المؤلفون: Ke F; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing., Wang N; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing., Zhang X; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing., Liu R; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing., Ren T; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing., Ke J; Department of Pharmacy., Yang J; Institute of Clinical Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan, China., Yan H; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing., Ma J; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing.

المصدر: Anti-cancer drugs [Anticancer Drugs] 2024 Aug 01; Vol. 35 (7), pp. 615-622. Date of Electronic Publication: 2024 May 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9100823 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5741 (Electronic) Linking ISSN: 09594973 NLM ISO Abbreviation: Anticancer Drugs Subsets: MEDLINE

مواضيع طبية MeSH: Retinoblastoma*/drug therapy , Retinoblastoma*/pathology , Nitriles*/pharmacology , Pyrimidines*/pharmacology , Vincristine*/pharmacology , Pyrazoles*/pharmacology , Janus Kinase 1*/antagonists & inhibitors , Janus Kinase 1*/metabolism , Drug Resistance, Neoplasm*/drug effects, Animals ; Humans ; Mice ; Janus Kinase 2/antagonists & inhibitors ; Janus Kinase 2/metabolism ; Janus Kinase Inhibitors/pharmacology ; Xenograft Model Antitumor Assays ; Cell Line, Tumor ; Retinal Neoplasms/drug therapy ; Retinal Neoplasms/pathology ; Drug Synergism ; Cell Proliferation/drug effects ; Antineoplastic Combined Chemotherapy Protocols/pharmacology

المؤلفون: Huang S; Shenzhen Chipscreen Biosciences Co., Ltd., Shenzhen, Guangdong 518057, China; Chengdu Chipscreen Pharmaceutical Ltd., Chengdu, Sichuan 610095, China., Yang Q; Shenzhen Chipscreen Biosciences Co., Ltd., Shenzhen, Guangdong 518057, China., Zhou Y; Shenzhen Chipscreen Biosciences Co., Ltd., Shenzhen, Guangdong 518057, China., Li L; Shenzhen Chipscreen Biosciences Co., Ltd., Shenzhen, Guangdong 518057, China., Shan S; Shenzhen Chipscreen Biosciences Co., Ltd., Shenzhen, Guangdong 518057, China. Electronic address: shansong@chipscreen.com.

المصدر: Transplant immunology [Transpl Immunol] 2024 Aug; Vol. 85, pp. 102075. Date of Electronic Publication: 2024 Jun 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9309923 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5492 (Electronic) Linking ISSN: 09663274 NLM ISO Abbreviation: Transpl Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Bone Marrow Transplantation* , Graft vs Host Disease*/drug therapy , Janus Kinase 3*/antagonists & inhibitors , Janus Kinase 3*/metabolism, Animals ; Humans ; Mice ; Acute Disease ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/drug effects ; Cells, Cultured ; Disease Models, Animal ; Interferon-gamma/metabolism ; Janus Kinase Inhibitors/therapeutic use ; Janus Kinase Inhibitors/pharmacology ; Lymphocyte Culture Test, Mixed ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Nitriles/therapeutic use ; Pyrimidines/therapeutic use ; Pyrimidines/pharmacology ; Transplantation, Homologous ; Tumor Necrosis Factor-alpha/metabolism

المؤلفون: Gobbo F; Department of Veterinary Medical Sciences, Alma Mater Studiorum University, 40126 Bologna, Italy., Martelli F; National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, 00161 Rome, Italy., Di Virgilio A; National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, 00161 Rome, Italy., Demaria E; Department of Medical and Surgical Sciences, Alma Mater Studiorum University, 40126 Bologna, Italy., Sarli G; Department of Veterinary Medical Sciences, Alma Mater Studiorum University, 40126 Bologna, Italy., Migliaccio AR; Altius Institute for Biomedical Sciences, Seattle, WA 98121, USA.; Institute of Nanotechnology, National Research Council (Cnr-NANOTEC), c/o Campus Ecotekne, 73100 Lecce, Italy.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 13; Vol. 25 (14). Date of Electronic Publication: 2024 Jul 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Primary Myelofibrosis*/drug therapy , Primary Myelofibrosis*/metabolism , Primary Myelofibrosis*/pathology , Transforming Growth Factor beta*/metabolism , Janus Kinase 1*/antagonists & inhibitors , Janus Kinase 1*/metabolism , P-Selectin*/metabolism , Receptors, Interleukin-8B*/antagonists & inhibitors , Receptors, Interleukin-8B*/metabolism , Pyrimidines*/pharmacology , Pyrimidines*/therapeutic use, Animals ; Receptors, Interleukin-8A/antagonists & inhibitors ; Receptors, Interleukin-8A/metabolism ; Mice ; Janus Kinase 2/metabolism ; Janus Kinase 2/antagonists & inhibitors ; Nitriles/therapeutic use ; Nitriles/pharmacology ; Disease Models, Animal ; Drug Therapy, Combination ; GATA1 Transcription Factor/metabolism ; GATA1 Transcription Factor/genetics ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use ; Humans

