المؤلفون: Hai-Yong Chen, Yibin Feng, Cheng Zhang, Ning Wang, Sha Li, Guoyi Tang

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)

مصطلحات موضوعية: LOX1, lectin-like oxidized LDL receptor 1, BUN, blood urea nitrogen, TGBM, thickness of glomerular basement membrane, NQO1, NAD(P)H:quinone oxidoreductase 1, STAT, signal transducers and activators of transcription, N/O, not observed, p62, sequestosome 1 protein, p-IRS1, phospho-IRS1, Review, NOX-4, nicotinamide adenine dinucleotide phosphate-oxidase-4, OCP, oxidative carbonyl protein, Traditional Chinese medicine, AGEs, advanced glycation end-products, N/A, not applicable, TRAF5, tumor-necrosis factor receptor-associated factor 5, Health problems, 0302 clinical medicine, ESRD, end-stage renal disease, LDL, low-density lipoprotein, BMP-7, bone morphogenetic protein-7, TGFβR-I/II, TGF-β receptor I/II, Medicine, P70S6K, 70-kDa ribosomal protein S6 kinase, General Pharmacology, Toxicology and Pharmaceutics, SOCS, suppressor of cytokine signaling proteins, HO-1, heme oxygenase-1, 0303 health sciences, TG, triglyceride, BW, body weight, HDL-C, high density lipoprotein-cholesterol, RASI, renin-angiotensin system inhibitor, ATK, protein kinase B, TBARS, thiobarbituric acid-reactive substance, BCL-XL, B-cell lymphoma-extra large, Gαq, Gq protein alpha subunit, GCK, glucokinase, PI3K, phosphatidylinositol 3 kinases, Systematic review, TLR-2/4, toll-like receptor 2/4, IR, insulin receptor, PERK, protein kinase RNA-like eukaryotic initiation factor 2A kinase, 030220 oncology & carcinogenesis, CRP, C-reactive protein, IRS, insulin receptor substrate, AM, mesangial area, JAK, Janus kinase, FBG, fasting blood glucose, ETAR, endothelium A receptor, LDL-C, low density lipoprotein-cholesterol, CD2AP, CD2-associated protein, eIF2α, eukaryotic initiation factor 2α, RM1-950, mTOR, mammalian target of rapamycin, CHOP, C/EBP homologous protein, STZ, streptozotocin, 03 medical and health sciences, ADE, adverse event, PKC, protein kinase C, LC3, microtubule-associated protein light chain 3, ORP150, 150-kDa oxygen-regulated protein, PGE2, prostaglandin E2, IL-1β/6, interleukin 1β/6, Diabetic kidney disease, IGF-1, insulin-like growth factor 1, EP, E-prostanoid receptor, FN, fibronectin, eGFR, estimated GFR, MDA, malondialdehyde, Chinese medicine, MMP-2, matrix metallopeptidase 2, XBP-1, spliced X box-binding protein 1, TGF-β, tumor growth factor β, GRB 10, growth factor receptor-bound protein 10, medicine.disease, Clinical trial, GRP78, glucose-regulated protein 78, UP, urinary protein, IGF-1R, insulin-like growth factor 1 receptor, ACEI, angiotensin-converting enzyme inhibitor, BCL-2, B-cell lymphoma 2, EMT, epithelial-to-mesenchymal transition, MAPK, mitogen-activated protein kinase, MYD88, myeloid differentiation primary response 88, PBG, postprandial blood glucose, RCT, randomized clinical trial, N/R, not reported, COL-I/IV, collagen I/IV, PINK1, PTEN-induced putative kinase 1, UACR, urinary albumin to creatinine ratio, C, control group, Diabetic nephropathy, GPX, glutathione peroxidase, ICAM-1, intercellular adhesion molecule-1, Bioinformatics, VCAM-1, vascular cell adhesion molecule-1, AMPKα, adenosine monophosphate-activated protein kinase α, DM, diabetes mellitus, TFEB, transcription factor EB, TNF-α, tumor necrosis factor α, Molecular target, IKK-β, IκB kinase β, Signaling pathway, GLUT4, glucose transporter type 4, BAX, BCL-2-associated X protein, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, PARP, poly(ADP-Ribose) polymerase, SMURF-2, SMAD ubiquitination regulatory factor 2, AREs, antioxidant response elements, MD, mean difference, SMAD, small mothers against decapentaplegic, MCP-1, monocyte chemotactic protein-1, VEGF, vascular endothelial growth factor, cAMP, cyclic adenosine monophosphate, ARB, angiotensin receptor blocker, PAI-1, plasminogen activator inhibitor-1, SMD, standard mean difference, JNK, c-Jun N-terminal kinase, NRF2, nuclear factor erythroid 2-related factor 2, IκB-α, inhibitory protein α, Herbal medicine, TCM, traditional Chinese medicine, DG, glomerular diameter, GSK-3, glycogen synthase kinase 3, SIRT1, sirtuin 1, D, duration, HbA1c, glycosylated hemoglobin, WMD, weight mean difference, CTGF, connective tissue growth factor, ER, endoplasmic reticulum, DN, diabetic nephropathy, ROS, reactive oxygen species, CCR, creatinine clearance rate, SOD, superoxide dismutase, Diabetes mellitus, PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1α, ET-1, endothelin-1, UMA, urinary microalbumin, SCr, serum creatinine, IRE-1α, inositol-requiring enzyme-1α, 030304 developmental biology, TII, tubulointerstitial injury index, RAGE, receptors of AGE, business.industry, GFR, glomerular filtration rate, PTEN, phosphatase and tensin homolog, CI, confidence interval, TC, total cholesterol, SD-rat, Sprague–Dawley rat, UAER, urinary albumin excretion rate, DKD, diabetic kidney disease, T, treatment group, Molecular targets, Therapeutics. Pharmacology, α-SMA, α smooth muscle actin, SD, standard deviation, business, DAG, diacylglycerol, GCLC, glutamate-cysteine ligase catalytic subunit, Kidney disease

