المؤلفون: Lanahan SM; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Yang L; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Jones KM; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Qi Z; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Cabrera EC; Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Cominsky LY; Immunology Graduate Group, Perelman School of Medicine, Philadelphia, PA, USA., Ramaswamy A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Barmada A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Gabernet G; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Uthaya Kumar DB; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Xu L; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Shan P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Wymann MP; Department of Biomedicine, University of Basel, Basel, Switzerland., Kleinstein SH; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA., Rao VK; Primary Immunodeficiency Clinic, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA., Mustillo P; Division of Allergy and Immunology, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA., Romberg N; Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, Philadelphia, PA, USA., Abraham RS; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA., Lucas CL; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. Carrie.Lucas@yale.edu.

المصدر: Nature immunology [Nat Immunol] 2024 Aug; Vol. 25 (8), pp. 1422-1431. Date of Electronic Publication: 2024 Jul 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Class Ib Phosphatidylinositol 3-Kinase*/metabolism , Class Ib Phosphatidylinositol 3-Kinase*/immunology , Cell Differentiation*/immunology , B-Lymphocytes*/immunology , B-Lymphocytes*/metabolism , Antibody Formation*/immunology, Animals ; Mice ; Humans ; Mice, Knockout ; Antibody-Producing Cells/immunology ; Lymphocyte Activation/immunology ; Mice, Inbred C57BL ; Signal Transduction/immunology ; Memory B Cells/immunology ; Memory B Cells/metabolism

المؤلفون: Chen CL; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA., Syahirah R; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Ravala SK; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA., Yen YC; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA., Klose T; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.; Purdue Cryo-EM Facility, Purdue University, West Lafayette, IN, USA., Deng Q; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Tesmer JJG; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA. jtesmer@purdue.edu.; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA. jtesmer@purdue.edu.

المصدر: Nature structural & molecular biology [Nat Struct Mol Biol] 2024 Aug; Vol. 31 (8), pp. 1198-1207. Date of Electronic Publication: 2024 Apr 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Class Ib Phosphatidylinositol 3-Kinase*/metabolism , Class Ib Phosphatidylinositol 3-Kinase*/chemistry , GTP-Binding Protein gamma Subunits*/metabolism , GTP-Binding Protein gamma Subunits*/chemistry , GTP-Binding Protein beta Subunits*/metabolism , GTP-Binding Protein beta Subunits*/chemistry , Cryoelectron Microscopy*, Animals ; Humans ; Binding Sites ; Zebrafish ; Protein Binding ; Neutrophils/metabolism ; Models, Molecular ; Enzyme Activation ; Protein Conformation ; Allosteric Regulation

المؤلفون: Xiong Y; Department of General & Vascular Surgery, Xiangya Hospital, Central South University, Changsha, China., Liu S; Department of General & Vascular Surgery, Xiangya Hospital, Central South University, Changsha, China., Liu Y; Department of General & Vascular Surgery, Xiangya Hospital, Central South University, Changsha, China., Zhao J; Department of General & Vascular Surgery, Xiangya Hospital, Central South University, Changsha, China., Sun J; Department of General & Vascular Surgery, Xiangya Hospital, Central South University, Changsha, China., Li Y; Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA., Pan B; Department of General & Vascular Surgery, Xiangya Hospital, Central South University, Changsha, China., Wang W; Department of General & Vascular Surgery, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

المصدر: JCI insight [JCI Insight] 2024 Jul 18; Vol. 9 (16). Date of Electronic Publication: 2024 Jul 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

مواضيع طبية MeSH: Aortic Aneurysm, Abdominal*/metabolism , Aortic Aneurysm, Abdominal*/pathology , Pyroptosis* , Class Ib Phosphatidylinositol 3-Kinase*/metabolism , Class Ib Phosphatidylinositol 3-Kinase*/genetics , Extracellular Traps*/metabolism , Neutrophils*/metabolism, Animals ; Mice ; Humans ; Male ; Signal Transduction ; Disease Models, Animal ; Mice, Knockout ; Mice, Inbred C57BL

المؤلفون: Yin X; Hebei University of Science & Technology, Shijiazhuang 050018, People's Republic of China.; Hebei Research Center of Pharmaceutical and Chemical Engineering, Shijiazhuang 050018, People's Republic of China., Wang J; Hebei University of Science & Technology, Shijiazhuang 050018, People's Republic of China.; Hebei Research Center of Pharmaceutical and Chemical Engineering, Shijiazhuang 050018, People's Republic of China., Ge M; Hebei University of Science & Technology, Shijiazhuang 050018, People's Republic of China.; Hebei Research Center of Pharmaceutical and Chemical Engineering, Shijiazhuang 050018, People's Republic of China., Feng X; Hebei University of Science & Technology, Shijiazhuang 050018, People's Republic of China., Zhang G; Hebei University of Science & Technology, Shijiazhuang 050018, People's Republic of China.; Hebei Research Center of Pharmaceutical and Chemical Engineering, Shijiazhuang 050018, People's Republic of China.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Jul 11; Vol. 67 (13), pp. 10530-10547. Date of Electronic Publication: 2024 Jun 19.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Class Ib Phosphatidylinositol 3-Kinase*/metabolism , Class Ib Phosphatidylinositol 3-Kinase*/chemistry , Drug Design* , Phosphoinositide-3 Kinase Inhibitors*/pharmacology , Phosphoinositide-3 Kinase Inhibitors*/chemistry , Phosphoinositide-3 Kinase Inhibitors*/chemical synthesis, Humans ; Structure-Activity Relationship ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Animals ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Molecular Structure

المؤلفون: Stonestrom AJ; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Levine RL; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. leviner@mskcc.org.