المؤلفون: Wei Q; MD Anderson Cancer Center., Xu J; MD Anderson Cancer Center.

المصدر: Blood [Blood] 2024 Jul 11; Vol. 144 (2), pp. 238.

نوع المنشور: Case Reports; Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

مواضيع طبية MeSH: Hypereosinophilic Syndrome*/genetics , Hypereosinophilic Syndrome*/drug therapy , Hypereosinophilic Syndrome*/pathology , Janus Kinase 1*/genetics , Janus Kinase 1*/antagonists & inhibitors , Mutation* , Nitriles*/therapeutic use , Pyrazoles*/therapeutic use , Pyrimidines*/therapeutic use, Humans ; Janus Kinase 2/genetics ; Janus Kinase 2/antagonists & inhibitors ; Leukemia ; Protein Kinase Inhibitors/therapeutic use ; Female ; Aged

SCR Disease Name: Pdgfra-Associated Chronic Eosinophilic Leukemia

المؤلفون: Isfort S; Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Carl-Neuberg-Str. 1, Hannover, 30625, Germany., von Bubnoff N; Department of Hematology and Oncology, University Hospital Lübeck, Lübeck, Germany., Al-Ali HK; University Hospital Halle (Saale), Krukenberg Cancer Center Halle, Halle, Germany., Becker H; Department of Medicine I - Medical Center - University of Freiburg, Faculty of Medicine, University of , Freiburg, Freiburg, Germany., Götze T; Krankenhaus Nordwest, University Cancer Center (UCT), Frankfurt, Germany.; Institut für Klinische Krebsforschung IKF Am Krankenhaus Nordwest, Frankfurt, Germany., le Coutre P; Department of Hematology, Oncology and Stem Cell Transplantation, Charite Berlin, Germany., Griesshammer M; Mühlenkreisklinikum Minden, Universitätsklinikum Bochum, Minden, Germany., Moskwa C; Internal Medicine C, Hematology, Oncology, Stem Cell Transplantation and Palliative Care, University Medicine Greifswald, Greifswald, Germany., Wohn L; Institut für Klinische Krebsforschung IKF Am Krankenhaus Nordwest, Frankfurt, Germany., Riedel J; Institut für Klinische Krebsforschung IKF Am Krankenhaus Nordwest, Frankfurt, Germany., Palandri F; IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Istituto Di Ematologia 'Seràgnoli', Bologna, Italy., Manz K; Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Carl-Neuberg-Str. 1, Hannover, 30625, Germany.; Institute for Community Medicine - SHIP-KEF, Universitätsmedizin Greifswald, Greifswald, Germany., Hochhaus A; Klinik für Innere Medizin II, Abteilung Hämatologie und Internistische Onkologie, Universitätsklinikum Jena, Jena, Germany., Döhner K; Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany., Heidel FH; Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Carl-Neuberg-Str. 1, Hannover, 30625, Germany. heidel.florian@mh-hannover.de.; Internal Medicine C, Hematology, Oncology, Stem Cell Transplantation and Palliative Care, University Medicine Greifswald, Greifswald, Germany. heidel.florian@mh-hannover.de.

المصدر: Annals of hematology [Ann Hematol] 2024 Aug; Vol. 103 (8), pp. 2775-2785. Date of Electronic Publication: 2024 Jul 05.