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517
https://doi.org/10.1016/j.apsb.2020.12.020

المؤلفون: Bruce D. Hammock, A. F. S. Mello, Natalie J. Török, Fawaz G. Haj, Jun Yang, Ming-Fo Hsu, Bryan Chu, Christophe Morisseau, Jeff Cheng, Shinichiro Koike

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 815-830 (2021)
Cellular and molecular gastroenterology and hepatology, vol 11, iss 3
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: Steatosis, Soluble Epoxide Hydrolase, Injury, Pharmacology, Alcohol-Associated Liver Disease, Transgenic, Alcohol Use and Health, Substance Misuse, Mice, 0302 clinical medicine, Hepatocyte, Aetiology, Original Research, chemistry.chemical_classification, Epoxide Hydrolases, EpETE, epoxyeicosatetraenoic acid, LC, liquid chromatography, Liver Diseases, Liver Disease, Gastroenterology, EpDPE, epoxydocosapentaenoic acid, Alcoholic, DiHDPE, dihydroxydocosapentaenoic acid, EpODE, epoxyoctadecadienoic acid, cardiovascular system, CYP, cytochrome P450, 030211 gastroenterology & hepatology, Epoxide hydrolase 2, PPARγ, peroxisome proliferator-activated receptor-γ, SOD-1, superoxide dismutase-1, eIF2α, eukaryotic initiation factor 2α, ADH, alcohol dehydrogenase, 03 medical and health sciences, 4-HNE, 4-hydroxynonenal, Liver Diseases, Alcoholic, EpFA, epoxy fatty acid, IRE1α, inositol-requiring enzyme-1α, MS, mass spectroscopy, Ethanol, Animal, medicine.disease, sEH, soluble epoxide hydrolase, 030104 developmental biology, ALDH, aldehyde dehydrogenase, chemistry, EpETrE, epoxyeicosatrienoic acid, Drug Evaluation, Digestive Diseases, 0301 basic medicine, TNFα, tumor necrosis factor-α, NOX, nicotinamide adenine dinucleotide phosphate oxidase, Drug Evaluation, Preclinical, DMSO, dimethyl sulfoxide, medicine.disease_cause, Oral and gastrointestinal, Liver disease, Piperidines, Pharmacologic Inhibition, 2.1 Biological and endogenous factors, IL1β, interleukin 1β, eNOS, endothelial nitric oxide synthase, Preclinical, mRNA, messenger RNA, Alcoholism, medicine.anatomical_structure, Liver, Female, medicine.symptom, Chronic Liver Disease and Cirrhosis, NF-κB, nuclear factor-κB, Inflammation, Mice, Transgenic, Stress, ER, endoplasmic reticulum, ROS, reactive oxygen species, ALT, alanine aminotransferase, HETE, hydroxyeicosatetraenoic acid, ALD, alcohol-associated liver disease, medicine, Animals, lcsh:RC799-869, Nutrition, EETs, epoxyeicosatrienoic acids, TPPU, 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea, Hepatology, business.industry, PERK, protein kinase R-like ER kinase, Phenylurea Compounds, Lipid signaling, Disease Models, Animal, Enzyme, Good Health and Well Being, Gene Expression Regulation, Disease Models, lcsh:Diseases of the digestive system. Gastroenterology, business, Oxidative stress

