المؤلفون: Shand EL; Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Sweeney K; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA., Sundling KE; Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., McClean MN; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.; University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Brow DA; Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

المصدر: MBio [mBio] 2024 Aug 14; Vol. 15 (8), pp. e0102124. Date of Electronic Publication: 2024 Jun 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

مواضيع طبية MeSH: IMP Dehydrogenase*/metabolism , IMP Dehydrogenase*/genetics , Saccharomyces cerevisiae*/genetics , Saccharomyces cerevisiae*/metabolism , Saccharomyces cerevisiae*/growth & development , Guanosine Triphosphate*/metabolism , Gene Expression Regulation, Fungal*, Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Mycophenolic Acid/pharmacology

المؤلفون: Bulvas O; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic., Knejzlík Z; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic., Sýs J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic., Filimoněnko A; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic., Čížková M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic., Clarová K; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic., Rejman D; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic., Kouba T; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic. tomas.kouba@uochb.cas.cz., Pichová I; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic. iva.pichova@uochb.cas.cz.

المصدر: Nature communications [Nat Commun] 2024 Aug 06; Vol. 15 (1), pp. 6673. Date of Electronic Publication: 2024 Aug 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: IMP Dehydrogenase*/metabolism , IMP Dehydrogenase*/chemistry , IMP Dehydrogenase*/antagonists & inhibitors , Guanosine Triphosphate*/metabolism, Allosteric Regulation ; Cryoelectron Microscopy ; Catalytic Domain ; Models, Molecular ; Bacterial Proteins/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Guanosine Pentaphosphate/metabolism ; Inosine Monophosphate/metabolism ; Inosine Monophosphate/chemistry ; Protein Binding ; Adenosine Triphosphate/metabolism ; Mycobacterium smegmatis/enzymology ; Mycobacterium smegmatis/metabolism

المؤلفون: Li L; Department of Liver Surgery, Renji Hospital (Punan Branch), School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai, 200127, China., Wu Y; Department of Liver Surgery, Renji Hospital (Punan Branch), School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai, 200127, China., Huang HT; Department of Liver Surgery, Renji Hospital (Punan Branch), School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China., Yong JK; Department of Liver Surgery, Renji Hospital (Punan Branch), School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China., Lv Z; Department of Liver Surgery, Renji Hospital (Punan Branch), School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.; Clinical Research Unit, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China., Zhou Y; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai, 200127, China., Xiang X; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai, 200127, China., Zhao J; Department of Liver Surgery, Renji Hospital (Punan Branch), School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China., Xi Z; Department of Liver Surgery, Renji Hospital (Punan Branch), School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai, 200127, China., Feng H; Department of Liver Surgery, Renji Hospital (Punan Branch), School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. surgeonfeng@live.com.; Clinical Research Unit, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. surgeonfeng@live.com.; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai, 200127, China. surgeonfeng@live.com., Xia Q; Department of Liver Surgery, Renji Hospital (Punan Branch), School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. xiaqiang@medmail.com.cn.; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai, 200127, China. xiaqiang@medmail.com.cn.

المصدر: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2024 Aug 01; Vol. 150 (8), pp. 377. Date of Electronic Publication: 2024 Aug 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7902060 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1335 (Electronic) Linking ISSN: 01715216 NLM ISO Abbreviation: J Cancer Res Clin Oncol Subsets: MEDLINE

مواضيع طبية MeSH: Hepatoblastoma*/pathology , Hepatoblastoma*/drug therapy , Hepatoblastoma*/metabolism , Hepatoblastoma*/genetics , IMP Dehydrogenase*/metabolism , IMP Dehydrogenase*/genetics , IMP Dehydrogenase*/antagonists & inhibitors , Liver Neoplasms*/pathology , Liver Neoplasms*/drug therapy , Liver Neoplasms*/metabolism , Liver Neoplasms*/genetics , Cell Proliferation*/drug effects , Apoptosis*/drug effects , Cell Cycle Checkpoints*/drug effects, Humans ; Female ; Male ; Child, Preschool ; Doxorubicin/pharmacology ; Child ; Mice ; Animals ; Cell Line, Tumor ; Infant ; Prognosis ; Mice, Nude

المؤلفون: Bearne SL; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada.