المصدر: Nature cancer [Nat Cancer] 2024 Jul; Vol. 5 (7), pp. 958-959.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Leukemia, Myeloid, Acute*/genetics , Class Ib Phosphatidylinositol 3-Kinase*/genetics , Class Ib Phosphatidylinositol 3-Kinase*/metabolism, Humans ; Phosphoinositide-3 Kinase Inhibitors/pharmacology ; Phosphoinositide-3 Kinase Inhibitors/therapeutic use ; Animals ; Protein Kinase Inhibitors/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/pharmacology

المؤلفون: Kelly LM; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France., Rutter JC; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Lin KH; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Ling F; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France., Duchmann M; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France., Latour E; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France., Arang N; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Pasquer H; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France., Ho Nhat D; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France., Charles J; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France., Killarney ST; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Ang HX; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Namor F; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France., Culeux C; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France., Lombard B; Curie Institute, Mass Spectrometry and Proteomics Facility, PSL Research University, Paris, France., Loew D; Curie Institute, Mass Spectrometry and Proteomics Facility, PSL Research University, Paris, France., Swaney DL; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Gladstone Institutes, San Francisco, California, USA., Krogan NJ; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Gladstone Institutes, San Francisco, California, USA., Brunel L; IBMM, University of Montpellier, CNRS, ENSCM, Montpellier, France., Carretero É; IBMM, University of Montpellier, CNRS, ENSCM, Montpellier, France., Verdié P; IBMM, University of Montpellier, CNRS, ENSCM, Montpellier, France., Amblard M; IBMM, University of Montpellier, CNRS, ENSCM, Montpellier, France., Fodil S; Department of Hematology and Immunology, Saint-Louis Hospital, AP-HP, Paris Cité University, Paris, France., Huynh T; Department of Hematology and Immunology, Saint-Louis Hospital, AP-HP, Paris Cité University, Paris, France., Sebert M; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France.; Department of Hematology and Immunology, Saint-Louis Hospital, AP-HP, Paris Cité University, Paris, France., Adès L; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France.; Department of Hematology and Immunology, Saint-Louis Hospital, AP-HP, Paris Cité University, Paris, France., Raffoux E; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France.; Department of Hematology and Immunology, Saint-Louis Hospital, AP-HP, Paris Cité University, Paris, France., Fenouille N; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France., Itzykson R; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France.; Department of Hematology and Immunology, Saint-Louis Hospital, AP-HP, Paris Cité University, Paris, France., Lobry C; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France., Benajiba L; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France.; Clinical Investigation Center, Saint-Louis Hospital, AP-HP, Paris Cité University, Paris, France., Forget A; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Martin AR; IBMM, University of Montpellier, CNRS, ENSCM, Montpellier, France. anthony.martin@umontpellier.fr., Wood KC; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA. kris.wood@duke.edu., Puissant A; INSERM UMR 944, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France. alexandre.puissant@inserm.fr.

المصدر: Nature cancer [Nat Cancer] 2024 Jul; Vol. 5 (7), pp. 1082-1101. Date of Electronic Publication: 2024 May 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/metabolism , Leukemia, Myeloid, Acute*/genetics , Signal Transduction*/drug effects , Proto-Oncogene Proteins c-akt*/metabolism , Class Ib Phosphatidylinositol 3-Kinase*/metabolism , Class Ib Phosphatidylinositol 3-Kinase*/genetics, Humans ; Animals ; Mice ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Sulfonamides/pharmacology ; Sulfonamides/therapeutic use ; Proteolysis/drug effects ; Female ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use

المؤلفون: Luo Q; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Raulston EG; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Prado MA; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Wu X; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Gritsman K; Department of Medical Oncology, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA., Whalen KS; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Yan K; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Booth CAG; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Xu R; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., van Galen P; Division of Hematology, Brigham and Women's Hospital, Boston, MA, USA., Doench JG; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shimony S; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Department of Hematology, Rabin Medical Center, Tel Aviv Faculty of Medicine, Tel Aviv, Israel., Long HW; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA., Neuberg DS; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Lane AA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. andrew_lane@dfci.harvard.edu.