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a37aec2ab2970ef64d585a65ffea8d3
http://www.sciencedirect.com/science/article/pii/S2352345X20301624

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المؤلفون: Weiping Yang, Yongjian Li, Jie Kuang, Haiyan Huang, Min-Min Shi, Yunyang Chen, Jiqi Yan

المصدر: International Journal of Molecular Medicine

مصطلحات موضوعية: 0301 basic medicine, Programmed cell death, autophagy, Cell Survival, Apoptosis, Biology, Protein Serine-Threonine Kinases, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, Caffeine, Endoribonucleases, Genetics, Hepatic Stellate Cells, Humans, Viability assay, Endoplasmic Reticulum Chaperone BiP, liver fibrosis, inositol-requiring enzyme-1α, Endoplasmic reticulum, Autophagy, General Medicine, Articles, Endoplasmic Reticulum Stress, Cell biology, 030104 developmental biology, chemistry, Unfolded protein response, Hepatic stellate cell, Cancer research, Calcium, Biomarkers, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cee5d0c7163816f6b096f337a60884b
https://pubmed.ncbi.nlm.nih.gov/28949381

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المؤلفون: Takao Iwawaki, Daisuke Oikawa, Ryoko Akai

المصدر: FEBS Letters. (5):1066-1070

مصطلحات موضوعية: Pregnancy-specific glycoproteins, Chromatin Immunoprecipitation, XBP1, RNase P, Placenta, Biophysics, Regulatory Factor X Transcription Factors, X-box binding protein 1, Biology, Pregnancy Proteins, Protein Serine-Threonine Kinases, Biochemistry, Inositol requiring enzyme-1α, Cell Line, Mice, Structural Biology, Pregnancy, Endoribonucleases, Genetics, medicine, Animals, Molecular Biology, Transcription factor, Gene, Regulation of gene expression, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Cell Biology, X-Box Binding Protein 1, Transmembrane protein, Cell biology, Carcinoembryonic Antigen, DNA-Binding Proteins, Ceacam, medicine.anatomical_structure, Gene Expression Regulation, Female, Cell Adhesion Molecules, Signal Transduction, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12fcdf3da15caafd518df1903b60cc4

المؤلفون: Wang Q; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Liver Transplantation, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, China.; School of Medicine, Southeast University, Nanjing, China., Bu Q; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Liver Transplantation, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, China., Liu M; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Liver Transplantation, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, China., Zhang R; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Liver Transplantation, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, China., Gu J; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Liver Transplantation, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, China., Li L; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Liver Transplantation, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, China., Zhou J; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Liver Transplantation, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, China., Liang Y; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Liver Transplantation, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, China., Su W; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Liver Transplantation, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, China., Liu Z; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Liver Transplantation, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, China., Wang M; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Liver Transplantation, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, China., Lian Z; Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China., Lu L; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Liver Transplantation, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, China.; School of Medicine, Southeast University, Nanjing, China.; Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China., Zhou H; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Liver Transplantation, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, China.

المصدر: JHEP reports : innovation in hepatology [JHEP Rep] 2022 Aug 18; Vol. 4 (11), pp. 100555. Date of Electronic Publication: 2022 Aug 18 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101761237 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-5559 (Electronic) Linking ISSN: 25895559 NLM ISO Abbreviation: JHEP Rep Subsets: PubMed not MEDLINE

المؤلفون: Tang G; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR 999077, China., Li S; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR 999077, China., Zhang C; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR 999077, China., Chen H; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR 999077, China., Wang N; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR 999077, China., Feng Y; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR 999077, China.

المصدر: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Sep; Vol. 11 (9), pp. 2749-2767. Date of Electronic Publication: 2021 Feb 02.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101600560 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2211-3835 (Print) Linking ISSN: 22113835 NLM ISO Abbreviation: Acta Pharm Sin B Subsets: PubMed not MEDLINE