نوع المنشور: Journal Article; Clinical Trial, Phase II; Clinical Trial Protocol; Multicenter Study

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE

مواضيع طبية MeSH: Primary Myelofibrosis*/drug therapy , Janus Kinase Inhibitors*/therapeutic use , Pyrrolidines*/therapeutic use , Nivolumab*/therapeutic use , Nivolumab*/administration & dosage, Humans ; Sulfonamides/therapeutic use ; Sulfonamides/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Female ; Male ; Middle Aged ; Aged ; Germany ; Myeloproliferative Disorders/drug therapy ; Nitriles/therapeutic use ; Janus Kinase 2/antagonists & inhibitors ; Janus Kinase 2/genetics ; Pyrimidines/therapeutic use ; Pyrazoles/therapeutic use ; Benzenesulfonamides

المؤلفون: Zhang T; Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China., Liu X; Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China., Zhang L; Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China., Jiang X; Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.

المصدر: Frontiers in immunology [Front Immunol] 2024 Jul 09; Vol. 15, pp. 1416004. Date of Electronic Publication: 2024 Jul 09 (Print Publication: 2024).

نوع المنشور: Case Reports; Review; Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Rosacea*/drug therapy , Heterocyclic Compounds, 3-Ring*/therapeutic use , Janus Kinase Inhibitors*/therapeutic use, Humans ; Female ; Middle Aged ; Pyrimidines/therapeutic use ; Pyrimidines/adverse effects ; Sulfonamides/therapeutic use ; Male ; Treatment Outcome ; Adult ; Janus Kinase 1/antagonists & inhibitors

المؤلفون: Hosomi S; Department of Gastroenterology, Graduate School of Medicine, Osaka Metropolitan University, Japan., Nishida Y; Department of Gastroenterology, Graduate School of Medicine, Osaka Metropolitan University, Japan., Fujiwara Y; Department of Gastroenterology, Graduate School of Medicine, Osaka Metropolitan University, Japan.

المصدر: Internal medicine (Tokyo, Japan) [Intern Med] 2024 Jul 01; Vol. 63 (13), pp. 1882-1885. Date of Electronic Publication: 2023 Nov 27.

نوع المنشور: Journal Article; Case Reports

بيانات الدورية: Publisher: Japanese Society of Internal Medicine Country of Publication: Japan NLM ID: 9204241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7235 (Electronic) Linking ISSN: 09182918 NLM ISO Abbreviation: Intern Med Subsets: MEDLINE

مواضيع طبية MeSH: Colitis, Ulcerative*/drug therapy , Heterocyclic Compounds, 3-Ring*/therapeutic use , Janus Kinase Inhibitors*/therapeutic use, Humans ; Male ; Female ; Middle Aged ; Adult ; Treatment Outcome ; Janus Kinase 1/antagonists & inhibitors ; Aged ; Remission Induction

المؤلفون: Hindmarch DC; Benaroya Research Institute, Translation Research Division, Seattle, WA, USA., Malashanka S; Virginia Mason Medical Center, Gastroenterology Division, Internal Medicine Department, Seattle, WA, USA., Shows DM; Benaroya Research Institute, Translation Research Division, Seattle, WA, USA., Clarke AS; Gilead Sciences, Research Division, Seattle, WA, USA., Lord JD; Benaroya Research Institute, Translation Research Division, Seattle, WA, USA.; Virginia Mason Medical Center, Gastroenterology Division, Internal Medicine Department, Seattle, WA, USA.

المصدر: Journal of Crohn's & colitis [J Crohns Colitis] 2024 Apr 23; Vol. 18 (4), pp. 628-637.

نوع المنشور: Journal Article; Comparative Study

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101318676 Publication Model: Print Cited Medium: Internet ISSN: 1876-4479 (Electronic) Linking ISSN: 18739946 NLM ISO Abbreviation: J Crohns Colitis Subsets: MEDLINE