المصدر: BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2024 Aug; Vol. 46 (8), pp. e2400063. Date of Electronic Publication: 2024 Jul 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 8510851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-1878 (Electronic) Linking ISSN: 02659247 NLM ISO Abbreviation: Bioessays Subsets: MEDLINE

مواضيع طبية MeSH: Carbon-Nitrogen Ligases*/metabolism , Carbon-Nitrogen Ligases*/genetics , IMP Dehydrogenase*/metabolism, Animals ; Humans ; Cytidine Triphosphate/metabolism ; Guanosine Triphosphate/metabolism

المؤلفون: Hu J; Hubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin, School of Life Sciences, Jianghan University, Wuhan, 430056, Hubei, China., Zheng S; Hubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin, School of Life Sciences, Jianghan University, Wuhan, 430056, Hubei, China., Hua M; Hubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin, School of Life Sciences, Jianghan University, Wuhan, 430056, Hubei, China., Ding M; Hubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin, School of Life Sciences, Jianghan University, Wuhan, 430056, Hubei, China., Hu Z; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Bio-medical Sciences, School of Medicine, Jianghan University, Wuhan, Hubei, 430056, China; Hubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin, School of Life Sciences, Jianghan University, Wuhan, 430056, Hubei, China. Electronic address: huzhangfenghzf@163.com., Jiang H; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Bio-medical Sciences, School of Medicine, Jianghan University, Wuhan, Hubei, 430056, China. Electronic address: jianghaochen@jhun.edu.cn.

المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Jul 05; Vol. 716, pp. 149998. Date of Electronic Publication: 2024 Apr 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

مواضيع طبية MeSH: Adipocytes*/metabolism , Adipogenesis*/genetics , Adipose Tissue, White*/metabolism , Diet, High-Fat* , Overnutrition*/metabolism , Overnutrition*/genetics , IMP Dehydrogenase*/genetics , IMP Dehydrogenase*/metabolism, Animals ; Male ; Mice ; Cell Proliferation ; Energy Metabolism/genetics ; Gene Deletion ; Mice, Inbred C57BL ; Mice, Knockout ; Stem Cells/metabolism ; Stem Cells/cytology ; Stem Cells/pathology

المؤلفون: Ruan X; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University International Cancer Institute, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, 100191, Beijing, China., Xiong Y; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University International Cancer Institute, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, 100191, Beijing, China., Li X; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University International Cancer Institute, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, 100191, Beijing, China. lixiaoman@bjmu.edu.cn., Yang E; Department of Medical Bioinformatics, Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, 100191, Beijing, China. yangence@pku.edu.cn., Wang J; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University International Cancer Institute, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, 100191, Beijing, China. wangjd@bjmu.edu.cn.; Department of Gastrointestinal Translational Research, Peking University Cancer Hospital, 100142, Beijing, China. wangjd@bjmu.edu.cn.

المصدر: Cancer gene therapy [Cancer Gene Ther] 2024 Jul; Vol. 31 (7), pp. 1081-1089. Date of Electronic Publication: 2024 Jun 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9432230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5500 (Electronic) Linking ISSN: 09291903 NLM ISO Abbreviation: Cancer Gene Ther Subsets: MEDLINE

مواضيع طبية MeSH: Glioma*/drug therapy , Glioma*/genetics , Glioma*/pathology , Glioma*/mortality , IMP Dehydrogenase*/genetics , IMP Dehydrogenase*/metabolism , Temozolomide*/therapeutic use , Temozolomide*/pharmacology, Humans ; Prognosis ; Brain Neoplasms/drug therapy ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Cell Line, Tumor ; DNA Damage/drug effects ; Female ; Male ; Guanosine Triphosphate/metabolism

المؤلفون: Dilip H; Department of Chemistry, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, Gujarat 382055, India., Thiruvenkatam V; Department of Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, Gujarat 382055, India., Kirubakaran S; Department of Chemistry, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, Gujarat 382055, India.

المصدر: ACS infectious diseases [ACS Infect Dis] 2024 Jun 14; Vol. 10 (6), pp. 2262-2275. Date of Electronic Publication: 2024 May 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Helicobacter pylori*/drug effects , Helicobacter pylori*/enzymology , Benzimidazoles*/pharmacology , Benzimidazoles*/chemistry , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Pyrazoles*/pharmacology , Pyrazoles*/chemistry , IMP Dehydrogenase*/antagonists & inhibitors , IMP Dehydrogenase*/metabolism , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry, Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/chemical synthesis ; Structure-Activity Relationship ; Humans ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Kinetics

المؤلفون: Nabi Afjadi M; Institute of Biochemistry and Biophysics, University of Tehran, P. O. Box 13145-1384, Tehran, Iran., Yazdanparast R; Institute of Biochemistry and Biophysics, University of Tehran, P. O. Box 13145-1384, Tehran, Iran. ryazdan@ut.ac.ir., Barzegari E; Institute of Biochemistry and Biophysics, University of Tehran, P. O. Box 13145-1384, Tehran, Iran.