المصدر: Nature [Nature] 2024 Jun; Vol. 630 (8015), pp. 198-205. Date of Electronic Publication: 2024 May 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Class Ib Phosphatidylinositol 3-Kinase*/genetics , Class Ib Phosphatidylinositol 3-Kinase*/metabolism , Leukemia*/drug therapy , Leukemia*/enzymology , Leukemia*/genetics , Leukemia*/metabolism , p21-Activated Kinases*/antagonists & inhibitors , p21-Activated Kinases*/metabolism , Signal Transduction*, Animals ; Humans ; Mice ; Cell Line ; Cytarabine/pharmacology ; Cytarabine/therapeutic use ; Mitochondria/drug effects ; Mitochondria/metabolism ; Oxidative Phosphorylation/drug effects ; Phosphorylation ; Xenograft Model Antitumor Assays

المؤلفون: Karvonen H; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Vasan N; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA; Division of Hematology and Oncology, Department of Medicine, Columbia University, New York, NY, USA. Electronic address: nv2379@cumc.columbia.edu.

المصدر: Cell chemical biology [Cell Chem Biol] 2024 Jul 18; Vol. 31 (7), pp. 1244-1246.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Class Ib Phosphatidylinositol 3-Kinase*/metabolism , Leukemia*/drug therapy , Leukemia*/pathology , Leukemia*/metabolism , Phosphoinositide-3 Kinase Inhibitors*/pharmacology , Phosphoinositide-3 Kinase Inhibitors*/chemistry , Phosphoinositide-3 Kinase Inhibitors*/therapeutic use, Humans ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry

المؤلفون: Shepard RM; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Ghebremedhin A; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Pratumchai I; Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA., Robinson SR; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.; New England Regional Biosafety Laboratory, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA., Betts C; Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USA., Hu J; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Sasik R; Center for Computational Biology and Bioinformatics, University of California, San Diego, La Jolla, CA 92093, USA., Fisch KM; Center for Computational Biology and Bioinformatics, University of California, San Diego, La Jolla, CA 92093, USA.; Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Zak J; Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA., Chen H; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Paradise M; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Rivera J; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Amjad M; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Uchiyama S; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Seo H; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Campos AD; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Dayao DA; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA., Tzipori S; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA., Piedra-Mora C; Department of Comparative Pathobiology, Section of Pathology, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA., Das S; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Hasteh F; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Russo H; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Sun X; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Xu L; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., E Alexander LC; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Duran JM; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Odish M; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Pretorius V; Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA., Kirchberger NC; Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USA., Chin SM; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Von Schalscha T; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Cheresh D; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Morrey JD; Institute for Antiviral Research, Animal, Dairy, and Veterinary Science, Utah State University, Logan, UT 84322, USA., Alargova R; Infinity Pharmaceuticals, Cambridge, MA 02138, USA., O'Connell B; Infinity Pharmaceuticals, Cambridge, MA 02138, USA., Martinot TA; Infinity Pharmaceuticals, Cambridge, MA 02138, USA., Patel SP; Department of Medicine/Medical Oncology, University of California, San Diego, La Jolla, CA 92093, USA., Nizet V; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Martinot AJ; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.; New England Regional Biosafety Laboratory, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.; Department of Comparative Pathobiology, Section of Pathology, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA., Coussens LM; Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97201, USA., Teijaro JR; Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA., Varner JA; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.

المصدر: Science translational medicine [Sci Transl Med] 2024 Jul 03; Vol. 16 (754), pp. eadi6887. Date of Electronic Publication: 2024 Jul 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Class Ib Phosphatidylinositol 3-Kinase*/metabolism , COVID-19*/pathology , Inflammation*/pathology , SARS-CoV-2*/physiology, Animals ; Humans ; Mice ; Capillary Permeability/drug effects ; COVID-19 Drug Treatment ; Cytokine Release Syndrome/drug therapy ; Lung/pathology ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Mice, Inbred C57BL ; Phosphoinositide-3 Kinase Inhibitors/pharmacology ; Phosphoinositide-3 Kinase Inhibitors/therapeutic use ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/pathology

المؤلفون: Gu H; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA., Chen C; Hongqiao International Institute of Medicine, Shanghai Tongren Hospital, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Hou ZS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA., He XD; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA., Xie S; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA., Ni J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA., Qian C; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA., Cheng X; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA., Jiang T; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA., Yang C; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA., Roberts TM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA., Zheng J; Hongqiao International Institute of Medicine, Shanghai Tongren Hospital, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Varner JA; Moores Cancer Center, University of California, San Diego, La Jolla, CA.; Department of Pathology and Medicine, University of California, San Diego, La Jolla, CA., Armstrong SA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA., Zhao JJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA.

المصدر: Blood [Blood] 2024 May 09; Vol. 143 (19), pp. 1965-1979.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

مواضيع طبية MeSH: Class Ib Phosphatidylinositol 3-Kinase*/metabolism , Class Ib Phosphatidylinositol 3-Kinase*/genetics , Leukemia, Myeloid, Acute*/pathology , Leukemia, Myeloid, Acute*/metabolism , Leukemia, Myeloid, Acute*/genetics , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Pentose Phosphate Pathway*/genetics, Animals ; Humans ; Mice ; Cell Self Renewal ; NF-E2-Related Factor 2/metabolism ; NF-E2-Related Factor 2/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Signal Transduction