مواضيع طبية MeSH: Janus Kinase Inhibitors*/pharmacology , Janus Kinase Inhibitors*/therapeutic use , Piperidines*/pharmacology , Piperidines*/therapeutic use , Pyrimidines*/pharmacology , Pyrimidines*/therapeutic use , Cytokines*/metabolism , Lymph Nodes*/pathology , Lymph Nodes*/drug effects , Pyrroles*/pharmacology , Pyrroles*/therapeutic use , Pyridines* , Triazoles*, Humans ; Crohn Disease/drug therapy ; Crohn Disease/pathology ; Signal Transduction/drug effects ; Pyrrolidines/pharmacology ; Pyrrolidines/therapeutic use ; Male ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/pathology ; Colitis, Ulcerative/immunology ; Adult ; Mesentery ; Female ; Janus Kinase 3/antagonists & inhibitors ; Janus Kinase 3/metabolism ; Heterocyclic Compounds, 3-Ring/pharmacology ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Middle Aged ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/pathology ; Quinazolinones/pharmacology ; Quinazolinones/therapeutic use ; Janus Kinase 1/antagonists & inhibitors ; Janus Kinase 1/metabolism ; Benzamides/pharmacology ; Benzamides/therapeutic use

المؤلفون: Zhang X; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, PR China., Wang W; The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Second Military Medical University (Naval Medical University), 325 Guohe Road, Shanghai 200433, PR China., Dong G; The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Second Military Medical University (Naval Medical University), 325 Guohe Road, Shanghai 200433, PR China., Song Y; School of Pharmaceutical Sciences, Hainan University, Haikou 570228, PR China., Zhai X; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: zhaixin_syphu@126.com., Sheng C; The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Second Military Medical University (Naval Medical University), 325 Guohe Road, Shanghai 200433, PR China. Electronic address: shengcq@smmu.edu.cn.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Sep 01; Vol. 109, pp. 129838. Date of Electronic Publication: 2024 Jun 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Janus Kinase 1*/antagonists & inhibitors , Janus Kinase 1*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Proteolysis*/drug effects , Cell Proliferation*/drug effects, Humans ; Structure-Activity Relationship ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Drug Discovery ; Molecular Structure ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Janus Kinase 2/antagonists & inhibitors ; Janus Kinase 2/metabolism ; Proteasome Endopeptidase Complex/metabolism

المؤلفون: Amaral JL; Federal University of Piauí, Bom Jesus, Piauí, Brazil, CEP 64.900-000. jacksoncesarc@gmail.com.; Department of Physics, Federal University of Ceará, Fortaleza, Ceará, Brazil, CEP 60.440-554., Lucredi NC; Department of Biochemistry, State University of Maringá, Maringá, Paraná, Brazil, CEP 87.020-900., França VLB; Department of Physics, Federal University of Ceará, Fortaleza, Ceará, Brazil, CEP 60.440-554., Santos SJM; Federal Institute of Education, Science, and Technology of Rio Grande do Sul, Feliz, Rio Grande do Sul, Brazil, CEP 95770-000., Maia FF Jr; Department of Natural Sciences, Mathematics, and Statistics, Federal Rural University of the Semi-Arid Region, Mossoró, RN, Brazil, 59625-900., Morais PA; Federal Institute of Education, Science and Technology of Ceará, Horizonte, Ceará, Brazil, CEP 62884-105., Souza PFN; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil, CEP 60.440-554., Comar JF; Department of Biochemistry, State University of Maringá, Maringá, Paraná, Brazil, CEP 87.020-900., Freire VN; Department of Physics, Federal University of Ceará, Fortaleza, Ceará, Brazil, CEP 60.440-554.

المصدر: Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2024 May 01; Vol. 26 (17), pp. 13420-13431. Date of Electronic Publication: 2024 May 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 100888160 Publication Model: Electronic Cited Medium: Internet ISSN: 1463-9084 (Electronic) Linking ISSN: 14639076 NLM ISO Abbreviation: Phys Chem Chem Phys Subsets: MEDLINE

مواضيع طبية MeSH: Niacinamide*/*analogs & derivatives, Pyrimidines*/chemistry , Pyrimidines*/pharmacology , Piperidines*/chemistry , Piperidines*/pharmacology , Piperidines*/therapeutic use , Niacinamide*/chemistry , Janus Kinase 1*/antagonists & inhibitors , Janus Kinase 1*/metabolism , Janus Kinase 1*/chemistry, Adamantane/*analogs & derivatives, Humans ; Quantum Theory ; Autoimmune Diseases/drug therapy ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Hydrogen Bonding ; Janus Kinase Inhibitors/chemistry ; Janus Kinase Inhibitors/therapeutic use ; Janus Kinase Inhibitors/pharmacology ; Adamantane/chemistry ; Pyrroles/chemistry ; Pyrroles/pharmacology ; Molecular Docking Simulation