University, 221002 Xuzhou, Jiangsu, China., Li J; Department of Surgery, Affiliated Xuzhou Children's Hospital of Xuzhou Medical University, 221002 Xuzhou, Jiangsu, China., Li S; Department of Surgery, Affiliated Xuzhou Children's Hospital of Xuzhou Medical University, 221002 Xuzhou, Jiangsu, China., Li Y; Department of Surgery, Affiliated Xuzhou Children's Hospital of Xuzhou Medical University, 221002 Xuzhou, Jiangsu, China., Wang R; Department of Ultrasound, The Affiliated Hospital of Xuzhou Medical University, 221006 Xuzhou, Jiangsu, China.

المصدر: Journal of bone oncology [J Bone Oncol] 2021 Nov 03; Vol. 31, pp. 100403. Date of Electronic Publication: 2021 Nov 03 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101610292 Publication Model: eCollection Cited Medium: Print ISSN: 2212-1366 (Print) Linking ISSN: 22121366 NLM ISO Abbreviation: J Bone Oncol Subsets: PubMed not MEDLINE

المؤلفون: Zhang K; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China., Zhu S; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China., Li J; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China., Jiang T; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China., Feng L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China., Pei J; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China., Wang G; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.; Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, China., Ouyang L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China., Liu B; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.

المصدر: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Oct; Vol. 11 (10), pp. 3015-3034. Date of Electronic Publication: 2021 Feb 26.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101600560 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2211-3835 (Print) Linking ISSN: 22113835 NLM ISO Abbreviation: Acta Pharm Sin B Subsets: PubMed not MEDLINE