المصدر: The protein journal [Protein J] 2024 Jun; Vol. 43 (3), pp. 592-602. Date of Electronic Publication: 2024 May 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 101212092 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8355 (Electronic) Linking ISSN: 15723887 NLM ISO Abbreviation: Protein J Subsets: MEDLINE

مواضيع طبية MeSH: IMP Dehydrogenase*/metabolism , IMP Dehydrogenase*/chemistry , IMP Dehydrogenase*/genetics, Animals ; Mice ; Isoenzymes/metabolism ; Isoenzymes/chemistry ; Isoenzymes/genetics ; DNA, Single-Stranded/metabolism ; DNA, Single-Stranded/chemistry ; DNA, Single-Stranded/genetics ; Retina/metabolism ; Retina/enzymology ; Protein Binding ; Humans

المؤلفون: Wang J; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guang-dong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.; Department of Ophthalmology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei, China., Wang Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guang-dong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China., Jiang Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guang-dong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China., Li S; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guang-dong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China., Jia X; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guang-dong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China., Xiao X; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guang-dong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China., Sun W; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guang-dong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China., Wang P; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guang-dong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China., Zhang Q; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guang-dong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.

المصدر: Current eye research [Curr Eye Res] 2024 Aug; Vol. 49 (8), pp. 853-861. Date of Electronic Publication: 2024 Apr 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8104312 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2202 (Electronic) Linking ISSN: 02713683 NLM ISO Abbreviation: Curr Eye Res Subsets: MEDLINE

مواضيع طبية MeSH: Retinitis Pigmentosa*/genetics , Retinitis Pigmentosa*/metabolism , Mutation, Missense* , Pedigree* , IMP Dehydrogenase*/genetics , Heterozygote*, Humans ; Female ; Male ; Adult ; Middle Aged ; Exome Sequencing ; DNA Mutational Analysis ; Genes, Dominant ; DNA/genetics ; Exons/genetics

المؤلفون: Xu C; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, Hubei, 430056, China. Electronic address: xucheng_2007@jhun.edu.cn., Wei Z; Hubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin, School of Life Sciences, Jianghan University, Wuhan, Hubei, 430056, China., Lv L; Hubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin, School of Life Sciences, Jianghan University, Wuhan, Hubei, 430056, China., Dong X; Hubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin, School of Life Sciences, Jianghan University, Wuhan, Hubei, 430056, China., Xia W; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, Hubei, 430056, China., Xing J; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, Hubei, 430056, China., Liu H; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, Hubei, 430056, China., Zhao X; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, Hubei, 430056, China., Liu Y; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, Hubei, 430056, China., Wang W; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, Hubei, 430056, China., Jiang H; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, Hubei, 430056, China., Gong Y; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, Hubei, 430056, China., Liu C; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China., Xu K; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China., Wang S; Department of Medicinal Chemistry, College of Pharmacy, Shenzhen Technology University, Shenzhen, Guangdong, 518118, China., Akimoto Y; Iskra Industry Co., Ltd., Tokyo, 103-0027, Japan., Hu Z; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, Hubei, 430056, China; Hubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin, School of Life Sciences, Jianghan University, Wuhan, Hubei, 430056, China; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Jianghan University, Wuhan, Hubei, 430056, China. Electronic address: huzhangfeng@jhun.edu.cn.

المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Oct 01; Vol. 727, pp. 150317. Date of Electronic Publication: 2024 Jun 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

مواضيع طبية MeSH: Ovariectomy* , Osteoporosis*/metabolism , Osteoporosis*/etiology , Osteoporosis*/genetics , Osteoporosis*/pathology , Osteoclasts*/metabolism , Osteoclasts*/pathology , Oxidative Phosphorylation* , Osteogenesis* , Mitochondria*/metabolism , Mitochondria*/pathology , IMP Dehydrogenase*/metabolism , IMP Dehydrogenase*/genetics , IMP Dehydrogenase*/deficiency, Animals ; Mice ; Female ; Mice, Knockout ; Mice, Inbred C57BL ; Cell Differentiation ; Bone Resorption/metabolism ; Bone Resorption/genetics ; Bone Resorption/pathology ; Bone Resorption/etiology